Tomoe Negishi

Profile Information

Affiliation: Associate Professor, Graduate School of Medicine ,Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University, Okayama University

Degree: 薬学博士(東京大学)
薬学修士(東京大学)

J-GLOBAL ID: 200901011659814927
researchmap Member ID: 1000202814

Research Interests

Research Areas

Research History

1996 - 2005

Faculty of Pharmaceutical Sciences, Okayama University
1996 - 2005

Associate Professor,Faculty of Pharmaceutical Sciences,Okayama University
2005

- 岡山大学医歯薬学総合研究科准教授
2005

- Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
1995 - 2000

Sanyo Gakuen Junior College
1991 - 1996

岡山女子短期大学非常勤講師
1986 - 1987

Faculty of Engineering, Okayama University
1986 - 1987

Research Associate,Faculty of Engineering,Okayama University
1985 - 1986

Faculty of Pharmaceutical Sciences, Okayama University
1985 - 1986

Research Associate,Faculty of Pharmaceutical Sciences,Okayama University
1978 - 1979

Faculty of Pharmaceutical Sciences, Okayama University
1978 - 1979

Research Associate,Faculty of Pharmaceutical Sciences,Okayama University

Education

- 1978

The University of Tokyo
- 1978

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
- 1973

Faculty of Medicine, Hiroshima University
- 1973

Faculty of Medicine, Hiroshima University

Committee Memberships

Awards

Misc.

120

Near ultraviolet radiation-mediated reaction between N-nitrosoproline and DNA: Isolation and identification of two new adducts, (R)- and (S)-8-(2-pyrrolidyl)-2 '-deoxyguanosine

Shuhei Aoyama, Kayoko Sano, Chiharu Asahi, Masaki Machida, Keinosuke Okamoto, Tomoe Negishi, Sachiko Kimura, Toshinori Suzuki, Tsutomu Hatano, Sakae Arimoto-Kobayashi

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 276(1) 1-7, Feb, 2014
Effects of oral administration of non-genotoxic hepato-hypertrophic compounds on metabolic potency of rat liver

Xing Fang, Tatsuo Nunoshiba, Midori Yoshida, Akiyoshi Nishikawa, Kiyomitsu Nemoto, Masakuni Degawa, Sakae Arimoto, Keinosuke Okamoto, Eizo Takahashi, Tomoe Negishi

Genes and Environment, 36(1) 1-9, 2014
Analysis of Carboxy Terminal Domain of Metalloprotease of Elastolytic Aeromonas hydrophila

Eizo Takahashi, Hidetomo Kobayashi, Hiroyasu Yamanaka, Mayu Nakanishi, Arisa Tateishi, Takemi Abe, Sakae Arimoto, Tomoe Negishi, Keinosuke Okamoto

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 36(7) 1174-1182, Jul, 2013
Distinct pathways for repairing mutagenic lesions induced by methylating and ethylating agents

Kentaro Taira, Satomi Kaneto, Kota Nakano, Shinji Watanabe, Eizo Takahashi, Sakae Arimoto, Keinosuke Okamoto, Roel M. Schaaper, Kazuo Negishi, Tomoe Negishi

MUTAGENESIS, 28(3) 341-350, May, 2013
Chemopreventive Effects of the Juice of Vitis coignetiae Pulliat on Two-Stage Mouse Skin Carcinogenesis

Sakae Arimoto-Kobayashi, Xiaomeng Zhang, Yuta Yuhara, Tomonori Kamiya, Tomoe Negishi, Goro Okamoto

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 65(3) 440-450, Apr, 2013
Effect of aflatoxin B1 on UDP-glucuronosyltransferase mRNA expression in HepG2 cells

Nobumitsu Hanioka, Yuko Nonaka, Keita Saito, Tomoe Negishi, Keinosuke Okamoto, Hiroyuki Kataoka, Shizuo Narimatsu

CHEMOSPHERE, 89(5) 526-529, Oct, 2012
Production and properties of lipase of Aeromonas sobria

