CHIBA Yoshihiko

J-GLOBAL         Last updated: Oct 1, 2019 at 11:39
 
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Name
CHIBA Yoshihiko
Affiliation
Hoshi University
Section
Department of Pharmacology
Job title
Associate Professor
Degree
(BLANK)

Research Areas

 
 

Published Papers

 
Yuki Kai, Momoko Motegi, Yuta Suzuki, Hiroto Takeuchi, Yui Harada, Fumiaki Sato, Yoshihiko Chiba, Junzo Kamei, Hiroyasu Sakai
Basic and Clinical Pharmacology and Toxicology   125 8-15   Jul 2019
© 2019 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society) There has been considerable research on the involvement of RhoA/Rho kinase signalling in smooth muscle contractions. However, only a few reports have add...
Yusuke Ando, Fumiaki Sato, Hazuki Fukunaga, Yusuke Iwasaki, Yoshihiko Chiba, Masahiko Tebakari, Yuki Daigo, Junichi Kawashima, Junzo Kamei
Nutrition and Metabolism   16    May 2019
© 2019 The Author(s). Background: Adipogenesis, the process of preadipocyte differentiation to mature adipocytes accompanied by accumulation of intracytoplasmic lipid droplets, is regulated by various genetic and environmental factors, and closely...
Hiroyasu Sakai, Taku Ishida, Ken Sato, Kazutaka Mandokoro, Saori Yabe, Fumiaki Sato, Yoshihiko Chiba, Risako Kon, Nobutomo Ikarashi, Junzo Kamei
Inflammation      Jan 2019
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. We recently reported that swelling resulting from 2,4,6-trinitrochlorobenzene (TNCB) challenge might be associated with recruitment of neutrophils. However, it is not known whe...
Yuki Kai, Momoko Motegi, Yuta Suzuki, Yui Harada, Hiroto Takeuchi, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei, Hiroyasu Sakai
Biological and Pharmaceutical Bulletin   42 1605-1607   Jan 2019
© 2019 The Pharmaceutical Society of Japan Recently, we demonstrated that Rac1 upregulation is involved in augmented bronchial smooth muscle (BSM) contractions of antigen-challenged mice. However, change in G protein-coupled receptor (GPCR)induced...
Wataru Suto, Hiroyasu Sakai, Yoshihiko Chiba
Journal of Smooth Muscle Research   55 1-13   Jan 2019
© 2019 The Japan Society of Smooth Muscle Research. Prostaglandin D 2 (PGD 2 ), one of the key lipid mediators of allergic airway inflammation, is increased in the airways of asthmatics. However, the role of PGD 2 in the pathogenesis of asthma is...
Hiroyasu Sakai, Minami Kimura, Yuka Tsukimura, Saori Yabe, Yosuke Isa, Yuki Kai, Fumiaki Sato, Risako Kon, Nobutomo Ikarashi, Minoru Narita, Yoshihiko Chiba, Junzo Kamei
Clinical and Experimental Pharmacology and Physiology   46 19-28   Jan 2019
© 2018 John Wiley & Sons Australia, Ltd Dexamethasone for antiemetic therapy is typically administered with anticancer drugs such as cisplatin. We previously reported that cisplatin upregulates the muscle-specific E3 ubiquitin ligase genes, name...
Yoshihiko Chiba, Wataru Suto, Hiroyasu Sakai
PLoS ONE   13    Aug 2018
© 2018 Chiba et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are c...
Hiroyasu Sakai, Yuki Kai, Ken Sato, Mitsuo Ikebe, Yohihiko Chiba
European Journal of Pharmacology   818 74-83   Jan 2018
© 2017 Elsevier B.V. Increasing evidence suggests a functional role of RhoA/Rho-kinase signalling as a mechanism for smooth muscle contraction; however, little is known regarding the roles of Rac1 and other members of the Rho protein family. This...
Wataru Suto, Yusuke Ando, Takahiro Hirabayashi, Fumiko Takenoya, Seiji Shioda, Junzo Kamei, Hiroyasu Sakai, Yoshihiko Chiba
International Journal of Molecular Sciences   19    Jan 2018
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Prostaglandin D2 (PGD2 ) is one of the key lipid mediators of allergic airway inflammation, including bronchial asthma. However, the role of PGD2 in the pathogenesis of asthma is not fully ...
