IZAWA Shingo

Last updated: Dec 10, 2019 at 09:48

Name	IZAWA Shingo
Affiliation	Kyoto Institute of Technology
Section	Graduate School of Science and technology, Division of Applied Biology
Degree	Master of Agriculture(Kyoto University), Doctor of Agriculture(Kyoto University)
ORCID ID	0000-0002-4920-2450

Research Interests

yeast(65) , ethanol stress(1) , brewing related stress(1) , P-bodies(1) , stress granules(3) , translation repression(1) , vanillin(1) , cold atmospheric pressure plasma(1) , trans fats(1) , Stress response(58) , mRNA export(2)

Research Areas

Agricultural chemistry / Applied microbiology / fermentation technology
Biological science / Molecular biology /
Biological science / Cell biology /
Agricultural chemistry / Applied biochemistry /

Academic & Professional Experience

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Feb 2009

Today

associate professor, Grad. School. Sci-Fi. Technology., Div. Appl. Biol., Kyoto Institute of Technology

Apr 2007

Feb 2009

assistant professor, Grad. School Agriculture, Div. Appl. Biosciences, Kyoto University

Apr 2001

Mar 2007

assistant professor, Grad. School Agriculture, Div. Appl. Biosciences, Kyoto University

Apr 2000

Apr 2001

Monbusyo Fellowship Researcher to Study Abroad, Dana-Farber Cancer Institute, Harvard University

Aug 1995

Apr 2000

assistant professor, Res. Inst. Food Sci., Kyoto University

Education

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Apr 1992

Aug 1995

Div. Food Technology, Grad. School Agriculture, Kyoto University

1995

Graduate School, Division of Agriculture, Kyoto University

Apr 1988

Mar 1992

Department of Food Technology, School of Agriculture, Kyoto University

1992

Dept of Food technology, Faculty of Agriculture, Kyoto University

Awards & Honors

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Apr 2017

Nagase award for science promotion, Nagase Science and Technology Foundation

Mar 2010

Breeding of high brands of traditional fermented foods of Kyoto, Hirameki award, 2nd Kyushin Chiki-no kizunadukuri awards, Kyoto Trust Bank

Mar 2008

encouragement award of JSBBA, The Japan Society for Bioscience, Biotechnology, and Agrochemistry

Nov 1999

Effects of thioredoxin and glutaredoxin systems on the activity of Yap1, an AP-1 like transcription factor in Saccharomyces cerevisiae, Best poster award, International Symposium for Oxidative Stress, Redox Regulation and Signal Transduction

Published Papers

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Xylene causes oxidative stress and pronounced translation repression in Saccharomyces cerevisiae.

Yoshimoto N, Kawai T, Yoshida M, Izawa S

Journal of bioscience and bioengineering 128(6) 697-703 Dec 2019 [Refereed]

Btn2 is involved in the clearance of denatured proteins caused by severe ethanol stress in Saccharomyces cerevisiae.

Kato S, Yoshida M, Izawa S

FEMS yeast research 19(8) Dec 2019 [Refereed]

Ferrous chloride and ferrous sulfate improve the fungicidal efficacy of cold atmospheric argon plasma on melanized Aureobasidium pullulans.

Fukuda S, Kawasaki Y, Izawa S

Journal of bioscience and bioengineering 128(1) 28-32 Jul 2019 [Refereed]

Nutrient Signaling via the TORC1-Greatwall-PP2A^B55δ Pathway Is Responsible for the High Initial Rates of Alcoholic Fermentation in Sake Yeast Strains of Saccharomyces cerevisiae.

Watanabe D, Kajihara T, Sugimoto Y, Takagi K, Mizuno M, Zhou Y, Chen J, Takeda K, Tatebe H, Shiozaki K, Nakazawa N, Izawa S, Akao T, Shimoi H, Maeda T, Takagi H

Applied and environmental microbiology 85(1) Jan 2019 [Refereed]

Protein synthesis of Btn2 under pronounced translation repression during the process of alcoholic fermentation and wine-making in yeast

Sae Kato, Yukina Yamauchi, Shingo Izawa

Applied Microbiology and Biotechnology 102(22) 9669 Nov 2018 [Refereed]

Persistent actin depolarization caused by ethanol induces the formation of multiple small cortical septin rings in yeast

Sena Homoto, Shingo Izawa

Journal of Cell Science jcs.217091 Aug 2018 [Refereed]

The VFH1 (YLL056C ) promoter is vanillin-inducible and enables mRNA translation despite pronounced translation repression caused by severe vanillin stress in Saccharomyces cerevisiae

Trinh Thi My Nguyen, Yoko Ishida, Sae Kato, Aya Iwaki, Shingo Izawa

Yeast Jul 2018 [Refereed]

Cold atmospheric pressure plasma causes protein denaturation and endoplasmic reticulum stress in Saccharomyces cerevisiae

Koki Itooka, Kazuo Takahashi, Yukio Kimata, Shingo Izawa

Applied Microbiology and Biotechnology Mar 2018 [Refereed]

The novel heme-dependent inducible protein, SRRD regulates heme biosynthesis and circadian rhythms.

