相澤信 (Shin AIZAWA) - マイポータル

基本情報

所属: 新所沢清和病院内科

研究者番号: 30202443
J-GLOBAL ID: 200901046633649241
researchmap会員ID: 1000211260

研究キーワード

研究分野

経歴

2001年11月 - 2023年3月

日本大学医学部, 機能形態学系生体構造医学分野, 教授

学歴

- 1984年

日本大学, 大学院医学研究科, 内科学
- 1980年

日本大学, 医学部

委員歴

受賞

1987年

The F. Trobough Hematology Young Investigator Award

論文

105

Macrophage depletion using clodronate liposomes reveals latent dysfunction of the hematopoietic microenvironment associated with persistently imbalanced M1/M2 macrophage polarization in a mouse model of hemophagocytic lymphohistiocytosis.

Takashi Koike, Katsuhiro Miura, Yoshihiro Hatta, Hideki Nakamura, Yoko Hirabayashi, Miyuki Yuda, Tomonori Harada, Shuichi Hirai, Isao Tsuboi, Shin Aizawa

Annals of hematology 102(12) 3311-3323 2023年12月
Kinetics of leukemic cells in 3D culture with stromal cells and with arginine deprivation stress

Harada T., Tsuboi I., Utsunomiya M., Yasuda M., Aizawa S.

J Biosci Bioeng 130 650-658 2020年査読有り最終著者
Dynamics of hematopoiesis is disrupted by impaired hematopoietic microenvironment in a mouse model of hemophagocytic lymphohistiocytosis

Tsuboi I., Harada T., Hirabayashi Y., Aizawa S.

Ann Hematol 99 1515-1523 2020年査読有り最終著者
Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes

Hino H., Iriyama N., Kokuba H., Kazama H., Moriya S., Takano N., Hiramoto M., Aizawa S., MiyazawaK.

Cancer Sci 111(6) 2132-2145 2020年査読有り
Measurement of the Whole and Midsubstance Femoral Insertion of the Anterior Cruciate Ligament: The Comparison with the Elliptically Calculated Femoral Anterior Cruciate Ligament Footprint Area

Iwama G., Iriuchishima T., Horaguchi T., Aizawa S.

Indian J Orthop 53 727-731 2019年査読有り
Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy

Makita K., Hara H., Sano E., Okamoto Y, Ochiai Y., Harada T., Ueda T., Nakayama T., Aizawa S., Yoshino A.

Int J Oncol 54(5) 1864-1874 2019年査読有り
Long-term hypoxia in murine cornea.

Kosaku K, Harada T, Jike T, Tsuboi I, Aizawa S

High Alt Med Biol 19 35-41 2018年3月査読有り
Pulmonary Injury from Waterproofing Spray During a Hike

Tomonori Harada, Yukio Hirabayashi, Yuriko Takayama-Isagawa, Hiroto Sakamoto, Makoto Kawaishi, Hiroyuki Hara, Shin Aizawa

WILDERNESS & ENVIRONMENTAL MEDICINE 28(4) 327-331 2017年12月査読有り
Morphological size evaluation of the mid-substance insertion areas and the fan-like extension fibers in the femoral ACL footprint

Makoto Suruga, Takashi Horaguchi, Takanori Iriuchishima, Yoshiyuki Yahagi, Genki Iwama, Yasuaki Tokuhashi, Shin Aizawa

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY 137(8) 1107-1113 2017年8月査読有り
The correlation of femoral tunnel length with the height and area of the lateral wall of the femoral intercondylar notch in anatomical single-bundle ACL reconstruction

Takanori Iriuchishima, Keinosuke Ryu, Makoto Suruga, Shin Aizawa, Freddie H. Fu

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 25(5) 1632-1637 2017年5月査読有り
The evaluation of muscle recovery after anatomical single-bundle ACL reconstruction using a quadriceps autograft

Takanori Iriuchishima, Keinosuke Ryu, Tatsumasa Okano, Makoto Suruga, Shin Aizawa, Freddie H. Fu

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 25(5) 1449-1453 2017年5月査読有り
Differential Regulation of Lympho-Myelopoiesis by Stromal Cells in the Early and Late Phases in BALB/c Mice Repeatedly Exposed to Lipopolysaccharide

Isao Tsuboi, Tomonori Harada, Yoko Hirabayashi, Jun Kanno, Shin Aizawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN 39(12) 1939-1947 2016年12月査読有り
Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats

Akiko Ohashi, Yusuke Saeki, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa

PLOS ONE 11(10) 2016年10月査読有り
Age-related functional changes in hematopoietic microenvironment

Tsboi I, Harada T, Aizawa S

J Phys Fitness Sports Med 5 167-175 2016年査読有り招待有り
In vitro chemosensitivity study of human leukemic cells in a three-dimensional bone marrow culture system

Fukino N., Harada T., Tsuboi I., Fukui S., Yasuda M., and Aizawa S.

