Shigeki Shibahara

Profile Information

Affiliation: Tohoku University

Degree: PhD(Tohoku University)

J-GLOBAL ID: 200901006973074195
researchmap Member ID: 1000202829

External link: http://db.tohoku.ac.jp/whois/detail/71830cd57592ebd436686a7942c2402b.html

Research Interests

Research Areas

Research History

Apr, 2016 - Present

Tohoku University
Apr, 2016 - Mar, 2021

Tohoku University
Apr, 2016 - Mar, 2021

Faculty of Sports Science, Sendai University
Apr, 2004 - Mar, 2016

Professor, Department of Medical Sciences, Cell Biology, Molecular Biology and Applied Physiology, Tohoku University Graduate School of Medicine
Apr, 1988 - Mar, 2004

Professor, School of Medicine, Tohoku University
Apr, 1984 - Mar, 1988

Staff Scientist (Staff Sceintist), Friedrich Miescher Institute
Dec, 1981 - Mar, 1984

Faculty of Medicine, Kyoto University
Jul, 1979 - Dec, 1981

(Visiting Associate), Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH)
Apr, 1979 - Jun, 1979

(医員), 東北大学医学部附属病院

Education

Apr, 1975 - Mar, 1979

Tohoku University Graduate School
Apr, 1969 - Mar, 1975

School of Medicine, Tohoku University

Committee Memberships

Apr, 2016 - Mar, 2021

客員教授, 東北大学大学院医学系研究科
2003 - Dec, 2020

Editor-In-Chief, The Tohoku Journal of Experimental Medicine
Dec, 2016

名誉会員, 日本色素細胞学会
2006 - 2015

理事, 日本色素細胞学会
2000 - 2014

理事, International Federation of Pigment Cell Societies
1989 - 2013

評議員, 日本生化学会東北支部
2008 - 2011

会長, International Federation of Pigment Cell Societies
2005 - 2008

理事, International Federation of Pigment Cell Societies
2003 - 2006

会長, 日本色素細胞学会
2002 - 2003

編集委員, 日本生化学会
2001

評議員, 日本生化学会
1994 - 2000

理事, 日本色素細胞学会
1994 - 1996

理事, 日本生化学会
1989

評議員, 日本色素細胞学会

Awards

Major Papers

248

Molecular biological aspects of human L-histidine decarboxy lase.

Yamauchi, K, Mamune-Sato, R, Tanno, Y, Ohtsu, H, Takishima, T, Shibahara, S, Maeyama, K, Watanabe, T

Advances in Biosciences, 89 177-196, 1993 Peer-reviewed
Decreased expression of neurotrophin-3 mRNA in the rat hippocampus following transient forebrain ischemia

Atsushi Takeda, Hiroshi Onodera, Yasundo Yamasaki, Katsutoshi Furukawa, Kyuya Kogure, Masuo Obinata, Shigeki Shibahara

Brain Research, 569(1) 177-180, Jan 8, 1992 Peer-reviewedLast author
MOLECULAR-BASES OF TYROSINASE-NEGATIVE OCULOCUTANEOUS ALBINISM - A SINGLE BASE INSERTION OR A MISSENSE POINT MUTATION IN THE TYROSINASE GENE

Y TOMITA, A TAKEDA, J MATSUNAGA, S OKINAGA, S SHIBAHARA, H TAGAMI

PIGMENT CELL RESEARCH, Suppl 2 96-100, 1992 Peer-reviewed
IDENTIFICATION OF MUTATIONS IN THE PIGMENT CELL-SPECIFIC GENE LOCATED AT THE BROWN LOCUS IN MOUSE

S SHIBAHARA, Y TOMITA, M YOSHIZAWA, K SHIBATA, H TAGAMI

PIGMENT CELL RESEARCH, Suppl 2 90-95, 1992 Peer-reviewedInvitedLead authorCorresponding author
Mutations of the Tyrosinase Gene in Oculocutaneous Albinism

SHIGEKI SHIBAHARA

Pigment Cell Research, 5(5) 279-283, 1992 Peer-reviewedInvitedLead author
Cloning and sequence analysis of the tyrosinase gene from a patient with tyrosinase-positive oculocutaneous albinism

Jun Matsunaga, Atsushi Takeda, Yasushi Tomita, Masahiro Hara, Shigeki Shibahara, Hachiro Tagami