Adachi Y, Umeda M, Kawazoe A, Sato T, Ohkawa Y, Kitajima S, Izawa S, Sagami I, Taketani S

Archives of Biochemistry and Biophysics Oct 2017 [Refereed]

Potential role of heme metabolism in the inducible expression of heme oxygenase-1.

Takeda TA, Sasai M, Adachi Y, Ohnishi K, Fujisawa JI, Izawa S, Taketani S

Biochimica et Biophysica Acta Jul 2017 [Refereed]

The yeast ADH7 promoter enables gene expression under pronounced translation repression caused by the combined stress of vanillin, furfural, and 5-hydroxymethylfurfural.

Ishida Y, Nguyen TTM, Izawa S

Journal of Biotechnology Jun 2017 [Refereed]

Trans 18-carbon monoenoic fatty acid has distinct effects from its isomeric cis fatty acid on lipotoxicity and gene expression in Saccharomyces cerevisiae.

Nakamura T, Nguyet VT, Kato S, Arii Y, Akino T, Izawa S

Journal of Bioscience and Bioengineering Jan 2017 [Refereed]

Acetic Acid Causes Endoplasmic Reticulum Stress and Induces the Unfolded Protein Response in Saccharomyces cerevisiae.

Kawazoe N, Kimata Y, Izawa S

Frontiers in Microbiology 2017 [Refereed]

Fluorescence microscopic analysis of antifungal effects of cold atmospheric pressure plasma in Saccharomyces cerevisiae

Koki Itooka, Kazuo Takahashi, Shingo Izawa

Applied Microbiology and Biotechnology 100(21) 9295 Nov 2016 [Refereed]

Enhancement of protein production via the strong DIT1 terminator and two RNA-binding proteins in Saccharomyces cerevisiae.

Ito Y, Kitagawa T, Yamanishi M, Katahira S, Izawa S, Irie K, Furutani-Seiki M, Matsuyama T

Scientific Reports Nov 2016 [Refereed]

Prioritized Expression of BDH2 under Bulk Translational Repression and Its Contribution to Tolerance to Severe Vanillin Stress in Saccharomyces cerevisiae.

Ishida Y, Nguyen TT, Kitajima S, Izawa S

Frontiers in Microbiology 2016 [Refereed]

Prioritized Expression of BTN2 of Saccharomyces cerevisiae under Pronounced Translation Repression Induced by Severe Ethanol Stress.

Yamauchi Y, Izawa S

Frontiers in Microbiology 2016 [Refereed]

The Histone Deacetylase Gene Rpd3 Is Required for Starvation Stress Resistance.

Nakajima E, Shimaji K, Umegawachi T, Tomida S, Yoshida H, Yoshimoto N, Izawa S, Kimura H, Yamaguchi M

PLoS One 2016 [Refereed]

Plasma membrane proteins Yro2 and Mrh1 are required for acetic acid tolerance in Saccharomyces cerevisiae.

Takabatake A, Kawazoe N, Izawa S

Applied Microbiology and Biotechnology Mar 2015 [Refereed]

The ADH7 Promoter of Saccharomyces cerevisiae is Vanillin-Inducible and Enables mRNA Translation Under Severe Vanillin Stress.

Nguyen TT, Iwaki A, Izawa S

Frontiers in Microbiology 2015 [Refereed]

Importance of glucose-6-phosphate dehydrogenase (G6PDH) for vanillin tolerance in Saccharomyces cerevisiae.

Nguyen TT, Kitajima S, Izawa S

Journal of Bioscience and Bioengineering Sep 2014 [Refereed]

Vanillin causes the activation of Yap1 and mitochondrial fragmentation in Saccharomyces cerevisiae.

Nguyen TT, Iwaki A, Ohya Y, Izawa S

Journal of Bioscience and Bioengineering Jan 2014 [Refereed]

Adaptive response in stress granule formation and bulk translational repression upon a combined stress of mild heat shock and mild ethanol stress in yeast.

Yamamoto Y, Izawa S

Genes to Cells : devoted to molecular & cellular mechanisms Nov 2013 [Refereed]

Biomass conversion inhibitors furfural and 5-hydroxymethylfurfural induce formation of messenger RNP granules and attenuate translation activity in Saccharomyces cerevisiae.