Yoshihiko Chiba, Shunta Danno, Rena Suto, Wataru Suto, Yamato Yamane, Motohiko Hanazaki, Hiroshi Katayama, Hiroyasu Sakai
American Journal of Physiology - Lung Cellular and Molecular Physiology   314    Jan 2018
© 2018 American Physiological Society. All rights reserved. Progranulin (PGRN) is a growth factor with multiple biological functions and has been suggested as an endogenous inhibitor of Tumor necrosis factor-α (TNF-α)-mediated signaling. TNF-α is ...
Hiroyasu Sakai, Saori Yabe, Ken Sato, Yuki Kai, Fumiaki Sato, Tetsuro Yumoto, Yuka Inoue, Minoru Narita, Kenjiro Matsumoto, Shinichi Kato, Yoshihiko Chiba
Clinical and Experimental Pharmacology and Physiology   45 27-33   Jan 2018
© 2017 John Wiley & Sons Australia, Ltd Contact dermatitis is a form of delayed-type hypersensitivity characterized by localized thickening, papules, redness and vesicles of the skin. A model of contact dermatitis involving repeated challenge of...
Hiroyasu Sakai, Minami Kimura, Yosuke Isa, Saori Yabe, Akihide Maruyama, Yukari Tsuruno, Yuki Kai, Fumiaki Sato, Tetsuro Yumoto, Yoshihiko Chiba, Minoru Narita
Pflugers Archiv European Journal of Physiology   469 1495-1505   Nov 2017
© 2017, Springer-Verlag GmbH Germany. Cisplatin, a platinum-based anti-cancer drug, is one of the most effective broad-spectrum anti-cancer agents used against various cancers. It has been recently suggested that low skeletal muscle mass is predic...
Hiroyasu Sakai, Ken Sato, Fumiaki Sato, Yuki Kai, Kazutaka Mandokoro, Kenjiro Matsumoto, Shinichi Kato, Tetsuro Yumoto, Minoru Narita, Yoshihiko Chiba
Inflammation Research   66 663-678   Aug 2017
© 2017, Springer International Publishing. Objectives: Contact dermatitis model involving repeated application of hapten is used as a tool to assess dermatitis, as characterized by thickening. Involvement of cell proliferation, elicited by repeate...
Yoshihiko Chiba, Gen Tanoue, Rena Suto, Wataru Suto, Motohiko Hanazaki, Hiroshi Katayama, Hiroyasu Sakai
Pharmacological Reports   69 377-385   Jun 2017
© 2016 Background Although interleukin-17 (IL-17) contributes to the induction of airway hyperresponsiveness in asthma, its effect on bronchial smooth muscle (BSM) remains largely unknown. Evidence support an involvement of RhoA/Rho-kinase in BSM ...
Hiroyasu Sakai, Wataru Suto, Yuki Kai, Yoshihiko Chiba
Journal of Smooth Muscle Research   53 37-47   Jan 2017
© 2017 The Japan Society of Smooth Muscle Research. Airway hyperresponsiveness (AHR) and inflammation are key pathophysiological features of asthma. Enhanced contraction of bronchial smooth muscle (BSM) is one of the causes of the AHR. It is thus ...
