MISC

1999年10月

Hypophosphorylation of pRB and repression of cyclin D3 and cdc25A during the granulocytic differentiation of human myeloblastic leukemia ML-1 cells

LEUKEMIA RESEARCH
  • T Shimizu
  • ,
  • Y Oka
  • ,
  • N Awai
  • ,
  • K Takeda

23
10
開始ページ
901
終了ページ
907
記述言語
英語
掲載種別
DOI
10.1016/S0145-2126(99)00106-X
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Recently we succeeded in inducing synergistic differentiation toward granulocytes in human myeloblastic leukemia ML-1 cells by treatment of ATRA in combination with GM-CSF. To research the mechanism of this differentiation process, we examined expression of cell cycle-related genes that are concerned with cell growth and differentiation. We detected change to the hypophosphorylated form of pRB and down-regulation of cyclin D3 and cdc25A during induced differentiation. Furthermore, these marked alterations were hardly detected in ML-1 cells treated with ATRA or GM-CSF alone. These results suggest that hypophosphorylation of pRB and repression of cyclin D3 and cdc25A are induced synergistically by treatment with ATRA plus GM-CSF in ML-1 cells. (C) 1999 Elsevier Science Ltd. All rights reserved.

Web of Science ® 被引用回数 : 8

リンク情報
DOI
https://doi.org/10.1016/S0145-2126(99)00106-X
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000083050500006&DestApp=WOS_CPL

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