2018年3月1日
Structure–activity relationships of flavanones, flavanone glycosides, and flavones in anti-degranulation activity in rat basophilic leukemia RBL-2H3 cells
Journal of Natural Medicines
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- 巻
- 72
- 号
- 2
- 開始ページ
- 551
- 終了ページ
- 556
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1007/s11418-017-1169-3
- 出版者・発行元
- Springer Tokyo
The incidence of type I allergies, which are associated with mast cell degranulation and local inflammation, is increasing, and new treatments are needed. To date, structure–activity relationships of flavonoids in their degranulation-inhibiting activity have not been systematically characterized. In the current study, the degranulation-inhibiting activity of a series of flavonoids was evaluated. The following three observations were made: (1) the activity disappears when a sugar moiety is introduced into the A ring of the flavanone
(2) the activity depends on the number of hydroxyl groups on the B ring
(3) the activity is markedly enhanced when a double bond is introduced into the C ring. The information obtained in the current study may guide the development of a therapy for type I allergies.
(2) the activity depends on the number of hydroxyl groups on the B ring
(3) the activity is markedly enhanced when a double bond is introduced into the C ring. The information obtained in the current study may guide the development of a therapy for type I allergies.
- リンク情報
- ID情報
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- DOI : 10.1007/s11418-017-1169-3
- ISSN : 1861-0293
- ISSN : 1340-3443
- PubMed ID : 29349649
- SCOPUS ID : 85040765001