J Hematol Ther 1(2) 7-15 2016年査読有り
Aquaporin 9, a promising predictor for cytocidal effect of arsenic trioxide in acute promyelocytic leukemia cell lines and primary blasts.

Iriyama Noriyoshi, Yuan Bo, Yoshino Yuta, Hatta Yoshihiro, Horikoshi Akira, Aizawa Shin, Takeuchi Jin, Toyoda Hiroo

Oncol Rep. 29(6), 2362-2368 2013年6月査読有り
Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein

Hotta K, Nashimoto A, Yasumura E, Suzuki M, Azuma M, Iizumi Y, Shima D, Nabeshima R, Hiramoto M, Okada A …

Mol Pharmacol 83(5) 930-938 2013年5月査読有り
Stress-related activities induced by predator odor may become indistinguishable by hinokitiol odor

Toyotaka Murakami, Mutsumi Matsukawa, Narumi Katsuyama, Masato Imada, Shin Aizawa, Takaaki Sato

NEUROREPORT 23(18) 1071-1076 2012年12月査読有り
Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment.

Tsuboi I, Harada T, Hirabayashi Y, Kanno J, Inoue T, Aizawa S

Experimental biology and medicine (Maywood, N.J.) 237(11) 1289-1297 2012年11月査読有り
Granulocyte colony-stimulating factor potentiates differentiation induction by al-trans retinoic acid and arsenic trioxide and enhances arsenic uptake in the acute promyelocytic leukemia cell line HT93A

Iriyama N., Yuan B., Hatta Y., Horikoshi A., Yoshino Y., Toyoda H., Aizawa S., Takeuchi J.

Oncol Rep 28 1875-1882 2012年9月査読有り

もっとみる

MISC

CDK4/6阻害薬abemaciclibが誘導する空胞の形成メカニズムの検討

日野浩嗣, 田中良法, 竹谷浩介, 高野直治, 平本正樹, 相澤信, 宮澤啓介, 江藤真澄, 平井宗一

日本生化学会大会プログラム・講演要旨集 94回 [P-493] 2021年11月
CDK4/6阻害薬abemaciclibはリソソームの酸性化、膨化により空胞形成を起こし、新規形式の細胞死を誘導する

日野浩嗣, 入山規良, 國場寛子, 風間宏美, 森谷昇太, 高野直治, 平本正樹, 相澤信, 宮澤啓介

日本生化学会大会プログラム・講演要旨集 93回 [P-359] 2020年9月
Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis.

Isao Tsuboi, Tomonori Harada, Yoko Hirabayashi, Shin Aizawa

Haematologica 104(10) 1995-2005 2019年10月査読有り
The correlation between the femoral anterior cruciate ligament footprint area and the morphology of the distal femur: three-dimensional CT evaluation in cadaveric knees

Suruga M., Horaguchi T., Iriuchishima T., Iwama G., Yahagi Y., Tokuhashi Y., Aizawa S.

Eur J Orthop Surg Traumatol 29 849-854 2019年査読有り
A murine model of atopic dermatitis can be generated by painting the dorsal skin with hapten twice 14 days apart

Ayaka Kitamura, Ryohei Takata, Shin Aizawa, Hajime Watanabe, Tadashi Wada

Scientific Reports 8(1) 2018年12月1日査読有り
Sagittal femoral condyle morphology correlates with femoral tunnel length in anatomical single bundle ACL reconstruction

Takanori Iriuchishima, Freddie H. Fu, Keinosuke Ryu, Makoto Suruga, Yoshiyuki Yahagi, Shin Aizawa

Knee Surgery, Sports Traumatology, Arthroscopy 26(4) 1110-1116 2018年4月1日査読有り
Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess

Akiko Ohashi, Kaori Mamada, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa

MOLECULAR AND CELLULAR BIOCHEMISTRY 435(1-2) 97-108 2017年11月査読有り
Predatory odor induced stress responses can be allayed by habitat odor

Mutsumi Matsukawa, Masato Imada, Shin Aizawa, Takaaki Sato

CHEMICAL SENSES 41(9) E145-E146 2016年11月
Runx1 contributes to the functional switching of bone morphogenetic protein 4 (BMP4) from neurite outgrowth promoting to suppressing in dorsal root ganglion

Masaaki Yoshikawa, Tomoyuki Masuda, Azusa Kobayashi, Kouji Senzaki, Shigeru Ozaki, Shin Aizawa, Takashi Shiga

MOLECULAR AND CELLULAR NEUROSCIENCE 72 114-122 2016年4月査読有り
Quantitative Analysis of Formaldehyde-induced Fluorescence in Paraffin-embedded Specimens of Malignant Melanomas and Other Melanocytic Lesions

