J-GLOBAL         Last updated: Jul 9, 2019 at 04:05
The University of Electro-Communications
Center For Neuroscience And Biomedical Engineering
Job title
Visiting Professor
Ph. D(Nagoya University)
Research funding number


1970-1973:Isolation, structure determination, and bionsynthesis of daphniphyllum alkaloids of the plant Daphniphyllaseae.
1973-1980:Synthesis and structure/activity relationship of prostaglandin analogs and leukotriene analogs.
1980-1994:Isolation, structure determination, total synthesis, and mode of action of putaquiloside, the active principle for carcinigenicity and cattle Bracken posoning caused by edible plant "Bracken Fern (Warabi in Japanese)"
1980-1994:Total Synthesis of neneurotoxic sesquiterpenoids (anisatin, neoanisatin, picrotoxinin, tutin, and coriamyrtin) of plant origin.
1980-1994:Total Synthesis of pyrrolizidine alkaloids (senecionine, integgerimine, monocrotaline, yamataimine, retronecine, and otonecine) of the plant origin.
1994-2013 :Bioorganic stydies on the molecular bases and molecular mechanism of the bioluminescence of various organisms such as firefly, the limpet-like snail Latia neritoides, the jellyfish Aequorea aequorea (OWANKURAGE in Japanese), the sea firefly Vargula (Cypridina) hilgendorfii (UMIBOTARU in Japanese), the fungi Mycea chlorophos (YAKOUTAKE in Japanese), the sea fireworm Odontosyllis undecimdonta and O. phosphrea, and the seahare Plocamopherus imperials.
2013-2014 :Appprication of Bioluminescence-based Bioimaging system for Brain Science inspired Life Support.

Research Areas


Academic & Professional Experience

Apr 1973
Jun 1980
Researcher, Central Reasearch Lab, Ono Pharmaceutical Co. Ltd.
Jun 1980
Mar 1984
Assistant Professor, Faculty of Science, Nagoya University
Mar 1984
Mar 1994
Associate Professor, Faculty of Science, Nagoya University
Apr 1994
Mar 2010
Professor, Faculty of Electro-communications, The University of Electro-communications
Apr 2010
Mar 2013
Professor, Graduate School of Informatics and Engineering, The University of Electro-communications


Mar 1971
化学科, Faculty of Science, Nagoya University
Mar 1973
化学専攻, Graduate School, Division of Natural Science, Nagoya University

Committee Memberships

The Chemical Society of Japan  Assocate editor of Bull. Chem. Soc. Jpn.
The Chemical Society of Japan  Assocate editor of Bull. Chem. Soc. Jpn.

Awards & Honors

Feb 1987
Incentive Award in Synthetic Organic Chemistry, Japan (The Society of Synthetic Organic Chemistry, Japan)

Published Papers

 Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution
Kitada, Nobuo; Saitoh, Tsuyoshi; Ikeda, Yuma; Iwano, Satoshi; Obata, Rika; Niwa, Haruki; Hirano, Takashi; Miyawaki, Atsushi; Suzuki, Koji; Nishiyama, Shigeru; Maki, Shojiro A.
Tetrahedron Letters   59(12) 1087-1090   2018   [Refereed]
The synthesis and bioluminescence of allyl-substituted luciferin derivs. as substrates for firefly luciferase are reported.  The allylation of luciferins induced bathochromic shift (15-40 nm) of the bioluminescence emission.  Upon combination with...
Multicolor Bioluminescence Obtained Using Firefly Luciferin
Masahiro Kiyama, Ryohei Saito, Satoshi Iwano, Rika Obata, Haruki Niwa and Shojiro A. Maki
Current Topics in Medicinal Chemistry   16(24) 2648-2655   2016   [Refereed]
Here, we characterize the bioluminescent properties of the newly synthesized luciferin analog, AkaLumine-HCl. The bioluminescence produced by AkaLumine-HCl in reactions with native firefly luciferase was red-shifted (λmax = 677 nm), and yielded si...
A luciferin analog achieves highly sensitive deep-tissue imaging using near-infrared bioluminescence (DOI: 10.1038/ncomms11856)
Takahiro Kuchimaru, Satoshi Iwano, Masahiro Kiyama, Shun Mitsumata, Tetsuya Kadonosono, Haruki Niwa, Shojiro Maki, Shinae Kizaka-Kondoh*
Nature Communications   7 11856   2016   [Refereed]
Here, we characterize the bioluminescent properties of the newly synthesized luciferin analog, AkaLumine-HCl. The bioluminescence produced by AkaLumine-HCl in reactions with native firefly luciferase was red-shifted (λmax = 677 nm), and yielded si...
Spectroscopic properties of BF2 complexes of N-(5-phenyl-2- pyrazinyl)pivalamides exhibiting fluorescence in solution and solid state (
Sojiro Hachiya, Daisuke Hashizume, Hiroshi Ikeda, Minoru Yamaji, Shojiro Maki, Haruki Niwa, and and Takashi Hirano
Journal of Photochemistry and Photobiology A: Chemistry   331 206-214   2016   [Refereed]
Boron difluoride (BF2) complexes of N-(5-phenyl-2-pyrazinyl)pivalamide and its derivatives having a substituent on the phenyl group were prepared and their spectroscopic properties were investigated. It was found that the BF2 complexes show fluore...
Fluorescence properties of diphenylthiazolo[4,5-b]pyrazines tuned by donor-acceptor substituent effects
Tatsuki Nakagawa, Minoru Yamaji, Shojiro Maki, Haruki Niwa, and Takashi Hirano
Photochemistry and Photobiology   91(4) 807-813   2015   [Refereed]
Fluorescence properties of 2,6- and 2,5-diphenylthiazolo[4,5-b]pyrazine (TPy) derivatives having an electron-donating substituent (methoxy and dimethylamino) on the the 6- and 5-phenyl groups were studied. It was found that 2,6-diphenyl derivative...


