Toshiaki Saitoh - My portal - researchmap

Profile Information

Affiliation: Professor (Dr.), Faculty of Pharmaceutical Sciences, Department of Pharmacy, Laboratory of Pharmacoinformatics, Nihon Pharmaceutical University

Degree: Ph. D.(Showa Pharmaceutical University)

J-GLOBAL ID: 200901098220313660
researchmap Member ID: 1000211030

External link: http://www.shoyaku.ac.jp/

Research Interests

2

Research Areas

1

Life sciences / Pharmaceuticals - chemistry and drug development /

Research History

1

Apr, 2022 - Present

Professor (Dr.), Department of Phaemaceutical Sciences, Nihon Pharmaceutical University

Education

2

Apr, 1991 - Mar, 1996

Graduate School Research Division in Pharmaceutical Sciences, Showa Pharmaceutical University
Apr, 1986 - Mar, 1990

Department of Pharmacy, Faculty of Pharmaceutical Sciences, Showa Pharmaceutical University

Papers

18

SHORT SYNTHESIS OF 5-SUBSTITUTED-2,3,4,5-TETRAHYDRO-BENZO[f][1,4]THIAZEPINES BY USING A MODIFIED PICTET-SPENGLER REACTION

Toshiaki Saitoh, Michikazu Kitabatake, Yuuko Sugihara, Yuuki Ono, Yoshie Horiguchi, Kunihiko Mohri

HETEROCYCLES, 94(6) 1063-1073, Jun, 2017 Peer-reviewed
FACILE AND SHORT-STEP SYNTHESIS OF 5-SUBSTITUTED 2,3,4,5-TETRAHYDROBENZO[f][1,4]OXAZEPINES USING A MODIFIED PICTET-SPENGLER REACTION

Toshiaki Saitoh, Michikazu Kitabatake, Takuya Sugimoto, Hiromu Kawakubo, Kunihiko Mohri, Yoshie Horiguchi

HETEROCYCLES, 94(2) 342-349, Feb, 2017 Peer-reviewed
AN EFFICIENT AND CONVENIENT SYNTHESIS OF 4,5,6,7-TETRAHYDROTHIENO[3,2-c]PYRIDINES BY A MODIFIED PICTET-SPENGLER REACTION VIA A FORMYLIMINIUM ION INTERMEDIATE

Michikazu Kitabatake, Aki Hashimoto, Toshiaki Saitoh, Takehiro Sano, Kunihiko Mohri, Yoshie Horiguchi

HETEROCYCLES, 81(8) 1903-1921, Aug, 2010 Peer-reviewed
FACILE SYNTHESIS OF 1-ARYL-2,3-DIHYDRO-1H-ISOINDOLES BY CYCLIZATION OF N-FORMYLIMINIUM ION VIA GEOMETRICALLY DISFAVORED 5-ENDO-TRIG PROCESS

Michikazu Kitabatake, Toshiaki Saitoh, Takehiro Sano, Yoshie Horiguchi

HETEROCYCLES, 78(5) 1177-1181, May, 2009 Peer-reviewed
Synthesis of chiral 3-methyl- and 3-methyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline and prevention of MPP+-induced cytotoxicity

Toshiaki Saitoh, Aki Yamashita, Kenji Abe, Keita Ogawa, Michikazu Kitabatake, Kyoji Taguchi, Yoshie Horiguchi

Medicinal Chemistry, 4(6) 531-538, Nov, 2008 Peer-reviewed
Generation and reaction of heteroaromatic zirconocene: synthetic application to polycyclic heterocycles

Yutaka Ikeuchi, Toshiaki Saitoh, Takeo Taguchi, Yuji Hanzawa

Tetrahedron Letters, 48(14) 2477-2480, Apr 2, 2007 Peer-reviewed
Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives

Toshiaki Saitoh, Kenji Abe, Masami Ishikawa, Masanao Nakatani, Seiichiro Shimazu, Noriyuki Satoh, Fumio Yoneda, Kyoji Taguchi, Yoshie Horiguchi

European Journal of Medicinal Chemistry, 41(2) 241-252, Feb, 2006 Peer-reviewed
A Synthesis of Heteroaromatic Analogues of 1-Methyl-1, 2, 3, 4-tetrahydroisoquinoline Using the Pummerer-Type Cyclization Reaction : Observation of Tandem Cyclization Reaction

HORIGUCHI Yoshie, OGAWA Keita, SAITOH Toshiaki, SANO Takehiro

Chemical and Pharmaceutical Bulletin, 52(2) 214-220, Feb 1, 2004
A synthesis of chiral 1,1,3-trisubstituted 1,2,3,4-tetrahydro-beta-carbolines by the Pictet-Spengler reaction of tryptophan and ketones: Conversion of (1R,3S)-diastereomers into their (1S,3S)-counterparts by scission of the C(1)-N(2) bond

Y Horiguchi, M Nakamura, T Saitoh, T Sano

CHEMICAL & PHARMACEUTICAL BULLETIN, 51(12) 1368-1373, Dec, 2003 Peer-reviewed
Super acid-induced pummerer-type cyclization reaction: Improvement in the synthesis of chiral 1,3-dimethyl-1,2,3,4-tetrahydroisoquinolines

T Saitoh, K Shikiya, Y Horiguchi, T Sano

CHEMICAL & PHARMACEUTICAL BULLETIN, 51(6) 667-672, Jun, 2003 Peer-reviewed
No reduction of dopamine transporter binding sites in mice following treatment with the TIQ analogue 1-benzyl-1,2,3,4-tetrahydroisoquinoline.

