MUKAI Takahiro

J-GLOBAL         Last updated: Nov 22, 2018 at 16:53
 
Avatar
Name
MUKAI Takahiro
Affiliation
Kobe Pharmaceutical University
Job title
Associate Professor

Research Areas

 
 

Academic & Professional Experience

 
1994
 - 
1996
Researcher, Formulation Research Laboratories, Sumitomo Pharmaceuticals Research Center.
 
1996
 - 
1999
Assistant Professor, School of Pharmaceutical Sciences, Nagasaki University.
 
1999
 - 
2004
Assistant Professor, Graduate School of Medicine, Kyoto University.
 
2004
   
 
- Associate Professor, Graduate School of Pharmaceutical Sciences, Kyushu University.
 

Education

 
 
 - 
1994
Graduate School, Division of Pharmaceutical Sciences, Kyoto University
 
 
 - 
1992
Faculty of Pharmaceutical Science, Kyoto University
 

Committee Memberships

 
1992
 - 
2005
Engaged in research on the Radiopharmaceuticals
 

Awards & Honors

 
2001
The 26th Conference on Pharmaceutical Technology, Postdoctoral Presentation Award
 
2003
Young Investigator Award, Kinki Branch of Pharmaceutical Society of Japan
 
2003
Young Investigator Award, Japanese Society of Nuclear Medicine
 
2004
2004 FIRST PLACE AWARD, OUTSTANDING BASIC SCIENCE INVESTIGATIONS, Society of Nuclear Medicine
 

