大谷清 (Kiyoshi Ohtani) - マイポータル

基本情報

所属: 関西学院大学生命環境学部生命医科学科教授

学位: 医学博士(東北大学)

J-GLOBAL ID: 200901089997144553
researchmap会員ID: 1000203866

研究キーワード

研究分野

経歴

2009年4月 - 現在

関西学院大学教授
1997年4月 - 2009年3月

東京医科歯科大学講師
1992年4月 - 1996年3月

米国Duke大学Howard Hughes医科学研究所研究員
1989年4月 - 1992年3月

東北大学医学部助手

論文

Murine Embryonic Stem Cells Possess Distinct <scp>E2F</scp> Activity That Activates Tumor Suppressor Promoter Elements

Yaxuan Zhou, Rinka Nakajima, Mashiro Shirasawa, Mariana Fikriyanti, Masaru Kitagawa, Thet Yoon San, Ritsuko Iwanaga, Andrew P. Bradford, Kenta Kurayoshi, Keigo Araki …

Genes to Cells 31(3) 2026年5月12日
Distinct Regulation of the ARF and TAp73 Tumor Suppressor Genes by the Transcription Factor E2F1 Enables Discrimination of Cancer Cells from Normal Growing Cells

Yaxuan Zhou, Rinka Nakajima, Mashiro Shirasawa, Mariana Fikriyanti, Ako Watanabe, Caiwei Yang, Ritsuko Iwanaga, Andrew P. Bradford, Kenta Kurayoshi, Keigo Araki …

Cells 15(1) 90-90 2026年1月5日
Utility of Tumor Suppressor E2F Target Gene Promoter Elements to Drive Gene Expression Specifically in Cancer Cells.

Kenta Kurayoshi, Masakazu Tanaka, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Jun-Ichi Fujisawa, Ritsuko Iwanaga, Andrew P Bradford, Keigo Araki …

Cells 14(24) 2025年12月9日
Transcriptional Activation Mechanisms and Target Genes of the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1

Mashiro Shirasawa, Rinka Nakajima, Yaxuan Zhou, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P. Bradford, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani

Genes 16(10) 1221-1221 2025年10月15日
The Transcriptional Coactivator DEAD/H Box 5 (DDX5) Gene Is a Target of the Transcription Factor E2F1 Deregulated from the Tumor Suppressor pRB

Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P. Bradford, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani

Genes 16(8) 929-929 2025年8月1日
DEAD/H Box 5 (DDX5) Augments E2F1-Induced Cell Death Independent of the Tumor Suppressor p53

Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Naoyasu Nishimura, Lin Zhao, Mariana Fikriyanti, Yuki Kamiya, Ritsuko Iwanaga, Andrew P. Bradford, Kaori Shinmyozu …

International Journal of Molecular Sciences 25(24) 13251-13251 2024年12月10日
The N-Terminal Region of the Transcription Factor E2F1 Contains a Novel Transactivation Domain and Recruits General Transcription Factor GTF2H2

Lin Zhao, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Yuki Kamiya, Hiroyuki Toh, Hideyuki Komori, Ritsuko Iwanaga, Andrew P. Bradford …

Biomolecules 14(11) 1357-1357 2024年10月25日
Activation of the CDK7 Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-1

Mashiro Shirasawa, Rinka Nakajima, Yaxuan Zhou, Lin Zhao, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P. Bradford, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani

Genes 15(8) 1080-1080 2024年8月15日
Trans-Activation of the Coactivator-Associated Arginine Methyltransferase 1 (Carm1) Gene by the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1.

Rahma F Hayati, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Lin Zhao, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P Bradford, Kenta Kurayoshi, Keigo Araki …

Genes 15(6) 2024年5月27日
Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression.

Yaxuan Zhou, Rinka Nakajima, Mashiro Shirasawa, Mariana Fikriyanti, Lin Zhao, Ritsuko Iwanaga, Andrew P Bradford, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani

Biology 12(12) 2023年12月11日
The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F.

