Akira Tohgo

Profile Information

Affiliation: 助手, 旧所属東北大学大学院医学系研究科医科学専攻

Degree: 医学博士

J-GLOBAL ID: 200901007705379699
researchmap Member ID: 1000202840

Research Areas

Life sciences / Pathobiochemistry /

Awards

1998

東北大学医学部奨励賞銀賞
1996

第33回ベルツ賞

Misc.

Autoantibodies against CD38 (ADP ribosyl cyclase cyclic ADP ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin-dependent diabetes patients

F Ikehata, J Satoh, K Nata, A Tohgo, T Nakazawa, Kato, I, S Kobayashi, T Akiyama, S Takasawa, T Toyota …

JOURNAL OF CLINICAL INVESTIGATION, 102(2) 395-401, Jul, 1998
Autoantibodies against CD38 (ADP ribosyl cyclase cyclic ADP ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin-dependent diabetes patients

F Ikehata, J Satoh, K Nata, A Tohgo, T Nakazawa, Kato, I, S Kobayashi, T Akiyama, S Takasawa, T Toyota …

JOURNAL OF CLINICAL INVESTIGATION, 102(2) 395-401, Jul, 1998
A missense mutation in the CD38 gene, a novel factor for insulin secretion: Association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro

K. Yagui, F. Shimada, M. Mimura, N. Hashimoto, Y. Suzuki, Y. Tokuyama, K. Nata, A. Tohgo, F. Ikehata, S. Takasawa …

Diabetologia, 41(9) 1024-1028, 1998
Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellular Ca2+ mobilization in normal and diabetic beta-cells

S Takasawa, T Akiyama, K Nata, M Kuroki, A Tohgo, N Noguchi, S Kobayashi, Kato, I, T Katada, H Okamoto

JOURNAL OF BIOLOGICAL CHEMISTRY, 273(5) 2497-2500, Jan, 1998
A missense mutation in the CD38 gene, a novel factor for insulin secretion: Association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro

K. Yagui, F. Shimada, M. Mimura, N. Hashimoto, Y. Suzuki, Y. Tokuyama, K. Nata, A. Tohgo, F. Ikehata, S. Takasawa …

Diabetologia, 41(9) 1024-1028, 1998
Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellular Ca2+ mobilization in normal and diabetic beta-cells

S Takasawa, T Akiyama, K Nata, M Kuroki, A Tohgo, N Noguchi, S Kobayashi, Kato, I, T Katada, H Okamoto

JOURNAL OF BIOLOGICAL CHEMISTRY, 273(5) 2497-2500, Jan, 1998
Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): Organization, nucleotide sequence and alternative splicing

Koji Nata, Toshinari Takamura, Tadahiro Karasawa, Tomoko Kumagai, Wataru Hashioka, Akira Tohgo, Hideto Yonekura, Shin Takasawa, Shinichi Nakamura, Hiroshi Okamoto

Gene, 186(2) 285-292, Feb 28, 1997
Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): Organization, nucleotide sequence and alternative splicing

K Nata, T Takamura, T Karasawa, T Kumagai, W Hashioka, A Tohgo, H Yonekura, S Takasawa, S Nakamura, H Okamoto

GENE, 186(2) 285-292, Feb, 1997
Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase

A Tohgo, H Munakata, S Takasawa, K Nata, T Akiyama, N Hayashi, H Okamoto

JOURNAL OF BIOLOGICAL CHEMISTRY, 272(7) 3879-3882, Feb, 1997
Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes

N Noguchi, S Takasawa, K Nata, A Tohgo, Kato, I, F Ikehata, H Yonekura, H Okamoto

JOURNAL OF BIOLOGICAL CHEMISTRY, 272(6) 3133-3136, Feb, 1997
Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38: Inhibition of hydrolysis by ATP and physiological significance

H Okamoto, S Takasawa, A Tohgo, K Nata, Kato, I, N Noguchi

VITAMINS AND COENZYMES, PT J, 280 306-318, 1997
Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 : Inhibition of hydrolysis by ATP and the physiological significance

Methods in Enzymology : Vitamins and Coenzymes Part I and J, 280 306-318, 1997
Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase

Akira Tohgo, Hiroshi Munakata, Shin Takasawa, Koji Nata, Takako Akiyama, Norio Hayashi, Hiroshi Okamoto

Journal of Biological Chemistry, 272(7) 3879-3882, 1997
Cyclic ADP-ribose binds to FK506-binding protein 12.6 to Release Ca2+ from islet microsomes

Naoya Noguchi, Shin Takasawa, Koji Nata, Akira Tohgo, Ichiro Kato, Fumiko Ikehata, Hideto Yonekura, Hiroshi Okatnoto

Journal of Biological Chemistry, 272(6) 3133-3136, 1997
Deficiency of phenylethanolamine N-methyltransferase in norepinephrine-producing pheochromocytoma

N Kimura, A Togo, T Sugimoto, K Nata, H Okamoto, Nagatsu, I, H Nagura

ENDOCRINE PATHOLOGY, 7(2) 131-136, May, 1996
Deficiency of phenylethanolamine N-methyltransferase in norepinephrine-producing pheochromocytoma

N Kimura, A Togo, T Sugimoto, K Nata, H Okamoto, Nagatsu, I, H Nagura

ENDOCRINE PATHOLOGY, 7(2) 131-136, May, 1996
Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization

Shin Takasawa, Atsuhiko Ishida, Koji Nata, Kei Nakagawa, Naoya Noguchi, Akira Tohgo, Ichiro Kato, Hideto Yonekura, Hitoshi Fujisawa, Hiroshi Okamoto

Journal of Biological Chemistry, 270(51) 30257-30259, Dec 22, 1995
Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization

Shin Takasawa, Atsuhiko Ishida, Koji Nata, Kei Nakagawa, Naoya Noguchi, Akira Tohgo, Ichiro Kato, Hideto Yonekura, Hitoshi Fujisawa, Hiroshi Okamoto

Journal of Biological Chemistry, 270(51) 30257-30259, Dec 22, 1995
ヒトcyclic ADP-ribose合成・分解酵素(CD38)遺伝子の構造と染色体座位

糖尿病, 38 236-236, 1995
セカンドメッセンジャ-cyclic ADP-ribose合成・分解反応に必須なCD38のCys119とCys201

糖尿病, 38 236-236, 1995

Books and Other Publications

A role of cyclic ADP-ribose, a NAD⁺ metabolite, in stimulus-secretion coupling in pancreatic B-cell.

Frontiers of Insulin Secretion and Pancreatic B-Cell Research (Fratt, P. and Lenzen, S., eds.), Smith-Gordon, 1995
A role of cyclic ADP-ribose, a NAD⁺ metabolite, in stimulus-secretion coupling in pancreatic B-cell.

Frontiers of Insulin Secretion and Pancreatic B-Cell Research (Fratt, P. and Lenzen, S., eds.), Smith-Gordon, 1995

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