Published Papers

 
Takeshi Fuchigami, Noriko Fujimoto, Terushi Haradahira, Yumiko Nojiri, Takashi Okauchi, Jun Maeda, Tetsuya Suhara, Fumihiko Yamamoto, Morio Nakayama, Minoru Maeda, Takahiro Mukai
Journal of Labelled Compounds & Radiopharmaceuticals      Oct 2018   [Refereed]
Kohei Sano, Kohei Sano, Yuko Kanada, Katsushi Takahashi, Ning Ding, Kengo Kanazaki, Kengo Kanazaki, Takahiro Mukai, Masahiro Ono, Hideo Saji
Molecular Pharmaceutics   15 3997-4003   Sep 2018
Copyright © 2018 American Chemical Society. In order to develop a radiopharmaceutical for internal radiotherapy that had a high anticancer effect while exposing normal tissues to low radiation levels, we synthesized a radiolabeled polyoxazoline (P...
Masafumi Tanaka, Akira Hosotani, Takahiro Mukai
Journal of labelled compounds & radiopharmaceuticals   61(11) 857-863   Sep 2018   [Refereed]
Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, Osamu Shibata
Colloids and Surfaces B: Biointerfaces   164 1-10   Apr 2018
© 2018 Elsevier B.V. The property of a newly synthesized tetrazine derivative comprised of double C18-saturated hydrocarbon chain (C18-rTz-C18) has been studied in situ at the air−water interface. C18-rTz-C18 or a gemini amphiphile contributes to ...
Masafumi Tanaka, Toru Kawakami, Nozomi Okino, Kaoru Sasaki, Kiwako Nakanishi, Hiroka Takase, Toshiyuki Yamada, Takahiro Mukai
Archives of Biochemistry and Biophysics   639 9-15   Feb 2018   [Refereed]
Masayori Hagimori, Masayori Hagimori, Takashi Temma, Takashi Temma, Shinji Kudo, Kohei Sano, Naoya Kondo, Naoya Kondo, Takahiro Mukai
Bioorganic and Medicinal Chemistry Letters   28 193-195   Jan 2018
© 2017 Elsevier Ltd Matrix metalloproteinase-12 (MMP-12, macrophage elastase) is a member of the MMP family that is responsible for the degradation of extracellular matrix, and is associated with the inflammatory process of chronic obstructive pul...
Aya Tanaka, Nodoka Minami, Yumi Yasuoka, Takeshi Iimoto, Yasutaka Omori, Hiroyuki Nagahama, Jun Muto, Takahiro Mukai
Radiation Protection Dosimetry   177 324-330   Dec 2017
© The Author 2017. Published by Oxford University Press. All rights reserved. AlphaGUARD is a low-effective volume detector and one of the most popular portable radon monitors which is currently available. This study investigated whether AlphaGUAR...
Masayori Hagimori, Masayori Hagimori, Eri Hatabe, Kohei Sano, Kohei Sano, Kohei Sano, Hirotaka Miyazaki, Hitoshi Sasaki, Hideo Saji, Takahiro Mukai
Biological and Pharmaceutical Bulletin   40 297-302   Jan 2017
© 2017 The Pharmaceutical Society of Japan. Sentinel lymph nodes (SLN) are the first lymph nodes (LN) where cancer cells metastasize from the primary tumor. We designed fluorophore-quencher-based activatable nanoparticles for SLN imaging. We selec...
Masafumi Tanaka, Naomi Tsujino, Takahiro Mukai
Chemistry Letters   46 944-946   Jan 2017
© 2017 The Chemical Society of Japan. Lipid nanodisks modified with folate (FA) were prepared and the cellular uptake was evaluated. FA-conjugated phospholipids were synthesized and incorporated into lipid nanodisks. Radiolabeled or fluorescently ...
Mikako Goto, Yumi Yasuoka, Hiroyuki Nagahama, Jun Muto, Yasutaka Omori, Hayato Ihara, Takahiro Mukai
Radiation Protection Dosimetry   174 376-381   Jan 2017
© The Author 2016. A significant increase in atmospheric radon concentration was observed in the area around the epicentre before and after the occurrence of the shallow inland earthquake in the northern Wakayama Prefecture on 5 July 2011 (Mj 5.5,...
Norihiko Takeda, Masafumi Ueda, Nagisa Mori, Tetsuya Miyoshi, Manami Shimoda, Yumina Uno, Hiroshi Kitagawa, Noriaki Emoto, Takahiro Mukai, Okiko Miyata
Heterocycles   94 750-762   Jan 2017
© 2017 The Japan Institute of Heterocyclic Chemistry. Treatment of a dienylimine bearing a boron-dipyrromethene (BODIPY) fluorophore with aryl and alkyl thiols afforded arylthio and alkylthio-indolines through an addition-aromatization reaction se...
Masafumi Tanaka, Ayaka Nishimura, Haruka Takeshita, Hiroka Takase, Toshiyuki Yamada, Takahiro Mukai
Chemistry and Physics of Lipids   202 6-12   Jan 2017   [Refereed]
Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, Osamu Shibata
Langmuir   32 6591-6599   Jul 2016
© 2016 American Chemical Society. Tetrazine (Tz) is expected to be used for bioimaging and as an analytical reagent. It is known to react very fast with trans-cyclooctene under water in organic chemistry. Here, to understand the interaction betwee...
Hiroka Takase, Masafumi Tanaka, Aki Yamamoto, Shiori Watanabe, Sanae Takahashi, Satomi Nadanaka, Hiroshi Kitagawa, Toshiyuki Yamada, Takahiro Mukai
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis   23(2) 67-75   Jun 2016   [Refereed]
Yumi Yamamoto, Jun Arai, Takuya Hisa, Yohei Saito, Takahiro Mukai, Takashi Ohshima, Minoru Maeda, Fumihiko Yamamoto
Bioorganic and Medicinal Chemistry   24 3727-3733   Jan 2016
© 2016 Elsevier Ltd Isomeric iodinated derivatives of nimesulide, with an iodine substituent on the phenoxy ring, were prepared with the aim of identifying potential candidate compounds for the development of imaging agents targeting cyclooxygenas...
Masayori Hagimori, Takahiro Murakami, Kinue Shimizu, Motohiro Nishida, Motohiro Nishida, Takashi Ohshima, Takahiro Mukai
MedChemComm   7 1003-1006   Jan 2016
© The Royal Society of Chemistry 2016. The transient receptor potential canonical 3 (TRPC3) channel is a member of the TRPC family that contributes to the entry of Ca2+through the plasma membrane or modulates the driving force for Ca2+entry channe...
Masayori Hagimori, Yasuhiro Shigemitsu, Yasuhiro Shigemitsu, Ryo Murakami, Kenichirou Yokota, Yasuhisa Nishimura, Naoko Mizuyama, Bo Cheng Wang, Chen Kuen Tai, San Lang Wang, Tzenge Lien Shih, Kuen Da Wu, Zhi Shuan Huang, Shih Chuw Tseng, Jian Wei Lu, Ho Hsiang Wei, Junko Nagaoka, Takahiro Mukai, Shinichi Kawashima, Keisuke Kawashima, Yoshinori Tominaga
Dyes and Pigments   124 196-202   Jan 2016
© 2015 Elsevier Ltd. All rights reserved. Novel highly emissive 2-pyridone-based compounds 3a,b and 4a-d were synthesized by a convenient one-pot method from 4-(dialkylamino)acetophenones (1a,b) and cyanoketene dithioacetal (2a) or sulfonyl ketene...
Yumi Yamamoto, Takuya Hisa, Jun Arai, Yohei Saito, Fumihiko Yamamoto, Takahiro Mukai, Takashi Ohshima, Minoru Maeda, Yasuhito Ohkubo
Bioorganic and Medicinal Chemistry   23 6807-6814   Nov 2015
© 2015 Elsevier Ltd. Nimesulide analogs bearing a methoxy substituent either at the ortho-, meta- or para-position on the phenyl ring, were designed, synthesized, and evaluated for potential as radioligands for brain cyclooxygenase-2 (COX-2) imagi...
Masafumi Tanaka, Akira Hosotani, Yuka Tachibana, Minoru Nakano, Kenji Iwasaki, Toru Kawakami, Takahiro Mukai
Langmuir : the ACS journal of surfaces and colloids   31(46) 12719-12726   Nov 2015   [Refereed]
Masayori Hagimori, Takashi Temma, Naoko Mizuyama, Takuhiro Uto, Yasuchika Yamaguchi, Yoshinori Tominaga, Takahiro Mukai, Hideo Saji
Sensors and Actuators, B: Chemical   213 45-52   Jul 2015
