Shigeo Sugiyama

Profile Information

Affiliation: Faculty of Pharmacy, Meiji Pharmaceutical University

Degree: Doctor's degree, specializing in Pharmaceutical Technology(Kyushu University)
Doctor's degree, specializing in Pharmaceuticals

J-GLOBAL ID: 200901003581756779
researchmap Member ID: 1000212555

External link: http://www.my-pharm.ac.jp/~ishiikei/index.html

Research Interests

不斉反応

Research Areas

Research History

1996 - Present

Meiji Pharmaceutical University
1990 - 1996

三菱化成(現・三菱化学)(株)医薬第1研究所副主任研究員
1990 - 1996

Mitsubishi Chemical Corporation,
Research Scientist
Pharmaceuticals Laboratory (]G0001[),

Education

Papers

Diastereoselective amidoallylation of glyoxylic acid with chiral tert-butanesulfinamide and allylboronic acid pinacol esters: Efficient synthesis of optically active γ,δ-unsaturated α-amino acids This work is dedicated to Dr. Masanori Sakamoto, Professor Emeritus of Meiji Pharmaceutical University, on the occasion of his 77th birthday (KIJU)

Shigeo Sugiyama, Saori Imai, Keitaro Ishii

Tetrahedron Asymmetry, 24(18) 1069-1074, Sep 30, 2013 Peer-reviewed
Non-enzymatic diastereoselective asymmetric desymmetrization of 2-benzylserinols giving optically active 4-benzyl-4-hydroxymethyl-2-oxazolidinones: asymmetric syntheses of alpha-(hydroxymethyl)phenylalanine, N-Boc-alpha-methylphenylalanine, cericlamine and BIRT-377

Shigeo Sugiyama, Satoshi Arai, Keitaro Ishii

TETRAHEDRON, 68(38) 8033-8045, Sep, 2012 Peer-reviewed
Total synthesis of (R)-(-)-actisonitrile via O-alkylation of optically active 4-hydroxymethyloxazolidin-2-one derivative

Shigeo Sugiyama, Akihiro Ishida, Moeko Tsuchida, Keitaro Ishii

TETRAHEDRON-ASYMMETRY, 22(20-22) 1918-1923, Nov, 2011 Peer-reviewed
Non-phosphorylated FTY720 Induces Apoptosis of Human Microglia by Activating SREBP2

Takashi Yoshino, Hiroko Tabunoki, Shigeo Sugiyama, Keitaro Ishii, Seung U. Kim, Jun-ichi Satoh

CELLULAR AND MOLECULAR NEUROBIOLOGY, 31(7) 1009-1020, Oct, 2011 Peer-reviewed
Studies on two different diastereoselective reaction pathways from a serinol derivative to 4-hydroxymethyl-2-oxazolidinones using 2-chloroethyl chloroformate and N,N '-disuccinimidyl carbonate

Shigeo Sugiyama, Keitaro Ishii

TETRAHEDRON-ASYMMETRY, 21(24) 2904-2910, Dec, 2010 Peer-reviewed
Photoreactions of bicyclic aziridines with alkenes and alkynes: a novel synthetic methodology for 8-azabicyclo[3.2.1]octane derivatives

Keitaro Ishii, Motohiro Kido, Masahiro Noji, Shigeo Sugiyama

ORGANIC & BIOMOLECULAR CHEMISTRY, 6(17) 3186-3195, Sep, 2008 Peer-reviewed
Diastereoselective intramolecular acyl transfer of 5-(alpha-methylbenzyl)amino-1,3-dioxan-2-one to 4-hydroxymethyl-2-oxazolidinones

Shigeo Sugiyama, Haruka Fukuchi, Keitaro Ishii

TETRAHEDRON, 63(48) 12047-12057, Nov, 2007 Peer-reviewed
Photoreactions of beta-aziridinylacrylonitriles and acrylates with alkenes: the substituent effects on the formation of [3+2] cycloadducts

Keitaro Ishii, Takuya Sone, Takahide Shigeyama, Masahiro Noji, Shigeo Sugiyama

TETRAHEDRON, 62(47) 10865-10878, Nov, 2006 Peer-reviewed
Enantioselective addition of diethylzinc to aldehydes catalyzed by monosubstituted [2.2]paracyclophane-based N,O-ligands: remarkable cooperative effects of planar and central chiralities