Iwaki A, Kawai T, Yamamoto Y, Izawa S

Applied and Environmental Microbiology Mar 2013 [Refereed]

Vanillin inhibits translation and induces messenger ribonucleoprotein (mRNP) granule formation in saccharomyces cerevisiae: application and validation of high-content, image-based profiling.

Iwaki A, Ohnuki S, Suga Y, Izawa S, Ohya Y

PLoS One 2013 [Refereed]

Acidic stress induces the formation of P-bodies, but not stress granules, with mild attenuation of bulk translation in Saccharomyces cerevisiae.

Iwaki A, Izawa S

The Biochemical Journal Sep 2012 [Refereed]

Temperature dependent N-glycosylation of plasma membrane heat shock protein Hsp30p in Saccharomyces cerevisiae.

Kamo K, Takabatake A, Inoue Y, Izawa S

Biochemical and Biophysical Research Communications Mar 2012 [Refereed]

Reduction of glucose uptake through inhibition of hexose transporters and enhancement of their endocytosis by methylglyoxal in Saccharomyces cerevisiae.

Yoshida A, Wei D, Nomura W, Izawa S, Inoue Y

The Journal of Biological Chemistry Jan 2012 [Refereed]

Glutathione peroxidase 2 in Saccharomyces cerevisiae is distributed in mitochondria and involved in sporulation.

Ukai Y, Kishimoto T, Ohdate T, Izawa S, Inoue Y

Biochemical and Biophysical Research Communications Aug 2011 [Refereed]

Severe ethanol stress induces assembly of stress granules in Saccharomyces cerevisiae.

Kato K, Yamamoto Y, Izawa S

Yeast (Chichester, England) May 2011 [Refereed]

Modification of yeast characteristics by soy peptides: cultivation with soy peptides represses the formation of lipid bodies.

Ikeda K, Kitagawa S, Tada T, Iefuji H, Inoue Y, Izawa S

Applied Microbiology and Biotechnology Mar 2011 [Refereed]

Vacuolar morphology of Saccharomyces cerevisiae during the process of wine making and Japanese sake brewing.

Izawa S, Ikeda K, Miki T, Wakai Y, Inoue Y

Applied Microbiology and Biotechnology Sep 2010 [Refereed]

Methylglyoxal activates Gcn2 to phosphorylate eIF2alpha independently of the TOR pathway in Saccharomyces cerevisiae.

Nomura W, Maeta K, Kita K, Izawa S, Inoue Y

Applied Microbiology and Biotechnology May 2010 [Refereed]

Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca(2+) in Saccharomyces cerevisiae.

Takatsume Y, Ohdate T, Maeta K, Nomura W, Izawa S, Inoue Y

The Biochemical Journal Apr 2010 [Refereed]

Regulatory mechanism for expression of GPX1 in response to glucose starvation and Ca in Saccharomyces cerevisiae: involvement of Snf1 and Ras/cAMP pathway in Ca signaling.

Ohdate T, Izawa S, Kita K, Inoue Y

Genes to Cells : devoted to molecular & cellular mechanisms Jan 2010 [Refereed]

Ethanol stress response in the mRNA flux of Saccharomyces cerevisiae.

Izawa S

Bioscience, Biotechnology, and Biochemistry 2010 [Refereed]

Post-transcriptional regulation of gene expression in yeast under ethanol stress.

Izawa S, Inoue Y

Biotechnology and Applied Biochemistry Jun 2009 [Refereed]

Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces cerevisiae: methylglyoxal attenuates protein synthesis through phosphorylation of eIF2alpha.

Nomura W, Maeta K, Kita K, Izawa S, Inoue Y

Biochemical and Biophysical Research Communications Nov 2008 [Refereed]

Heat shock and ethanol stress provoke distinctly different responses in 3'-processing and nuclear export of HSP mRNA in Saccharomyces cerevisiae.

Izawa S, Kita T, Ikeda K, Inoue Y

The Biochemical Journal Aug 2008 [Refereed]

Modulation of Spc1 stress-activated protein kinase activity by methylglyoxal through inhibition of protein phosphatase in the fission yeast Schizosaccharomyces pombe.

Takatsume Y, Izawa S, Inoue Y

Biochemical and Biophysical Research Communications Nov 2007 [Refereed]

Formation of cytoplasmic P-bodies in sake yeast during Japanese sake brewing and wine making.

Izawa S, Kita T, Ikeda K, Miki T, Inoue Y

Bioscience, Biotechnology, and Biochemistry Nov 2007 [Refereed]

Release of thioredoxin from Saccharomyces cerevisiae with environmental stimuli: solubilization of thioredoxin with ethanol.

Takeuchi Y, Nomura W, Ohdate T, Tamasu S, Masutani H, Murata K, Izawa S, Yodoi J, Inoue Y

Applied Microbiology and Biotechnology Jul 2007 [Refereed]

Improvement of tolerance to freeze-thaw stress of baker's yeast by cultivation with soy peptides.

