Toshiyuki Kobayashi

Profile Information

Affiliation: Department of Radiobiology, Institute for Environmental Sciences

Degree: Doctor(Science)(Nagoya University)

J-GLOBAL ID: 200901007562513135
researchmap Member ID: 1000205307

Research Interests

Research Areas

Research History

1996 - 2004

（財）癌研究会癌研究所実験病理部研究員
1996 - 2004

Associate, Dept. of Exp. Pathol., Cancer
1993 - 1996

（財）癌研究会癌研究所実験病理部嘱託研究員
1993 - 1996

Attending Associate, Dept. of Exp. Pathol.,
Institute, Japanese
Cancer Institute, Japanese

Education

- 1992

Nagoya University
- 1992

Graduate School, Division of Natural Science, Nagoya University
- 1987

Faculty of Science, Niigata University
- 1987

Faculty of Science, Niigata University

Awards

1999

癌学会奨励賞

Papers

100

Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex

Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Ikeda

Oct 31, 2022
A Farnesyltransferase Inhibitor Restores Cognitive Deficits in Tsc2^+/– Mice through Inhibition of Rheb1

Hiroko Sugiura, Tadayuki Shimada, Keiko Moriya-Ito, Jun-Ichi Goto, Hiroki Fujiwara, Rie Ishii, Hiroshi Shitara, Choji Taya, Satoshi Fujii, Toshiyuki Kobayashi …

The Journal of Neuroscience, 42(12) 2598-2612, Mar 23, 2022
糖尿病症例における内臓脂肪と皮下脂肪の組成の違いについて

折田創, 李賢哲, 小林敏之, 中岡博史, 吉本雄太郎, 山内卓, 加治早苗, 岡伸一, 綿田裕孝, 福永哲

日本消化器外科学会総会, 76回 P270-7, Jul, 2021
Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation

Tatsuhiro Sato, Satomi Mukai, Haruna Ikeda, Emi Mishiro-Sato, Ken Akao, Toshiyuki Kobayashi, Okio Hino, Wataru Shimono, Yoshio Shibagaki, Seisuke Hattori …

Molecular Cancer Research, 19(5) 921-931, May, 2021
カルボキシルエステラーゼ2の消化器癌における発現調節機構の解明(The regulatory mechanisms of carboxylesterases 2 in gastrointestinal cancers)

張順, 伊志嶺百々子, 小平佳典, 折田創, 小林敏之, 樋野興夫, 横溝岳彦, 福永哲, 李賢哲

日本薬学会年会要旨集, 140年会 26L-am01, Mar, 2020
Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells

Han B, Lee-Okada H-C, Ishimine M, Orita H, Nishikawa K, Takagaki T, Kajino K, Yokomizo T, Hino O, Kobayashi T

FEBS Open Bio, 10(11) 2375-2387, 2020 Peer-reviewedLast authorCorresponding author
Interstitial chromosomal deletion of the Tsc2 locus is a signature for radiation-associated renal tumors in Eker rats

Inoue T, Kokubo T, Daino K, Yanagihara H, Watanabe F, Tsuruoka C, Amasaki, Y, Morioka T, Homma-Takeda S, Kobayashi T …

Cancer Science, 111(3) 840-848, 2020 Peer-reviewed
Vasculitis and crescentic glomerulonephritis in a newly established congenic mouse strain derived from ANCA-associated vasculitis-prone SCG/Kj mice

Hamano Y, Ito F, Suzuki O, Koura M, Matsuoka S, Kobayashi T, Sugitani Y, Wali N, Koyanagi A, Hino O …

Autoimmunity, 52(5-6) 208-219, 2019 Peer-reviewed
Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero

Kotajima-Murakami H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino S, Ikeda K

Mol Brain, 12(1) 3-3, 2019 Peer-reviewed
Sensitization of gastric cancer cells to irinotecan by p53 activation

Zhang S, Kohira Y, Orita H, Ishimine M, Kobayashi T, Mae S, Chua B, Nakaoka H, Inoue I, Hino O …