Shigeo Sugiyama, Yoshinori Aoki, Keitaro Ishii

TETRAHEDRON-ASYMMETRY, 17(20) 2847-2856, Nov, 2006 Peer-reviewed
Stereoselective gram-scale synthesis of (S)-5,5-dimethyl-4-phenyloxazolidin-2-one

Shigeo Sugiyama, Satoshi Arai, Keitaro Ishii

Heterocycles, 65(1) 149-159, Jan 1, 2005 Peer-reviewed
A Convenient Synthesis of Immunosuppressive Agent FTY720 Using the Petasis Reaction

Sugiyama, S, Arai, S, Kiriyama, M, Ishii, K

Chemical and Pharmaceutical Bulletin, 53 (1), 100-102, 2005 Peer-reviewed
Photoreactions of (3-aziridinylacrylonitriles and acrylates with alkenes: formation of head-to-head adducts and application to the preparation of pyrrolizidine alkaloid

K Ishii, T Sone, Y Shimada, T Shigeyama, M Noji, S Sugiyama

TETRAHEDRON, 60(48) 10887-10898, Nov, 2004 Peer-reviewed
Short Synthesis of Both Enantiomers of Cytoxazone Using Petasis Reaction and Acidic Removal of 1-Naphthylethyl Groups

Sugiyama, S, Arai, S, Ishii, K

Tetrahedron: Asymmetry, 15, 3149–3153, 2004 Peer-reviewed
One-pot acylation and fractional crystallization: preparation of optically active serinol monobenzoates

S Sugiyama, T Inoue, K Ishii

TETRAHEDRON-ASYMMETRY, 14(15) 2153-2160, Aug, 2003 Peer-reviewed
A novel dynamic kinetic resolution accompanied by intramolecular transesterification: asymmetric synthesis of a 4-hydroxymethyl-2-oxazolidinone from serinol derivatives

S Sugiyama, S Watanabe, T Inoue, R Kurihara, T Itou, K Ishii

TETRAHEDRON, 59(19) 3417-3425, May, 2003 Peer-reviewed
Chemoselective debezylation of the N-1-phenylethyl group in 2-oxazolidinones by the anisole-methanesulfonic acid system

S Sugiyama, K Morishita, M Chiba, K Ishii

HETEROCYCLES, 57(4) 637-+, Apr, 2002 Peer-reviewed
Novel photoadditions of tertiary amines to the alpha-position of alpha,beta-unsaturated gamma,delta-epoxy nitriles

K Ishii, S Hakamada, M Nagano, M Noji, S Sugiyama, M Kotera, M Sakamoto

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, (13) 1592-1598, 2002 Peer-reviewed
A three-step synthesis of optically active 5-halomethyl-2-oxazolidinones; Asymmetric desymmetrization of prochiral 1,3-dihalo-2-propyl carbamates

S Sugiyama, K Morishita, K Ishii

HETEROCYCLES, 55(2) 353-364, Feb, 2001 Peer-reviewed
Photoreactions of beta-aziridinylacrylonitrile. 1,3-dipolar cycloadditions of photoinduced azomethine ylide

K Ishii, Y Shimada, S Sugiyama, M Noji

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, (18) 3022-3024, 2000 Peer-reviewed
Asymmetric synthesis of the 4-hydroxymethyl-2-oxazolidinone from the serinol derivative and chloroformates

S Sugiyama, S Watanabe, K Ishii

TETRAHEDRON LETTERS, 40(42) 7489-7492, Oct, 1999 Peer-reviewed

Misc.

光学活性N‐(tert‐ブチルスルフィニル)イミノ酢酸へのジアステレオ選択的アリル化反応

今井沙織, 須永晋輔, 杉山重夫, 石井啓太郎

日本薬学会関東支部大会講演要旨集, 56th 94, Oct 13, 2012
光学活性オキサゾリジノン体からのmyriocinの合成研究

杉山重夫, 伊藤茉鈴, 石井啓太郎

反応と合成の進歩シンポジウム講演要旨集, 37th 290-291, Oct 14, 2011
イオン液体中でのα,β‐不飽和‐γ,δ‐エピミノエステルとオレフィンとの光付加環化反応

