竹下淳 (Sunao Takeshita) - マイポータル

基本情報

所属: 国立研究開発法人国立長寿医療研究センター運動器疾患研究部室長

J-GLOBAL ID: 200901005813476304
researchmap会員ID: 1000203985

外部リンク: http://www.ncgg.go.jp/department/bjd/bjd/index.htm

研究キーワード

研究分野

学歴

論文

WAIF1 Is a Cell-Surface CTHRC1 Binding Protein Coupling Bone Resorption and Formation.

Kazuhiko Matsuoka, Yukihiro Kohara, Yoshinori Naoe, Atsushi Watanabe, Masako Ito, Kyoji Ikeda, Sunao Takeshita

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 33(8) 1500-1512 2018年8月査読有り
Serum CTX levels and histomorphometric analysis in Src versus RANKL knockout mice

Sunao Takeshita, Toshio Fumoto, Masako Ito, Kyoji Ikeda

Journal of Bone and Mineral Metabolism 36(3) 264-273 2018年5月1日査読有り
A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages

Lijun Wang, Caterina Iorio, Kevin Yan, Howard Yang, Sunao Takeshita, Sumin Kang, Benjamin G. Neel, Wentian Yang

FASEB Journal 32(2) 875-887 2018年2月1日査読有り
[Coupling of bone resorption and formation.]

Takeshita S

Clinical calcium 27(12) 1705-1711 2017年査読有り
The role of osteoclast differentiation and function in skeletal homeostasis

Kyoji Ikeda, Sunao Takeshita

JOURNAL OF BIOCHEMISTRY 159(1) 1-8 2016年1月査読有り
Proliferation-coupled osteoclast differentiation by RANKL: Cell density as a determinant of osteoclast formation

M. Motiur Rahman, Sunao Takeshita, Kazuhiko Matsuoka, Keiko Kaneko, Yoshinori Naoe, Asako Sakaue-Sawano, Atsushi Miyawaki, Kyoji Ikeda

BONE 81 392-399 2015年12月査読有り
Secretion of PDGF isoforms during osteoclastogenesis and its modulation by anti-osteoclast drugs

M. Motiur Rahman, Kazuhiko Matsuoka, Sunao Takeshita, Kyoji Ikeda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 462(2) 159-164 2015年6月査読有り
Factors and mechanisms involved in the coupling from bone resorption to formation: how osteoclasts talk to osteoblasts.

Ikeda K, Takeshita S

Journal of bone metabolism 21(3) 163-167 2014年8月査読有り
Osteoclast-Derived Complement Component 3a Stimulates Osteoblast Differentiation

Kazuhiko Matsuoka, Kyoung-ae Park, Masako Ito, Kyoji Ikeda, Sunao Takeshita

JOURNAL OF BONE AND MINERAL RESEARCH 29(7) 1522-1530 2014年7月査読有り
Age-related Marrow Adipogenesis Is Linked to Increased Expression of RANKL

Sunao Takeshita, Toshio Fumoto, Yoshinori Naoe, Kyoji Ikeda

JOURNAL OF BIOLOGICAL CHEMISTRY 289(24) 16699-16710 2014年6月査読有り
Physiological Functions of Osteoblast Lineage and T Cell-Derived RANKL in Bone Homeostasis

Toshio Fumoto, Sunao Takeshita, Masako Ito, Kyoji Ikeda

JOURNAL OF BONE AND MINERAL RESEARCH 29(4) 830-842 2014年4月査読有り
Metabolic Regulation of Osteoclast Differentiation and Function

Yoriko Indo, Sunao Takeshita, Kiyo-Aki Ishii, Takayuki Hoshii, Hiroyuki Aburatani, Atsushi Hirao, Kyoji Ikeda

JOURNAL OF BONE AND MINERAL RESEARCH 28(11) 2392-2399 2013年11月査読有り
Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation

