1992年1月8日
Decreased expression of neurotrophin-3 mRNA in the rat hippocampus following transient forebrain ischemia
Brain Research
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- 巻
- 569
- 号
- 1
- 開始ページ
- 177
- 終了ページ
- 180
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/0006-8993(92)90388-P
The expression profile of neurotrophin-3 (NT-3) mRNA in the rat hippocampus after forebrain ischemia was investigated by Northern blot and S1 nuclease protection analyses. The NT-3 transcripts in the hippocampus immediately decreased after ischemic insult, became undetectable within 3 h and remained at undetectable levels for at least 7 days. In contrast, the expression of c-fos and c-jun mRNA transiently increased both in the cerebral cortex and in the hippocampus. These results suggest that brain ischemia triggers dynamic changes in gene expression including a neurotrophic factor, which may cause functional and/or morphological changes of the neuronal network. © 1992.
- リンク情報
- ID情報
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- DOI : 10.1016/0006-8993(92)90388-P
- ISSN : 0006-8993
- PubMed ID : 1611477
- SCOPUS ID : 0026558376