Izawa S, Ikeda K, Takahashi N, Inoue Y

Applied Microbiology and Biotechnology Jun 2007 [Refereed]

Efficient extraction of thioreodoxin from Saccharomyces cerevisiae by ethanol.

Inoue Y, Nomura W, Takeuchi Y, Ohdate T, Tamasu S, Kitaoka A, Kiyokawa Y, Masutani H, Murata K, Wakai Y, Izawa S, Yodoi J

Applied and Environmental Microbiology Mar 2007 [Refereed]

Green tea polyphenols function as prooxidants to activate oxidative-stress-responsive transcription factors in yeasts.

Maeta K, Nomura W, Takatsume Y, Izawa S, Inoue Y

Applied and Environmental Microbiology Jan 2007 [Refereed]

Msn2p/Msn4p-activation is essential for the recovery from freezing stress in yeast.

Izawa S, Ikeda K, Ohdate T, Inoue Y

Biochemical and Biophysical Research Communications Jan 2007 [Refereed]

Asr1, an alcohol-responsive factor of Saccharomyces cerevisiae, is dispensable for alcoholic fermentation.

Izawa S, Ikeda K, Kita T, Inoue Y

Applied Microbiology and Biotechnology Sep 2006 [Refereed]

Methylglyoxal as a signal initiator for activation of the stress-activated protein kinase cascade in the fission yeast Schizosaccharomyces pombe.

Takatsume Y, Izawa S, Inoue Y

The Journal of Biological Chemistry Apr 2006 [Refereed]

GPX2, encoding a phospholipid hydroperoxide glutathione peroxidase homologue, codes for an atypical 2-Cys peroxiredoxin in Saccharomyces cerevisiae.

Tanaka T, Izawa S, Inoue Y

The Journal of Biological Chemistry Dec 2005 [Refereed]

Characterization of Rat8 localization and mRNA export in Saccharomyces cerevisiae during the brewing of Japanese sake.

Izawa S, Takemura R, Ikeda K, Fukuda K, Wakai Y, Inoue Y

Applied Microbiology and Biotechnology Nov 2005 [Refereed]

Characterization of the export of bulk poly(A)+ mRNA in Saccharomyces cerevisiae during the wine-making process.

Izawa S, Takemura R, Miki T, Inoue Y

Applied and Environmental Microbiology Apr 2005 [Refereed]

Unique regulation of glyoxalase I activity during osmotic stress response in the fission yeast Schizosaccharomyces pombe: neither the mRNA nor the protein level of glyoxalase I increase under conditions that enhance its activity.

Takatsume Y, Izawa S, Inoue Y

Archives of Microbiology Mar 2005 [Refereed]

Diagnosis of cell death induced by methylglyoxal, a metabolite derived from glycolysis, in Saccharomyces cerevisiae.

Maeta K, Mori K, Takatsume Y, Izawa S, Inoue Y

FEMS Microbiology Letters Feb 2005 [Refereed]

Methylglyoxal, a metabolite derived from glycolysis, functions as a signal initiator of the high osmolarity glycerol-mitogen-activated protein kinase cascade and calcineurin/Crz1-mediated pathway in Saccharomyces cerevisiae.

Maeta K, Izawa S, Inoue Y

The Journal of Biological Chemistry Jan 2005 [Refereed]

Enrichment of yeast thioredoxin by green tea extract through activation of Yap1 transcription factor in Saccharomyces cerevisiae.

Takatsume Y, Maeta K, Izawa S, Inoue Y

Journal of Agricultural and Food Chemistry Jan 2005 [Refereed]

Deficiency in the glycerol channel Fps1p confers increased freeze tolerance to yeast cells: application of the fps1delta mutant to frozen dough technology.

Izawa S, Ikeda K, Maeta K, Inoue Y

Applied Microbiology and Biotechnology Dec 2004 [Refereed]

Intracellular glycerol influences resistance to freeze stress in Saccharomyces cerevisiae: analysis of a quadruple mutant in glycerol dehydrogenase genes and glycerol-enriched cells.

Izawa S, Sato M, Yokoigawa K, Inoue Y

Applied Microbiology and Biotechnology Nov 2004 [Refereed]

Activity of the Yap1 transcription factor in Saccharomyces cerevisiae is modulated by methylglyoxal, a metabolite derived from glycolysis.

Maeta K, Izawa S, Okazaki S, Kuge S, Inoue Y

Molecular and Cellular Biology Oct 2004 [Refereed]

Gle2p is essential to induce adaptation of the export of bulk poly(A)+ mRNA to heat shock in Saccharomyces cerevisiae.

