1999年5月
Avidin-biotin system for delivery of diagnostic agents
ADVANCED DRUG DELIVERY REVIEWS
- ,
- 巻
- 37
- 号
- 1-3
- 開始ページ
- 89
- 終了ページ
- 101
- 記述言語
- 英語
- 掲載種別
- 書評論文,書評,文献紹介等
- 出版者・発行元
- ELSEVIER SCIENCE BV
Radiolabeled monoclonal antibodies specific for tumor-associated antigens are used for the diagnosis and therapy of malignant tumors. However, the blood clearance of antibodies is slow and tumor-to-nontumor ratios of radioactivity in the current system are not high. To increase tumor-to-nontumor ratios, the concept of pretargeting has been proposed. The strategy is based on the separate administration of the monoclonal antibody and the radiolabel. Because avidin and streptavidin bind to biotin selectively with extremely high affinity, the avidin-biotin system has been applied for pretargeting. With this method, high tumor-to-nontumor ratios are reported, not only in animal experiments, but also in clinical trials. The avidin-biotin system is also used to reduce the background radioactivity of the directly labeled antibody as well as radioimmunoguided surgery. (C) 1999 Elsevier Science BN. All rights reserved.
- リンク情報
- ID情報
-
- ISSN : 0169-409X
- Web of Science ID : WOS:000079979400007