TAMURA Kazuhiro

J-GLOBAL         Last updated: Sep 16, 2019 at 09:24
TAMURA Kazuhiro
Tokyo University of Pharmacy and Life Science
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences Department of Endocrine Pharmacology
Job title
Associate Professor
Ph. D.(medicine)(Tokyo Medical and Dental University)
Research funding number

Research Areas


Academic & Professional Experience

Apr 2019
Professor, Dept. of Endocrine Pharmacology, Tokyo Uni. of Pharmacy & Life Sciences
- Tokyo University of Pharmacy & Life Science,
Tokyo University of Pharmacy & Life Science,
University of Kansas Medical Center, Postdoctoral
Assistant Professor


Graduate School, Division of Medicine, Tokyo Medical and Dental University
Faculty of Pharmaceutical Science, Tokyo University of Pharmacy and Life Science

Published Papers

Exchange protein directly activated by cAMP promotes transcriptional activation of the
Kusama K, Tamura K, Bai H, Sakurai T, Nishi H, Isaka K, Imakawa K , Yoshie M.
Reproduction, Fertility and Development   30 1454-1461   2018   [Refereed]
Impact pioglitazone on macrophage dynamics in adipose tissues of cecal ligation and puncture-treated mice.
Matsutani T, Tamura K, Kutsukake M, Matsuda A, Tachikawa E, Uchida E.
Biol. Pharm. Bull.   40 638-644   2017   [Refereed]
Glybenclamide inhibits NLRP3 inflammasome-mediated IL-1beta secretion in human trophoblasts
Tamura K, Ishikawa G, Ohneda W, Yoshie M, Nakai A, Takeshita T, Tachikawa E.
135 89-95   2017   [Refereed]
Endometrial androgen signaling and decidualization regulate trophoblastexpansion and invasion in co-culture: A time-lapse study.
Wongwananuruk T, Sato T, Kajihara T, Matsumoto S, Akita M, Tamura K, Brosens JJ, Ishihara O.
Placenta   47 56-62   2016   [Refereed]
A positive feedback loop between progesterone and microsomal prostaglandin E synthase-1-mediated PGE2 promotes production of both in mouse granulosa cells.
Tamura K, Naraba H, Hara T, Nakamura K, Yoshie M, Kogo H, Tachikawa E.
Prostaglandins & other Lipid Mediators   123 56-62   2016   [Refereed]
Tamura K, Takashima H, Fumoto K, Kajihara T, Uchino S, Ishihara O, Yoshie M, Kusama K, Tachikawa E
Reproductive sciences (Thousand Oaks, Calif.)      Feb 2015   [Refereed]
Kusama K, Yoshie M, Tamura K, Imakawa K, Tachikawa E
Journal of Molecular Endocrinology   54(1) 17-24   Feb 2015   [Refereed]
Role of careticulin in decidualization of rat endometrium
Yoshie M, Kusama K, Tamura K et al.
日本生殖内分泌学会雑誌 (研究フロンティア, Minireview)   20 35-40   2015   [Refereed]
Molecular mechanisms of human endometrial decidualization activated by cyclic adenosine monophosphate signaling pathways.
Yoshie M, Kusama K, Tamura K.
J. Mamm. Ova Res.   32 95-102   2015   [Refereed]
Kutsukake M, Matsutani T, Tamura K, Matsuda A, Kobayashi M, Tachikawa E, Uchida E
The Journal of surgical research   189(2) 295-303   Jun 2014   [Refereed]
Kusama K, Yoshie M, Tamura K, Daikoku T, Takarada T, Tachikawa E
Reproduction (Cambridge, England)   147(6) 897-906   Jun 2014   [Refereed]
Kusama K, Yoshie M, Tamura K, Nakayama T, Nishi H, Isaka K, Tachikawa E
Endocrinology   155(1) 240-248   Jan 2014   [Refereed]
Tamura K, Yoshie M, Hashimoto K, Tachikawa E
The Journal of Reproduction and Development   60(6) 447-453   2014   [Refereed]
Gu HF, Gu T, Hilding A, Zhu Y, Kärvestedt L, Ostenson CG, Lai M, Kutsukake M, Frystyk J, Tamura K, Brismar K
Clinical Epigenetics   5(1) 20   Nov 2013   [Refereed]
Regulation of decidualization in human endometrial stromal cells through exchange protein directly activated by cyclic AMP (Epac).
Kusama K, Yoshie M, Tamura K, Kodaka Y, Hirata A, Sakurai T, Bai H, Imakawa K, Nishi H, Isaka K, Nagai T, Nagao T, Tachikawa E.
Placenta   34 212-221   2013   [Refereed]