Sakai H, Sato K, Kai Y, Chiba Y, Narita M
Biological & pharmaceutical bulletin   39(1) 33-41   Jan 2016   [Refereed]
Shibata K, Sakai H, Huang Q, Kamata H, Chiba Y, Misawa M, Ikebe R, Ikebe M
Journal of cellular physiology   230(6) 1352-1364   Jun 2015   [Refereed]
Sakai H, Sagara A, Arakawa K, Sugiyama R, Hirosaki A, Takase K, Jo A, Sato K, Chiba Y, Yamazaki M, Matoba M, Narita M
Toxicology and applied pharmacology   278(2) 190-199   Jul 2014   [Refereed]
Sakai H, Watanabe A, Fujita A, Misawa M, Narita M, Chiba Y
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   50 39-47   2014   [Refereed]
Sakai H, Watanabe A, Fujita A, Misawa M, Narita M, Chiba Y
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   50 39-47   2014   [Refereed]
Sakai H, Hara T, Todoroki K, Igarashi Y, Misawa M, Narita M, Chiba Y
Microvascular research   90 150-153   Nov 2013   [Refereed]
Sakai H, Watanabe Y, Honda M, Tsuiki R, Ueda Y, Nagai Y, Narita M, Misawa M, Chiba Y
Anesthesiology   118(5) 1076-1085   May 2013   [Refereed]
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
Chiba Y, Goto K, Misawa M
Pharmacological reports : PR   64(2) 454-458   2012   [Refereed]
Yoshioka N, Hanazaki M, Fujita Y, Nakatsuka H, Katayama H, Chiba Y
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   48(2-3) 59-64   2012   [Refereed]
Sakai H, Hirahara M, Chiba Y, Misawa M
International immunopharmacology   11(8) 1133-1136   Aug 2011   [Refereed]
Chiba Y, Todoroki M, Misawa M
Immunopharmacology and immunotoxicology   33(1) 43-48   Mar 2011   [Refereed]
Sakai H, Enzaka J, Sakai-Oshita M, Uto F, Chiba Y, Misawa M
Microvascular research   81(1) 129-134   Jan 2011   [Refereed]
Sphingosine-1-phosphate augments agonist-mediated contraction in the bronchial smooth muscles of mice.
Chiba Y, Takeuchi H, Sakai H, Misawa M
Pharmacological reports : PR   63(2) 544-547   2011   [Refereed]
Sakai H, Fujita A, Watanabe A, Chiba Y, Kamei J, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   47(1) 1-10   2011   [Refereed]
Sakai H, Nishimura A, Watanabe Y, Nishizawa Y, Hashimoto Y, Chiba Y, Misawa M
Peptides   31(12) 2216-2221   Dec 2010   [Refereed]
Chiba Y, Suzuki K, Uechi M, Kurihara E, Goto K, Sakai H, Misawa M
Pharmacological research   62(4) 357-363   Oct 2010   [Refereed]
Sakai H, Enzaka J, Sakai-Oshita M, Chiba Y, Misawa M
European journal of pharmacology   644(1-3) 215-219   Oct 2010   [Refereed]
Chiba Y, Tanabe M, Sakai H, Kimura S, Misawa M
Biochemical and biophysical research communications   401(3) 487-490   Oct 2010   [Refereed]
H. Sakai, Y. Kurihara, Y. Hashimoto, Y. Chiba, M. Misawa
Respiratory Physiology and Neurobiology   173 120-124   Sep 2010
Increasing evidence suggests that protein kinase C (PKC) is involved in the Ca 2+ sensitization of various smooth muscle contractions. However, the exact role of PKC on bronchial smooth muscle (BSM) contraction is still unclear. In the present stu...
Sakai H, Nishizawa Y, Nishimura A, Chiba Y, Goto K, Hanazaki M, Misawa M
Pflugers Archiv : European journal of physiology   460(3) 645-655   Aug 2010   [Refereed]
Chiba Y, Suzuki K, Kurihara E, Uechi M, Sakai H, Misawa M
The open respiratory medicine journal   4 82-85   Aug 2010   [Refereed]
Yu Y, Chiba Y, Sakai H, Misawa M
Inflammation research : official journal of the European Histamine Research Society ... [et al.]   59(6) 419-428   Jun 2010   [Refereed]
Goto K, Chiba Y, Matsusue K, Hattori Y, Maitani Y, Sakai H, Kimura S, Misawa M
Pharmacological research   61(5) 466-472   May 2010   [Refereed]
Chiba Y, Todoroki M, Misawa M
Pharmacological research   61(2) 188-192   Feb 2010   [Refereed]
Chiba Y, Goto K, Matsusue K, Kimura S, Misawa M
Journal of pharmacological sciences   112(4) 467-472   2010   [Refereed]
Chiba Y, Onoda S, Todoroki M, Nishida Y, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   46(1) 49-55   2010   [Refereed]
Chiba Y, Sato S, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   46(1) 57-64   2010   [Refereed]
Goto K, Chiba Y, Sakai H, Misawa M
Biological & pharmaceutical bulletin   33(4) 710-713   2010   [Refereed]