Eizo Takahashi, Hidenobu Ito, Hidetomo Kobayashi, Hiroyasu Yamanaka, Yoshifumi Takeda, Gopinath Balakrish Nair, Sakae Arimoto, Tomoe Negishi, Keinosuke Okamoto

MICROBIOLOGY AND IMMUNOLOGY, 56(5) 295-307, May, 2012
Novel antimutagenic proteins in the edible mushroom Agrocybe cylindracea

Kasane Yoneda, Akiko Shiozawa, Aiko Kitahara, Eizo Takahashi, Sakae Arimoto, Keinosuke Okamoto, Tomoe Negishi

Genes and Environment, 34(1) 9-17, 2012
Exposure to cigarette smoke increases urate level and decreases glutathione level in larval Drosophila melanogaster

Masaru Fujiwara, Yuko Hamatake, Sakae Arimoto, Keinosuke Okamoto, Toshinori Suzuki, Tomoe Negishi

Genes and Environment, 33(3) 89-95, 2011
近紫外光（UVA）の生体影響 −ショウジョウバエを用いた研究-

根岸友惠

日本レーザー治療学会誌, 9 29, 2010
Hypersensitivity of a Urate-null Strain of Drosophila melanogaster to the Toxic Effects of Environmental Cigarette Smoke

Yuko Hamatake, Ayumi Morita, Yoko Yuma, Keinosuke Okamoto, Sakae Arimoto, Toshinori Suzuki, Hiroshi Kasai, Kazuaki Kawai, Tomoe Negishi

Genes and Environment, 31(2) 43-46, 2009
Influence of neighbouring base sequences on the mutagenesis induced by 7,8-dihydro-8-oxoguanine in yeast

Chin-Wei Yung, Yoji Okugawa, Chie Otsuka, Keinosuke Okamoto, Sakae Arimoto, David Loakes, Kazuo Negishi, Tomoe Negishi

MUTAGENESIS, 23(6) 509-513, Nov, 2008
Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency

Kentaro Taira, Shintaro Nakamura, Khota Nakano, Daisuke Maehara, Keinosuke Okamoto, Sakae Arimoto, David Loakes, Leroy Worth, Roel M. Schaaper, Kohji Seio …

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 640(1-2) 107-112, Apr, 2008
Kinetics of dCTP incorporation opposite to 7,8-dihydro-8-oxoguanine with different 5’ nearest neighbors by yeast polymerase eta

Yung, C.-W, Loakes, D, Arimoto, S, Negishi, K, Negishi, T

Nucleic Acids Symposium Series, 52 531-532, 2008
Increased levels of 8-hydroxy-2'-deoxyguanosine increase in Drosophila larval DNA after irradiation with 364 nm laser-light but not X-ray

Negishi, T, Kawai, K, Arakawa, R, Higashi, H, Nakamura, T, Watanabe, M, Kasai, H, Fujikawa, K

Photochem. Photobiol., 83 658-663, 2007
Enhancement of phase II enzyme activity by purpurin resulting in the suppression of MeIQx-DNA-adduct formation in mice

Eizo Takahashi, Sakae Arimoto, Keinosuke Okamoto, Tomoe Negishi

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 626(1-2) 128-134, Jan, 2007
Cleavage specificity of the serine protease of Aeromonas sobria, a member of the kexin family of subtilases

H Kobayashi, E Takahashi, K Oguma, Y Fujii, H Yamanaka, T Negishi, S Arimoto-Kobayashi, T Tsuji, K Okamoto

FEMS MICROBIOLOGY LETTERS, 256(1) 165-170, Mar, 2006
Evaluation of Oxidative Damage Induced by Natural Sunlight in Drosophila

Ritsuo Arakawa, Mie Terao, Hiroe Hayashi, Hiroshi Kasai, Tomoe Negishi

Genes and Environment, 28(4) 153-159, 2006
Oxidative DNA Damage Induced by 364-nm UVA Laser in Yeast Cells

