大津浩 (Hiroshi Ohtsu) - マイポータル

基本情報

学位: 博士(医学)(東北大学)

J-GLOBAL ID: 200901054892538167
researchmap会員ID: 1000202849

外部リンク: http://db.tohoku.ac.jp/whois/detail/fa70fac75b204ae49a018de85d6e4d01.html

研究キーワード

研究分野

ライフサイエンス / 薬理学 /

経歴

東北大学大学院工学研究科量子エネルギー工学専攻粒子ビーム工学講座応用量子医工学分野, 教授

学歴

受賞

2005年

Research Grand
2005年

Research Grand
2005年

Research Grand
2002年

研究助成金
2002年

研究助成金
1997年

省令助成金
1997年

研究助成金
1997年

省令助成金
1997年

研究助成金
1996年

研究助成金
1996年

研究助成金

MISC

168

Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens

Li LiHua, Soichiro Yoshikawa, Takuya Ohta, Kayo Horiguchi, Yohei Kawano, Hiroshi Ohtsu, Yoshinori Yamanishi, Hajime Karasuyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 467(1) 70-75 2015年11月
Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency

Stefano Bastianini, Alessandro Silvani, Chiara Berteotti, Viviana Lo Martire, Gary Cohen, Hiroshi Ohtsu, Jian-Sheng Lin, Giovanna Zoccoli

PLOS ONE 10(10) e0140520 2015年10月
Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear

Meiyu Xu, Lina Li, Hiroshi Ohtsu, Christopher Pittenger

NEUROSCIENCE LETTERS 595 50-53 2015年5月
Histamine Promotes Locomotion Recovery After Spinal Cord Hemisection via Inhibiting Astrocytic Scar Formation

Yan-Yan Zhao, Yang Yuan, Ying Chen, Lei Jiang, Ru-Jia Liao, Lu Wang, Xiang-Nan Zhang, Hiroshi Ohtsu, Wei-Wei Hu, Zhong Chen

CNS NEUROSCIENCE & THERAPEUTICS 21(5) 454-462 2015年5月
Histamine suppresses regulatory T cells mediated by TGF-β in murine chronic allergic contact dermatitis.

Masahiro Seike, Tamio Hagiwara, Atsushi Sato, Hiroshi Ohtsu

Exp Dermatol 24(4) 280-284 2015年4月
Histamine suppresses regulatory T cells mediated by TGF-beta in murine chronic allergic contact dermatitis

Kyoko Tamaka, Masahiro Seike, Tamio Hagiwara, Atsushi Sato, Hiroshi Ohtsu

EXPERIMENTAL DERMATOLOGY 24(4) 280-284 2015年4月
Protective effect of carnosine on febrile seizures in immature mice

Yun-Jian Dai, Deng-Chang Wu, Bo Feng, Wei-wei Hou, Ceng-Lin Xu, Hiroshi Ohtsu, Zhong Chen, Wei-Wei Hu

NEUROSCIENCE LETTERS 588 95-100 2015年2月
Close relationship between T helper (Th)17 and Th2 response in murine allergic contact dermatitis

A. Matsushita, M. Seike, T. Hagiwara, A. Sato, H. Ohtsu

CLINICAL AND EXPERIMENTAL DERMATOLOGY 39(8) 924-931 2014年12月
The Role of Histamine in the Retina: Studies on the Hdc Knockout Mouse

Ursula Greferath, Kirstan A. Vessey, Andrew I. Jobling, Samuel A. Mills, Bang V. Bui, Zheng He, Nupur Nag, Hiroshi Ohtsu, Erica L. Fletcher

PLOS ONE 9(12) e116025 2014年12月
Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of burette syndrome

Maximiliano Rapanelli, Luciana R. Frick, Vladimir Pogorelov, Kristie T. Ota, Eeman Abbasi, Hiroshi Ohtsu, Christopher Pittenger

EUROPEAN NEUROPSYCHOPHARMACOLOGY 24(12) 1896-1906 2014年12月
Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line

Yi Wang, Yang Jiang, Jun-ichiro Ikeda, Tian Tian, Atsushi Sato, Hiroshi Ohtsu, Eiichi Morii

CANCER MEDICINE 3(5) 1126-1135 2014年10月
Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms

Haijing Yan, Xiangnan Zhang, Weiwei Hu, Jing Ma, Weiwei Hou, Xingzhou Zhang, Xiaofen Wang, Jieqiong Gao, Yao Shen, Jianxin Lv …

NATURE COMMUNICATIONS 5 33334 2014年2月
Histamine synthesis is required for granule maturation in murine mast cells

Shunsuke Nakazawa, Mariko Sakanaka, Kazuyuki Furuta, Mayuko Natsuhara, Hirotsugu Takano, Soken Tsuchiya, Yasushi Okuno, Hiroshi Ohtsu, Masahiro Nishibori, Robin L. Thurmond …

EUROPEAN JOURNAL OF IMMUNOLOGY 44(1) 204-214 2014年1月
Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice

Lissandra Castellan Baldan, Kyle A. Williams, Jean-Dominique Gallezot, Vladimir Pogorelov, Maximiliano Rapanelli, Michael Crowley, George M. Anderson, Erin Loring, Roxanne Gorczyca, Eileen Billingslea …

NEURON 81(1) 77-90 2014年1月
Roles played by histamine in strenuous or prolonged masseter muscle activity in mice

Hiroyuki Yoneda, Fukie Niijima-Yaoita, Masahiro Tsuchiya, Hiroyuki Kumamoto, Makoto Watanbe, Hiroshi Ohtsu, Kazuhiko Yanai, Takeshi Tadano, Keiichi Sasaki, Shunji Sugawara …

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 40(12) 848-855 2013年12月
Greatly increased numbers of histamine cells in human narcolepsy with cataplexy

Joshi John, Thomas C. Thannickal, Ronald McGregor, Lalini Ramanathan, Hiroshi Ohtsu, Seiji Nishino, Noriaki Sakai, Akhiro Yamanaka, Carly Stone, Marcia Cornford …

Annals of Neurology 74(6) 786-793 2013年12月
Histamine Modulation of Acute Nociception Involves Regulation of Na(v)1.8 in Primary Afferent Neurons in Mice

Jie Yu, Qi Fang, Guo-Dong Lou, Wen-Ting Shou, Jia-Xing Yue, Ying-Ying Tang, Wei-Wei Hou, Tian-Le Xu, Hiroshi Ohtsu, Shi-Hong Zhang …

CNS NEUROSCIENCE & THERAPEUTICS 19(9) 649-658 2013年9月
Effects of histamine on spontaneous neuropathic pain induced by peripheral axotomy

Jie Yu, Guo-Dong Lou, Jia-Xing Yue, Ying-Ying Tang, Wei-Wei Hou, Wen-Ting Shou, Hiroshi Ohtsu, Shi-Hong Zhang, Zhong Chen

Neuroscience Bulletin 29(3) 261-269 2013年6月
Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis

Ayuko Matsushita, Masahiro Seike, Haruka Okawa, Yayoi Kadawaki, Hiroshi Ohtsu

EXPERIMENTAL DERMATOLOGY 21(9) 714-715 2012年9月
Pathophysiologic role of histamine: Evidence clarified by histidine decarboxylase gene knockout mice

Hiroshi Ohtsu

International Archives of Allergy and Immunology 158(1) 2-6 2012年5月