BPB Reports, 2(6) 130-133, 2019 Peer-reviewed
Elucidation of inhibitory effects on metastatic sentinel lymph nodes of breast cancer during One-Step Nucleic Acid Amplification /631/67/1347 /631/67/322 /82/58 /38/77 article

Yoshiya Horimoto, Masahiko Tanabe, Saiko Kazuno, Yoshiki Miura, Kaoru Mogushi, Hiroshi Sonoue, Atsushi Arakawa, Kazunori Kajino, Toshiyuki Kobayashi, Mitsue Saito

Scientific Reports, 8(1) 7563, Dec 1, 2018 Peer-reviewed
Predictive markers for efficacy of everolimus plus exemestane in patients with luminal HER2-nagative metastatic breast cancer

Okazaki M, Horimoto Y, Tanabe M, Ichikawa Y, Tokuda E, Arakawa A, Kobayashi T, Saito M

Med Oncol, 35 48, 2018 Peer-reviewed
The relationship between TP53 gene status and carboxylesterase 2 expression in human colorectal cancer

Momoko Ishimine, Hyeon-Cheol Lee, Hirofumi Nakaoka, Hajime Orita, Toshiyuki Kobayashi, Konomi Mizuguchi, Mikumi Endo, Ituro Inoue, Koichi Sato, Takehiko Yokomizo

Disease Markers, 2018 5280736, 2018 Peer-reviewed
mTOR阻害剤投与による胎生期バルプロ酸曝露マウスの自閉症様行動への影響

村上浩子, 小林敏之, 柏井洋文, 佐藤敦志, 萩野洋子, 田中美歩, 西藤泰昌, 高松幸雄, 内野茂夫, 池田和隆

生命科学系学会合同年次大会, 2017年度 [2P-1079], Dec, 2017
胎生期バルプロ酸曝露マウスの社会性行動障害のラパマイシン投与による改善

古田島浩子[村上], 小林敏之, 柏井洋文, 佐藤敦志, 萩野洋子, 田中美歩, 西藤泰昌, 高松幸雄, 内野茂夫, 池田和隆

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回 182-182, Sep, 2017
Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex

Okio Hino, Toshiyuki Kobayashi

CANCER SCIENCE, 108(1) 5-11, Jan, 2017 Peer-reviewed
Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt-Hogg–Dubï¿½ syndrome

Yoshito Hoshika, Fumiyuki Takahashi, Shinsaku Togo, Muneaki Hashimoto, Takeshi Nara, Toshiyuki Kobayashi, Fariz Nurwidya, Hideyuki Kataoka, Masatoshi Kurihara, Etsuko Kobayashi …

Physiological Reports, 4(21) e13025, Nov 1, 2016 Peer-reviewed
Metabolic abnormalities induced by mitochondrial dysfunction in skeletal muscle of the renal carcinoma Eker (TSC2+/-) rat model

Yumi Aizawa, Tomomi Shirai, Toshiyuki Kobayashi, Okio Hino, Yoshimasa Tsujii, Hirofumi Inoue, Machiko Kazami, Tadahiro Tadokoro, Tsukasa Suzuki, Ken-Ichi Kobayashi …

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80(8) 1513-1519, Aug, 2016 Peer-reviewed
The tuberous sclerosis complex model Eker (TSC2+/-) rat exhibits hyperglycemia and hyperketonemia due to decreased glycolysis in the liver

Yumi Aizawa, Tomomi Shirai, Toshiyuki Kobayashi, Okio Hino, Yoshimasa Tsujii, Hirofumi Inoue, Machiko Kazami, Tadahiro Tadokoro, Tsukasa Suzuki, Ken-Ichi Kobayashi …

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 590 48-55, Jan, 2016 Peer-reviewed
Metabolic abnormalities induced by mitochondrial dysfunction in skeletal muscle of the Eker (TSC2+/-) rat.