Rinka Nakajima, Reika Deguchi, Hideyuki Komori, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Arlene Angelina, Yasuko Goto, Fumiya Tohjo, Kengo Nakahashi …

Biochemical and biophysical research communications 663 154-162 2023年6月30日
Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool.

Rinka Nakajima, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Ayato Uchida, Hikaru Murakawa, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P Bradford, Keigo Araki …

Genes 14(2) 2023年2月2日
Engineered Polymeric Nanovector for Intracellular Peptide Delivery in Antitumor Therapy.

Xi Zhang, Mingming Zhang, Sijun Huang, Kiyoshi Ohtani, Li Xu, Yi Guo

International journal of nanomedicine 18 5343-5363 2023年
Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells.

Keigo Araki, Keiko Kawauchi, Wataru Sugimoto, Daisuke Tsuda, Hiroya Oda, Ryosuke Yoshida, Kiyoshi Ohtani

Communications biology 2 3-3 2019年
Early detection of virus infection in live human cells using Raman spectroscopy.

Kamila Moor, Yusuke Terada, Akinori Taketani, Hiroko Matsuyoshi, Kiyoshi Ohtani, Hidetoshi Sato

Journal of biomedical optics 23(9) 1-7 2018年9月
Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes.

Hideyuki Komori, Yasuko Goto, Kenta Kurayoshi, Eiko Ozono, Ritsuko Iwanaga, Andrew P Bradford, Keigo Araki, Kiyoshi Ohtani

Scientific reports 8(1) 8438-8438 2018年5月31日査読有り
Ectopic expression of the CDK inhibitor p21Cip1 enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by the ARF tumor suppressor promoter.

Kenta Kurayoshi, Ayumi Shiromoto, Eiko Ozono, Ritsuko Iwanaga, Andrew P Bradford, Keigo Araki, Kiyoshi Ohtani

Biochemical and biophysical research communications 483(1) 107-114 2017年1月29日査読有り
The phosphatidyl inositol 3 kinase pathway does not suppress activation of the ARF and BIM genes by deregulated E2F1 activity.

Kenta Kurayoshi, Junko Okuno, Eiko Ozono, Ritsuko Iwanaga, Andrew P Bradford, Kazuyuki Kugawa, Keigo Araki, Kiyoshi Ohtani

Biochemical and biophysical research communications 482(4) 784-790 2017年1月22日査読有り
The Interaction Mode of the Acidic Region of the Cell Cycle Transcription Factor DP1 with TFIIH.

Masahiko Okuda, Keigo Araki, Kiyoshi Ohtani, Yoshifumi Nishimura

Journal of molecular biology 428(24 Pt B) 4993-5006 2016年12月4日査読有り
Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts.

Hodaka Kitamura, Eiko Ozono, Ritsuko Iwanaga, Andrew P Bradford, Junko Okuno, Emi Shimizu, Kenta Kurayoshi, Kazuyuki Kugawa, Hiroyuki Toh, Kiyoshi Ohtani

Genes to cells : devoted to molecular & cellular mechanisms 20(9) 739-57 2015年9月査読有り

もっとみる

MISC

Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.

Hisao Masai, Chika Taniyama, Keiko Ogino, Etsuko Matsui, Naoko Kakusho, Seiji Matsumoto, Jung-Min Kim, Ai Ishii, Taku Tanaka, Toshiko Kobayashi …

The Journal of biological chemistry 281(51) 39249-61 2006年12月22日
Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners

R Iwanaga, H Komori, S Ishida, N Okamura, K Nakayama, KI Nakayama, K Ohtani

ONCOGENE 25(12) 1786-1798 2006年3月
Distinct E2F-mediated transcriptional program regulates p14ARF gene expression.

Hideyuki Komori, Mitsuru Enomoto, Masataka Nakamura, Ritsuko Iwanaga, Kiyoshi Ohtani

The EMBO journal 24(21) 3724-36 2005年11月2日
Differential regulation of expression of the mammalian DNA repair genes by growth stimulation.