Izawa S, Takemura R, Inoue Y

The Journal of Biological Chemistry Aug 2004 [Refereed]

Distinct regulatory mechanism of yeast GPX2 encoding phospholipid hydroperoxide glutathione peroxidase by oxidative stress and a calcineurin/Crz1-mediated Ca2+ signaling pathway.

Tsuzi D, Maeta K, Takatsume Y, Izawa S, Inoue Y

FEBS Letters Jul 2004 [Refereed]

Regulation of the yeast phospholipid hydroperoxide glutathione peroxidase GPX2 by oxidative stress is mediated by Yap1 and Skn7.

Tsuzi D, Maeta K, Takatsume Y, Izawa S, Inoue Y

FEBS Letters May 2004 [Refereed]

Identification of thermostable glyoxalase I in the fission yeast Schizosaccharomyces pombe.

Takatsume Y, Izawa S, Inoue Y

Archives of Microbiology May 2004 [Refereed]

Regulation of the yeast Yap1p nuclear export signal is mediated by redox signal-induced reversible disulfide bond formation.

Kuge S, Arita M, Murayama A, Maeta K, Izawa S, Inoue Y, Nomoto A

Molecular and Cellular Biology Sep 2001 [Refereed]

Cooperative regulation of DOG2, encoding 2-deoxyglucose-6-phosphate phosphatase, by Snf1 kinase and the high-osmolarity glycerol-mitogen-activated protein kinase cascade in stress responses of Saccharomyces cerevisiae.

Tsujimoto Y, Izawa S, Inoue Y

Journal of Bacteriology Sep 2000 [Refereed]

Molecular identification of glutathione synthetase (GSH2) gene from Saccharomyces cerevisiae.

Inoue Y, Sugiyama K, Izawa S, Kimura A

Biochimica et Biophysica Acta Feb 1998 [Refereed]

Evaluation of catechin and its derivatives as antioxidant: recovery of growth arrest of Escherichia coli under oxidative conditions.

Inoue Y, Trevanich S, Tsujimoto Y, Miki T, Miyabe S, Sugiyama K, Izawa S, Kimura A

Journal of the Science of Food and Agriculture Jul 1996 [Refereed]

Correlation of the OSR/ZRCI gene product and the intracellular glutathione levels in Saccharomyces cerevisiae.

Kobayashi S, Miyabe S, Izawa S, Inoue Y, Kimura A

Biotechnology and Applied Biochemistry Feb 1996 [Refereed]

Effects of alcohols on the hydrolysis of colominic acid catalyzed by Streptococcus neuraminidase.

Inouye K, Izawa S, Saito A, Tonomura B

Journal of Biochemistry Mar 1995 [Refereed]

Misc

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Application of cold atmospheric pressure plasma in the food industry ad agriculture

IZAWA Shingo

ILSI Japan 2020 [Invited]

Formation of multiple small rings of yeast septin under long-term severe ethanol stress

HOMOTO Sena and IZAWA Shingo

Bioscience and Industry 77(3) 233-235 May 2019 [Invited]

mRNA flux in yeast cells under stress conditions

IZAWA Shingo

Kyokugenkankyoseibutsugakkaishi 14(2) 46-53 Feb 2015 [Refereed][Invited]

Translation repression and mRNAP granule formation by fermentation inhibitors derived from lignocellulosic biomass

IZAWA Shingo

Bioscience and Industry 71(5) 416-419 May 2013 [Invited]

Utilization of edible natural ingredients for the modification of microorganisms

IZAWA Shingo

New Food Industry 52(9) 11-16 Sep 2011 [Invited]

Modification of food microorganisms using soy peptides

IZAWA Shingo

Shyokuhin kako gijutsu 30(4) 1-8 Apr 2010 [Invited]

mRNA hyperadenylation and the formation of P-body/stress granule in yeast response to ethanol

IZAWA Shingo

J Japanese Society of Brewing 105(2) 63-68 Feb 2010 [Invited]

Ethanol stress response in mRNA flux of Saccharomyces cerevisiae

IZAWA Shingo

Biosci. Biotechnol. Biochem. 74(1) 7-12 Jan 2010 [Refereed][Invited]

Ethanol stress response and post transcriptional regulation of gene expression in yeast

IZAWA S, INOUE Y

Bioscience and Industry 66(10) 557-561 Oct 2008 [Invited]

Neutral fats problems in yeast

IZAWA Shingo

Seibutsukougakukaishi 86(8) 397-397 Aug 2008 [Invited]

Stress response at the level of mRNA nuclear export

IZAWA S, TAKEMURA R, INOUE Y

Kagaku to shibutsu 44(6) 361-363 May 2006 [Invited]

Ethanol stress response of yeast

IZAWA Shingo

J Japanese Society of Brewing 100(5) 305-309 2005 [Invited]

Ethanol stress and organelle membrane

IZAWA Shingo

Shibutsukougakukaishi 82(7) 307-307 2004 [Invited]

Activity of the Yapl transcription factor in Saccharomyces cerevisiae is modulated by methylglyoxal, a metabolite derived from glycolysis.