Sunao Takeshita, Toshio Fumoto, Kazuhiko Matsuoka, Kyoung-Ae Park, Hiroyuki Aburatani, Shigeaki Kato, Masako Ito, Kyoji Ikeda

Journal of Clinical Investigation 123(9) 3914-3924 2013年9月3日査読有り
Coordination of PGC-1 beta and iron uptake in mitochondrial biogenesis and osteoclast activation

Kiyo-aki Ishii, Toshio Fumoto, Kazuhiro Iwai, Sunao Takeshita, Masako Ito, Nobuyuki Shimohata, Hiroyuki Aburatani, Shigeru Taketani, Christopher J. Lelliott, Antonio Vidal-Puig …

NATURE MEDICINE 15(3) 259-266 2009年3月査読有り
Activation of Renin-Angiotensin System Induces Osteoporosis Independently of Hypertension

Yutaro Asaba, Masako Ito, Toshio Fumoto, Ken Watanabe, Rvoji Flikuhara, Sunao Takeshita, Yuji Nimura, Junji Ishida, Akiyoshi Fukamizu, Kyoji Ikeda

JOURNAL OF BONE AND MINERAL RESEARCH 24(2) 241-250 2009年2月査読有り
Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis

Kiyoshi Hiramatsu, Yutaro Asaba, Sunao Takeshita, Yuji Nimura, Sawako Tatsumi, Nobuyoshi Katagiri, Shumpei Niida, Toshihiro Nakajima, Sakae Tanaka, Masako Ito …

ENDOCRINOLOGY 148(6) 2708-2715 2007年6月査読有り
c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages

Sunao Takeshita, Roberta Faccio, Jean Chappel, Ling Zheng, Xu Feng, Jason D. Weber, Steven L. Teitelbaum, F. Patrick Ross

JOURNAL OF BIOLOGICAL CHEMISTRY 282(26) 18980-18990 2007年6月査読有り
M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Tyr-559/697/721

Roberta Faccio, Sunao Takeshita, Graziana Colaianni, Jean Chappel, Alberta Zallone, Steven L. Teitelbaum, F. Patrick Ross

JOURNAL OF BIOLOGICAL CHEMISTRY 282(26) 18991-18999 2007年6月査読有り
NF-kappa B p50 and p52 regulate receptor activator of NF-kappa B ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1

Teruhito Yamashita, Zhenqiang Yao, Fang Li, Qian Zhang, I. Raul Badell, Edward M. Schwarz, Sunao Takeshita, Erwin F. Wagner, Masaki Noda, Koichi Matsuo …

JOURNAL OF BIOLOGICAL CHEMISTRY 282(25) 18245-18253 2007年6月査読有り
Targeted ablation of Osteocytes induces osteoporosis with defective mechanotransduction

Sawako Tatsumi, Kiyoaki Ishii, Norio Amizuka, Minqi Li, Toshihiro Kobayashi, Kenji Kohno, Masako Ito, Sunao Takeshita, Kyoji Ikeda

CELL METABOLISM 5(6) 464-475 2007年6月査読有り

もっとみる

MISC

Functional association of CD9 with the Fc gamma receptors in macrophages

K Kaji, S Takeshita, K Miyake, T Takai, A Kudo

JOURNAL OF IMMUNOLOGY 166(5) 3256-3265 2001年3月
The transition of cadherin expression in osteoblast differentiation from mesenchymal cells: Consistent expression of cadherin-11 in osteoblast lineage

J Kawaguchi, Kii, I, Y Sugiyama, S Takeshita, A Kudo

JOURNAL OF BONE AND MINERAL RESEARCH 16(2) 260-269 2001年2月
Targeted disruption of cadherin-11 leads to a reduction in bone density in calvaria and long bone metaphyses.

J. Bone Mener. Res 2001年
Identification and characterization of mouse bone marrow stroal cell lines immortalized by temperature sensitive SV40T antigen: supportive activity for osteoclast diferentiation.