Chiba Y, Goto K, Momata M, Kobayashi T, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   46(4) 217-224   2010   [Refereed]
Chiba Y, Matsusue K, Misawa M
Journal of pharmacological sciences   114(3) 239-247   2010   [Refereed]
Chiba Y, Takeuchi H, Sakai H, Misawa M
Journal of pharmacological sciences   114(3) 304-310   2010   [Refereed]
Chiba Y, Misawa M
Journal of pharmacological sciences   114(3) 264-268   2010   [Refereed]
Chiba Y, Hijikata T
Journal of pharmacological sciences   114(3) 262-263   2010   [Refereed]
Sakai H, Kurihara Y, Hashimoto Y, Chiba Y, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   46(5) 225-233   2010   [Refereed]
Sakai H, Kurihara Y, Hashimoto Y, Chiba Y, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   46(5) 259-266   2010   [Refereed]
Chiba Y, Todoroki M, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   45(6) 279-288   Dec 2009   [Refereed]
Chiba Y, Todoroki M, Nishida Y, Tanabe M, Misawa M
American journal of respiratory cell and molecular biology   41(5) 516-524   Nov 2009   [Refereed]
Chiba Y, Sato S, Hanazaki M, Sakai H, Misawa M
American journal of physiology. Lung cellular and molecular physiology   297(5) L984-91   Nov 2009   [Refereed]
Chiba Y, Tanabe M, Goto K, Sakai H, Misawa M
American journal of respiratory and critical care medicine   180(8) 713-719   Oct 2009   [Refereed]
Sakai H, Yamamoto M, Chiba Y, Misawa M
European journal of pharmacology   618(1-3) 58-62   Sep 2009   [Refereed]
Goto K, Chiba Y, Sakai H, Misawa M
Journal of pharmacological sciences   110(4) 437-444   Aug 2009   [Refereed]
Sakai H, Kozutsumi Y, Goto K, Chiba Y, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   45(2-3) 97-108   Jun 2009   [Refereed]
Chiba Y, Onoda S, Hattori Y, Maitani Y, Sakai H, Misawa M
Lung   187(3) 179-185   May 2009   [Refereed]
Goto K, Chiba Y, Misawa M
Cytokine   46(1) 96-99   Apr 2009   [Refereed]
Chiba Y, Nakazawa S, Todoroki M, Shinozaki K, Sakai H, Misawa M
American journal of respiratory cell and molecular biology   40(2) 159-167   Feb 2009   [Refereed]
Sakai H, Yamamoto M, Kozutsumi Y, Chiba Y, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   45(1) 55-62   Feb 2009   [Refereed]
Y. Chiba, S. Sato, M. Misawa
Inflammation Research   58 363-369   Jan 2009
Objective and design: Statins have been proposed as a novel treatment of respiratory diseases. To determine the beneficial effects of statins on allergic bronchial asthma, the effect of systemic treatment with lovastatin on antigen-induced airway ...
Yoshihiko Chiba, S. Sato, M. Misawa
International Journal of Immunopathology and Pharmacology   22 929-935   Jan 2009
Statins have been proposed as a novel treatment of respiratory diseases including asthma. Although the mechanism of anti-inflammatory effect of statins is still unclear, an inhibition of protein prenylation by depleting the downstream metabolites ...
Hanazaki M, Chiba Y, Yokoyama M, Morita K, Kohjitani A, Sakai H, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   44(6) 189-193   Dec 2008   [Refereed]
Goto K, Chiba Y, Sakai H, Misawa M
European journal of pharmacology   591(1-3) 231-236   Sep 2008   [Refereed]
Hanazaki M, Yokoyama M, Morita K, Kohjitani A, Sakai H, Chiba Y, Misawa M
Anesthesia and analgesia   106(6) 1765-1771   Jun 2008   [Refereed]
Chiba Y, Arima J, Sakai H, Misawa M
American journal of physiology. Lung cellular and molecular physiology   294(4) L705-13   Apr 2008   [Refereed]
Chiba Y, Goto K, Hirahara M, Sakai H, Misawa M
Journal of pharmacological sciences   106(4) 615-625   Apr 2008   [Refereed]
Chiba Y, Shinozaki K, Ueno A, Sakai H, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   44(2) 95-100   Apr 2008   [Refereed]
Sakai H, Yamamoto M, Chiba Y, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   44(1) 9-16   Feb 2008   [Refereed]
Chiba Y, Sato S, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   44(3-4) 123-128   2008   [Refereed]
[Hoshi Pharmaceutical Company and Korea in the early half of the 20th century].