Mol. Cell. Biol. 24, 8753-8764 2004

GleZ is essential to induce adaptation of the expnt of bulk poly (A)⁺ mRNA to heat shock in Saccharomyces serevisiae

J. Biol. Chem. 279, 35469-35478 2004

reversible change in the localization of Rat8p is caused by ethanol stress but not heat shock.

J. Cell Sci. 117, 4189-4197 2004

S. Izawa, N. Kuroki, and Y. Inoue Nuclear thioredoxin peroxidase Dot5 in Saccharomyces cerevisiae: roles in oxidative stress response and disruption of telomeric silencing

Appl. Microbiol. Biotechnol. 2003

S. Izawa and Y. Inoue A Screening system for antioxidants using thioredoxin-deficient yeast: discovery of thermostable antioxidant activity from Agaricus blazei Murill

Appl. Microbiol. Biotechnol. 2003

RNA repair

IZAWA Shingo

Kagaku to shibutsu 41(5) 318-320 2003 [Invited]

Oxidative stress sensor in yeast

IZAWA S, INOUE Y

Kagaku to seibutsu 39(8) 500-501 2001 [Invited]

Regulation on the yeast Yaplp nuclear export signal is Mediated by redox signal-induced reversible disulfide bond formation

Mol. Cell. Biol. 21, 6139-6150 2001

The Zrcl is involved in zinc transport system between vacuole and cytosol in Saccharomyces cerevisiae

Biochem. Biophys. Res. Commun. 282(1) 79-83 2001

Expression of ZRC1 coding for suppressor of zinc toxity is induced by zinc-starvation stress in ZAP1-dependent fashion in Saccharomyces cerevisiae

Biochem. Biophs. Res. Commun. 276(3) 879-884 2000

Role of glutathione in heat shock induced cell death of Saccharomyces cerevisiae

Biochem. J 352(1) 71-78 2000

Cooperative regulation of DOG2 encoding2-decxyglucose-6-phosphate phosphatase by Snfl kinase and high-osmo-rality glycerol MAP kinase in stress response of Sicerevisiae

J. Bacteriol. 182(18) 5121-5126 2000

The Yapl-dependent induction of glutathione synthesis in heat shock response of Saccharomyces cerevisiae

J. Biol. Chem. 275(20) 15535-15540 2000

Thioredoxin deficiency causes the constitutive activation of Yap1, an AP-1 like transcription factor in Saccharomyces cerevisiae

Journal of Biological Chemistry 274(40) 28459-28465 1999

Genetic analysis of glutathione peroxidase in oxidative stress response in Saccharomyces cerevisiae

Journal of Biological Chemistry 274(38) 27002-27009 1999

Molecular identification of glutathione synthetase(GSH2)gene from Saccharomyces cerevisiae.

Biochimica et Biophysica Acta 1395(2) 315-320 1998

Importance of glucose-6-phosphate dehydrogenase in the adaptive response to hydrogen peroxide in Saccharomyces cerevisiae.

Biochemical Journal 330(2) 811-817 1998

Roles of esterase and alcohol acetyltransferase on production of isoamyl acetate in Hansenula mrakii.

J. Agric. Food Chem. 45(3) 644-649 1997

Oxidative stress response in yeast : purification and characterization of glutathione reductase from Hansenula mrakii.

Takeo MIKI, Yoshiyuki TSUJIMOTO, Shinji MIYABE, Kei-ichi SUGIYAMA, Shingo IZAWA, Yoshiharu INOUE, Akira KIMURA

Biosci. Biotech. Biochem. 60(7) 1207-1209 1996

Modification of Escherichia coli B glutathione synthetase with poly ethylene glycol for clinical application to enzyme replacement therapy for glutathione deficiency.

Clinic. Diagno. Lab. Immunol. 3(6) 663-668 1996

Oxidative stress response in yeast : purification and some properties of oxidative stress-inducible glucose-6-phosphate dehydrogenase from Hansenula mrakii

Takeo MIKI, Yoshiyuki TSUJIMOTO, Shinji MIYASE, Kei-ichi SUGIYAMA, Shingo IZAWA, Yoshiharu INOUE, Akira KIMURA

Biosci. Biotech. Biochem. 60(6) 966-970 1996

Evaluation of catechin and its derivatives as antioxidant : recovery of growth arrest of Escherichia coli under oxidative conditions

Journal of the Science of Food and Agriculture 71(3) 297-300 1996

Importance of catalase in the adaptive response to hydrogen peroxide : analysis of acatalasaemic Saccharomyces cerevisiae

Biochemical Journal 320(1) 61-67 1996

Correlation of the OSR/ZRC1 gene product and the intracellular glutathione levels in Saccharomyces cerevisiae

Biotechnol. Appl. Biochem 23(1) 3-6 1996

Oxidative stress response and glutathione

IZAWA Shingo

Bioindustry 13(1) 21-26 1996 [Invited]

Oxidative stress response in yeast : induction of glucose-6-phosphate dehydrogenase by lipid hydroperoxide in Hansenula mrakii.

