Atsushi Takeda

Profile Information

Affiliation: School of Pharmaceutical Sciences, University of Shizuoka

Degree: Ph.D.(University of Shizuoka)

J-GLOBAL ID: 200901015560897850
researchmap Member ID: 1000207437

External link: http://w3pharm.u-shizuoka-ken.ac.jp/bioorg/saito/Home.html

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Research History

2012 - Present

University of Shizuoka
2000 - 2012

- 静岡県立大学助教授
2000 - 2012

University of Shizuoka
1991 - 2000

University of Shizuoka
1991 - 2000

University of Shizuoka, Assistant Professor
2000

- University of Shizuoka, Associate Professor
1995 - 1996

The Pennsylvania State University
1995 - 1996

Pennsylvania State University, Postdoctoral fellowship
1987 - 1991

University of Shizuoka
1987 - 1991

University of Shizuoka, Research Assistant
1981 - 1987

静岡薬科大学助手
1981 - 1987

Shizuoka College of Pharmacy, Research Assistant

Committee Memberships

Awards

Papers

Corticosteroid receptor-mediated synaptic Zn2+ dynamics in the hippocampus and its significance

Miki Suzuki, Haruna Tamano, Atsushi Takeda

Metallomics Research, 1(1) 22-30, Oct, 2021 Peer-reviewedInvited
Rapid Intracellular Zn2+ Dysregulation via Membrane Corticosteroid Receptor Activation Affects In Vivo CA1 LTP.

Miki Suzuki, Yuichi Sato, Kotaro Tamura, Haruna Tamano, Atsushi Takeda

Molecular neurobiology, 56(2) 1356-1365, Feb, 2019 Peer-reviewed
Blockade of intracellular Zn2+ signaling in the basolateral amygdala affects object recognition memory via attenuation of dentate gyrus LTP.

Yuki Fujise, Mitsuyasu Kubota, Miki Suzuki, Haruna Tamano, Atsushi Takeda

Neurochemistry international, 108 1-6, Sep, 2017
Influences of yokukansankachimpihange on aggressive behavior of zinc-deficient mice and actions of the ingredients on excessive neural exocytosis in the hippocampus of zinc-deficient rats

Haruna Tamano, Enya Yusuke, Kazuki Ide, Atsushi Takeda

EXPERIMENTAL ANIMALS, 65(4) 353-361, Oct, 2016 Peer-reviewed
Significance of the degree of synaptic Zn2+ signaling in cognition

Atsushi Takeda, Haruna Tamano

BIOMETALS, 29(2) 177-185, Apr, 2016 Peer-reviewed
Zn²⁺ signaling is involved in glucocorticoid-induced in vivo CA1 LTP attenuation

SUZUKI Miki, HAGA Suzuka, NAKADA Hiroyuki, TAMANO Haruna, TAKEDA Atsushi

Annual Meeting of the Japanese Society of Toxicology, 43 O-20, 2016
Modification of Hippocampal Excitability in Brain Slices Pretreated With a Low Nanomolar Concentration of Zn2+

Atsushi Takeda, Yukina Shakushi, Haruna Tamano

JOURNAL OF NEUROSCIENCE RESEARCH, 93(11) 1641-1647, Nov, 2015 Peer-reviewed
INFLUX OF EXTRACELLULAR ZN(2+) INTO THE HIPPOCAMPAL CA1 NEURONS IS REQUIRED FOR COGNITIVE PERFORMANCE VIA LONG-TERM POTENTIATION

A. Takeda, M. Suzuki, M. Tempaku, K. Ohashi, H. Tamano

NEUROSCIENCE, 304 209-216, Sep, 2015 Peer-reviewed
Excess influx of Zn2+ into dentate granule cells affects object recognition memory via attenuated LTP

Miki Suzuki, Yuki Fujise, Yuka Tsuchiya, Haruna Tamano, Atsushi Takeda

NEUROCHEMISTRY INTERNATIONAL, 87 60-65, Aug, 2015 Peer-reviewed
Advantageous effect of theanine intake on cognition

Haruna Tamano, Kotaro Fukura, Miki Suzuki, Kazuhiro Sakamoto, Hidehiko Yokogoshi, Atsushi Takeda

NUTRITIONAL NEUROSCIENCE, 17(6) 279-283, Nov, 2014 Peer-reviewed
Enhanced Susceptibility to Spontaneous Seizures of Noda Epileptic Rats by Loss of Synaptic Zn2+

Atsushi Takeda, Masashi Iida, Masaki Ando, Masatoshi Nakamura, Haruna Tamano, Naoto Oku

PLOS ONE, 8(8) e71372, Aug, 2013 Peer-reviewed
Preventive effect of theanine intake on stress-induced impairments of hippocamapal long-term potentiation and recognition memory

Haruna Tamano, Kotaro Fukura, Miki Suzuki, Kazuhiro Sakamoto, Hidehiko Yokogoshi, Atsushi Takeda

BRAIN RESEARCH BULLETIN, 95 1-6, Jun, 2013 Peer-reviewed
Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice.

