Yasuo Takehara
(竹原 康雄)Profile Information
- Affiliation
- Director (Director of the Imaging Center), Imaging Center, HIMEDIC NAGOYA
- Degree
-
(BLANK)(Hamamatsu University School of Medicine)
- J-GLOBAL ID
- 200901092890395031
- researchmap Member ID
- 1000206747
1988年UCSFのC.B.Higginsに師事し、黎明期の循環器MRIとMR造影剤研究に従事(Radiology 1990, 175(3):633-7, Radiology. 1992, 182(3):675-83)。帰国後の1992年fast spin echo法を用いて造影剤や内視鏡の挿入を必要としない胆道膵管の3次元投影画像を撮影する技術開発に成功。世界初の息止めMRCP(magnetic resonance cholangiopancreatography)として1993年に邦文で発表(Nihon Igaku Hoshasen Gakkai Zasshi. 1993, 25;53(7):868-70)、同年1993年の北米放射線学会で国外発表、続く1994年に英文で発表 (Radiology 1994, 192(1):73-8.)。引き続いて、世界初のセクレチン負荷MRCPを考案するなど(Nihon Igaku Hoshasen Gakkai Zasshi. 1995, 55(4):255-6. Top Magn Reson Imaging 1996, 8(5):290-301. Review.)、MRCP技術の改良と普及に努めた(JMRI 1998, 8(3):517-34. Review.)。このfast spin echo系列によるMRCPは現在では肝胆膵検査のスタンダードの一つとなっている。国際共通略号であるMRCPの名付け親でもある(Radiology 1994, 192(1):19-21.(editorial))。
その後、造影MR angiography研究( AJR 2001,176(5):1213-9)や胸腹部拡散強調画像DWIBSの研究(Radiology 2009, 252(1):247-54.)、新規造影剤開発(Br J Cancer 2001, 15;84(12):1681-5, Magn Reson Med 2002, 47(3):549-53, JMRI 2004, 20(2):294-9. Org Biomol Chem 2014, 21;12(43):8611-8)を経て、膵臓のMRエラストグラフィ(JMRI 2016, 43(2):384-90.)、中枢神経系のエラストグラフィの研究(AJNR 2016 Oct;37(10):1851-1859. )や3D ASL(arterial spin labeling)やIVIM(Intravoxel incoherent motion magnetic resonance imaging)による組織灌流研究(J Neurooncol 2015 121(3):549-56, J Neuroradiol 2013 40(4):303-6.,Lung Cancer. 2020;143:47-54. )、ultrashort TEによる個体イメージングの研究(Magn Reson Med Sci. 2021;20(4):359-370.)を行っている。また、過去10年にわたる、Stanford大学のDr.Alley、Wisconsin大学Madison校のDr.Wieben、聖隷クリストファー大学の礒田教授、早稲田大学T*AFSMの滝沢教授らとの国内・国際共同研究で、3D cine phase contrast法(4D-Flow MRI)を用いた血流解析の臨床応用と普及への取り組みを継続しており、MRを用いた血流と血管病変との関連を明らかにする研究で成果をあげつつある( JMRI 2007 25(3):473-8, Neuroradiology 2010 52(10):921-8, JMRI 2012 36(5):1231-3, Eur J Vasc Endovasc Surg 2013 46(3):321-8, AJNR 2013 34(11):2139-43, J Neuroradiol 2013 40(4):303-6, BMC Res Notes. 2014 Aug 14;7:527, Circ J 2015 79(1):144-52, Heart Vessels 2015 30(6):779-88, JMRI 2015 Jan;41(1):165-8, Circ J 2015 79(1):144-52, Intern Med 2015 54(13):1669-70, JMRI 2016 44(6):1493-1503. Circ J. 2016 25;80(8):1715-25, J Thorac Cardiovasc Surg. 2017 153(6):1413-1420, JMRI 2017 46(2):595-603, Heart Vessels 2017 32(8):1032-1044.,,PLoS One. 2021 Jan 27;16(1):e0245878., Hepatol Res. 2021 Mar;51(3):343-349., Magn Reson Med Sci.2020 Aug 3;19(3):235-246.J Magn Reson Imaging. 2023 Apr;57(4):1199-1211., Radiology. 2023 Sep;308(3):e230709. doi: 10.1148/radiol.230709. )。
Research Interests
6Research Areas
1Research History
22-
Apr, 2024 - Present
-
Oct, 2016 - Mar, 2024
-
Oct, 2001
-
Jul, 1995
-
Apr, 1991
-
Oct, 1989
-
Jul, 1988
-
Apr, 1987
-
Jul, 1986
-
May, 1986
Committee Memberships
16-
2016 - Present
-
2016 - Present
-
2002 - Present
-
- Present
-
- Present
-
2019 - Sep, 2023
-
- Mar, 2022
-
2002 - 2020
-
Apr, 2014 - Mar, 2015
-
Apr, 2009 - Mar, 2015
-
2009 - 2015
-
Jul, 1999 - Mar, 2000
Awards
6-
Feb, 2010
-
Jun, 2008
-
Apr, 2006
-
Dec, 1993
Papers
107-
Japanese journal of medical electronics and biological engineering, 29 142-145, 1991 Peer-reviewed
-
NeuroImage, 5(4 PART II), 1997 Peer-reviewed
-
NeuroImage, 5(4 PART II), 1997 Peer-reviewed
-
NeuroImage, 7(4 PART II), 1998 Peer-reviewed
-
NeuroImage, 7(4 PART II), 1998 Peer-reviewed
-
NeuroImage, 7(4 PART II), 1998 Peer-reviewed
-
NeuroImage, 7(4 PART II), 1998 Peer-reviewed
-
Nippon rinsho. Japanese journal of clinical medicine, 56(11) 2911-2917, Nov, 1998 Peer-reviewed
-
NeuroImage, 9(6 PART II), 1999 Peer-reviewed