Journal of Dermatological Science, 3(3) 181-185, 1992 Peer-reviewed
Phylogeny of Regulatory Regions of Vertebrate Tyrosinase Genes

HIROAKI YAMAMOTO, TOSHIYUKI KUDO, NORIO MASUKO, HIROHITO MIURA, SHIGERU SATO, MIKA TANAKA, SATOSHI TANAKA, SAKAE TAKEUCHI, SHIGEKI SHIBAHARA, TAKUJI TAKEUCHI

Pigment Cell Research, 5(5) 284-294, 1992 Peer-reviewedInvited
BRAIN-TUMORS PREDOMINANTLY EXPRESS THE NEUROFIBROMATOSIS TYPE-1 GENE TRANSCRIPTS CONTAINING THE 63 BASE INSERT IN THE REGION CODING FOR GTPASE ACTIVATING PROTEIN-RELATED DOMAIN

Y SUZUKI, H SUZUKI, T KAYAMA, T YOSHIMOTO, S SHIBAHARA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 181(3) 955-961, Dec, 1991 Peer-reviewedLast authorCorresponding author
SEQUENTIAL ACTIVATION OF GENES FOR HEME PATHWAY ENZYMES DURING ERYTHROID-DIFFERENTIATION OF MOUSE FRIEND VIRUS-TRANSFORMED ERYTHROLEUKEMIA-CELLS

H FUJITA, M YAMAMOTO, T YAMAGAMI, N HAYASHI, TR BISHOP, H DEVERNEUIL, T YOSHINAGA, S SHIBAHARA, R MORIMOTO, S SASSA

BIOCHIMICA ET BIOPHYSICA ACTA, 1090(3) 311-316, Nov, 1991 Peer-reviewed
STRUCTURAL ORGANIZATION OF THE PIGMENT CELL-SPECIFIC GENE LOCATED AT THE BROWN LOCUS IN MOUSE - ITS PROMOTER ACTIVITY AND ALTERNATIVELY SPLICED TRANSCRIPTS

S SHIBAHARA, H TAGUCHI, RM MULLER, K SHIBATA, T COHEN, Y TOMITA, H TAGAMI

JOURNAL OF BIOLOGICAL CHEMISTRY, 266(24) 15895-15901, Aug, 1991 Peer-reviewedLead authorCorresponding author
NUCLEOTIDE-SEQUENCE OF THE PUTATIVE HUMAN TYROSINASE PSEUDOGENE

A TAKEDA, J MATSUNAGA, Y TOMITA, H TAGAMI, S SHIBAHARA

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 163(4) 295-297, Apr, 1991 Peer-reviewedLast authorCorresponding author
MOLECULAR-BASIS OF TYROSINASE-NEGATIVE OCULOCUTANEOUS ALBINISM - A SINGLE BASE MUTATION IN THE TYROSINASE GENE CAUSING ARGININE TO GLUTAMINE SUBSTITUTION AT POSITION-59

A TAKEDA, Y TOMITA, J MATSUNAGA, H TAGAMI, S SHIBAHARA

JOURNAL OF BIOLOGICAL CHEMISTRY, 265(29) 17792-17797, Oct, 1990 Peer-reviewedLast authorCorresponding author
A POINT MUTATION IN THE TYROSINASE GENE OF BALB/C ALBINO MOUSE CAUSING THE CYSTEINE-]SERINE SUBSTITUTION AT POSITION 85

S SHIBAHARA, S OKINAGA, Y TOMITA, A TAKEDA, H YAMAMOTO, M SATO, T TAKEUCHI

EUROPEAN JOURNAL OF BIOCHEMISTRY, 189(2) 455-461, Apr, 1990 Peer-reviewedLead authorCorresponding author

Misc.

104

A Message for Young Authors: The Past 100 Years and Future of the Tohoku Journal of Experimental Medicine.

