MISC

1995年10月

IDENTIFICATION OF THE AMINO-ACID-RESIDUES INVOLVED IN SELECTIVE AGONIST BINDING IN THE FIRST EXTRACELLULAR LOOP OF THE DELTA-OPIOID AND MU-OPIOID RECEPTORS

FEBS LETTERS
  • K FUKUDA
  • ,
  • K TERASAKO
  • ,
  • S KATO
  • ,
  • K MORI

373
2
開始ページ
177
終了ページ
181
記述言語
英語
掲載種別
DOI
10.1016/0014-5793(95)01034-C
出版者・発行元
ELSEVIER SCIENCE BV

Effects of amino acid substitutions in the first extracellular loop region of the delta- and mu-opioid receptors were examined. Substitution of lysine-108 of the delta-receptor (delta K108) with asparagine improved affinity to [D-Ala(2),MePhe(4),Gly-ol(5)]enk ephalin (DAGO), a mu-selective peptide agonist, to be comparable with that of the mu-receptor. On the other hand, replacement of mN127 with lysine decreased the affinity to DAGO by similar to 15-fold. These results suggest that dK108 and mN127, which correspond to each other in the aligned amino acid sequences, mainly determine the difference in DAGO binding affinity between the delta- and mu-receptors.

Web of Science ® 被引用回数 : 33

リンク情報
DOI
https://doi.org/10.1016/0014-5793(95)01034-C
CiNii Articles
http://ci.nii.ac.jp/naid/80008568547
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/7589460
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1995RZ24600017&DestApp=WOS_CPL

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