-
NeuroImage, 9(6 PART II), 1999 Peer-reviewed
-
NeuroImage, 9(6 PART II), 1999 Peer-reviewed
-
NeuroImage, 9(6 PART II), 1999 Peer-reviewed
-
Magnetic Resonance Imaging, 17(10) 1445-1455, Dec, 1999 Peer-reviewed
-
NeuroImage, 11(5 PART II), 2000 Peer-reviewed
-
NeuroImage, 11(5 PART II), 2000 Peer-reviewed
-
NeuroImage, 11(5 PART II), 2000 Peer-reviewed
-
Nihon Geka Gakkai zasshi, 105(6) 359-363, Jun, 2004 Peer-reviewed
-
Journal of hepato-biliary-pancreatic surgery, 12(1) 88-92, 2005 Peer-reviewed
-
Heterocyclic Communications, 13(2-3) 101-108, 2007 Peer-reviewed
-
Nihon rinsho. Japanese journal of clinical medicine, 65(2) 342-351, Feb, 2007 Peer-reviewed
Misc.
853-
INNERVISION, 36(5) 7-9, Apr, 2021
-
日本呼吸器学会誌, 10(増刊) 156-156, Apr, 2021
-
臨床放射線, 65(12) 1275-1294, Nov, 2020
-
肺癌, 60(6) 636-636, Oct, 2020
-
日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) 290-290, Aug, 2020
-
診断と治療, 108(2) 197-204, Feb, 2020
-
臨床画像, 36(1) 42-48, Jan, 2020
-
胆と膵, 40(10) 841-844, Oct, 2019
-
INNERVISION, 34(9) 45-48, Aug, 2019
-
Rad Fan, 17(10) 37-40, Aug, 2019
-
静脈学, 30(2) 102-102, Jun, 2019
-
臨床画像, 35(4月増刊) 166-168, Apr, 2019
-
臨床画像, 35(4月増刊) 170-171, Apr, 2019
-
臨床画像, 35(4月増刊) 172-173, Apr, 2019
-
Abdominal radiology (New York), 44(4) 1213-1216, Apr, 2019
-
日本外科学会雑誌, 120(1) 56-61, Jan, 2019
-
臨床消化器内科, 33(7) 789-793, May, 2018
-
Neuroradiology, 60(5) 545-555, May 1, 2018 Peer-reviewed
-
臨床画像, 34(1) 40-52, Jan, 2018
-
Rad Fan, 15(15) 43-47, Nov, 2017
Books and Other Publications
3-
メディカルサイエンスインターナショナル(東京), 2000
-
中山書店, 1997
-
中山書店, 1997
Presentations
121-
Eighth Annual Meeting of society of Magnetic Resonance in Medicine., 1989
-
Eighth Annual Meeting of society of Magnetic Resonance in Medicine., 1989
-
Eighth Annual Meeting of society of Magnetic Resonance in Medicine., 1989
-
American Heart Association, 62nd Scientific Sessions., 1989
-
Radiological Society of North America 75th Scientific Assembly and Annual Meeting., 1989
-
Radiological Society of North America 75th Scientific Assembly and Annual Meeting., 1989
-
Radiological Society of North America 75th Scientific Assembly and Annual Meeting., 1989
-
Radiological Society of North America 75th Scientific Assembly and Annual Meeting., 1989
-
37th Annual Meeting of Society of Nuclear Medicine., 1990
-
Society of Magnetic Resonance in Medicine 9th Annual Meeting., 1990
-
Society of Magnetic Resonance in Medicine 9th Annual Scientific Meeting and Exhibition., 1990
-
American Roentgen Ray Society., 1991
-
American Roentgen Ray Society., 1991
-
American Roentgen Ray Society., 1991
-
Radiological Society of North America 76th Scientific Assembly and Annual Meeting., 1991
-
Radiological Society of North America 76th Scientific Assembly and Annual Meeting., 1991
-
Society of Magnetic Resonance in Medicine 11th Annual Scientific Meeting and Exhibition., 1992
-
Society of Magnetic Resonance in Medicine 12th Annual Scientific Meeting., 1993
-
Radiological Society of North America 79th Scientific Assembly and Annual Meeting., 1993
-
Radiological Society of North America 79th Scientific Assembly and Annual Meeting., 1993
Teaching Experience
10Professional Memberships
12Works
8Research Projects
18-
科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2009 - 2011
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)., Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1999 - 2000
-
科学研究費助成事業 萌芽的研究, 萌芽的研究, 日本学術振興会, 1998 - 1999
-
科学研究費助成事業 萌芽的研究, 萌芽的研究, 日本学術振興会, 1997 - 1997
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1996 - 1997