IFPA Meeting 2012 Workshop Reports: Epigenetics and imprinting in the placenta, growth factors and villous trophoblast differentiation, role of the placenta in regulating fetal exposure to xenobiotics during pregnancy, infection and the placenta.
Ahmed MS, Aleksunes LM, (省略16名), Tamura K, (省略7名), Yoshie M, Lah G.E.
Placenta   34 S6-S10   2013   [Refereed]
Tamura K, Yoshie M, Miyajima E, Kano M, Tachikawa E
ISRN pharmacology   2013 279593   2013   [Refereed]
Shinohara A, Kutsukake M, Takahashi M, Kyo S, Tachikawa E, Tamura K
Journal of pharmacological sciences   119(1) 40-51   2012   [Refereed]
Tsujimura Y, Matsutani T, Matsuda A, Kutsukake M, Uchida E, Sasajima K, Tamura K
The Journal of surgical research   171(2) e215-21   Dec 2011   [Refereed]
TAMURA Kazuhiro
J Endocrinol   209(1) 33-43   Apr 2011   [Refereed]
Nishioka H, Tamura K, Iida H, Kutsukake M, Endo A, Ikeda Y, Haraoka J
Molecular and cellular endocrinology   331(1) 73-78   Jan 2011   [Refereed]
Ichiro Ohbayashi K, Tanaka K, Kitajima K, Tamura K, Hara T
Genes to cells : devoted to molecular & cellular mechanisms   15(7) 699-710   Jun 2010   [Refereed]
Kutsukake M, Tamura K, Yoshie M, Tachikawa E
Molecular reproduction and development   77(3) 265-272   Mar 2010   [Refereed]
Yoshie M, Miyajima E, Kyo S, Tamura K
Endocrinology   150(5) 2413-2418   May 2009   [Refereed]
[Role of implantation-related factors, stathmin and insulin-like growth factor-binding protein 7 in reproductive endocrinology].
Kogo H, Yoshie M, Kutsukake M, Tamura K
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan   128(4) 565-574   Apr 2008   [Refereed]
Kutsukake M, Ishihara R, Yoshie M, Kogo H, Tamura K
Molecular human reproduction   13(10) 737-743   Oct 2007   [Refereed]
Tamura K, Yoshie M, Hara T, Isaka K, Kogo H
The Journal of reproduction and development   53(3) 525-533   Jun 2007   [Refereed]
Tamura K, Suzuki Y, Matsushita M, Fujii H, Miyaura C, Aizawa S, Kogo H
European journal of pharmacology   558(1-3) 159-166   Mar 2007   [Refereed]
Tamura K, Hara T, Kutsukake M, Iwatsuki K, Yanagida M, Yoshie M, Kogo H
Endocrinology   145(11) 5243-5251   Nov 2004   [Refereed]
Sakurai T, Tamura K, Okamoto S, Hara T, Kogo H
Biology of reproduction   69(3) 835-842   Sep 2003   [Refereed]
[Suppressive effects of bisphosphonates on the vascular calcification in ESRD patients].
Tamura K, Hashiba H, Kogo H, Aizawa S, Shigematsu T
Clinical calcium   12(8) 1129-1135   Aug 2002   [Refereed]


Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region.
Immunity   11 567-578   1999
Blockage of gonadotropin-induced first ovulation caused by thyroidectomy and its possible mechanisms in rats.
Am. J. Physiol.(   275(Endocrinol.Metab.38) E380-385   1998
Effects of interleukin-3 on ovine trophoblast interferon during early conceptus development.
Endocrine   3 511-517   1995
Protein kinase C-dependent down-regulation of basic fibroblast growth factor(FGF-2)receptor by phorbol ester and epidermal growth factor in porcine granulosa cells.
Endocrinology   136 3470-3479   1995
Basic fibroblast growth factor receptor decreases with luteal age in rat ovarian luteal cells : Colocalization of the receptor and its ligand in luteal cells.
Endocrinology   133 1074-1084   1993
Tohoku J. Exp. Med.   168(2) 283-286   1992


US-Japan Cooperative Research regarding to the effects of environmental endocrin disruptor on teh reproductive function
1999 - 2001

Research Grants & Projects

Pharmacotherapy for chronic and intractable diseases on reproductive organs
Grant-in-Aid for Scientific Research
Project Year: 2007 - 2015
To explore the molecular mechanisms of disorders on the ovary and uterus and find new targets for drug treatment