Kiichi Ishiwata, Yasuhiro Koyanagi, Kenji Abe, Kazunori Kawamura, Kyoji Taguchi, Toshiaki Saitoh, Jun Toda, Takehiro Sano

Brain research, 960(1-2) 282-5, Jan 17, 2003
A chiral synthesis of four stereoisomers of 1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline, and indicator of Parkinson-like syndrome (vol 48, pg 91, 2002)

J Toda, S Matsumoto, T Saitoh, T Sano

CHEMICAL & PHARMACEUTICAL BULLETIN, 50(12) 1641-1642, Dec, 2002
Synthesis of 1,2-dihydrobenz[c]azepin-3-one via acid-catalyzed cyclization of N-arylmethyl-N-methyl-3-phenylsulfanylacrylamide

Y Horiguchi, T Saitoh, T Kashiwagi, L Katura, M Itagaki, J Toda, T Sano

HETEROCYCLES, 57(6) 1063-1077, Jun, 2002 Peer-reviewed
A convenient synthesis of 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines via Pictet-Spengler reaction using titanium(IV) isopropoxide and acetic-formic anhydride

Yoshie Horiguchi, Hirokazu Kodama, Masayoshi Nakamura, Tsuyoshi Yoshimura, Kaori Hanezi, Hiroko Hamada, Toshiaki Saitoh, Takehiro Sano

Chemical and Pharmaceutical Bulletin, 50(2) 253-257, Feb, 2002
Intramolecular capture of Pummerer reaction intermediates by an aromatic nucleophile: Selective construction of 1,4-benzothiazine and indole ring systems

Y Horiguchi, A Sonobe, T Saitoh, J Toda, T Sano

CHEMICAL & PHARMACEUTICAL BULLETIN, 49(9) 1132-1137, Sep, 2001 Peer-reviewed
Synthesis of 2,3,4,5-tetrahydro-1H-2-benzazepines via Pummerer-type cyclization of N-arylmethyl-N-(3-phenylsulfinylpropyl)formamides

Y Horiguchi, T Saitoh, S Terakado, K Honda, T Kimura, J Toda, T Sano

HETEROCYCLES, 54(2) 967-+, Feb, 2001 Peer-reviewed
Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism-preventing effect of 1-MeTIQ by in vivo measurement of pre-synaptic dopamine transporters and post-synaptic dopamine D2 receptors in the mouse striatum

Kiichi Ishiwata, Yasuhiro Koyanagi, Kenji Abe, Kazunori Kawamura, Kyoji Taguchi, Toshiaki Saitoh, Jun Toda, Michio Senda, Takehiro Sano

Journal of Neurochemistry, 79(4) 868-876, 2001
マウスの脳内における[11C]ラクロプライドのドーパミンD2レセプターへの結合能に対する1,2,3,4-テトラヒドロイソキノリン類の単回および繰り返し投与による影響

Journal of Neural Transmission, Vol.108, pp.1111-1125, 2001

Misc.

27

N-アリールメチル－N-メチル－3-フェニルスルファニルアクリルアミドの酸触媒環化反応を経由した1,2-ジヒドロベンズ[c]アゼピン-3-オンの合成

Heterocycles, Vol. 57, pp.1063-1077, 2002
A synthesis of 3-phenyl-1,2,3,4-tetrahydroisoquinoline and 2-Phenyl-1,2,4,5-tetrahydro-3H-3-benzazepine via Pummerer-type cyclization: Enhancing effect of boron trifluoride diethyl etherate on the cyclization

T Saitoh, T Ichikawa, Y Horiguchi, J Toda, T Sano

CHEMICAL & PHARMACEUTICAL BULLETIN, 49(8) 979-984, Aug, 2001
Intramolecular capture of pummerer reaction intermediates by an aromatic nucleophile: Selective construction of 1,4-benzothiazine and indole ring systems

Y. Horiguchi, A. Sonobe, T. Saitoh, J. Toda, T. Sano

Chemical and Pharmaceutical Bulletin, 49(9) 1132-1137, 2001
N-アリールメチル－N-(３－フェニルスルフィニルプロピル）ホルムアミドのプンメラー型環化反応を利用した2,3,4,5-テトラヒドロ-1H-2-ベンズアゼピン類の合成