© 2015 Elsevier B.V. All rights reserved. A high-affinity and low-molecular-weight fluorescent Zn2+sensor 1 based on a 2,2′-bipyridine scaffold, which functions as both the chelating moiety for Zn2+and the fluorophore, was developed and evaluated ...
Masayori Hagimori, Naoko Mizuyama, Yoshinori Tominaga, Takahiro Mukai, Hideo Saji
Dyes and Pigments   113 205-209   Jan 2015
Novel, low-molecular-weight fluorescent sensors based on a pyridine-pyridone core structure, which functions as both the chelating part moiety for Zn2+and as the fluorophore, were investigated. The length of the methylene spacer between the phenyl...
Koseki Hayashi, Yumi Yasuoka, Hiroyuki Nagahama, Jun Muto, Tetsuo Ishikawa, Yasutaka Omori, Toshiyuki Suzuki, Yoshimi Homma, Takahiro Mukai
Journal of Environmental Radioactivity   139 149-153   Jan 2015
© 2014 Elsevier Ltd. Anomalous radon readings in air have been reported before an earthquake activity. However, careful measurements of atmospheric radon concentrations during a normal period are required to identify anomalous variations in a prec...
Yuka Kobayashi, Yumi Yasuoka, Yasutaka Omori, Hiroyuki Nagahama, Tetsuya Sanada, Jun Muto, Toshiyuki Suzuki, Yoshimi Homma, Hayato Ihara, Kazuhito Kubota, Takahiro Mukai
Journal of Environmental Radioactivity   146 110-118   Jan 2015
© 2015 Elsevier Ltd. Anomalous atmospheric variations in radon related to earthquakes have been observed in hourly exhaust-monitoring data from radioisotope institutes in Japan. The extraction of seismic anomalous radon variations would be greatly...
Effect of a desiccant on the measurement of radon concentration in air
Yukari Tajika, Yumi Yasuoka, Yasutaka Omori, Atsuyuki Sorimachi, Tetsuo Ishikawa, Yasunori Mori, Takahiro Mukai
Japanese Journal of Health Physics   49(4) 190-193   Dec 2014   [Refereed]
Kohei Sano, Yuriko Iwamiya, Tomoaki Kurosaki, Mikako Ogawa, Yasuhiro Magata, Hitoshi Sasaki, Takashi Ohshima, Minoru Maeda, Takahiro Mukai, Takahiro Mukai
Journal of Controlled Release   194 310-315   Nov 2014
© 2014 Elsevier B.V. We established a ternary anionic complex constructed with polyamidoamine dendrimer (4th generation; G4) modified with chelating agents (diethylenetriamine pentaacetic acid (DTPA) derivative), polyethyleneimine (PEI), and γ-pol...
Junichi Sasaki, Kohei Sano, Masayori Hagimori, Mai Yoshikawa, Minoru Maeda, Takahiro Mukai, Takahiro Mukai
Bioorganic and Medicinal Chemistry   22 6039-6046   Nov 2014
© 2014 Elsevier Ltd. All rights reserved. NAD(P)H: quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase and is highly expressed in many human solid cancers. Because NQO1 can be induced immediately after exposure to ionizing radiat...
Hiroka Takase, Hiroki Furuchi, Masafumi Tanaka, Toshiyuki Yamada, Kyoko Matoba, Kenji Iwasaki, Toru Kawakami, Takahiro Mukai
Biochimica et Biophysica Acta -Molecular and Cell Biology of Lipids   1842(10) 1467-1474   Oct 2014   [Refereed]
Experimental demonstration for measurement of radon in water by a liquid scintillation counter using large vials
Yumi Yasuoka, Yasunori Mori, Kae Murakami, Yuka Kobayashi, Shoko Ohnuma, Hideo Takizawa, Tetsuo Ishikawa, Takahiro Mukai
Radiation Emergency Medicine   3(2) 39-42   Aug 2014   [Refereed]
Kohei Sano, Kohei Sano, Ryo Masuda, Hayato Hisada, Shinya Oishi, Kenta Shimokawa, Masahiro Ono, Nobutaka Fujii, Hideo Saji, Takahiro Mukai, Takahiro Mukai
Bioorganic and Medicinal Chemistry Letters   24 1386-1388   Mar 2014
We have developed a novel radiogallium (Ga)-DOTA-based bivalent peptidic ligand targeting a chemokine receptor, CXCR4, for tumor imaging. A CXCR4 imaging probe with two CXCR4 antagonists (Ac-TZ14011) on Ga-DOTA core, Ga-DOTA-TZ2, was synthesized, ...
Hiroka Takase, Masafumi Tanaka, Sachiko Miyagawa, Toshiyuki Yamada, Takahiro Mukai
Biochemical and Biophysical Research Communicationss   444(1) 92-97   Jan 2014   [Refereed]
Tetsuya Miyoshi, Yuka Aoki, Yumina Uno, Mina Araki, Takahiro Kamatani, Daichi Fujii, Yoshinori Fujita, Norihiko Takeda, Masafumi Ueda, Hiroshi Kitagawa, Noriaki Emoto, Takahiro Mukai, Masafumi Tanaka, Okiko Miyata
Journal of Organic Chemistry   78 11433-11443   Nov 2013
The reaction of a dienylimine with thiols was found to proceed smoothly to afford the corresponding indolines bearing aromatic carbon-sulfur bonds as a result of a Michael addition-aromatization sequence. Furthermore, this reaction was applied to ...
Risa Tanaka, Saori Araki, Yumi Yasuoka, Takahiro Mukai, Shoko Ohnuma, Tetsuo Ishikawa, Nobutoshi Fukuhori, Tetsuya Sanada
Radioisotopes   62(7) 423-438   Jul 2013   [Refereed]
Kohei Sano, Mayumi Okada, Hayato Hisada, Kenta Shimokawa, Hideo Saji, Minoru Maeda, Takahiro Mukai, Takahiro Mukai
Biological and Pharmaceutical Bulletin   36 602-608   Apr 2013
On the basis of the findings obtained by X-ray crystallography of Ga-DOTA chelates and the drug design concept of bifunctional radiopharmaceuticals, we previously designed and synthesized a radiogallium-labeled DOTA chelate containing two metronid...
Yukari Tajika, Yumi Yasuoka, Hiroyuki Nagahama, Toshiyuki Suzuki, Yoshimi Homma, Tetsuo Ishikawa, Shinji Tokonami, Takahiro Mukai, Takahiro Mukai, Miroslaw Janik, Atsuyuki Sorimachi, Masahiro Hosoda
Journal of Radioanalytical and Nuclear Chemistry   295 1709-1714   Mar 2013
Gas-flow ionization chambers for radioisotope (RI) monitoring systems at RI institutes throughout Japan are commonly used to measure RIs which leak from the RI institutes. Before the Japan's 2011 Tohoku earthquake [11 March 2011, moment magnitude ...
Masafumi Tanaka, Yuki Takamura, Toru Kawakami, Saburo Aimoto, Hiroyuki Saito, Takahiro Mukai
FEBS Letters   587(5) 510-515   Mar 2013   [Refereed]
Jintaek Kim, Tomohiro Kino, Hiroharu Kato, Fumihiko Yamamoto, Kohei Sano, Takahiro Mukai, Takahiro Mukai, Minoru Maeda, Minoru Maeda
Chemical and Pharmaceutical Bulletin   60 235-240   Feb 2012
As a part of our efforts to develop potential imaging agents for ascorbate bioactivity, 5-O-(4-[125I] iodobenzyl)-L-ascorbic acid ([125I]1) was prepared through a two-step sequence which involved radioiodo-destannylation of a protected tributylsta...
Takashi Kudo, Masashi Ueda, Masashi Ueda, Hiroaki Konishi, Hidekazu Kawashima, Hidekazu Kawashima, Yuji Kuge, Yuji Kuge, Takahiro Mukai, Azusa Miyano, Shotaro Tanaka, Shinae Kizaka-Kondoh, Masahiro Hiraoka, Hideo Saji
Molecular Imaging and Biology   13 1003-1010   Oct 2011
Purpose: We aimed to evaluate the feasibility of using streptavidin-biotin- based pretargeting for positron emission tomography (PET) imaging of hypoxia-inducible factor (HIF)-1-active tumors. Procedures: We used POS, a genetically engineered form...
Yumi Yamamoto, Jun Toyohara, Kiichi Ishiwata, Kohei Sano, Fumihiko Yamamoto, Takahiro Mukai, Takahiro Mukai, Minoru Maeda
Chemical and Pharmaceutical Bulletin   59 938-946   Aug 2011
There is great potential in the use of positron emission tomography (PET) and suitable radiotracers for the study of cyclooxygenase type 2 (COX-2) enzyme in living subjects. In the present study, we prepared and evaluated five11C-labeled ester and...
