2021年6月
Development and chemical properties of retinal prostheses using photoelectric dyes coupled to polyethylene films with various anions to achieve high durability
POLYMER JOURNAL
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- ,
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- 巻
- 53
- 号
- 6
- 開始ページ
- 719
- 終了ページ
- 729
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41428-021-00468-0
- 出版者・発行元
- SPRINGERNATURE
Photoelectric dyes, which absorb light and generate electric potential, have been shown to stimulate retinal neurons. Therefore, in the present work, a photoelectric dye was used to develop a retinal prosthesis to restore vision loss due to diseases, such as retinitis pigmentosa. The retinal prosthesis, referred to as a dye-coupled film, was prepared by chemically coupling the dyes to a polyethylene film surface. However, the amount of coupled dye decreased during an implantation test in a monkey's eye. The dye consisted of a cation with photoresponsivity and Br-. Because thermal stability can be improved by anion exchange, we expected anion exchange to lead to stabilization of the chemical structure, resulting in improvement of the long-term durability of a retinal prosthesis. Therefore, the effects of exchanging Br- anions for PF6-, BF4-, and bis(trifluoromethanesulfonyl)imide (TFSI-) anions on the durability were investigated. The long-term durability of the dye-coupled films was found to be strongly related to the thermal stability of the photoelectric dye. The long-term durability of the dye-coupled film-PF6- and dye-coupled film-TFSI- improved by 637 and 215%, respectively, compared with that of the dye-coupled film-Br-.
- リンク情報
- ID情報
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- DOI : 10.1038/s41428-021-00468-0
- ISSN : 0032-3896
- eISSN : 1349-0540
- Web of Science ID : WOS:000620434700002