Heterocycles, Vol.54(2), pp.967-984, 2001
A synthesis of 3-phenyl-1,2,3,4-tetrahydroisoquinoline and 2-phenyl-1,2,4,5-tetrahydro-3H-3-benzazepine via Pummerer-type cyclization: Enhancing effect of boron trifluoride diethyl etherate on the cyclization

T. Saitoh, T. Ichikawa, Y. Horiguchi, J. Toda, T. Sano

Chemical and Pharmaceutical Bulletin, 49(8) 979-984, 2001
Synthesis of methoxy-2-quinolones via Pummerer-type cyclization of N-aryl-N-methyl-3-(phenylsulfinyl)propionamides

J Toda, M Sakagami, Y Goan, M Simakata, T Saitoh, Y Horiguchi, T Sano

CHEMICAL & PHARMACEUTICAL BULLETIN, 48(12) 1854-1861, Dec, 2000
A synthesis of 2,3,4,5-tetrahydro-1H-3-benzazepines via Pummerer-type cyclization of N-(2-arylethyl)-N-(2-phenylsulfinylethyl)formamides

J Toda, T Ichikawa, T Saitoh, Y Horiguchi, T Sano

HETEROCYCLES, 53(9) 2009-2018, Sep, 2000
[2+2] photocycloaddition reaction of 5-phenyl-1H-furan-2,3-dione to phenylethylene

Y Horiguchi, T Saitoh, N Koseki, H Suzuki, J Toda, T Sano

HETEROCYCLES, 53(6) 1329-1336, Jun, 2000
N-アリールエチル-N-(2-フェニルスルフィニルエチル)ホルムアミド類のプンメラー型環化反応を利用した2,3,4,5-テトラヒドロ-1H-ベンズアゼピン類の合成

Heterocycles, Vol.53(9), pp.2009-2018, 2000
Synthesis of methoxy-2-quinolones via Pummerer-type cyclization of N-aryl-N-methyl-3-(phenylsulfinyl)propionamides

J. Toda, M. Sakagami, Y. Goan, M. Simakata, T. Saitoh, Y. Horiguchi, T. Sano

Chemical and Pharmaceutical Bulletin, 48(12) 1854-1861, 2000
5-フェニル-1H-フラン-2,3-ジオンのフェニルエチレンへの[2+2]光付加反応

Heterocycles, Vol.53(6), pp.1329-1336, 2000
N-(アリルメチル)-N-メチル-2-アリル-2-フェニルスルフェニルアセトアミドのプンメラータイプ分子内環化反応を利用した4-アリル-2-メチル-1,2,3,4-テトラハイドロイソキノリン類の合成

ARKIVOC, Vol.1(2), pp.165-180, 2000
パーキンソン病様症状を誘発する1,3-ジメチル-1,2,3,4-テトラハイドロイソキノリンの4つの立体異性体のキラル合成

Chemical and Pharmaceutical Bulletin, Vol.48(1), pp.91-98, 2000
Synthesis of 4-aryl-2-methyl-1,2,3,4-tetrahydroisoquindines via Pummerer-type cydization of N-(aryl-methyl)-N-methyl-2-aryl-2-(phenylsulfinyl)acetamides

ARKIVOC, 1(2) 165-180, 2000
A chiral synthesis of four stereoisomers of 1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline, an inducer of Parkinson-like syndrome

J Toda, S Matsumoto, T Saitoh, T Sano

CHEMICAL & PHARMACEUTICAL BULLETIN, 48(1) 91-98, Jan, 2000
Synthesis of 2-aroylmethylquinolin-4-ones via the addition reaction of ortho-nitrobenzoylketene to 1-aryl-1-trimethylsilyloxyethylenes

J Toda, T Saitoh, T Sano

HETEROCYCLES, 45(10) 1937-1944, Oct, 1997
[2+2] photocycloaddition reaction of 5-arylfuran-2,3-diones to trimethylsilyloxyethylenes

T Sano, N Koseki, T Saitoh, Y Horiguchi, J Toda, F Kiuchi, Y Tsuda

CHEMICAL & PHARMACEUTICAL BULLETIN, 45(4) 608-612, Apr, 1997
オルトニトロベンゾイルケテンの1-アリール1-トリメチルシリルオキシエチレンへの付加反応を利用した2-アロイルメチルキノリン-4-オンの合成

Heterocycles, Vol.45(10), pp.1937-1944, 1997
[2+2] Photocycloaddition reaction of 5-arylfuran-2,3-diones to trimethylsilyloxyethylenes

Takehiro Sano, Nobuyuki Koseki, Toshiaki Saitoh, Yoshie Horiguchi, Jun Toda, Fumiyuki Kiuchi, Yoshisuke Tsuda

Chemical and Pharmaceutical Bulletin, 45(4) 608-612, 1997
Thermal addition reaction of aroylketene with ethyl vinyl ether: Aromatic substituent effect on aroylketene reactivity

J Toda, T Saitoh, T Oyama, Y Horiguchi, T Sano

HETEROCYCLES, 43(11) 2457-2464, Nov, 1996

More

Professional Memberships

4

Research Projects

4