Takahiro Mukai, Masayori Hagimori, Kenji Arimitsu, Takahiro Katoh, Misa Ukon, Tetsuya Kajimoto, Hiroyuki Kimura, Yasuhiro Magata, Eiji Miyoshi, Naoyuki Taniguchi, Manabu Node, Hideo Saji
Bioorganic and Medicinal Chemistry   19 4312-4321   Jul 2011
N-acetylglucosaminyltransferase V (GnT-V) is one of the most relevant glycosyltransferases to tumor invasion and metastasis. Based on previous findings of molecular recognition between GnT-V and synthetic substrates, we designed and synthesized a ...
Masashi Ueda, Masashi Ueda, Takashi Kudo, Yuji Kuge, Yuji Kuge, Takahiro Mukai, Shotaro Tanaka, Hiroaki Konishi, Azusa Miyano, Masahiro Ono, Shinae Kizaka-Kondoh, Masahiro Hiraoka, Hideo Saji
European Journal of Nuclear Medicine and Molecular Imaging   37 1566-1574   Aug 2010
Purpose: Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant tumour progression. For the imaging of HIF-1-active tumours, we previously developed a protein, POS, which is effectively delivered to and selectively stabilized in H...
Yuuhei Sano, Tomokazu Motomura, Fumihiko Yamamoto, Miki Fukuda, Takahiro Mukai, Minoru Maeda
Chemical and Pharmaceutical Bulletin   58 1020-1025   Aug 2010
3-Methyl-1-phenyl-2-pyrazolin-5-one (edaravone, 1), known as a potent free radical scavenger, has been developed as a medical drug for the treatment of acute cerebral infarction. With the aim of developing radiotracers for imaging free radicals in...
Jintaek Kim, Fumihiko Yamamoto, Shigeki Gondo, Toshihiko Yanase, Takahiro Mukai, Minoru Maeda
Biological and Pharmaceutical Bulletin   32 1906-1911   Nov 2009
Normal female rat distribution studies showed high and specific uptake of 6-deoxy-6-[131I]iodo-L-ascorbic acid (6-131IAsA) into the adrenal glands, known to highly express the ascorbate sodium-dependent vitamin C transporter-2 (SVCT-2), and the ad...
Takeshi Fuchigami, Takeshi Fuchigami, Terushi Haradahira, Noriko Fujimoto, Yumiko Nojiri, Takahiro Mukai, Fumihiko Yamamoto, Takashi Okauchi, Jun Maeda, Kazutoshi Suzuki, Tetsuya Suhara, Hiroshi Yamaguchi, Mikako Ogawa, Yasuhiro Magata, Yasuhiro Magata, Minoru Maeda
Bioorganic and Medicinal Chemistry   17 5665-5675   Aug 2009
In this study, we synthesized and evaluated several amino 4-hydroxy-2(1H)-quinolone (4HQ) derivatives as new PET radioligand candidates for the glycine site of the NMDA receptors. Among these ligands, we discovered that 7-chloro-4-hydroxy-3-{3-(4-...
Jintaek Kim, Fumihiko Yamamoto, Satoru Karasawa, Takahiro Mukai, Minoru Maeda
Journal of Labelled Compounds and Radiopharmaceuticals   52 366-371   Jul 2009
An ascorbate analog labeled with iodine-131, 6-deoxy- 6-[ 131I]iodo-L-ascorbic acid was prepared for evaluation as an in vivo tracer of L-ascorbic acid. The no-carrier-added radiosynthesis was conducted by nucleophilic bromine-iodine exchange betw...
Takahiro Mukai, Jun Suwada, Kohei Sano, Mayumi Okada, Fumihiko Yamamoto, Minoru Maeda
Bioorganic and Medicinal Chemistry   17 4285-4289   Jul 2009
From the X-ray crystal structures of Ga-DOTA chelates, we were able to deduce that two free carboxylate groups of the radiogallium-DOTA complex may be utilized for coupling to functional moieties that recognize molecular targets for in vivo imagin...
Takashi Kudo, Masashi Ueda, Masashi Ueda, Yuji Kuge, Takahiro Mukai, Shotaro Tanaka, Maki Masutani, Yasushi Kiyono, Yasushi Kiyono, Shinae Kizaka-Kondoh, Masahiro Hiraoka, Hideo Saji, Hideo Saji
Journal of Nuclear Medicine   50 942-949   Jun 2009
Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant tumor progression and in the development of resistance to radiotherapy. We designed a novel fusion protein (PTD-ODD-SAV [POS]) consisting of a protein transduction domain (PTD...
Takahiro Mukai, Masato Taketomi, Masaaki Tashiro, Fumihiko Yamamoto, Minoru Maeda
Journal of Labelled Compounds and Radiopharmaceuticals   52 146-150   May 2009
Thymidine phosphorylase (TP) is expressed at higher levels in many types of malignant tumors than in adjacent nonneoplastic tissues. The aim of this study was to develop a radiolabeled TP inhibitor, 6-[(2-iminopyrrolidinyl)methyl]-5- [125I]iodoura...
Jintaek Kim, Fumihiko Yamamoto, Yasuo Kuwabara, Hiroshi Honda, Takahiro Mukai, Minoru Maeda
Radioisotopes   58(2) 47-55   Feb 2009   [Refereed]
Kazuma Ogawa, Kazuma Ogawa, Takahiro Mukai, Takahiro Mukai, Keiichi Kawai, Keiichi Kawai, Norito Takamura, Hirofumi Hanaoka, Kazuyuki Hashimoto, Kazuhiro Shiba, Hirofumi Mori, Hideo Saji
European Journal of Nuclear Medicine and Molecular Imaging   36 115-121   Jan 2009
Purpose: We have developed a186Re- mercaptoacetylglycylglycylglycine complex-conjugated bisphosphonate (186Re-MAG3-HBP) for the treatment of painful bone metastases. We assumed competitive inhibitors of protein binding to be useful for procuring a...
Seigo Ishino, Takahiro Mukai, Yuji Kuge, Noriaki Kume, Mikako Ogawa, Nozomi Takai, Junko Kamihashi, Masashi Shiomi, Manabu Minami, Toru Kita, Hideo Saji, Hideo Saji
Journal of Nuclear Medicine   49 1677-1685   Oct 2008
Lectinlike oxidized low-density lipoprotein (LDL) receptor 1 (LOX-1), a cell surface receptor for oxidized LDL, has been implicated in vascular cell dysfunction related to plaque instability, which could be a potential target for an atherosclerosi...
Yuji Kuge, Yuji Kuge, Noriaki Kume, Seigo Ishino, Nozomi Takai, Yuki Ogawa, Takahiro Mukai, Manabu Minami, Masashi Shiomi, Hideo Saji
Biological and Pharmaceutical Bulletin   31(8) 1475-1482   Aug 2008
Background: Despite increasing in vitro evidence that lectin-like oxidized low density lipoprotein (LDL) receptor-1 (LOX-1), a cell-surface receptor for oxidized LDL, is implicated in the atherogenesis and thrombus formation, its in vivo participa...
Yumiko Nojiri, Kiichi Ishiwata, Qinggeletu, Shintaro Tobiishi, Toru Sasada, Fumihiko Yamamoto, Takahiro Mukai, Minoru Maeda
Biological and Pharmaceutical Bulletin   31(6) 1274-1278   Jun 2008
The suitability of an18F-labeled form of N-(piperidin-1-yl)-1- (2,4-dichlorophenyl)-5-{4′-(5-fluoropentyl)-phenyl}-4-methyl-1H-pyrazole- 3-carboxamide (1), a CB1 cannabinoid ligand with high binding affinity (Ki=0.91 nM) and moderate lipophilicity...
Takahiro Mukai, Noriko Suganuma, Kenta Soejima, Junichi Sasaki, Fumihiko Yamamoto, Minoru Maeda
Chemical and Pharmaceutical Bulletin   56(3) 260-265   Mar 2008
Matrix metalloproteinase-2 (MMP-2) is an attractive target for the diagnosis of cancer and atherosclerosis in nuclear imaging. A cyclic decapeptide, cCTTHWGFTLC (cCTT), has been used as the mother compound for the development of MMP-2-imaging agen...
Takeshi Fuchigami, Takeshi Fuchigami, Terushi Haradahira, Noriko Fujimoto, Takashi Okauchi, Jun Maeda, Kazutoshi Suzuki, Tetsuya Suhara, Fumihiko Yamamoto, Shigeki Sasaki, Takahiro Mukai, Hiroshi Yamaguchi, Mikako Ogawa, Yasuhiro Magata, Yasuhiro Magata, Minoru Maeda
Nuclear Medicine and Biology   35(2) 203-212   Feb 2008
High-affinity iodine- and ethyl-C-5 substituted analogs of 4-hydroxy-3-(3-[11C]methoxyphenyl)-2(1H)-quinolone ([11C]4HQ) were synthesized as new positron emission tomography radioligands for the glycine-binding sites of the N-methyl-d-aspartate (N...
