論文

査読有り
2003年9月

Induction of plasminogen activator inhibitor-2 is associated with suppression of invasive activity in TPA-mediated differentiation of human prostate cancer cells

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • T Shimizu
  • ,
  • K Sato
  • ,
  • T Suzuki
  • ,
  • K Tachibana
  • ,
  • K Takeda

309
2
開始ページ
267
終了ページ
271
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2003.08.004
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

We previously reported that 12-O-tetra-decanoylphorbol-13-acetate (TPA) induces microglia-like differentiation and decreases malignancy in human prostate cancer TSU-Pr1 cells. To investigate the mechanism underlying differentiation and decrease of 9 malignancy in TSU-Pr1 cells treated with TPA, we attempted to identify genes expressed differentially during the differentiation using differential display. We successfully detected plasminogen activator inhibitor type-2 (PAI-2) as one gene up-regulated by TPA treatment. The change in expression of PAI-2 by TPA was blocked by treatment with protein kinase C or mitogen-activated protein kinase inhibitors. We also found that secretion of PAI-2 protein was increased by TPA treatment. Moreover, we demonstrated that suppression of invasive activity of TSU-Prl cells by TPA treatment was blocked by co-treatment with anti-PAI-2 antibody. These results suggest that induction of PAI-2 is associated with suppression of invasive activity in TSU-Pr1 cells treated with TPA. (C) 2003 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2003.08.004
CiNii Articles
http://ci.nii.ac.jp/naid/80016174763
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/12951044
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000185264300001&DestApp=WOS_CPL

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