J. Ferment. Bioeng. 80(6) 606-609 1995

Molecular cloning and nucleotide sequence of purine nucleoside phosphorylase and uridine phosphorylase genes from Klebsiella sp.

Munenori Takehara, Feng Ling, Shingo Izawa, Yoshiharu Inoue, Akira Kimura

Biosci. Biotech. Biochem. 59(10) 1987-1990 1995

Oxidative stress response in yeast : glutathione peroxidase of Hansenula mrakii is bound to the membrane of both mitochondria and cytoplasm

Biochimica et Biophysica Acta 1245 325-330 1995

Oxidative stress response in yeast : effect of glutathione on adaptation to hydrogen peroxide stress in Saccharomyces cerevisiae

FEBS letter 368(1) 73-76 1995

Books etc

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Applied RNA Bioscience (ed. S. Masuda & S. Izawa)

KATO S, IZAWA S (Part:Joint Editor, mprovement of yeast fermentation efficiency utilizing mRNAs preferentially translated under translational repression)

Springer Verlag Tokyo 2018

Stress Biology of Yeast and Fungi (ed. Takagi H & Kitagaki H.)

IZAWA Shingo (Part:Contributor, Yeast mRNA flux during brewing and under ethanol stress conditions)

Springer Verlag Tokyo 2015

Frontiers in fermented foods

KITAMOTO K (ed) IZAWA S (Part:Contributor, Yeast translation regulation during the process of brewing)

CMC press 2014

Life science and biotechnology of yeasts

HARASHIMA S, TAKAGI H (eds) IZAWA S (Part:Contributor, Regulation of yeast RNA flux)

Kagaku Dojin 2013

New technology and functions of fermented foods 2

KITAMOTO K (ed) IZAWA S (Part:Contributor, mRNA flux of yeast during the process of ethanol stress response and brewing)

CMC press 2011

Conference Activities & Talks

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Survival strategy of yeast cells under severe ethanol stress [Invited]

IZAWA Shingo

The 14th open seminar of Applied Biological Chemistry Research Center, Kagawa University 5 Dec 2019

Survival strategy of yeast under severe ethanol stress [Invited]

IZAWA Shingo

22nd Yeast godo symposium 13 Sep 2018

Survival strategy of yeast at the final stage of brewing process [Invited]

IZAWA Shingo

112nd meeting of fermentation technology 29 Jan 2018

Study on yeast genes preferentialy translated under severe ethanol stress [Invited]

IZAWA Shingo

H29 annual meeting of sake yeast and kouji research 10 Oct 2017

Yeast responses and adaptation to long-time severe ethanol stress [Invited]

IZAWA Shingo

20th annual meeting of eukaryotic microorganisms 22 Sep 2017

Prioritized translation under pronounced translation repression caused by severe ethanol stress [Invited]

IZAWA Shingo

190th Meeting of yeast cell research 8 Jul 2016

Yeast mRNA flux under severe ethanol stress [Invited]

IZAWA Shingo

16th symposium of Society of Extremophiles 6 Jun 2015

Healthy long life supported by Japanese traditional fermented foods [Invited]

IZAWA Shingo

274th Senri Lifescience Forum 20 May 2015

Effects of vanillin on mitochondria in yeast cells [Invited]

IZAWA Shingo

Symposium in the 66th annual meeting of Society of Biotechnology, Japan 11 Sep 2014

Yeast stress response to fermentation inhibitors derived from biomass [Invited]

IZAWA Shingo

45th autumn annual meeting of SCEJ 18 Sep 2013

Fermented foods using game [Invited]

IZAWA Shingo

4th matching forum of unused resources usage 23 Feb 2013

Development of high value foods via fermentation [Invited]

IZAWA Shingo

2nd Research meeting for creating bio business [health and environments] 15 Feb 2013

mRNA flux in the ethanol stress response of Saccharomyces cerevisiae [Invited]

IZAWA Shingo

13th International Congress on Yeasts 29 Aug 2012

Translation control and mRNP granule formation under fermentation stress

IZAWA Shingo

JSBBA 2012 annual meeting 25 Mar 2012

mRNA flux and translation control in the stress response of yeast [Invited]