Hiroharu Kato, Tomohiro Kino, Fumihiko Yamamoto, Tetsuo Kaneshiro, Takahiro Mukai, Minoru Maeda
Chemical and Pharmaceutical Bulletin   55(12) 1700-1703   Dec 2007
As part of our program to develop potential imaging agents for ascorbate bioactivity in the brain, 5-O-(4′-iodobenzyl)-L-ascorbic acid was prepared through a seven-step sequence which involved C5-O-alkylation with piodobenzyl bromide in the presen...
Nobuhiro Handa, Nobuhiro Handa, Yasuhiro Magata, Takahiro Mukai, Takeshi Nishina, Junji Konishi, Masashi Komeda, Masashi Komeda
Annals of Nuclear Medicine   21(10) 569-576   Dec 2007
Background: Quantitative myocardial fluorodeoxyglucose positron emission tomography (FDG-PET) for assessing glucose uptake in vivo is reliable in normal rat heart. Objective: To assess the applicability of myocardial FDG-PET on multiple occasions ...
Seigo Ishino, Takahiro Mukai, Noriaki Kume, Daigo Asano, Mikako Ogawa, Yuji Kuge, Manabu Minami, Toru Kita, Masashi Shiomi, Hideo Saji
Atherosclerosis   195(1) 48-56   Nov 2007
Lectin-like oxidized LDL receptor-1 (LOX-1), a cell-surface receptor for oxidized LDL (Ox-LDL), has been implicated in vascular cell dysfunction related to atherosclerotic plaque instability, according to cell culture experiments. In the present s...
Marcelo Mamede, Koichi Ishizu, Koichi Ishizu, Masashi Ueda, Takahiro Mukai, Yasuhiko Iida, Hidekazu Kawashima, Hidenao Fukuyama, Kaori Togashi, Hideo Saji
Journal of Nuclear Medicine   48(11) 1829-1835   Nov 2007
Nicotinic acetylcholine receptors (nAChRs) are of great interest because they are implicated in various brain functions. They also are thought to play an important role in nicotine addiction of smokers. Chronic (-)-nicotine, a nAChR agonist, treat...
Shintaro Tobiishi, Toru Sasada, Yumiko Nojiri, Fumihiko Yamamoto, Takahiro Mukai, Kiichi Ishiwata, Minoru Maeda
Chemical and Pharmaceutical Bulletin   55(8) 1213-1217   Aug 2007
Methoxy and fluorine analogs substituted on the terminal carbon of the pentyl chain of N-(piperidinyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4- pentylphenyl)-1H-pyrazole-3-carboxamide (O-1302) were synthesized in a multi-step process from 5-phenyl-1-...
Hirofumi Hanaoka, Hirofumi Hanaoka, Takahiro Mukai, Takahiro Mukai, Sayo Habashita, Daigo Asano, Kazuma Ogawa, Yoshihiro Kuroda, Hiromichi Akizawa, Yasuhiko Iida, Keigo Endo, Tsuneo Saga, Hideo Saji
Nuclear Medicine and Biology   34(5) 503-510   Jul 2007
Since elevated levels of gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] are associated with a poor prognosis in cancer patients, these enzymes are potential targets for tumor imaging. In the present study, a cyclic decapeptide, cCTTHWGFT...
Kazuma Ogawa, Kazuma Ogawa, Takahiro Mukai, Takahiro Mukai, Daigo Asano, Hidekazu Kawashima, Seigo Kinuya, Kazuhiro Shiba, Kazuyuki Hashimoto, Hirofumi Mori, Hideo Saji, Hideo Saji
Journal of Nuclear Medicine   48 122-127   Jan 2007
Previously, based on the concept of bifunctional radiopharmaceuticals, we developed a highly stable186Re-mercaptoacetylglycylglycylglycine (MAG3) complex-conjugated bisphosphonate, [[[[(4-hydroxy-4,4-diphosphonobutyl) carbamoylmethyl]carbamoylmeth...
Takashi Temma, Yasuhiro Magata, Yasuhiro Magata, Yuji Kuge, Sayaka Shimonaka, Kohei Sano, Yumiko Katada, Hidekazu Kawashima, Takahiro Mukai, Hiroshi Watabe, Hidehiro Iida, Hideo Saji
Journal of Cerebral Blood Flow and Metabolism   26(12) 1577-1583   Dec 2006
The threshold of cerebral blood flow (CBF) into infarction in rats has been indicated to be similar to that in patients. However, CBF does not reflect metabolic function, and so estimations of oxygen metabolism have been required. Here, we estimat...
Kazuma Ogawa, Kazuma Ogawa, Takahiro Mukai, Takahiro Mukai, Yasuyuki Inoue, Masahiro Ono, Hideo Saji, Hideo Saji
Journal of Nuclear Medicine   47 2042-2047   Dec 2006
In bone scintigraphy using99mTc with methylenediphosphonate (99mTc-MDP) and hydroxymethylenediphosphonate (99mTc-HMDP) , it takes 226 h after an injection before imaging can start. This interval could be shortened with a new radiopharmaceutical wi...
Tsuneo Saga, Tsuneo Saga, Hidekazu Kawashima, Norio Araki, Jun A. Takahashi, Yasuaki Nakashima, Tatsuya Higashi, Natsuo Oya, Takahiro Mukai, Masato Hojo, Nobuo Hashimoto, Toshiaki Manabe, Masahiro Hiraoka, Kaori Togashi
Clinical Nuclear Medicine   31(12) 774-780   Dec 2006
PURPOSE OF THE REPORT: The purpose of this report was to investigate the potential of positron emission tomography using F-18 fluorodeoxythymidine (FLT-PET) in evaluating primary brain tumors. MATERIALS AND METHODS: FLT-PET was performed in 25 pat...
Mikako Ogawa, Yasuhiro Magata, Takashi Kato, Kentaro Hatano, Seigo Ishino, Takahiro Mukai, Masashi Shiomi, Kengo Ito, Hideo Saji, Hideo Saji
Journal of Nuclear Medicine   47 1845-1850   Nov 2006
The rupture of atherosclerotic vulnerable plaques and subsequent formation of thrombi are the main factors responsible for myocardial and cerebral infarctions. Because macrophage infiltration plays an essential role in plaque rupturing, pharmacolo...
Mariko Tanaka, Yoshihiko Fujisaki, Kazunori Kawamura, Kiichi Ishiwata, Qinggeletu, Fumihiko Yamamoto, Takahiro Mukai, Minoru Maeda
Biological and Pharmaceutical Bulletin   29(10) 2087-2094   Oct 2006
11C-Labeled analogs of 4-chloro-5-(3-fluoro-4-methoxyphenyl)-1- (4-methylsulfonylphenyl)imidazole ([11C]1), 4-[4-chloro-5-(3-fluoro- 4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide ([11C]2) and 2-(4-aminosulfonylphenyl)-3-(4-methoxyphenyl)indole ...
Ryohei Hosokawa, Naoshige Kambara, Muneo Ohba, Takahiro Mukai, Mikako Ogawa, Hiroshi Motomura, Noriaki Kume, Hideo Saji, Toru Kita, Ryuji Nohara, Ryuji Nohara
Journal of Nuclear Medicine   47(5) 863-867   May 2006
Detection of vulnerable plaques before rupture is important in preventing acute coronary events such as myocardial infarction. Although therapeutic strategies such as percutaneous transluminal coronary angioplasty appear to prevent coronary occlus...
Hirofumi Hanaoka, Hirofumi Hanaoka, Takahiro Mukai, Takahiro Mukai, Hirokazu Tamamura, Hirokazu Tamamura, Tomohiko Mori, Seigo Ishino, Kazuma Ogawa, Yasuhiko Iida, Ryuichiro Doi, Nobutaka Fujii, Hideo Saji
Nuclear Medicine and Biology   33(4) 489-494   May 2006
The chemokine receptor CXCR4 is highly expressed in tumor cells and plays an important role in tumor metastasis. The aim of this study was to develop a radiopharmaceutical for the imaging of CXCR4-expressing tumors in vivo. Based on structure-acti...
Kazuma Ogawa, Kazuma Ogawa, Takahiro Mukai, Takahiro Mukai, Yasushi Arano, Akira Otaka, Masashi Ueda, Tomoya Uehara, Yasuhiro Magata, Kazuyuki Hashimoto, Hideo Saji
Nuclear Medicine and Biology   33(4) 513-520   May 2006
To develop a radiopharmaceutical for the palliation of painful bone metastases based on the concept of bifunctional radiopharmaceuticals, we synthesized a bisphosphonate derivative labeled with rhenium-186 (186Re) that contains a hydroxyl group at...