Hiroyuki Hara, Michiko Naito, Tomonori Harada, Isao Tsuboi, Tadashi Terui, Shin Aizawa

ACTA DERMATO-VENEREOLOGICA 96(3) 309-313 2016年査読有り
Habitat odor can alleviate innate stress responses in mice

Mutsumi Matsukawa, Masato Imada, Shin Aizawa, Takaaki Sato

BRAIN RESEARCH 1631 46-52 2016年1月査読有り
The difference in centre position in the ACL femoral footprint inclusive and exclusive of the fan-like extension fibres

Takanori Iriuchishima, Keinosuke Ryu, Shin Aizawa, Freddie H. Fu

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 24(1) 254-259 2016年1月査読有り
Contribution of the Runx1 transcription factor to axonal pathfinding and muscle innervation by hypoglossal motoneurons

Masaaki Yoshikawa, Mizuki Hirabayashi, Ryota Ito, Shigeru Ozaki, Shin Aizawa, Tomoyuki Masuda, Kouji Senzaki, Takashi Shiga

DEVELOPMENTAL NEUROBIOLOGY 75(11) 1295-1314 2015年11月査読有り
Kinetics of hematopoietic stem cells and supportive activities of stromal cells in a three-dimensional bone marrow culture system

Tomonori Harada, Yukio Hirabayashi, Yoshihiro Hatta, Isao Tsuboi, Wilhelm Robert Glomm, Masahiro Yasuda, Shin Aizawa

GROWTH FACTORS 33(5-6) 347-355 2015年9月査読有り
Decreased “ineffective erythropoiesis” preserves polycythemia in mice under long-term hypoxia

Harada T, Tsuboi I, Hirabayashi Y, Kosaku K, Naito M, Hara H, Inoue T, Aizawa S

Clin Exp Med 15(2) 179-188 2015年5月査読有り
Lipopolysaccharide Reciprocally Alters the Stromal Cell-Regulated Positive and Negative Balance between Myelopoiesis and B Lymphopoiesis in C57BL/6 Mice

Masafumi Taki, Isao Tsuboi, Tomonori Harada, Michiko Naito, Hiroyuki Hara, Tohru Inoue, Shin Aizawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN 37(12) 1872-1881 2014年12月査読有り
The prevalence of and factors related to calcium pyrophosphate dihydrate crystal deposition in the knee joint

K. Ryu, T. Iriuchishima, M. Oshida, Y. Kato, A. Saito, M. Imada, S. Aizawa, Y. Tokuhashi, J. Ryu

OSTEOARTHRITIS AND CARTILAGE 22(7) 975-979 2014年7月査読有り
Increased Expression of Vascular Endothelial Growth Factor Attenuates Contusion Necrosis without Influencing Contusion Edema after Traumatic Brain Injury in Rats

Masahiro Tado, Tatsuro Mori, Masamichi Fukushima, Hideki Oshima, Takeshi Maeda, Atsuo Yoshino, Shin Aizawa, Yoichi Katayama

JOURNAL OF NEUROTRAUMA 31(7) 691-698 2014年4月査読有り
Enhancement of differentiation induction and upregulation of CCAAT/enhancer-binding proteins and PU.1 in NB4 cells treated with combination of ATRA and valproic acid

Noriyoshi Iriyama, Bo Yuan, Yuta Yoshino, Yoshihiro Hatta, Akira Horikoshi, Shin Aizawa, Masami Takei, Jin Takeuchi, Norio Takagi, Hiroo Toyoda

INTERNATIONAL JOURNAL OF ONCOLOGY 44(3) 865-873 2014年3月査読有り
Stimulation of brain-serotonin production by peripherally administered sepiapterin, a precursor of the salvage pathway of tetrahydrobiopterin

Hiroyuki Hasegawa, Akiko Ohashi, Tomonori Harada, Shin Aizawa

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 191P-191P 2012年

もっとみる

所属学協会

共同研究・競争的資金等の研究課題

造血微小環境におけるストローマ細胞の構成様式と造血支持機能

2018年 - 2020年
骨髄造血微小環境におけるストローマ細胞の構成様式と造血制御機能発現の検討

基盤研究(C) 2015年 - 2017年
三次元解析による骨髄ストローマ細胞の造血制御機構の検討

基盤研究(C) 2012年 - 2015年
がん幹細胞特異的発現トランスポーターを標的とした化学療法の基盤構築

日本学術振興会科学研究費助成事業基盤研究(C) 2011年 - 2013年

中西猛夫, 玉井郁巳, 相澤信, 相沢信

相澤信

基本情報

研究キーワード

研究分野

経歴

学歴

委員歴

受賞

論文

MISC

所属学協会

共同研究・競争的資金等の研究課題

産業財産権

メニュー

共著者の一覧