Kazuhiro Takahashi, Shigeki Shibahara

The Tohoku journal of experimental medicine, 250(1) 1-3, Jan, 2020 Last author
100 Years of the Tohoku Journal of Experimental Medicine, and the Tohoku Medical Megabank Project in the Japanese New Era, Reiwa

Takahashi Kazuhiro, Shibahara Shigeki

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 248(1) 1-2, May, 2019
(Pro)renin receptor in melanoma

Ohba Koji, Suzuki Tamio, Takeda Kazuhisa, Shibahara Shigeki, Takahashi Kazuhiro

CANCER SCIENCE, 109 343, Jan, 2018
南山堂医学大辞典第20版

柴原茂樹

2015
ヒト赤芽球特異的5-アミノレブリン酸合成酵素遺伝子の新たな赤芽球特異的エンハンサーの同定

古山和道, 金子桐子, 藤原亨, 張替秀郎, 柴原茂樹

日本生化学会大会プログラム・講演要旨集, 85回 3T12-08, Dec, 2012
https://www.med.tohoku.ac.jp/d_report/report/index.html

柴原茂樹, 他多数

Mar, 2012 Invited
赤芽球特異的5-アミノレブリン酸合成酵素のカルボキシル末端は内因性抑制ドメインとして機能する

Senkottuvelan Kadirvel, 古山和道, 金子桐子, 張替秀郎, 柴原茂樹

日本生化学会大会プログラム・講演要旨集, 84回 2T10a-2, Sep, 2011
Pigment production for maintaining epidermal homeostasis: lessons from keratinocytes and melanocytes

S. Shibahara, K. Takeda

PIGMENT CELL & MELANOMA RESEARCH, 24(4) 760-760, Aug, 2011
The 2011 Tohoku Earthquake and Devastating Tsunami

Shigeki Shibahara

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 223(4) 305-307, Apr, 2011
網膜色素上皮発生メカニズムに関わるMitfの機能とその制御

西原大輔, 築地長治, 西原(川崎)あきは, 矢嶋伊知朗, 武田和久, 柴原茂樹, 仲村春和, 山本博章

日本動物学会大会予稿集, 81st, 2010
The Upcoming 90(th) Anniversary of the Tohoku Journal of Experimental Medicine

Shigeki Shibahara

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 218(3) 161-163, Jul, 2009
Mitf negatively regulates the cell proliferation through p27^Kip1 during the development of retinal pigment epithelium

西原大輔, 築地長治, 矢嶋伊知朗, 武田和久, 柴原茂樹, 山本博章

日本動物学会大会予稿集, 80th (Web), 2009
生体のホメオスタシスの維持におけるヘムの役割酸素恒常性の制御因子としてのヘム換気-灌流ミスマッチに関する新たな知見(Heme as a regulator of oxygen homeostasis: New insights for ventilation-perfusion mismatch)

柴原茂樹, 丸山芳夫, 武田和久, 吉澤美季, 古山和道

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 81回・31回 2S15-8, Nov, 2008
低酸素は肝癌由来細胞株におけるヘム生合成系酵素の発現を抑制する

パトリック・バルガス, 古山和道, 金子桐子, 柴原茂樹

生化学, 80(6) 592-592, Jun, 2008
Analysis of multiple function of Mitf in chick RPE development

Nagaharu Tsukiji, Kazuhisa Takeda, Shigeki Shibahara, Hiroaki Yamamoto

PIGMENT CELL & MELANOMA RESEARCH, 21(2) 307-307, Apr, 2008
Epidermal homeostasis revisited with heme catabolism: lessons from newborns

Shigeki Shibahara

PIGMENT CELL & MELANOMA RESEARCH, 21(2) 288-288, Apr, 2008
The functional expression of Heme Oxygenase-1 in normal human epidermis

I. Numata, S. Shibahara, S. Aiba

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128 S101-S101, Apr, 2008
Prostaglandin D2 represses the growth of human melanoma cells through a mechanism independent of prostaglandin D2 receptors

Kazuhisa Takeda, Naho Takahashi, Shigeki Shibahara

PIGMENT CELL & MELANOMA RESEARCH, 21(2) 314-314, Apr, 2008
低酸素刺激によるヘモグロビン合成誘導機構

金子桐子, 古山和道, 柴原茂樹

生化学, 4P-0419, 2008
化学物質による表皮ヘムオキシゲナーゼ1の発現解析

沼田郁子, 武田和久, 伊藤由美子, 齋藤るみ子, 古山和道, 柴原茂樹, 相場節也

Journal of Environmental Dermatology and Cutaneous Allergology, 1(Suppl.1) 126-126, Dec, 2007

Books and Other Publications

医学大辞典第20版

柴原茂樹 (Role: Joint author)