Yumi AIZAWA, Tomomi SHIRAI, Toshiyuki KOBAYASHI, Hino OKIO, Yoshimasa TSUJII, Tsukasa SUZUKI, Ken-ichi KOBAYASHI, Yuji YAMAMOTO

Archives of Biochemistry and Biophysics, 590 48-55, 2016 Peer-reviewed

Misc.

135

Rapamycin Improves Social Deficits in the Mice Treated Prenatally with Valproic Acid

Hiroko Kotajima, Toshiyuki Kobayashi, Hirofumi Kashii, Atsushi Sato, Yoko Hagino, Miho Tanaka, Yasumasa Nishito, Yukio Takamatsu Takamatsu, Shigeo Uchino, Kazutaka Ikeda

NEUROPSYCHOPHARMACOLOGY, 43 S272-S273, Dec, 2018
結節性硬化症モデルマウスの自閉症様行動に関わる遺伝子発現変化の解析

柏井洋文, 佐藤敦志, 笠井慎也, 萩野洋子, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 池田和隆, 岡明 …

脳と発達, 50(Suppl.) S362-S362, May, 2018
肺結節性病変の中に小血管炎と著明な好酸球浸潤を認めたPR3-ANCA陽性の一例

濱野慶朋, 梶野一徳, 林大久生, 佐伯春美, 松岡周二, 小林敏之, 杉谷善信, 折茂彰, 岸川さつき, 荒川敦 …

脈管学, 58(3) 36-36, Mar, 2018
Tsc2ヘテロ欠損マウスの自閉症様行動に対するrapamycinの継続投与の効果とその副作用の検討

柏井洋文, 笠井慎也, 萩野洋子, 佐藤敦志, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 水口雅, 池田和隆

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回 151-151, Sep, 2017
結節性硬化症モデルマウスにおける幼若期NMDA投与による点頭様発作の解析

柏井洋文, 笠井慎也, 萩野洋子, 佐藤敦志, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 岡明, 水口雅 …

てんかん研究, 35(2) 539-539, Sep, 2017
mTOR阻害剤投与による胎生期バルプロ酸曝露マウスの自閉症様行動への影響

村上浩子, 村上浩子, 小林敏之, 柏井洋文, 佐藤敦志, 萩野洋子, 田中美歩, 西藤泰昌, 高松幸雄, 内野茂夫 …

日本生化学会大会(Web), 90th, 2017
胎生期バルプロ酸曝露マウスの社会性行動障害のラパマイシン投与による改善

古田島(村上)浩子, 古田島(村上)浩子, 小林敏之, 柏井洋文, 柏井洋文, 佐藤敦志, 萩野洋子, 田中美歩, 田中美歩, 西藤泰昌 …

日本神経精神薬理学会プログラム・抄録集, 47th, 2017
ヌードマウス移植モデルでの抗C-ERC抗体22A31を用いた大腸癌治療

谷口源太郎, 梶野一徳, 韓博, 小林敏之, 樋野興夫

日本癌学会総会記事, 75回 P-2396, Oct, 2016
Transcriptome analysis in Tsc2 heterozygous knockout mice

Shinya Kasai, Okio Hino, Kazutaka Ikeda, Hirofumi Kashii, Toshiyuki Kobayashi, Masashi Mizuguchi, Atsushi Sato

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19 303-304, Jun, 2016
Tsc2ヘテロ遺伝子欠損による脳内遺伝子発現変化の網羅的解析

笠井慎也, 佐藤敦志, 柏井洋文, 小林敏之, 樋野興夫, 水口雅, 池田和隆

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 37回・45回 187-187, Sep, 2015
Tsc2 Haploinsufficiency is Associated with More Severe Autism-related Behavioral Deficits in Mouse Models of Tuberous Sclerosis Complex

