MISC

2004年8月

C-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinoma SAS-H1 cells

CANCER LETTERS
  • K Okumura
  • ,
  • A Itoh
  • ,
  • E Isogai
  • ,
  • K Hirose
  • ,
  • Y Hosokawa
  • ,
  • Y Abiko
  • ,
  • T Shibata
  • ,
  • M Hirata
  • ,
  • H Isogai

212
2
開始ページ
185
終了ページ
194
記述言語
英語
掲載種別
DOI
10.1016/j.canlet.2004.04.006
出版者・発行元
ELSEVIER SCI IRELAND LTD

Mammalian myeloid and epithelial cells express many antimicrobiotic peptides that contribute to innate host defense against invading microbes. In the present study, a 27-mer peptide of the C-terminal domain (hCAP18(109-135)) and analogs of the antimicrobial peptide human cathelicidin LL-37/human cationic antimicrobial protein 18 (hCAP18) were examined for tumoricidal activity. In vitro results showed that hCAP18(109-135) induced apoptosis in human oral squamous cell carcinoma (OSCC), SAS-H1 cells. The hCAP18(109-135) induced mitochondrial depolarization and apoptosis in SAS-HI cells, but not in healthy human gingival fibroblasts (HGF) and human keratinocyte line HaCaT cells. Caspases were not activated during hCAP18(109-135)-induced apoptosis in SAS-H1 cells. The results indicate that hCAP18(109-135) may induce caspase-independent apoptosis in OSCC but not in normal cells. hCAP18(109-135) can therefore be a useful anti-tumor therapeutic agent in the treatment of OSCC. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 95

リンク情報
DOI
https://doi.org/10.1016/j.canlet.2004.04.006
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000223392400007&DestApp=WOS_CPL

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