Misawa M, Chiba Y, Ushikubo H
Yakushigaku zasshi   43(1) 40-47   2008   [Refereed]
[On the Chosen Pharmaceutical Association and "The Journal of the Chosen Pharmaceutical Association"].
Ushikubo H, Chiba Y, Misawa M
Yakushigaku zasshi   43(1) 48-53   2008   [Refereed]
[List of literature existing in Japan related to the history of Korean pharmacy in the early half of the 20th century].
Chiba Y, Misawa M
Yakushigaku zasshi   43(1) 54-60   2008   [Refereed]
Chiba Y, Oshita M, Sakai H, Misawa M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   43(4) 139-144   Aug 2007   [Refereed]
Chiba Y, Matsuo K, Sakai H, Abe K, Misawa M
Auris, nasus, larynx   34(2) 197-201   Jun 2007   [Refereed]
Chiba Y, Yu Y, Sakai H, Misawa M
Biological & pharmaceutical bulletin   30(2) 318-323   Feb 2007   [Refereed]
Sakai H, Chiba Y, Misawa M
Pulmonary pharmacology & therapeutics   20(6) 734-739   2007   [Refereed]
Chiba Y, Matsuo K, Sakai H, Abe K, Misawa M
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society   15(2) 142-147   Sep 2006   [Refereed]
Sakai H, Chiba Y, Misawa M
Biological & pharmaceutical bulletin   29(9) 1897-1899   Sep 2006   [Refereed]
Chiba Y, Matsuo K, Sakai H, Misawa M
American journal of rhinology   20(4) 477-479   Jul 2006   [Refereed]
Chiba Y, Kurotani R, Kusakabe T, Miura T, Link BW, Misawa M, Kimura S
American journal of respiratory and critical care medicine   173(9) 958-964   May 2006   [Refereed]
Chiba Y, Matsuo K, Sakai H, Abe K, Misawa M
American journal of rhinology   20(3) 336-341   May 2006   [Refereed]
Chiba Y, Oshita M, Matsuo K, Sakai H, Misawa M
American journal of rhinology   20(3) 349-352   May 2006   [Refereed]
Tomoo Hosoe, Toru Iizuka, Yoshihiko Chiba, Takeshi Itabashi, Hiroshi Morita, Takayuki Ishizaki, Ken Ichi Kawai
Journal of Natural Medicines   60 130-134   Apr 2006
The organic extract of the basidiomycete Phellinus gilvus TMC-1117 showed biphasic vasodilator activity on rat aorta with endothelium. Two lanostane-type triterpenes, eburicoic acid (1) and trametenolic acid B (2), were isolated from the organic e...
Sakai H, Hirano T, Chiba Y, Misawa M
American journal of physiology. Lung cellular and molecular physiology   289(6) L925-30   Dec 2005   [Refereed]
Chiba Y, Murata M, Ushikubo H, Yoshikawa Y, Saitoh A, Sakai H, Kamei J, Misawa M
American journal of respiratory cell and molecular biology   33(6) 574-581   Dec 2005   [Refereed]
Sakai H, Chiba Y, Hirano T, Misawa M
Molecular pharmacology   68(1) 145-151   Jul 2005   [Refereed]
Chiba Y, Sakai H, Misawa M
European journal of pharmacology   517(3) 182-185   Jul 2005   [Refereed]
Chiba Y, Sakai H, Yu Y, Misawa M
Journal of biochemistry   137(6) 751-756   Jun 2005   [Refereed]
Sakai H, Shirai T, Yamamoto M, Chiba Y, Misawa M
Biological & pharmaceutical bulletin   28(4) 625-628   Apr 2005   [Refereed]
Sakai H, Hirano T, Takeyama H, Chiba Y, Misawa M
Canadian journal of physiology and pharmacology   83(4) 375-381   Apr 2005   [Refereed]
Chiba Y, Srisodsai A, Supavilai P, Kimura S
Immunology letters   97(1) 123-129   Feb 2005   [Refereed]
Chiba Y, Ueno A, Shinozaki K, Takeyama H, Nakazawa S, Sakai H, Misawa M
Respiratory research   6 4   Jan 2005   [Refereed]
Sakai H, Otogoto S, Chiba Y, Abe K, Misawa M
Journal of applied physiology (Bethesda, Md. : 1985)   97(6) 2154-2159   Dec 2004   [Refereed]
Srisodsai A, Kurotani R, Chiba Y, Sheikh F, Young HA, Donnelly RP, Kimura S
The Journal of biological chemistry   279(52) 54358-54368   Dec 2004   [Refereed]
Chiba Y, Kusakabe T, Kimura S
American journal of physiology. Lung cellular and molecular physiology   287(6) L1193-8   Dec 2004   [Refereed]
Y. Chiba, A. Ueno, H. Sakai, M. Misawa
Inflammation Research   53 636-642   Nov 2004
Objective: To determine a change in airway smooth muscle contractility in a murine model of allergic asthma, the responsiveness of airway smooth muscles isolated from ovalbumin (OA)-sensitized and -challenged mice was compared with that from contr...

