論文

査読有り 責任著者
2021年6月

Development and chemical properties of retinal prostheses using photoelectric dyes coupled to polyethylene films with various anions to achieve high durability

POLYMER JOURNAL
  • Koichiro Yamashita
  • ,
  • Tenu Tanaka
  • ,
  • Toshihiko Matsuo
  • ,
  • Tetsuya Uchida

53
6
開始ページ
719
終了ページ
729
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41428-021-00468-0
出版者・発行元
SPRINGERNATURE

Photoelectric dyes, which absorb light and generate electric potential, have been shown to stimulate retinal neurons. Therefore, in the present work, a photoelectric dye was used to develop a retinal prosthesis to restore vision loss due to diseases, such as retinitis pigmentosa. The retinal prosthesis, referred to as a dye-coupled film, was prepared by chemically coupling the dyes to a polyethylene film surface. However, the amount of coupled dye decreased during an implantation test in a monkey's eye. The dye consisted of a cation with photoresponsivity and Br-. Because thermal stability can be improved by anion exchange, we expected anion exchange to lead to stabilization of the chemical structure, resulting in improvement of the long-term durability of a retinal prosthesis. Therefore, the effects of exchanging Br- anions for PF6-, BF4-, and bis(trifluoromethanesulfonyl)imide (TFSI-) anions on the durability were investigated. The long-term durability of the dye-coupled films was found to be strongly related to the thermal stability of the photoelectric dye. The long-term durability of the dye-coupled film-PF6- and dye-coupled film-TFSI- improved by 637 and 215%, respectively, compared with that of the dye-coupled film-Br-.

リンク情報
DOI
https://doi.org/10.1038/s41428-021-00468-0
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000620434700002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/s41428-021-00468-0
  • ISSN : 0032-3896
  • eISSN : 1349-0540
  • Web of Science ID : WOS:000620434700002

エクスポート
BibTeX RIS