Ritsuko Iwanaga, Hideyuki Komori, Kiyoshi Ohtani

Oncogene 23(53) 8581-90 2004年11月11日
Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factors

N Funato, K Ohtani, K Ohyama, T Kuroda, M Nakamura

MOLECULAR AND CELLULAR BIOLOGY 21(21) 7416-7428 2001年11月
Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I

R Iwanaga, K Ohtani, T Hayashi, M Nakamura

ONCOGENE 20(17) 2055-2067 2001年4月
Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I

YP Huang, K Ohtani, R Iwanaga, Y Matsumura, M Nakamura

ONCOGENE 20(9) 1094-1102 2001年3月
Molecular mechanism of activation of E2F by HTLV-I Tax

M Nakamura, R Iwanaga, K Ohtani

AIDS RESEARCH AND HUMAN RETROVIRUSES 17 S50-S50 2001年
ヒトT細胞白血病ウイルス癌遺伝子産物Taxによる細胞周期循廻の分子機構

20 2001年
ヒトT細胞白血病ウイルス癌遺伝子産物TaxによるヒトサイクリンD2遺伝子の通接の活性化

20 2001年
Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I

K Ohtani, R Iwanaga, M Arai, YP Huang, Y Matsumura, M Nakamura

JOURNAL OF BIOLOGICAL CHEMISTRY 275(15) 11154-11163 2000年4月
Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F

Kiyoshi Ohtani, Ritsuko Iwanaga, Masataka Nakamura, Masa-Aki Ikeda, Norikazu Yabuta, Hiromichi Tsuruga, Hiroshi Nojima

Oncogene 18(14) 2299-2309 1999年4月8日
Implication of transcription factor E2F in regulation of DNA replication

Frontiers in Bioscience 4 d793-804 1999年
Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F

K Ohtani, A Tsujimoto, M Ikeda, M Nakamura

ONCOGENE 17(14) 1777-1785 1998年10月
Molecular mechanisms of promoter regulation of the gp34 gene that is trans-activated by an oncoprotein tax of human T cell leukemia virus type I

K Ohtani, A Tsujimoto, T Tsukahara, N Numata, S Miura, K Sugamura, M Nakamura

JOURNAL OF BIOLOGICAL CHEMISTRY 273(23) 14119-14129 1998年6月
Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals

R Sears, K Ohtani, Nevins, JR

MOLECULAR AND CELLULAR BIOLOGY 17(9) 5227-5235 1997年9月
Cell growth control by the E2F transcription factor

K. Ohtani, M. Ikeda

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 42(10) 1603-1611 1997年
Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor

K Ohtani, J DeGregori, G Leone, DR Herendeen, TJ Kelly, Nevins, JR

MOLECULAR AND CELLULAR BIOLOGY 16(12) 6977-6984 1996年12月
E2F-1 ACCUMULATION BYPASSES A G(1) ARREST RESULTING FROM THE INHIBITION OF G(1) CYCLIN-DEPENDENT KINASE-ACTIVITY

J DEGREGORI, G LEONE, K OHTANI, A MIRON, NEVINS, JR

GENES & DEVELOPMENT 9(23) 2873-2887 1995年12月
Regulation of the cyclin E gene by transcription factor E2F1

K Ohtani, J DeGregori, Nevins, JR

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92(26) 12146-12150 1995年12月

もっとみる

所属学協会

共同研究・競争的資金等の研究課題

がん細胞特異性のより高いがん細胞傷害性組換えアデノウイルスの開発

科学技術振興機構産学が連携した研究開発成果の展開/研究成果展開事業/研究成果最適展開支援プログラム(A-STEP)/探索タイプ 2012年 - 2013年

大谷清
HTLV-Iによる発癌機序
E2Fの新しい標的遺伝子の同定
細胞周期制御
Oncogenesis by HTLV-I
Functional analyses of new E2F target genes and distinct transcriptional regulation mediated by E2F
Regulation of the Cell Cycle Progression

大谷清

基本情報

研究キーワード

研究分野

経歴

論文

MISC

所属学協会

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