IZAWA Shingo

Seminar of fermentation and metabolism research meeting 29 Feb 2012

Invitation to Kyoto pickles [Invited]

IZAWA Shingo

Kyoto Asny Seminar 9 Dec 2011

Improvement of food microorganisms by soy peptides [Invited]

IZAWA Shingo

Research meeting on peptides for functional foods 19 Nov 2010

Japanese sake for young generation [Invited]

IZAWA Shingo

Kozakura Seminar 9 Oct 2010

Effects of soy peptides on budding yeast [Invited]

IZAWA Shingo

Soy peptide fermentation seminar 31 Mar 2010

Strategy for value-added foods development [Invited]

IZAWA Shingo

Wellness Industry Education Seminar 4 Feb 2010

Novel functions of soy beans for the improvement of food microorganisms [Invited]

IZAWA Shingo

2nd Soy Bean Research Symposium in Kinki Area / 49th Kinki Agriculture. High-tech Symposium 15 Jan 2010

Ethanol stress responses in budding yeast [Invited]

IZAWA Shingo

16th Japanese Microbial Resource Symposium 26 Jun 2009

Yeast RNA flux under ethanol stress conditions [Invited]

IZAWA Shingo

18th Yeast Godo Symposium 5 Jun 2008

Yeast mRNA export and ethanol stress [Invited]

IZAWA Shingo

H17 Research Meeting on Sake Yeast and Kouji 4 Oct 2005

Study on the yeast stress responses in mRNA export [Invited]

IZAWA Shingo

62nd Yeast Research Meeting 29 Aug 2005

Yeast mRNA export under ethanol stress [Invited]

IZAWA Shingo

169th Yeast Cell Research Meeting 19 Nov 2004

Association Memberships

Yeast Research Community(1) , JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY(266) , Yeast Genetics Society of Japan(32) , Society of Free Radical Research Japan(1)

Research Grants & Projects

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Study on the molecular mechanisms of preferential translation in yeast under stress conditions

JSPS: KAKENHI KibanB

Project Year: Apr 2017 - Mar 2020 Investigator(s): IZAWA Shingo

Selective gene expression under brewing-related stress in yeast cells

Noda Inst. Sci. Res.: Research Grant of NISC 2017

Project Year: Apr 2017 - Mar 2018 Investigator(s): IZAWA Shingo

Selective insulation and effective fermentation of lignocellulosic biomass

NAGASE Science Technology Foundation: Research Grant of Nagase Science Technology Foundation 2017

Project Year: Apr 2017 - Mar 2018 Investigator(s): IZAWA Shingo

Improvement of fermentation ability and stress tolerance of yeast cells through the modification of mRNA flux

JSPS: KAKENHI KibanB

Project Year: Apr 2014 - Mar 2017 Investigator(s): IZAWA Shingo

Interaction of trans fats in yeast cells

The Foundation for Dietary Scientific Research: Research grant of the Foundation for Dietary Scientific Research 2014

Project Year: Apr 2014 - Mar 2015 Investigator(s): IZAWA Shingo

Study on the mRNA flux of yeast during the process of ethanol stress response and brewing

JSPS: KAKENHI KibanC

Project Year: Apr 2011 - Mar 2014 Investigator(s): IZAWA Shingo

Safety evaluation of trans fats using yeast system

The Institute for Fermentation, Osaka: Research grant for general issues

Project Year: Apr 2011 - Mar 2013 Investigator(s): IZAWA Shingo

Post-transcriptional regulation of gene expression under stress conditions

JSPS: KAKENHI KibanC

Project Year: Apr 2008 - Mar 2011 Investigator(s): IZAWA Shingo

Study on the adaptive mechanism against hydrogen peroxide stress in yeast

Grant-in-Aid for Scientific Research

Project Year: 1995 - 2003

Regulation of mRNA export in the stress response

Grant-in-Aid for Promotion of Private Scientific Research

Project Year: 2002

Patents

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特許4412658 : Production method of yeast cells containing high level thioredoxin

INOUE Y, IZAWA S, YODOI J, TANAKA Y, HAMADA K, FUJITA T, FURUKAWA S, MURATA K

特願2014-253886 : Production methods of high value yeast

SHIMOMURA Y, KITAURA C, KAWAZOE N, IZAWA S

特願2006-283233 : Yeast with high tolerance to freezing/thawing stress

IZAWA S, INOUE Y, IKEDA K, KITAGWA S, FURUKAWA Y

特願2005-270353 : Production of thioredoxin

INOUE Y, IZAWA S, YODOI J, MASUTANI H, MURATA K, TAMASU S

特願平10-251390 : Stress responsive promoter of yeast

TSUJIMOTO Y, IZAWA, INOUE Y, KIMURA A, SATO N