HIGASHI Shouichi

J-GLOBAL         Last updated: Apr 4, 2019 at 14:42
 
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Name
HIGASHI Shouichi
Affiliation
Yokohama City University
Section
School of Science, Graduate School of Nanobioscience Department of Life and Environmental System Science
Degree
Science(Kyushu University)

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
Professor, Yokohama City University International College of Arts and Sciences Life and Environmental Science Graduate School of Nanobioscience Department of Life and Environmental System Science
 

Education

 
 
 - 
1994
Molecular Biology, Graduate School, Division of Medical Sciences, Kyushu University
 

Published Papers

 
Matrix metalloproteinase-7 induces homotypic tumor cell aggregation via proteolytic cleavage of the membrane-bound Kunitz-type inhibitor HAI-1.
Ishikawa T, Kimura Y, Hirano H, Higashi S.
The Journal of biological chemistry   292(50) 20769-20784   Dec 2017   [Refereed]
Kamoshida G, Tansho-Nagakawa S, Kikuchi-Ueda T, Nakano R, Hikosaka K, Nishida S, Ubagai T, Higashi S, Ono Y
Journal of leukocyte biology      Jun 2016   [Refereed]
Kakei Y, Yamazaki C, Suzuki M, Nakamura A, Sato A, Ishida Y, Kikuchi R, Higashi S, Kokudo Y, Ishii T, Soeno K, Shimada Y
The Plant journal : for cell and molecular biology   84(4) 827-837   Sep 2015   [Refereed]
Sato H, Higashi S, Miyazaki K
Clinical & experimental metastasis   32(5) 405-415   Jun 2015   [Refereed]
Yamamoto K, Miyazaki K, Higashi S
The FEBS journal   281(15) 3346-3356   Aug 2014   [Refereed]

Misc

 
HIGASHI Shouichi
Biochemical and Biophysical Research Communications   278    2000
HIGASHI Shouichi
International Journal of Hematology   67    1998
Monoclonal Antibody (VII-M31) to Bovine Factor VII: a Specific Epitope in the γ-Carboxyglutamic Acid Domain
HIGASHI Shouichi
Journal of Biochemistry   108    1990

Conference Activities & Talks

 
Interaction between Active Matrilysin and Cell Surface Cholesterol Sulfate: Its Impact on Pericellular Proteolysis and Cancer Metastasis
2007   
Mechanism of cancer metastasis mediated by pericellular proteolytic action of MMP-7 or MMP-2 and design of their selective inhibitors
2008   
Matrilysin (matrix metalloproteinase-7) is a processing enzyme for human laminin332 (laminin-5)
7th Pan Pacific Connective Tissue Societies Symposium   2007   
Interaction between active matrilysin and cell surface cholesterol sulfate: ITS IMPACT ON PERICELLULAR PROTEOLYSIS
2007   
Insulin-like growth factor binding protein-related protein 1 (rP1/TAF) synergistically modulates tumor cell adhesion with laminin-332(laminin-5).
Yokosuka Science Festa 2009 8th Pan-pacific connective Tissue Societies Symposium   2009   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2011 - 2013    Investigator(s): KAORU MIYAZAKI
Non-invasive tumor cells are fixed on basement membranes (BMs) by stably binding to cell adhesion proteins such as laminin-332 (Lm332). However, they start to invade the BMs and then stroma during tumor progression. In this study, we investigated ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2009 - 2011    Investigator(s): Shouichi HIGASHI
(1) We determined the crystal structure of the catalytic domain of MMP-2 in complex with decapeptide inhibitor APP-IP, and clarified its mode of the MMP-2-selective inhibition.(2) We designed a highly selective and strong inhibitor against MMP-2 b...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2005 - 2010    Investigator(s): Kaoru MIYAZAKI
Tumor microenvironments play important roles in tumor progression. The present study demonstrated that the cell adhesion protein laminin-332 (Lm332 ; α3β3γ2) in the basement membrane was converted to a soluble factor capable of strongly promoting ...
Studies on regulatory mechanisms of matrix metalloproteinases (MMPs) activity
Project Year: 1995   
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(国際学術研究)
Project Year: 1991 - 1993    Investigator(s): Sadaaki IWANAGA
Initiation of the extrinsic blood coagulation pathway is mediated by a complex formed between plasma-derived factor VII/VIIa and cell-derived tissue factor (TF). To identify the site(s) of interaction, zymogen VII and VIIa were enzymatically and c...