Bone 2001年
Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts

S Takeshita, K Kaji, A Kudo

JOURNAL OF BONE AND MINERAL RESEARCH 15(8) 1477-1488 2000年8月
TNF-alpha induces differentiation and bone resorption by osteoclasts.

J. Biol. Chem. 275(7) 4858-4864 2000年
Tumor necrosis factor-alpha induces differentration of and bone resorption by osteoclasts,

J. Biol. Chem 275(7) 4858-4864 2000年
Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta

K Horiuchi, N Amizuka, S Takeshita, H Takamatsu, M Katsuura, H Ozawa, Y Toyama, LF Bonewald, A Kudo

JOURNAL OF BONE AND MINERAL RESEARCH 14(7) 1239-1249 1999年7月
Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11.

J. Bone Miner. Res. 14 764-774 1999年
Anomanous cahderin expression in osteosarcoma: possible relationships to metastasis and morphogenesis.

Am. J. Pathol. 155 1549-1555 1999年
Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene.

Genomics 60(1) 87-95 1999年
Lambda 5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines.

Int. Immunol. 11(8) 1195-1201 1999年
Pax-5 is identical to EBB-1/KLP and binds to the VpreB and λ5 promoters as well as the κI and κII sites upstream of the Jκ genes (共著)

European Journal of Immunology 27(3) 750-755 1997年
BMP-2-Producing L cells induce osteogenesis in vivo and in vitro

Yuko Yasuda, Mizuho Inazu, Hiroaki Kooama, Sunao Takeshita, Akira Kudo

Journal of Bone and Mineral Metabolism 14(1) 15-20 1996年
MOLECULAR-CLONING AND CHARACTERIZATION OF OB-CADHERIN, A NEW MEMBER OF CADHERIN FAMILY EXPRESSED IN OSTEOBLASTS

M OKAZAKI, S TAKESHITA, S KAWAI, R KIKUNO, A TSUJIMURA, A KUDO, E AMANN

JOURNAL OF BIOLOGICAL CHEMISTRY 269(16) 12092-12098 1994年4月
Cloning and Characterization of OSF-3, a New Member of the MERS Family, Expressed in Mouse Osteoblastic Cells (共著)

Journal of Biochemistry 115 641-643 1994年
Osteoblast-specific factor 2 : cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I (共著)

Biochemical Journal (294) 271-278 1993年
GENOMIC ORGANIZATION OF THE MOUSE OSF-1 GENE

KI KATOH, S TAKESHITA, M SATO, T ITO, E AMANN

DNA AND CELL BIOLOGY 11(10) 735-743 1992年12月
Participation of a dominant cytotoxic T cell population defined by a monoclonal antibody in syngeneic anti-tumor responses (共著)

Europian Journal of Immunology 20(9) 2095-2103 1990年
Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblast and brain tissues (共著)

Biochemical and Biophysical Research Communications 173(1) 246-251 1990年

もっとみる

共同研究・競争的資金等の研究課題

骨カップリング因子Cthrc1の骨形成促進機構の解明と創薬への応用

文部科学省基盤研究C 2016年 - 2018年

竹下淳
破骨細胞の骨基質認識に関わる遺伝子群の網羅的機能解析

文部科学省挑戦的萌芽研究 2014年 - 2015年

竹下淳
骨吸収特異的転写制御機構の解明

文部科学省基盤研究C 2010年 - 2012年

竹下淳
Study for the Regulatory Mechanisms of Bone Metabolism by Osteoclastic factors

Basic Science Research Program 2005年 - 2009年
破骨細胞因子による骨代謝制御機構の解明

文部科学省基盤研究C 2007年 - 2008年
高齢者の骨関節疾患の発症因子と新しい治療法に関する研究

共同研究 2005年 - 2007年
Study for the Cansative Factors and the New Therapy of Aged Bone and Joint Diseases

Cooperative Research 2005年 - 2007年