Takeda A, Iwaki H, Ide K, Tamano H, Oku N

Brain research bulletin, 87(6) 551-555, Apr, 2012 Peer-reviewed
Involvement of N-methyl-D-aspartate receptor subunits in zinc-mediated modification of CA1 long-term potentiation in the developing hippocampus.

Takeda A, Itagaki K, Ando M, Oku N

Journal of neuroscience research, 90(3) 551-558, Mar, 2012 Peer-reviewed
Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress.

Takeda A, Suzuki M, Tamano H, Takada S, Ide K, Oku N

Neurochemistry international, 60(4) 394-399, Mar, 2012 Peer-reviewed
Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response.

Takeda A, Tamano H, Suzuki M, Sakamoto K, Oku N, Yokogoshi H

Cellular and molecular neurobiology, 32(1) 41-48, Jan, 2012 Peer-reviewed
Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency.

Takeda A, Tamano H, Ogawa T, Takada S, Ando M, Oku N, Watanabe M

Behavioural brain research, 226(1) 259-264, Jan, 2012 Peer-reviewed
Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit

Atsushi Takeda, Shunsuke Takada, Masatoshi Nakamura, Miki Suzuki, Haruna Tamano, Masaki Ando, Naoto Oku

PLOS ONE, 6(12) e28615, Dec, 2011 Peer-reviewed
IMPAIRMENT OF RECOGNITION MEMORY AND HIPPOCAMPAL LONG-TERM POTENTIATION AFTER ACUTE EXPOSURE TO CLIOQUINOL

A. Takeda, S. Takada, M. Ando, K. Itagaki, H. Tamano, M. Suzuki, H. Iwaki, N. Oku

NEUROSCIENCE, 171(2) 443-450, Dec, 2010 Peer-reviewed
Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice

Haruna Tamano, Fumika Kan, Naoto Oku, Atsushi Takeda

BRAIN RESEARCH BULLETIN, 83(6) 351-355, Nov, 2010 Peer-reviewed

Misc.

Regulation of extracellular Zn2+ homeostasis in the hippocampus as a therapeutic target for Alzheimer's disease

Atsushi Takeda, Haruna Tamano

EXPERT OPINION ON THERAPEUTIC TARGETS, 19(8) 1051-1058, Aug, 2015
Is interaction of amyloid beta-peptides with metals involved in cognitive activity?

Haruna Tamano, Atsushi Takeda

METALLOMICS, 7(8) 1205-1212, 2015
Cognitive decline due to excess synaptic Zn2+ signaling in the hippocampus

Atsushi Takeda, Haruna Tamano

FRONTIERS IN AGING NEUROSCIENCE, 6, Feb, 2014
アミロイドβ投与による視床下部-下垂体-副腎皮質系の機能亢進と周辺症状様行動.

Ide K, Tamano H, Ando M, Oku N, Takeda A

日本薬学会第133年会., Mar, 2013
Social isolation-induced aggressive behavior of zinc-deficient mice and effect of yokukansan.

Ide K, Iwaki H, Tamano H, Oku N, Takeda A

ICPF2012, Nov, 2012
Isolation-induced aggressive behavior and object recognition memory of amyloid β protein-injected mice.

Ide K, Takada S, Tamano H, Oku N, Takeda A

35th Annual Meeting of Japan Neuroscience Society., Nov, 2012
アミロイドβタンパク質の脳室内等よによる認知症周辺症状モデルの確立.

Ide K, Takada S, Tamano H, Oku N, Takeda A

フォーラム2012: 衛生薬学・環境トキシコロジー., Oct, 2012
グルタミン酸神経系の調節を介した抑肝散の攻撃行動抑制効果.

Ide K, Iwaki H, Tamano H, Oku N, Takeda A

第58回日本薬学会東海支部総会・大会., Jul, 2012
Proposed glucocorticoid-mediated zinc signaling in the hippocampus

Atsushi Takeda, Haruna Tamano

METALLOMICS, 4(7) 614-618, 2012
亜鉛不足による隔離飼育マウスの攻撃性増大メカニズムと抑肝散の効果.

Ide K, Iwaki H, Tamano H, Takeda A, Oku N

フォーラム2011: 衛生薬学・環境トキシコロジー, Oct, 2011
Depression-like behavior and object recognition memory in zinc deficiency; involvement of glucocorticoid

Haruna Tamano, Taisuke Ogawa, Shunsuke Takada, Masaki Ando, Naoto Oku, Tomomi Hagiwara, Mitsugu Watanabe, Atsushi Takeda

NEUROSCIENCE RESEARCH, 71 E368-E368, 2011
Impairment of learning and memory by transient reduction of synaptic zinc in the hippocampus

Shunsuke Takada, Atsushi Takeda, Masatoshi Nakamura, Masaki Ando, Naoto Oku

NEUROSCIENCE RESEARCH, 71 E277-E277, 2011
Dynamic action of neurometals at the synapse