Misc

 
Yoshihiko Chiba, Miwa Misawa
Folia Pharmacol. Jpn.   111 249-256   Apr 1998
Nonspecific airway hyperresponsiveness (AHR) is a common feature of allergic bronchial asthmatics, but the underlying mechanisms of AHR have yet to be elucidated. The importance of AHR in the pathogenesis of asthma has been suggested by its releva...
. 5(2), 44-47, 2008.
CHIBA Yoshihiko
5(2) 44-47   2008
Inhibition of antigen-induced airway hyperresponsiveness in rats : effects of ozagrel(a thromboxane A2 Synthase inhibitor)and of CV-3988(a platelet activating factor antagonist).
Res. Commun. Chem. Pathol. Pharmacol.   84 341   1994
Inhibition of neutral endopeptidase increases airway responsiveness to acetylcholine in nonsensitized normal rats.
J. Appl. Physiol.   78(2) 394   1995
Characteristics of muscarinic cholinecoptors in airways of antigen-induced airway hyperresponsive rats.
Comp. Biochem. Physiol.   111C(3) 351   1995

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2011 - 2013    Investigator(s): Yoshihiko CHIBA
Current study was carried out to make clear the mechanism(s) of development of airway hyperresponsiveness in asthmatics. In bronchial smooth muscles of mice with allergic asthma, an up-regulation of RhoA protein and a down-regulation of miR-140-3p...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2009 - 2011    Investigator(s): Motohiko HANAZAKI
It has been reported that an airway hyperresponsiveness(AHR) was observed in the non-asthmatic recipients who received lung transplantation. The mechanism of AHR after lung transplantation is unclear, and various factors seem to be involved in. Im...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010    Investigator(s): Yoshihiko CHIBA
Interleukin-13 (IL-13) is one of the central mediators for development of airway hyperresponsiveness in asthma. However, its effect on bronchial smooth muscle (BSM) is not well known. Recent studies revealed an involvement of RhoA/Rho-kinase in BS...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2006 - 2007    Investigator(s): Miwa MISAWA
The mechanisms of pathogenesis of airway hyperresponsiveness(AHR) in allergic bronchial asthma were investigated pharmacologically and molecular biologically. The following results were obtained.1. The contractile responsiveness to endothelin-1(ET...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2006 - 2007    Investigator(s): Yoshihiko CHIBA
Interleukin-13(IL-13) is one of the central mediators for development of airway hyperresponsiveness in asthma. However, its effect on bronchial smooth muscle(BSM) is not well known Recent studies revealed an involvement of RhoA/Rho-kinase in BSM c...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2003 - 2005    Investigator(s): Miwa MISAWA
(1)The authors have found for the first time that expression of rhoA mRNA and upregulation of RhoA protein in bronchial smooth muscle of airway hyperresponsive (AHR) rats which received repeated antigen-challenge. We propose that enhanced Ca^<2+> ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2000 - 2002    Investigator(s): Miwa MISAWA
1. When bronchial smooth muscle contracted by ACh in normal rats, a monomeric GTP binding protein, RhoA, translocated to plasma membrane (RhoA activation). The bronchial muscle from repeatedly antigen-challenged rats more markedly contracted by AC...
Mechanisms involved in the pathogenesis of airway hyperresponsiveness in allergic asthma.