Negishi Kazuo, Higashi Shoichi, Nakamura Takanori, Otsuka Chie, Watanabe Masakatsu, Negishi Tomoe

Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 28(2) 74-76, 2006
Involvemenr of the drug efflux protein TolC in mutagenicity induced by MNNG or Trp-P-2

Eizo Takahashi, Keinosuke Okamoto, Sakae Arimoto, Hiroyasu Yamanaka, Tomoe Negishi

Mutat. Res., 2006

Books and Other Publications

クロロフィリン(緑色色素)(共著)

がん予防食品の開発
ショウジョウバエを用いた検出法

変異原物質試験法
変異原検出法の種類

変異原物質試験法
発がん性、変異原物質などの運命-ベンチピレンなどの多環芳香族(共著)

「生体と有害・発がん物質」
Inhibitory activity of natural chlorophylls on the mutagenicity of 4-nitroguinoline 1-oxide and 3-amino-1-methyl-5H-pyrido-[4,3-b]indole in Drosophila(共著)

Food factors for Cancer Prevention
A list of mutagenic heterocyclic amines.(共著)

Mutagens in Food : Detection and Prevention
Inhibitory activity of natural chlorophylls on the mutagenicity of 4-nitroguinoline 1-oxide and 3-amino-1-methyl-5H-pyrido-[4,3-b]indole in Drosophila(共著)

Food factors for Cancer Prevention
A list of mutagenic heterocyclic amines.(共著)

Mutagens in Food : Detection and Prevention

Presentations

140

ショウジョウバエ尿酸欠損株を用いた突然変異の研究

日本薬学会第134年会, 2014
クロロエチル化抗がん剤による変異とその修復機構

日本環境変異第42回大会, 2013
Somatic mutation induced by LED-UVA irradiation

第6回アジア・オセアニア光生物学会, 2013
尿酸欠損が体細胞突然変異に及ぼす影響

日本薬学会第133年会, 2013
バイオフォトン測定による酸化・抗酸化活性の新たな測定方法の検討

第41回日本環境変異原学会, 2012
LED-UVAの遺伝毒性

第41回日本環境変異原学会, 2012
Phototoxicity of titanium dioxide nano-particles on Drosophila melanogaster

第３回アジア環境変異原学会, 2012
Somatic cell mutation induced by environmental cigarette smoke in Drosophila

第３回アジア環境変異原学会, 2012
ナノ粒子の光毒性

第51回日本薬学会中国四国支部大会, 2012
尿酸欠損が体細胞突然変異に及ぼす影響

第51回日本薬学会中国四国支部大会, 2012
タバコ副流煙の体細胞突然変異誘発活性

日本薬学会第132年会, 2012
バイオフォトン（生物微弱発光）測定による酸化・抗酸化活性の新たな測定方法の検討

日本薬学会第132年会, 2012
LED-UVAの遺伝毒性

日本光医学・光生物学会, 2012
ショウジョウバエミスマッチ修復欠損株の突然変異誘導脳と遺伝子不安定性について

第40回日本環境変異原学会, 2011
尿酸欠損が体細胞突然変異に及ぼす影響

第40回日本環境変異原学会, 2011
バイオフォトン（生物微弱発光）測定による酸化・抗酸化活性の新たな測定方法の検討

第33回日本光医学光生物会, 2011
Mutagenesis induced by ACNU (nimustine) and BCNU (carmustine), anticancer nitrosourea derivatives

第２回アジア環境変異原学会, 2010
Exposure to cigarette smoke decreases glutathione and increases uric acid and precursor levels in third instar drosophila larvae

第２回アジア環境変異原学会, 2010
近紫外光(UVA)の生体影響—ショウジョウバエを用いた研究–

第22回日本レーザー治療学会, 2010
アルキル化抗がん剤の変異特性

日本薬学会第130年会, 2010

Profile Information

Research Interests

Research Areas

Research History

Education

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Awards

Misc.

Books and Other Publications

Presentations

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