南山堂, 2015
色素細胞第２版基礎から臨床へ

慶應義塾大学出版会, 2015
The Pigmentary System. Physiology and Pathophysiology, 2e

Blackwell Publishing, 2006
Heme Oxygenase

Nova Science Publishers, 2005
Blood: Principles and Practice of Hematology, 2e

Lippincott Williams &Wilkins, 2003
Mechanisms of Suntannig

Martin Dunitz, 2002
一般医化学改訂7版

南山堂, 2002
色素細胞

2001
酸化ストレス・レドックスの生化学

共立出版, 2000
The Pigmentary System. Physiology and Pathophysiology

1998
Oxygen Homeostasis and Its Dynamics.

1998
MCH and Seizures: Neuromolecular and Neuroendocrine Aspects

1997
Molecular Biology of Hematopoiesis

Plenum Press, 1996
ポルフィリン・ヘムの生命科学：遺伝病・がん・工学応用などへの展開

東京化学同人, 1995
図説分子病態学

中外医学社, 1995
Regulation of Heme Protein Synthesis

Alpha Med Press, 1994
一般医化学

南山堂, 1993
新生化学実験講座９ホルモン１ペプチドホルモン

東京化学同人, 1991
バイオエンジニアリング最新の話題を集めて

培風館, 1991

Presentations

Founded with an eye to the world

Tohoku J. Exp. Med. 編集長のインタビュー http;www.journal.med.tohoku.ac.jp;medicine/en/index;html, Oct, 2015
Pigment Production for Maintaining Epidermal Homeostasis: Lessons from Keratinocytes and Melanocytes

21st International Pigment Cell Conference, 2011
Pigment Production for Maintaining Epidermal Homeostasis: Lessons from Keratinocytes and Melanocytes

21st International Pigment Cell Conference, 2011
Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signaling in melanocytes

第２３回日本色素細胞学会, 2010
Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signaling in melanocytes

第２３回日本色素細胞学会, 2010
Lipocalin-type prostaglandin D synthase sensitizes melanocyte-lineage cells to retinoic acid-mediated proliferation inhibition

第２２回日本色素細胞学会, 2009
Lipocalin-type prostaglandin D synthase sensitizes melanocyte-lineage cells to retinoic acid-mediated proliferation inhibition

第２２回日本色素細胞学会, 2009
PROSTAGLANDIN D2 REPRESSES THE GROWTH OF HUMAN MELANOMA CELLS THROUGH A MECHANISM INDEPENDENT OF PROSTAGLANDIN D2 RECEPTORS

20th International Pigment Cell Conference, 2008
The MITF history and perspective

20th International Pigment Cell Conference, 2008
Epidermal Homeostasis Revisited with Heme Catabolism: Lessons from Newborns

20th International Pigment Cell Conference, 2008
低酸素は肝癌由来細胞株におけるヘム生合成系酵素の発現を抑制する

日本生化学会東北支部第74回例会, 2008
低酸素刺激によるヘモグロビン合成誘導機構

第81回日本生化学会大会, 2008
Prostaglandin D2 as an endogenous inducer of heme oxygenase-1 expression in human retinal pigment epithelial cells

Biochemistry and Molecular Biology 2008, 2008
Lipocalin-type prostaglandin D synthase as a potential tumor suppressor in human melanoma cells

Biochemistry and Molecular Biology, 2008
Heme as a regulator of oxygen homeostasis: New insights for ventilation-perfusion mismatch

第81回日本生化学会大会, 2008
PROSTAGLANDIN D2 REPRESSES THE GROWTH OF HUMAN MELANOMA CELLS THROUGH A MECHANISM INDEPENDENT OF PROSTAGLANDIN D2 RECEPTORS

20th International Pigment Cell Conference, 2008
The MITF history and perspective

20th International Pigment Cell Conference, 2008
Epidermal Homeostasis Revisited with Heme Catabolism: Lessons from Newborns

20th International Pigment Cell Conference, 2008
低酸素は肝癌由来細胞株におけるヘム生合成系酵素の発現を抑制する

日本生化学会東北支部第74回例会, 2008
低酸素刺激によるヘモグロビン合成誘導機構

第81回日本生化学会大会, 2008

Professional Memberships

Works

ヘム分解の制御に関する研究

2013 - 2016
肺特異的低酸素応答と換気・血流比維持機構の解明

2011
肺循環血流の制御と換気応答の分子基盤の解明

2011
シグナル伝達病の治療戦略創生拠点

2003 - 2008
メラノサイト由来リポカリン型プロスタグランジンD合成酵素が関与する皮膚組織の恒常性維持機構

2006 - 2007
低酸素応答の分子機構の解明と制御法の開発

2002 - 2003
メラニンモノマーの生理活性に関する研究

1999
NOと臓器障害

1996 - 1997
ヒト白血病細胞におけるヘム分解の調節機構

1991 - 1992
メラニン生合成の調節

1991 - 1992
ストレスによるヘム分解の調節機構

1989 - 1990

Research Projects

Homeostasis of retinal pigment epithelium essential for survival of photorecptor cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