Yasushi Fujioka, Satoshi Satake, Tomoya Uehara, Takahiro Mukai, Hiromichi Akizawa, Kazuma Ogawa, Hideo Saji, Keigo Endo, Yasushi Arano
Bioconjugate Chemistry   16(6) 1610-1616   Nov 2005
Renal localization of radiolabeled antibody fragments presents a problem in targeted imaging and radiotherapy. We recently reported that Fab fragments labeled with 3′-[131I]iodohippuryl Nε-maleoyl- L-lysine (HML) demonstrated markedly low renal ra...
Yasushi Ishida, Keiichi Kawai, Yasuhiro Magata, Yasuhiro Magata, Hiroshi Abe, Mitsuyoshi Yoshimoto, Ryuichiro Takeda, Hiroyuki Hashiguchi, Takahiro Mukai, Takahiro Mukai, Hideo Saji
Neuroscience Letters   389(1) 30-34   Nov 2005
We studied the positron emission tomography (PET) tracer distributions of ligands for dopamine D1receptors ([11C]SCH23390) and D2receptors ([11C]raclopride) and of the dopamine precursor analog 6-[18F]fluoro-l-3,4-dihydroxyphenylalanine ([18F]FDOP...
Fumihiko Yamamoto, Tetsuo Kaneshiro, Hiroharu Kato, Takahiro Mukai, Yasuo Kuwabara, Hiroshi Honda, Minoru Maeda
Biological and Pharmaceutical Bulletin   28(10) 1943-1947   Oct 2005
The relationship between in vivo biodistribution of 6-deoxy-6-[18F]fluoro-L-ascorbic acid (18F-DFA) and the content of tissue glutathione (GSH) was investigated in Wistar male rats. Following intravenous administration of18F-DFA, the accumulation ...
Koyo Nishida, Rie Fujiwara, Yukinobu Kodama, Shintaro Fumoto, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki, Junzo Nakamura
Pharmaceutical Research   22(8) 1331-1337   Aug 2005
Purpose. The purpose of this study was to examine drug distribution in the liver after drug application to the rat liver surface. Methods. Phenolsulfonphthalein (PSP) and fluorescein isothiocyanate dextran (MW 4400, FD-4) as model compounds or 5-f...
Kazuma Ogawa, Takahiro Mukai, Yasushi Arano, Masahiro Ono, Hirofumi Hanaoka, Seigo Ishino, Kazuyuki Hashimoto, Hiroshi Nishimura, Hideo Saji
Bioconjugate Chemistry   16(4) 751-757   Jul 2005
Rhenium-186-1-hydroxyethylidene-1,1-diphosphonate (186Re-HEDP) has been used for the palliation of metastatic bone pain. Delayed blood clearance and high gastric uptake of radioactivity have been observed upon injection, due to the instability of1...
Junzo Nakamura, Kazuko Kobayashi, Shintaro Fumoto, Junya Nishi, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki, Koyo Nishida
Biological and Pharmaceutical Bulletin   28(6) 1049-1053   Jun 2005
The present study was undertaken to elucidate the stomach- and site-selective delivery of 5-fluorouracil (5-FU) following its application on the gastric serosal surface in rats. An experimental system utilizing a cylindrical diffusion cell attache...
Koyo Nishida, Manabu Kamenosono, Akiko Kuma, Shintaro Fumoto, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki, Junzo Nakamura
Journal of Drug Targeting   13(4) 215-223   May 2005
The objective of this study was to evaluate the drug delivery advantage to the unilateral kidney by direct drug application to the rat kidney surface based on a physiological pharmacokinetic model. Under anesthesia, a cylindrical diffusion cell (i...
Koyo Nishida, Koyo Nishida, Naoki Tomiyama, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki, Junzo Nakamura
European Journal of Pharmaceutics and Biopharmaceutics   58(3) 705-711   Nov 2004
The aim of the present study is to clarify the absorption mechanism of a drug from the kidney surface membrane in rats. We studied the absorption characteristics of phenolsulfonphthalein (PSP) and other compounds with different molecular weights a...
Manabu Inoue, Yukinori Katsumi, Takuya Hayashi, Takahiro Mukai, Koichi Ishizu, Kazuo Hashikawa, Hideo Saji, Hidenao Fukuyama
Brain Research   1026(2) 179-184   Nov 2004
We report herein the modulation of dopamine release in the basal ganglia during peripheral electrical stimulation in animals. The endogenous dopamine release during electrical stimulation was measured in anesthetized cats by positron emission tomo...
Kazuma Ogawa, Takahiro Mukai, Yasushi Arano, Hirofumi Hanaoka, Kazuyuki Hashimoto, Hiroshi Nishimura, Hideo Saji
Journal of Labelled Compounds and Radiopharmaceuticals   47(11) 753-761   Oct 2004
To develop a radiopharmaceutical for the palliation of painful bone metastases based on the concept of bifunctional radiopharmaceuticals, we designed a bisphosphonate derivative attached to a stable186Re- monoaminemonoamidedithiol (MAMA) chelate (...
Yasushi Ishida, Yasushi Ishida, Keiichi Kawai, Yasuhiro Magata, Yasuhiro Magata, Ryuichiro Takeda, Hiroyuki Hashiguchi, Hiroshi Abe, Takahiro Mukai, Hideo Saji
Neurodegenerative Diseases   1(2-3) 109-112   Oct 2004
We studied tracer distributions in positron emission tomography of ligands for dopamine D1 receptors ([11C]SCH23390) and D 2 receptors ([11C]raclopride) and the dopamine precursor analog 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine ([ 18F]FDOPA), as...
Marcelo Mamede, Koichi Ishizu, Koichi Ishizu, Masashi Ueda, Takahiro Mukai, Yasuhiko Iida, Hidenao Fukuyama, Tsuneo Saga, Hideo Saji
Journal of Nuclear Medicine   45(9) 1458-1470   Sep 2004
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the human brain, especially the α4β2 subtype of nAChR. The cholinergic systems have roles in various neurophysiologic functions, such as learning, memory, and cognition,...
Takahiro Mukai, Ryuji Nohara, Mikako Ogawa, Seigo Ishino, Naoshige Kambara, Kazuaki Kataoka, Toru Kanoi, Kazuhiro Saito, Hiroshi Motomura, Junji Konishi, Hideo Saji
European Journal of Nuclear Medicine and Molecular Imaging   31(9) 1299-1303   Sep 2004
Purpose: Although various radiopharmaceuticals have been developed for the detection of atheromas, external imaging techniques have limitations when it comes to the detection of small plaques. In this study, we developed a charged particle-sensiti...
Takashi Temma, Yasuhiro Magata, Takahiro Mukai, Haruhiro Kitano, Junji Konishi, Hideo Saji
Nuclear Medicine and Biology   31(6) 811-814   Aug 2004
Since a very complicated technique is necessary to measure cerebral blood flow (CBF) with [14C]iodoantipyrine in small animals, a practical and easy method is needed. In this paper, the differential uptake ratio (DUR) at 5 min after injection of N...
Mikako Ogawa, Seigo Ishino, Takahiro Mukai, Daigo Asano, Noboru Teramoto, Hiroshi Watabe, Nobuyuki Kudomi, Masashi Shiomi, Yasuhiro Magata, Hidehiro Iida, Hideo Saji, Hideo Saji
Journal of Nuclear Medicine   45(7) 1245-1250   Jul 2004
The rupture of atherosclerotic plaques and the subsequent formation of thrombi are the main factors responsible for myocardial and cerebral infarctions. Thus, the detection of vulnerable plaques in atherosclerotic lesions is a desirable goal, and ...
Yasuhiko Iida, Mikako Ogawa, Masashi Ueda, Akiko Tominaga, Hidekazu Kawashima, Yasuhiro Magata, Shingo Nishiyama, Hideo Tsukada, Takahiro Mukai, Hideo Saji, Hideo Saji
Journal of Nuclear Medicine   45(5) 878-884   May 2004