The Application of Electroorganic Chemical Reaction.
Shojiro Maki and Haruki Niwa
J. Synth. Org. Chem., Jpn.   56(9) 725-735   1998   [Refereed]
丹羽治樹、 山田靜之.
ファルマシア(日本薬学会)   27(7) 924-927   1991
山田靜之、 丹羽治樹、 木越英夫.
化学増刊118「生体機能解明のための化学合成」 化学同人(京都)   191-201   1990
Total Synthesis of Polyfunctionalized Biologically Active Natural Products: Total Synthesis of Macrocyclic Pyrrolizidine Alkaloids.
Haruki Niwa
J. Synth. Org. Chem., Jpn.   46(7) 693-703   1988
Total Synthesis of Sesquiterpenoids of Picrotoxane Type.
Haruki Niwa and Kiyoyuki Yamada
J. Synth. Org. Chem., Jpn.   44(3) 180-190   1986

Books etc

丹羽治樹(コラム執筆分担:監修 永田和宏、塩田浩平) (Part:Joint Work)
南山堂   Aug 2009   
岩波:科学 Vol. 71, No. 4 (2009).特集「クラゲ」-オワンクラゲの生物発光機構-
丹羽治樹 (Part:Joint Work, クラゲの生物発光)
岩波書店   Apr 2009   
天然物化学ー 海洋生物編:  1.2.7「海洋生物の発光現象」
丹羽治樹(執筆分担:監修 山村庄助、長谷川宏司) (Part:Joint Work, 1.2.7「海洋生物の発光現象)
アイピーシー   Jun 2008   
別冊『化学:分子イメージング最前線』  1.4 入門「自然界に光る生き物とその原理」
丹羽治樹(執筆分担) (Part:Joint Work, 1.4:入門「自然会の”光る生物”とその原理」)
化学同人   Apr 2007   
生物物理学ハンドブック: 7.6 生物発光
丹羽治樹(執筆分担) (Part:Joint Work, 7.6 生物発光)
朝倉書店   Apr 2007   

Conference Activities & Talks

生物発光の化学とその イメージングへの応用
平成19年度日本バイオイメージング学会公開講座 「理学と工学が拓くバイオイメージング」 (2007.10.31、東京理科大学野田キャンパス)   Oct 2007   平成19年度日本バイオイメージング学会公開講座 「理学と工学が拓くバイオイメージング」 (2007.10.31、東京理科大学野田キャンパス)
Aug 2005   『夏休み子供のための公開シンポジウム:生物の情報通信を探る』(平成17年度文部科学省「科学研究補助金研究成果公開促進費」補助事業)補助資料(2005.8.9)
第19回「大学と科学」公開シンポジウム 『不思議な生物現象の化学』   Jan 2005   第19回「大学と科学」公開シンポジウム 『不思議な生物現象の化学』(2005.1.29)
生物発光化学発光研究会第30学術講演会(東工大大岡山キャンパス, 目黒区)、抄録集PLxx(2013.11.02)   Nov 2013   生物発光化学発光研究会第30学術講演会(東工大大岡山キャンパス, 目黒区)、抄録集PLxx(2013.11.02)
第八回神奈川ハイテク・リサーチ・センター研究発表会 (神奈川大学、2006.6.10)   Jun 2006   第八回神奈川ハイテク・リサーチ・センター研究発表会 (神奈川大学、2006.6.10)

Teaching Experience



特開昭51-86447 : 特開昭51-86447: 1β,5β-2-オキサ-3-ヒドロキシ-6β-置換メチル-7α-置換オキシ-ビシクロ[3.3.0]オクタン類の製造法
特開昭52-53833 : 特開昭52-53833: α置換フェニル・アルカン・カルボン酸の製造法
特開昭52-62237 : 特開昭52-62237: α置換フェニル・アルカン・カルボン酸の製造法
特開昭52-77027 : 特開昭52-77027: 2-(4-イソブチルフェニル)プロピオン酸
特開昭52-91847 : 特開昭52-91847: プロスタグランジン関連化合物