SHIBAHARA Shigeki, TAKEDA Kazuhisa, FURUYAMA Kazumichi, YOSHIZAWA Miki
Regulatory mechanisms for heme biosynthesis in response to the change of regulatory heme pool.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

FURUYAMA Kazumichi, SHIBAHARA Shigeki, KANEKO Kiriko
Post-translational modification of erythroid-specific 5-aminolevulinate synthase and its' role in erythroid differentiation.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

FURUYAMA Kazumichi, SHIBAHARA Shigeki
Tohoku University Graduate School of Medicine

The 21st Century Center of Excellence Program, 2003 - 2008
The Regulatory Mechanism of Differentiation and Growth by Prostaglandin D2 in Pigment Cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

TAKEDA Kazuhisa, SHIBAHARA Shigeki
肺がんの進展に関与する肺循環血流の制御機構の解明

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2006 - 2007

柴原茂樹, 古山和道, 丸山芳夫
Multiple mechanisms for the regulation of heme biosynthesis and catabolism.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006

FURUYAMA Kazumichi, SHIBAHARA Shigeki, HARIGAE Hideo
Molecular basis for hypoxic sensing and regulation of ventilatory responses

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2004 - 2006

SHIBAHARA Shigeki, HIDA Wataru, FURUYAMA Kazumichi, TAKEDA Kazuhisa
肺がんの発生と進展に関与する肺特異的低酸素応答の分子機構の解明

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2005 - 2005

柴原茂樹, 古山和道
Analysis of the mutant mice for transcription factor Mitf, which exhibit abnormalities of respiratory control and circadian rhythm

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

TAKEDA Kazuhisa, SHIBAHARA Shigeki
肺特異的低酸素応答と換気・血流比維持機構の解明

科学研究費助成事業萌芽研究, 萌芽研究, 日本学術振興会, 2004 - 2005

柴原茂樹, 飛田渉, 古山和道
腫瘍の形成と維持を規定する低酸素応答の分子基盤

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2003 - 2003

柴原茂樹, 古山和道
Analysis of Wnt signal transduction via cAMP responsive element

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003

TAKEDA Kazuhisa, SHIBAHARA Shigeki
睡眠時無呼吸に対する防御機構としての低酸素応答の分子基盤

科学研究費助成事業萌芽研究, 萌芽研究, 日本学術振興会, 2002 - 2003

柴原茂樹, 武田和久, 飛田渉, 高橋和広
Evaluation of toxicities of porphyrin derivatives and its possible application

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2003

FUJITA Hiroyoshi, IGARASHI Kazuhiko, SHIBAHARA Shigeki, SATO Haruo, OGAWA Kazuhiro
Studies on expression of bioactive substances under hypoxia and relation to diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2003

TAKAHASHI Kazuhiro, TAKEDA Kazuhisa, FUJII Yoshiaki, SHIBAHARA Shigeki
網膜色素上皮細胞におけるWntシグナル関連転写因子群の機能発現機構

科学研究費助成事業特定領域研究(C), 特定領域研究(C), 日本学術振興会, 2001 - 2001

柴原茂樹, 武田和久
色素細胞分化におけるWntシグナル関連因子とMITFとの機能的相互作用

科学研究費助成事業特定領域研究(A), 特定領域研究(A), 日本学術振興会, 2000 - 2000

安元研一, 武田和久, 柴原茂樹
マラリアの重症化に関与する宿主因子の分子制御

科学研究費助成事業特定領域研究(A), 特定領域研究(A), 日本学術振興会, 1999 - 1999

柴原茂樹, 武田和久
腸管筋層における転写因子MITF isoformによるC-KIT発現調節

科学研究費助成事業萌芽的研究, 萌芽的研究, 日本学術振興会, 1998 - 1999

大井龍司, 安元研一, 仁尾正記, 柴原茂樹

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Research History

Education

Committee Memberships

Awards

Major Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Works

Research Projects

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