東郷暁 (Akira Tohgo) - マイポータル

基本情報

所属: 旧所属東北大学大学院医学系研究科医科学専攻助手

学位: 医学博士

J-GLOBAL ID: 200901007705379699
researchmap会員ID: 1000202840

研究分野

ライフサイエンス / 病態医化学 /

受賞

1998年

東北大学医学部奨励賞銀賞
1996年

第33回ベルツ賞

MISC

Autoantibodies against CD38 (ADP ribosyl cyclase cyclic ADP ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin-dependent diabetes patients

F Ikehata, J Satoh, K Nata, A Tohgo, T Nakazawa, Kato, I, S Kobayashi, T Akiyama, S Takasawa, T Toyota …

JOURNAL OF CLINICAL INVESTIGATION 102(2) 395-401 1998年7月
Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellualr Ca²⁺ mobilization in normal and diabetic β-cells.

TAKASAWA S, NATA K, KUROKI M, TOHGO A, NOGUCHI N, KOBAYASHI S, KATO I, KATADA T, OKAMOTO H

The Journal of Biological Chemistry 273(5) 2497-2500 1998年1月
A missense mutation in the CD38 gene, a novel factor for insulin secretion: Association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro

K. Yagui, F. Shimada, M. Mimura, N. Hashimoto, Y. Suzuki, Y. Tokuyama, K. Nata, A. Tohgo, F. Ikehata, S. Takasawa …

Diabetologia 41(9) 1024-1028 1998年
Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellular Ca2+ mobilization in normal and diabetic beta-cells

S Takasawa, T Akiyama, K Nata, M Kuroki, A Tohgo, N Noguchi, S Kobayashi, Kato, I, T Katada, H Okamoto

JOURNAL OF BIOLOGICAL CHEMISTRY 273(5) 2497-2500 1998年1月
Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): Organization, nucleotide sequence and alternative splicing

Koji Nata, Toshinari Takamura, Tadahiro Karasawa, Tomoko Kumagai, Wataru Hashioka, Akira Tohgo, Hideto Yonekura, Shin Takasawa, Shinichi Nakamura, Hiroshi Okamoto

Gene 186(2) 285-292 1997年2月28日
Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): Organization, nucleotide sequence and alternative splicing

K Nata, T Takamura, T Karasawa, T Kumagai, W Hashioka, A Tohgo, H Yonekura, S Takasawa, S Nakamura, H Okamoto

GENE 186(2) 285-292 1997年2月
Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase

A Tohgo, H Munakata, S Takasawa, K Nata, T Akiyama, N Hayashi, H Okamoto

JOURNAL OF BIOLOGICAL CHEMISTRY 272(7) 3879-3882 1997年2月
Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes

N Noguchi, S Takasawa, K Nata, A Tohgo, Kato, I, F Ikehata, H Yonekura, H Okamoto

JOURNAL OF BIOLOGICAL CHEMISTRY 272(6) 3133-3136 1997年2月
Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38: Inhibition of hydrolysis by ATP and physiological significance

H Okamoto, S Takasawa, A Tohgo, K Nata, Kato, I, N Noguchi

VITAMINS AND COENZYMES, PT J 280 306-318 1997年
Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 : Inhibition of hydrolysis by ATP and the physiological significance

Methods in Enzymology : Vitamins and Coenzymes Part I and J 280 306-318 1997年
Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase

Akira Tohgo, Hiroshi Munakata, Shin Takasawa, Koji Nata, Takako Akiyama, Norio Hayashi, Hiroshi Okamoto

Journal of Biological Chemistry 272(7) 3879-3882 1997年
Cyclic ADP-ribose binds to FK506-binding protein 12.6 to Release Ca2+ from islet microsomes

Naoya Noguchi, Shin Takasawa, Koji Nata, Akira Tohgo, Ichiro Kato, Fumiko Ikehata, Hideto Yonekura, Hiroshi Okatnoto

Journal of Biological Chemistry 272(6) 3133-3136 1997年
Deficiency of phenylethanolamine N-methyltransferase in norepinephrine-producing pheochromocytoma

N Kimura, A Togo, T Sugimoto, K Nata, H Okamoto, Nagatsu, I, H Nagura

ENDOCRINE PATHOLOGY 7(2) 131-136 1996年5月
Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization

Shin Takasawa, Atsuhiko Ishida, Koji Nata, Kei Nakagawa, Naoya Noguchi, Akira Tohgo, Ichiro Kato, Hideto Yonekura, Hitoshi Fujisawa, Hiroshi Okamoto

Journal of Biological Chemistry 270(51) 30257-30259 1995年12月22日
ヒトcyclic ADP-ribose合成・分解酵素(CD38)遺伝子の構造と染色体座位

糖尿病 38 236-236 1995年
セカンドメッセンジャ-cyclic ADP-ribose合成・分解反応に必須なCD38のCys119とCys201

糖尿病 38 236-236 1995年
ラットcyclic ADP-ribose合成酵素関連遺伝子産物BST-1の構造と発現

生化学 67 697-697 1995年
CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase)とアメフラシADP-ribosyl cyclaseの遺伝子構造

生化学 67 540-540 1995年
CD38とアメフラシADP-ribosyl cyclaseのアミノ酸置換による酵素活性の変換

生化学 67 540-540 1995年
A role of cyclic ADP-ribose in stimulus-secretion coupling in pancreatic β-cells.

Diabetes 1994 (Baba, S. ed.), Elsevier ,244-246 1995年

もっとみる

書籍等出版物

A role of cyclic ADP-ribose, a NAD⁺ metabolite, in stimulus-secretion coupling in pancreatic B-cell.

Frontiers of Insulin Secretion and Pancreatic B-Cell Research (Fratt, P. and Lenzen, S., eds.), Smith-Gordon 1995年
A role of cyclic ADP-ribose, a NAD⁺ metabolite, in stimulus-secretion coupling in pancreatic B-cell.

Frontiers of Insulin Secretion and Pancreatic B-Cell Research (Fratt, P. and Lenzen, S., eds.), Smith-Gordon 1995年

東郷暁

基本情報

研究分野

受賞

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

メニュー