佐藤敦志, 高松幸雄, 笠井慎也, 小林敏之, 樋野興夫, 池田和隆, 水口雅

日本神経精神薬理学雑誌, 35(2) 51-52, Apr 25, 2015
結節性硬化症モデル動物の幹細胞を用いた新規治療法の開発

河野春奈, 小林敏之, 樋野興夫, 堀江重郎

日本腎臓学会誌, 57(3) 461-461, Apr, 2015
Eker TSC2(+/-)ラットは,ミトコンドリア減少により解糖系・脂肪酸分解が低下する

相澤有美, 飯田美咲, 小林敏之, 樋野興夫, 鈴木司, 小林謙一, 山本祐司

がんと代謝研究会プログラム&抄録集, 3rd, 2015
Eker(TSC2+/-)ラットは,肝臓の解糖系の低下によりケトン体合成が亢進する

相澤有美, 飯田美咲, 酒巻弘昌, 佐藤美会, 小林敏之, 樋野興夫, 鈴木司, 小林謙一, 山本祐司

日本栄養・食糧学会関東支部大会シンポジウム講演要旨集, 96th, 2015
Autistic-like Behavioral Deficits in Mouse Models of Tuberous Sclerosis Complex Are Severer in TSC2 Mutation than in TSC1 Mutation

Atsushi Sato, Yukio Takamatsu, Miho Tanaka, Shinya Kasai, Toshiyuki Kobayashi, Okio Hino, Kazutaka Ikeda, Masashi Mizuguchi

NEUROPSYCHOPHARMACOLOGY, 39 S120-S121, Dec, 2014
Tsc2欠損胚性幹細胞の遺伝子発現異常(Aberrant gene expression in Tsc2-deficient embryonic stem cells)

河野春奈, 伊藤敬孝, 堀江重郎, 小林敏之, 樋野興夫

日本癌学会総会記事, 73回 P-1183, Sep, 2014
Mouse models of tuberous sclerosis complex show autism-related behavioral deficits severer in Tsc2 than Tsc1 haploinsufficiency

A. Sato, Y. Takamatsu, S. Kasai, T. Kobayashi, O. Hino, K. Ikeda, M. Mizuguchi

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 17 121-122, Jun, 2014
EkerラットES細胞を用いた腎癌発生機序の解明

河野春奈, 伊藤敬孝, 小林敏之, 樋野興夫, 堀江重郎

日本腎臓学会誌, 56(3) 394-394, May, 2014
結節性硬化症モデルマウスの自閉症様行動におけるmTORシグナル系の関与

佐藤敦志, 笠井慎也, 小林敏之, 高松幸雄, 樋野興夫, 池田和隆, 水口雅

日本神経精神薬理学雑誌, 34(2) 51-52, Apr 25, 2014
結節性硬化症におけるmTORC1非依存的スパイン形態制御

山形要人, 安田新, 杉浦弘子, 島田忠之, 桂林秀太郎, 岩崎克典, 小林敏之, 樋野興夫

日本薬理学会関東部会プログラム・要旨集, 131st 39, 2014

Books and Other Publications

結節性硬化症の診断と治療最前線

小林敏之, 樋野興夫 (Role: Contributor, 腫瘍病変発生モデル動物)

診断と治療社, 2016
細胞工学

樋野興夫, 小林敏之 (Role: Contributor, がんモデルマウス・ラットライブラリ：腎がんモデル)

学研メディカル秀潤社, 2013
Seriesモデル動物利用マニュアル：疾患モデルの作製と利用—がん

樋野興夫, 小林敏之 (Role: Contributor, 腎がんの自然発症モデルおよびTscモデル)

エル・アイ・シー, 2012
Annual Review 腎臓 2012

小林敏之 (Role: Contributor, TSC1/TSC2-mTOR axisの異常が関わる病態発生機構)

中外医薬社, 2012
Cancer: Cell Structure, Carcinogenesis and Genomic Instability

Hino O, Kobayashi T, Okimoto K (Role: Contributor, Genetic and environmental factors in hereditary predisposition to tumors: a conceptual overview)

Birkhäuser Verlag, 2006
Molecular Medicine

小林敏之, 樋野興夫 (Role: Contributor, 家族性腫瘍：結節性硬化症遺伝子(Tsc1/Tsc2)変異モデル動物)

