論文

査読有り 最終著者
2009年12月

Computer simulation of wound closure in epithelial tissues: Cell-basal-lamina adhesion

PHYSICAL REVIEW E
  • Tatsuzo Nagai
  • ,
  • Hisao Honda

80
6
開始ページ
061903
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1103/PhysRevE.80.061903
出版者・発行元
AMER PHYSICAL SOC

The mechanism of wound closure in epithelial tissues, i.e., cell monolayer sheets, is investigated through computer simulations. A wound means an area in which some cells have been removed from the normal tissue. The vertex dynamics cell model [T. Nagai and H. Honda, Philos. Mag. B 81, 699 (2001)], which describes morphogenesis of epithelial tissues using the concepts of statistical physics, is modified and applied to the closure of small wounds without mitosis. It is shown that cell-basal-lamina adhesion governs the wound closure competing with cell-cell adhesion and cell elasticity. The simulation results reproduce the actual wound closure process qualitatively and partly quantitatively. The closing proceeds with the translation of the edges of wound polygons toward the wound center and the intermittent reduction in the number of polygon edges. Over time, the process leads to an exponential decrease in the wound area. A shape factor is introduced to describe the wound shape quantitatively and is used to examine the time variation thereof. A method for determining model parameters by comparison with the experiments is given.

リンク情報
DOI
https://doi.org/10.1103/PhysRevE.80.061903
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000273227500086&DestApp=WOS_CPL
ID情報
  • DOI : 10.1103/PhysRevE.80.061903
  • ISSN : 1539-3755
  • Web of Science ID : WOS:000273227500086

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