Haruna Tamano, Atsushi Takeda

METALLOMICS, 3(7) 656-661, 2011
Enhancement of seizure susceptibility of Noda epileptic rat (NER) by zinc chelators

Masashi Iida, Atsushi Takeda, Masaki Ando, Syunsuke Takada, Masatoshi Nakamura, Naoto Oku

NEUROSCIENCE RESEARCH, 71 E295-E295, 2011
Zinc Signaling Through Glucocorticoid and Glutamate Signaling in Stressful Circumstances

Atsushi Takeda, Haruna Tamano

JOURNAL OF NEUROSCIENCE RESEARCH, 88(14) 3002-3010, Nov, 2010
Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components

Miki Suzuki, Haruna Tamano, Masaki Ando, Atsushi Takeda, Naoto Oku

NEUROSCIENCE RESEARCH, 68 E338-E338, 2010
Differential action of zinc in hippocampal CA1 long-term potentiation between 3-week-old and 6-week-old rats

Kosuke Itagaki, Atsushi Takeda, Masaki Ando, Naoto Oku

NEUROSCIENCE RESEARCH, 68 E339-E339, 2010
Insight into zinc signaling from dietary zinc deficiency

Atsushi Takeda, Haruna Tamano

BRAIN RESEARCH REVIEWS, 62(1) 33-44, Dec, 2009
Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar concentrations of zinc

Atsushi Takeda, Masaki Ando, Shingo Kanno, Naomi Sakurada, Naoto Oku

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 128 26-26, 2008
Zinc action in hippocampal mossy fiber long-term potentiation

SAKURADA Naomi, TAKEDA Atsushi, FUKE Sayuri, MINAMI Akira, OKU Naoto

17(2) 179-179, Jul 1, 2006

Books and Other Publications

生命元素事典 (桜井弘編)

オーム社, 2006
The suppression of metallothionein synthesis inhibits the growth of leukemia P388 cells.

Metallothionein (]G0004[), 1999

Presentations

Zinc-mediated modulation and disturbance of long-term potentiation in the hippocampus

International Society for Zinc Biology 2009 Meeting, 2009

Teaching Experience

Professional Memberships

Works

亜鉛に関する研究

2009
Iron Metabolism in the Brain

1996 - 2001
Functional Analysis of Metallothionein

1999
Functional Analysis of Trace Elements

1999

Research Projects

Preventive strategy against Alzheimer's disease by metallothionein induction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Takeda Atsushi
New development of diagnostic and therapeutic modality for ischemia/reperfusion injury by intelligent DDS

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

OKU Naoto, SHIMIZU Kosuke, TAKEDA Atsushi
亜鉛シグナルによる記憶障害から視たアルツハイマー病克服に向けた戦略的新展開

科学研究費補助金（基盤研究B）, 日本学術振興会, 2013 - 2015

武田厚司
海馬亜鉛による学習・記憶の調節と障害

科学研究費補助金（基盤研究B）, 日本学術振興会, 2010 - 2013

武田厚司
Mechanism and prevention of stress-induced neurological diseases focused on the action of trace metals

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

TAMANO Haruna, TAKEDA Atsushi
認知、ストレス感知における海馬亜鉛のユニークな応答とストレス性精神障害の予防

科学研究費補助金（基盤研究B）, 日本学術振興会, 2007 - 2010
生体微量金属の作用に着目した脳機能解析と脳疾患の予防

科学研究費補助金（基盤研究B）, 日本学術振興会, 2004 - 2007
生体必須微量金属の動態を利用した新規脳腫瘍画像診断薬剤の開発

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2004 - 2004

武田厚司
生体必須微量金属の動態を利用した新規脳腫瘍画像診断薬剤の開発

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2003 - 2003

武田厚司
Analysis of Brain Function Focused on Transition Metals

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2003

TAKEDA Atsushi
生体必須微量金属の動態を利用した新規脳腫瘍画像診断薬剤の開発

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2002 - 2002

武田厚司
Zinc functions in the central nervous system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1997 - 2000

TAKEDA Atsushi
Role of Essential Trace Metals in brain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1995 - 1996

TAKEDA Atsushi, OKADA Shoji
メタロチオネインの遺伝子発現に着目した悪性腫瘍の早期画像診断薬と治療薬の開発

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1995 - 1995

岡田昌二, 武田厚司
メタロチオネインの遺伝子発現に着目した悪性腫瘍の早期画像診断薬と治療薬の開発

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1994 - 1994

岡田昌二, 武田厚司
Development of Brain-Imagin Agent Focused on Behavior of Essential Trance Metals

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1993 - 1994

TAKEDA Atushi, OKADA Shoji
癌親和性^<99m>Tc-ホモシステインをモデルにした新しい癌検出用画像診断薬剤の開発

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1990 - 1990

武田厚司
ポリマーを形成する^<99m>Tc含硫アミノ酸の癌イメージング剤への利用

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1987 - 1987

武田厚司
ストレス起因性うつ病の予防・改善に関する研究

科学研究費補助金
Zinc and Depression

Profile Information

Research Interests

Research Areas

Research History

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

Works

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