東隆親 (Takachika Azuma) - マイポータル

基本情報

学位: 理学博士(大阪大学)

J-GLOBAL ID: 200901050424758952
researchmap会員ID: 1000212537

研究キーワード

研究分野

ライフサイエンス / 免疫学 /

学歴

MISC

Initial repertoire of anti-(4-hydroxy-3-nitrophenylacetyl) antibodies as potential donors for effective affinity maturation

K Furukawa, A Manabe, A Furukawa, H Kuba, T Okajima, T Azuma

MOLECULAR IMMUNOLOGY 43(11) 1751-1760 2006年4月
Regional and segmental flexibility of antibodies in interaction with antigens of different size

M Oda, S Uchiyama, CV Robinson, K Fukui, Y Kobayashi, T Azuma

FEBS JOURNAL 273(7) 1476-1487 2006年4月
Generation of monoclonal antibodies against chromosomal antigens that have a high sequence similarity between human and mouse

T Higashi, S Miyakawa, S Uchiyama, S Matsunaga, H Takata, S Fujimoto, M Noda, A Terauchi, T Shimizu, M Oda …

JOURNAL OF BIOTECHNOLOGY 120(3) 262-272 2005年11月
DNA polymerase θ contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.

Masuda, K, Ouchida, R, Takeuchi, A, Saito, T, Koseki, H, Kawamura, K, Tagawa, M, Tokuhisa, T, Azuma, T, O-wang,J

Proc. Natl. Acad. Sci. USA. 102(39) 13986-13991 2005年9月
DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

K Masuda, R Ouchida, A Takeuchi, T Saito, H Koseki, K Kawamura, M Tagawa, T Tokuhisa, T Azuma, JY O-Wang

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102(39) 13986-13991 2005年9月
Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice

T Shimizu, T Azuma, M Ishiguro, M Kanjo, S Yamada, H Ohmori

IMMUNOLOGY LETTERS 98(2) 259-264 2005年5月
Conformational changes in the antibody constant domains upon hapten-binding

T Sagawa, M Oda, H Morii, H Takizawa, H Kozono, T Azuma

MOLECULAR IMMUNOLOGY 42(1) 9-18 2005年1月
Molecular characterization of monovalent and multivalent hapten-protein conjugates for analysis of the antigen-antibody interaction

M Oda, N Sato-Nakamura, T Azuma

ANALYTICAL BIOCHEMISTRY 333(2) 365-371 2004年10月
Identification of a novel plant MAR DNA binding protein localized on chromosomal surfaces

Satoru Fujimoto, Sachihiro Matsunaga, Masataka Yonemura, Susumu Uchiyama, Takachika Azuma, Kiichi Fukui

Plant Molecular Biology 56(2) 225-239 2004年9月
Bound peptide-dependent thermal stability of major histocompatibility complex clans Ⅱmolecule-IE

Saito K, Oda M, Sarai A, Azuma T, Kozono H

Biochemistry 43(31) 10186-10191 2004年8月
Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid

A Nobuoka, T Takayama, K Miyanishi, T Sato, K Takanashi, T Hayashi, T Kukitsu, Y Sato, M Takahashi, T Okamoto …

GASTROENTEROLOGY 127(2) 428-443 2004年8月
BASH-deficient mice: limited primary repertoire and antibody formation, but sufficient affinity maturation and memory B cell generation, in anti-NP response

M Yamamoto, T Nojima, K Hayashi, R Goitsuka, K Furukawa, T Azuma, D Kitamura

INTERNATIONAL IMMUNOLOGY 16(8) 1161-1171 2004年8月
Bound peptide-dependent thermal stability of major histocompatibility complex class II molecule I-E-k

K Saito, M Oda, A Sarai, T Azuma, H Kozono

BIOCHEMISTRY 43(31) 10186-10191 2004年8月
A landscape for the dynamics of an immune response

A Furukawa, K Furukawa, T Azuma

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 319(2) 469-478 2004年6月
Affinity maturation of secreted IgM pentamers on B cells

T Shimizu, Y Kozono, H Kozono, M Oda, T Azuma

INTERNATIONAL IMMUNOLOGY 16(5) 675-684 2004年5月
Identification of a novel plant MAR DNA binding protein localiged on chromosomal surfaces

Fujimoto S, Matsunaga S, Yonemura M, Uchiyama S, Azuma T, Fukui K

Plant.Mol,Biol 56(2) 225-239 2004年
The absence of DNA polymerase kappa does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene

T Shimizu, Y Shinkai, T Ogi, H Ohmori, T Azuma

IMMUNOLOGY LETTERS 86(3) 265-270 2003年5月
Estimation of the relative affinity of B cell receptor by flow cytometry

T Shimizu, M Oda, T Azuma

JOURNAL OF IMMUNOLOGICAL METHODS 276(1-2) 33-44 2003年5月
Thermodynamic and kinetic aspects of antibody evolution during the immune response to hapten

T Sagawa, M Oda, M Ishimura, K Furukawa, T Azuma

MOLECULAR IMMUNOLOGY 39(13) 801-808 2003年3月
Evidence of allosteric conformational changes in the antibody constant region upon antigen binding

M Oda, H Kozono, H Morii, T Azuma

INTERNATIONAL IMMUNOLOGY 15(3) 417-426 2003年3月

もっとみる

書籍等出版物

抗体のアフィニティーマチュレーション

最新医学第58巻 2003年

共同研究・競争的資金等の研究課題

抗体の構造と機能に関する研究抗体の親和性成熟に関する研究

基礎科学研究 2000年 - 2010年
Studies on the structure and function of antibodies Affinity maturation of antibodies

Basic Science Research Program 2000年 - 2010年