Central nicotinic acetylcholine receptors (nAChRs) represent major neurotransmitter receptors responsible for various brain functions, and changes in the density of nAChRs have recently been reported in several neurodegenerative diseases. Visualiz...
Shigeto Kubo, Eiji Tadamura, Hiroshi Toyoda, Marcelo Mamede, Masaki Yamamuro, Yasuhiro Magata, Takahiro Mukai, Haruhiro Kitano, Nagara Tamaki, Junji Konishi
Journal of Nuclear Medicine   45(5) 730-738   May 2004
The aims of this study were (a) to compare absolute myocardial blood flow (MBF) during adenosine triphosphate (ATP) infusion with that after dipyridamole administration without caffeine intake and (b) to evaluate the effect of caffeine intake on t...
Koyo Nishida, Seiichi Nose, Akiko Kuma, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki, Junzo Nakamura
Journal of Pharmacy and Pharmacology   56(5) 683-687   May 2004
The purpose of this study was to clarify the absorption characteristics of a drug across the mesenteric surface, which occupies a large area of absorption in the peritoneal cavity, in order to determine the drug absorption route after intraperiton...
Ihara, H. Tomimoto, K. Ishizu, T. Mukai, H. Yoshida, N. Sawamoto, M. Inoue, T. Doi, K. Hashikawa, J. Konishi, H. Shibasaki, H. Shibasaki, H. Shibasaki, H. Fukuyama
Stroke   35(4) 942-947   Apr 2004
Background and Purpose-[11C]flumazenil (FMZ), a ligand that selectively binds to the central benzodiazepine receptor in the neuronal membrane, is useful for evaluating neuronal viability in a positron emission tomography (PET) scan. Using this lig...
Takahiro Mukai, Kunihiro Mera, Koyo Nishida, Mikiro Nakashima, Hitoshi Sasaki, Junzo Nakamura
Biological and Pharmaceutical Bulletin   27 595-597   Apr 2004
Animal models prepared by treatment with carbon tetrachloride (CCl4) have been used to examine drug disposition in hepatic disorder. However, previous studies demonstrated that systemic administration of CCl4impaired not only hepatic but also rena...
Yasuhiro Magata, Takayoshi Kawaguchi, Misa Ukon, Norio Yamamura, Tomoya Uehara, Kazuma Ogawa, Yasushi Arano, Takashi Temma, Takahiro Mukai, Eiji Tadamura, Hideo Saji
Bioconjugate Chemistry   15(2) 389-393   Mar 2004
C-11- and I-123-labeled long chain fatty acid derivatives have been reported as useful radiopharmaceuticals for the estimation of myocardial fatty acid metabolism. We have reported that Tc-99m-labeled N-[[[(2-mercaptoethyl)amino]carbonyl]methyl]-N...
Hiromichi Akizawa, Hirokazu Takimoto, Madoka Saito, Akimasa Iwado, Masaki Mifune, Yutaka Saito, Tomoya Uehara, Yasushi Arano, Takahiro Mukai, Hirofumi Hanaoka, Hideo Saji
Biological and Pharmaceutical Bulletin   27(2) 271-272   Feb 2004
For purpose of reducing renal accumulation of radioactivity of a known radiopharmaceutical agent, i.e.,111In-DTPA (diethylenetriaminepentaacetic acid)-D-Phe1-octreotide, a derivative in which p-carboxy-L-phenylalanine is substituted for D-Phe1was ...
Tatsuya Higashi, Tsuneo Saga, Takayoshi Ishimori, Marcelo Mamede, Koichi Ishizu, Toru Fujita, Takahiro Mukai, Seiji Sato, Hironori Kato, Yoshio Yamaoka, Keiichi Matsumoto, Michio Senda, Junji Konishi
Annals of Nuclear Medicine   18(2) 105-114   Jan 2004
Purpose: To evaluate the appropriate post-injection timing for hand-held-gamma-ray-detecting probe (GDP) scanning for the intraoperative detection of malignancy after preoperative F-18 FDG (FDG) injection. Methods: Patient study with superficially...
Takayoshi Ishimori, Tsuneo Saga, Tsuneo Saga, Yasushi Nagata, Yuji Nakamoto, Tatsuya Higashi, Marcelo Mamede, Takahiro Mukai, Yoshiharu Negoro, Tetsuya Aoki, Masahiro Hiraoka, Junji Konishi
Annals of Nuclear Medicine   18(8) 669-674   Jan 2004
This study was performed to investigate the feasibility of FDG- and L-[methyl-11C]methionine (Met)-PET for the follow up of lung cancer after stereotactic radiotherapy (SRT). Nine patients (pt) with solitary lung cancer underwent SRT. Met- and FDG...
Masashi Ueda, Yasuhiko Iida, Takahiro Mukai, Marcelo Mamede, Koichi Ishizu, Mikako Ogawa, Yasuhiro Magata, Junji Konishi, Hideo Saji, Hideo Saji
Annals of Nuclear Medicine   18(4) 337-344   Jan 2004
Recently, 5-[123I]iodo-3-(2(S)-azetidinylmethoxy)pyridine ([123I]5IA) was developed as a ligand for imaging the nicotinic acetylcholine receptor (nAChR) in human brain using single photon emission computed tomography (SPECT). In the present study,...
Junzo Nakamura, Tomomi Horimoto, Ryu Hirayama, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki, Koyo Nishida
Biological and Pharmaceutical Bulletin   26(12) 1761-1764   Dec 2003
The present study was undertaken to elucidate the kidney- and site-selective delivery of 5-fluorouracil (5-FU) following kidney surface application in rats. We selected an experimental system utilizing a cylindrical diffusion cell attached to the ...
Junzo Nakamura, Tomomi Horimoto, Ryu Hirayama, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki, Koyo Nishida
Biological and Pharmaceutical Bulletin   26(7) 1049-1051   Jul 2003
The present study was undertaken to examine the effects of the absorption enhancer saponin on the intrarenal distribution of 5-fluorouracil (5-FU) following the kidney surface application of 5-FU in rats. We selected an experimental system utilizi...
Yasuhiro Magata, Takashi Temma, Hidehiro Iida, Mikako Ogawa, Mikako Ogawa, Takahiro Mukai, Yasuhiko Iida, Takayuki Morimoto, Junji Konishi, Hideo Saji
Journal of Cerebral Blood Flow & Metabolism   23(6) 671-676   Jun 2003
Cerebral metabolic rate for oxygen (CMRO2) and cerebral oxygen extraction fraction (OEF) are some of the most fundamental parameters to characterize the pathophysiologic status of cerebral tissue. Although O-15-labeled gases inhalation method is p...
Tsuneo Saga, Tatsuya Higashi, Takayoshi Ishimori, Marcelo Mamede, Yuji Nakamoto, Takahiro Mukai, Toru Fujita, Kaori Togashi, Shigeo Yura, Toshihiro Higuchi, Masato Kita, Shingo Fujii, Junji Konishi
Annals of Nuclear Medicine   17(3) 197-203   May 2003
Objective: The clinical usefulness of FDG-PET in the follow up of post-operative patients with endometrial cancer was retrospectively evaluated. Methods: Twenty-one post-operative patients with endometrial cancer received 30 FDG-PET examinations t...
Yasuhiro Magata, Takahiro Mukai, Masafumi Ihara, Sadahiko Nishizawa, Haruhiro Kitano, Koichi Ishizu, Hideo Saji, Junji Konishi
Journal of Nuclear Medicine   44(3) 417-421   Mar 2003
11C-Flumazenil (11C-FMZ) is useful to estimate central benzodiazepine receptors by PET. The binding potential (BP) can be calculated with dynamic PET and continual blood sampling. Because conventional metabolite analysis of plasma samples is compl...
Marcelo Mamede, Tsuneo Saga, Takayoshi Ishimori, Yuji Nakamoto, Noriko Sato, Tatsuya Higashi, Takahiro Mukai, Hisataka Kobayashi, Hisataka Kobayashi, Junji Konishi
Neoplasia   5(2) 179-183   Mar 2003
PURPOSE: To study the contribution of immunologic background to the uptake of fluorine-18-fluorodeoxyglucose (18F-FDG) by the tumor tissues. METHODS: The uptakes of18F-FDG to the same experimental tumor model (SCCVII) xenografted into immunocompet...

