2018年10月
Cathepsin K inhibitor causes changes in crystallinity and crystal structure of newly-formed mandibular bone in rats
British Journal of Oral and Maxillofacial Surgery
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- 巻
- 56
- 号
- 8
- 開始ページ
- 732
- 終了ページ
- 738
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bjoms.2018.08.003
- 出版者・発行元
- Elsevier BV
Cathepsin K inhibitors are new drugs with the potential for the treatment of osteoporosis because they sustain bony remodelling better than bone resorption inhibitors such as bisphosphonates. The treatment of osteoporosis with inhibitors of bony resorption is associated with osteonecrosis of the jaw, as the deterioration in bony quality that they induce is thought to be one of its causes. The quality of bone is delineated by structural and material characteristics (which include the degree and quality of mineralisation, and depends on the content of proteoglycan and the structural integrity of the bony collagen).1,2 Animal and clinical studies have shown that cathepsin K inhibitors improve the mineral density and structural characteristics of bone, but their effect on the rest remains unknown. We therefore hypothesised that these inhibitors will affect the material characteristics of newly-formed mandibular bone. To verify our hypothesis, we used Raman microspectroscopy to examine such bone in rats that were given a cathepsin K inhibitor, and found unusual crystallinity and an increased substitution of carbonate (CO32-) in its crystal structure.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bjoms.2018.08.003
- ISSN : 0266-4356
- PubMed ID : 30131193