中山書店, 2005
発生における細胞増殖制御

小林敏之, 樋野興夫 (Role: Contributor, がん抑制遺伝子と発生)

シュプリンガー・フェアラーク東京, 2004
実験医学別冊ゲノム研究ハンドブック

樋野興夫, 小林敏之 (Role: Contributor, 疾患モデル動物ゲノミクス)

羊土社, 2004
医学のあゆみ

樋野興夫, 小林敏之 (Role: Contributor, 遺伝性腎癌)

医歯薬出版, 2003
病理と臨床

安井英明, 福田智一, 小林敏之, 樋野興夫 (Role: Contributor, TSC2/Tsc2遺伝子産物の発現に関する最近の知見と問題点)

文光堂, 1997
別冊実験医学ザ・プロトコールシリーズ cDNAクローニング

小林敏之, 樋野興夫 (Role: Contributor, サブトラクション法)

羊土社, 1996

Presentations

Exploring downstream pathways of Erc/Msln as therapeutic targets of TSC

Kobayashi T

International Tuberous Sclerosis Complex Research Conference 2018, Sep 14, 2018 Invited

Professional Memberships

Research Projects

極長鎖脂肪酸をターゲットとした新規抗癌治療戦略

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

折田創, 李賢哲, 小林敏之
Mechanism elucidation for influences of the Parkinson disease after appendectomy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Anticancer treatment targeted fot VLCFA

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Orita Hajime
Devolopment for highly sensitive and quantitative methods with a facile, fast and low-cost protocol.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2020

NOMURA Sachio
結節性硬化症遺伝子変異が惹起する代謝変動とエピゲノム制御異常の解明

科学研究費補助金, Apr, 2017 - Mar, 2020

小林敏之
Investigation on the pathomechanism of autism spectrum disorder associated with hyperactivated mTOR signaling pathway

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Atsushi Sato, KOBAYASHI Toshiyuki, IKEDA Kazutaka, KASHII Hirofumi, TANAKA Miho
多能性幹細胞の分化異常機構を標的とする結節性硬化症の治療薬開発

科学研究費補助金, 2014 - 2016

小林敏之
The mechanism of loss of Erc gene ameliorates renal carcinogenesis and modulates integrin related pathway

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

ZHANG Danqing, KOBAYASHI Toshiyuki, HINO Okio
Analysis of signal transduction regulated by BHD gene product.

Grant-in-Aid for Scientific Research, 2009 - 2010
腫瘍抑制遺伝子BHD産物が制御するシグナル伝達系の解明

科学研究費補助金, 2008 - 2010
The study of multistep carcinogenesis using unique animal models

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2005 - 2009

HINO Okio, KOBAYASHI Toshiyuki, KAJINO Kazunori, MOMOSE Shuji
Birt-Hogg-Dube症候群原因遺伝子(BHD)の腫瘍抑制機能の解明

科学研究費補助金, 2006 - 2007
The functional analysis of Erc gene encoding GPI anchor protein

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

ZHANG Danqing, KOBAYASHI Toshiyuki, HINO Okio
糖・アミノ酸輸送及びATP量感知のシグナル伝達系の異常と腎発がん

科学研究費補助金, 2004 - 2005
Multi-step carcinogenesis using genetically retired models

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2000 - 2004

HINO Okio, KOBAYASHI Toshiyuki, HAMANO Yoshitomo
Functional Analysis of tuberin using Tsc2 mutant animal models

科学研究費補助金, 2002 - 2003
Functional Analysis of tuberin using Tsc2 mutant animal models

Grant-in-Aid for Scientific Research, 2002 - 2003
Functional analysis of tuberin by using animal models of tumor suppressor Tsc2-mutant.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003

KOBAYASHI Toshiyuki
癌抑制遺伝子Tscl産物の機能解析

科学研究費助成事業, 特定領域研究(C), 日本学術振興会, 2001 - 2001

小林敏之
Functional analysis of hamartin by use of Tscl knockout mice.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2001

KOBAYASHI Toshiyuki

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