MORIO Tomohiro


MORIO Tomohiro

J-GLOBAL         Last updated: Jan 17, 2020 at 02:59
 
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Name
MORIO Tomohiro
E-mail
tmorio.pedtmd.ac.jp
Affiliation
Tokyo Medical and Dental University
Section
Graduate School of Medical and Dental Sciences Medical and Dental Sciences Bio-Environmental Response Pediatrics and Developmental Biology
Job title
Professor
Degree
MD, PhD
Other affiliation
Tokyo Medical and Dental UniversityTokyo Medical and Dental UniversityTokyo Medical and Dental UniversityTokyo Medical and Dental UniversityTokyo Medical and Dental UniversityTokyo Medical and Dental UniversityTokyo Medical and Dental UniversityTokyo Medical and Dental UniversityTokyo Medical and Dental UniversityTokyo Medical and Dental University
Research funding number
30239628

Research Areas

 
 

Academic & Professional Experience

 
Apr 2019
 - 
Mar 2020
Director, Medical Hospital Central Clinical Facilities Intractable Disease Treatment, Tokyo Medical and Dental University
 
Sep 2018
 - 
May 2019
Institute of Research, Tokyo Medical and Dental University
 
Apr 2018
 - 
Today
-, Tokyo Medical and Dental University
 
Apr 2017
 - 
Today
Deputy Director, Board Member, Tokyo Medical and Dental University
 
Apr 2017
 - 
Today
Director, Board Member, Tokyo Medical and Dental University
 

Education

 
 
 - 
1983
Faculty of Medicine, Tokyo Medical and Dental University
 

Committee Memberships

 
Apr 2006
 - 
Today
Japanese Society of Pediatrics(Councilor)
 
Oct 2008
 - 
Today
Japanese Society for Pediatric Infectious Diseases (Councilor)
 

Published Papers

 
Tomohiro Morio, Gautam Baheti, Michael A Tortorici, Jutta Hofmann, Mikhail A Rojavin
Immunol Med   42(4) 162-168   Dec 2019   [Refereed]
PK characteristics in Japanese patients were similar between dosing regimens and to previously-reported results in non-Japanese patients with PID.
Hasegawa S, Kumada S, Tanuma N, Tsuji-Hosokawa A, Kashimada A, Mizuno T, Moriyama K, Sugawara Y, Shirai I, Miyata Y, Nishida H, Mashimo H, Hasegawa T, Hosokawa T, Hisakawa H, Uematsu M, Fujine A, Miyata R, Sakuma H, Kashimada K, Imai K, Morio T, Hayashi M, Mizutani S, Takagi M.
Pediatr Neurol   100 60-66   Nov 2019   [Refereed]
Ataxia telangiectasia is an autosomal recessive disorder characterized by cerebellar ataxia, telangiectases, immune defects, and a predisposition to malignancy. Quality of life is severely impaired by neurological symptoms. However, curative optio...
Takeru Yamauchi, Kei Takasawa, Takahiro Kamiya, Shizuka Kirino, Maki Gau, Kento Inoue, Akihiro Hoshino, Kenichi Kashimada, Hirokazu Kanegane, Tomohiro Morio
Pediatr Diabetes   20(7) 1035-1040   Nov 2019   [Refereed]
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked (IPEX) syndrome is an autoimmune disorder caused by the dysfunction of FOXP3, which leads to regulatory T (Treg) cell dysfunction and subsequently autoimmunity including type 1 di...
Takahiro Fukaishi, Isao Minami, Seizaburo Masuda, Yasutaka Miyachi, Kazutaka Tsujimoto, Hajime Izumiyama, Koshi Hashimoto, Masayuki Yoshida, Sayako Takahashi, Kenichi Kashimada, Tomohiro Morio, Kenjiro Kosaki, Yoshiro Maezawa, Koutaro Yokote, Takanobu Yoshimoto, Tetsuya Yamada
Endocr. J.      Nov 2019   [Refereed]
, and he had a short stature, birdlike facies, dental crowding due to micrognathia, partial graying and loss of hair, and a high-pitched voice, all of which are typical features of the progeroid syndrome. Laboratory examinations and abdominal ultr...
Minako Mori, Asuka Hira, Kenichi Yoshida, Hideki Muramatsu, Yusuke Okuno, Yuichi Shiraishi, Michiko Anmae, Jun Yasuda, Shu Tadaka, Kengo Kinoshita, Tomoo Osumi, Yasushi Noguchi, Souichi Adachi, Ryoji Kobayashi, Hiroshi Kawabata, Kohsuke Imai, Tomohiro Morio, Kazuo Tamura, Akifumi Takaori-Kondo, Masayuki Yamamoto, Satoru Miyano, Seiji Kojima, Etsuro Ito, Seishi Ogawa, Keitaro Matsuo, Hiromasa Yabe, Miharu Yabe, Minoru Takata
Haematologica   104(10) 1962-1973   Oct 2019   [Refereed]
gene variants, excluding missense mutations. This is the largest series of subtyped Japanese Fanconi anemia patients to date and the results will be useful for future clinical management.

Misc

 
Takeshi Isoda, Tomohiro Morio, Masatoshi Takagi
Cancer Sci.   110(8) 2328-2336   Aug 2019   [Refereed]
Changes of nuclear localization of lineage-specific genes from a transcriptionally inert to permissive environment is a crucial step in establishing the identity of a cell. Noncoding RNA transcription-mediated genome folding and activation of targ...
Risa Nomura, Kentaro Miyai, Gen Nishimura, Kenichi Kashimada, Tomohiro Morio
Pediatr Int   59(11) 1205-1206   Nov 2017   [Refereed]
Tomohiro Morio
Int. J. Hematol   106(3) 357-365   Oct 2017   [Refereed]
DNA breaks can be induced by exogenous stimuli or by endogenous stress, but are also generated during recombination of V, D, and J genes (V(D)J recombination), immunoglobulin class switch recombination (CSR). Among various DNA breaks generated, DN...
Hirokazu Kanegane, Kohsuke Imai, Tomohiro Morio
Nihon Rinsho Meneki Gakkai Kaishi   40(3) 145-154   Mar 2017
  Severe combined immunodeficiency (SCID) is impaired in lymphocyte development and function. Affected children have extreme susceptibility to infections, which are fatal in the first year of life without treatment. The estimate of incidence is on...
Shigeyoshi Fujiwara, Hiroshi Kimura, Ken-ichi Imadome, Ayako Arai, Eiichi Kodama, Tomohiro Morio, Norio Shimizu, Hiroshi Wakiguchi
Pediatr Int   56(2) 159-166   Apr 2014   [Refereed]

Conference Activities & Talks

 
Intrinsically Vancomycin resistant enterococcal (Enterococcus gallinarum) meningitis occurred early after hematopoietic stem cell transplantation for activated PI3K delta syndrome type2
16 Nov 2019   
Succesful case of donor lymphocyte infusion for refractory T cell acute lymphoblastic leukemia which lead to one year of remission
16 Nov 2019   
Pay attention to selective Immunoglobulin G2 deficiency - a case of Invasive pneumococcal infection after allogenic hematopietic stem cell transplantation
16 Nov 2019   
Usefulness of respiratory infection early diagnosis with multiplex PCR method for immunocompromised patients
16 Nov 2019   
A case with relapsed acute lymphoblastic leukemia treated with blinatumomab under the active GVHD after unrelated bone marrow transplantation
15 Nov 2019