Misc

 
中原広道, 萩森政頼, 向高弘, 柴田攻
日本油化学会年会講演要旨集   57th 96   Sep 2018
佐野紘平, 金田侑子, 山田真智子, 小野正博, 佐治英郎, 向高弘
医療薬学フォーラム講演要旨集   26th 193   Jun 2018
甘中健登, 佐野紘平, 萩森政頼, 萩森政頼, 山崎俊栄, 宗兼将之, 向高弘
日本DDS学会学術集会プログラム予稿集   34th 194   May 2018
中原広道, 萩森政頼, 向高弘, 柴田攻
日本薬学会年会要旨集(CD-ROM)   138th ROMBUNNO.27PA‐am340   2018
萩森政頼, 川上茂, 向高弘
ファルマシア   54(7) 688‐692(J‐STAGE)   2018
萩森政頼, 狩峯寧, 加藤直也, 水山奈央子, 渕上由貴, 佐治英郎, 向高弘, 川上茂
日本薬学会九州支部大会講演要旨集   34th 63   Nov 2017
中原広道, 萩森政頼, 向高弘, 柴田攻
日本薬学会九州支部大会講演要旨集   34th 135   Nov 2017
神代悠希, 石原万己, 藤井さとみ, 安岡由美, 細田正洋, 岩岡和輝, 床次眞司, JANIK Miroslaw, 武藤潤, 長濱裕幸, 向高弘
KEK Proceedings (Web)   (2017-6) 333‐338 (WEB ONLY)   Nov 2017
萩森政頼, 水山奈央子, 小川昂輝, 川上茂, 向高弘, 佐治英郎
亜鉛栄養治療   8(1) 12‐18   Oct 2017
田中将史, 弓削文乃, 三宅央泰, 岡覚子, 向高弘
膜シンポジウム   (29) 23‐25   Oct 2017

Research Grants & Projects

 
Development of Radiopharmaceuticals for PET and SPECT Studies.
Grant-in-Aid for Scientific Research
Project Year: 1992   
Development of Radiopharmaceuticals for Cancer Therapy
Grant-in-Aid for Scientific Research
Project Year: 1999   
Development of Radiopharmaceuticals for Molecular Imaging
Grant-in-Aid for Scientific Research