石澤理穂, 小野仁美, 杉山重夫, 石井啓太郎

日本薬学会関東支部大会講演要旨集, 55th 15, Oct 8, 2011
光学活性オキサゾリジノン体からのactisonitrileの全合成

石田晃浩, 土田萌子, 杉山重夫, 石井啓太郎

日本薬学会関東支部大会講演要旨集, 55th 15, Oct 8, 2011
明治薬科大学における長期薬局実務実習の問題点に関する一考察

山崎紀子, 石橋芳雄, 菱沼滋, 日野文男, 浦辺宏明, 杉山重夫, 鈴木俊宏, 宮沢伸介, 高取薫, 田中靖子 …

日本薬学会年会要旨集, 131st(4) 349, Mar 5, 2011
不斉非対称化反応を鍵反応としたmyriocin類の合成研究

杉山重夫, 伊藤茉鈴, 椙山聡一郎, 石井啓太郎

日本薬学会年会要旨集, 131st(2) 129, Mar 5, 2011
FTY720のSREBP2活性化を介するヒトミクログリアのアポトーシス誘導

佐藤準一, 吉野隆, 天竺桂弘子, 杉山重夫, 石井啓太郎, KIM Seung U

日本神経免疫学会学術集会抄録集, 23rd 83, 2011
不斉非対称化反応を利用したmyriocinの全合成研究

伊藤茉鈴, 杉山重夫, 石井啓太郎

日本薬学会関東支部大会講演要旨集, 54th 39, Oct 2, 2010
光学活性4‐メチル‐4‐ホルミル‐2‐オキサゾリジノン体のWittig反応

杉山重夫, 八木橋昌代, 三浦康寛, 石井啓太郎

日本薬学会年会要旨集, 130th(2) 137, Mar 5, 2010
培養ヒトミクログリアにおけるFTY720のアポトーシス誘導能

吉野隆, 天竺桂弘子, 杉山重夫, 石井啓太郎, SEUNG U Kim, 佐藤準一

日本薬学会年会要旨集, 130th(3) 76, Mar 5, 2010
光学活性オキサゾリジノン体から2‐ヒドロキシメチルグルタミン酸の合成

杉山重夫, 八木橋昌代, 石井啓太郎

反応と合成の進歩シンポジウム講演要旨集, 35th 192-193, Oct 30, 2009
不斉非対称化反応を利用したFTY720リン酸の合成

杉山重夫, 八木橋昌代, 三浦康寛, 石井啓太郎

日本薬学会関東支部大会講演要旨集, 53rd 45, Oct 3, 2009
授業改善に必要な情報

和田義親, 井上忠也, 杉山重夫, 日野文男

明治薬科大学研究紀要, (38) 61-64, May 31, 2009
セリノール体に高い適応能力をもつ不斉非対称化反応による光学活性オキサゾリジノン体の合成

杉山重夫, 八木橋昌代, 石井啓太郎

日本薬学会年会要旨集, 129th(2) 233, Mar 5, 2009
CDIを利用した不斉非対称化反応による4‐メチル‐2‐オキサゾリジノン体の形成

杉山重夫, 八木橋昌代, 石井啓太郎

日本薬学会年会要旨集, 128th(2) 161, Mar 5, 2008
トシル酸α‐メチルセリノール誘導体の合成化学的利用

杉山重夫, 早川なつみ, 石井啓太郎

日本薬学会年会要旨集, 128th(2) 161, Mar 5, 2008
環状炭酸エステルを経由する2‐メチルセリノール体からオキサゾリジノン体の不斉非対称化反応

杉山重夫, 八木橋昌代, 沼尾由佳理, 石井啓太郎

反応と合成の進歩シンポジウム講演要旨集, 33rd 272-273, Oct 20, 2007
Formation of oxazolidinones from cyclic carbonate via intramolecular acyl transfer

SUGIYAMA SHIGEO, FUKUCHI HARUKA, ISHII KEITARO

複素環化学討論会講演要旨集, 37th 89-90, Sep 20, 2007
明治薬科大学における長期実務実習に関する一考察〈第2報〉―関東地区調整機構エリア制受け入れにおける学習満足度―

山崎紀子, 和田義親, 足立茂, 石橋芳雄, 兎川忠靖, 菱沼滋, 日野文男, 三田充男, 植沢芳広, 浦辺宏明 …

日本医療薬学会年会講演要旨集, 17th 290, Sep 1, 2007
不斉非対称化反応を利用した4‐メチル‐2‐オキサゾリジノン体の合成と利用

杉山重夫, 小林大志, 水野真美子, 石井啓太郎

日本薬学会年会要旨集, 127th(4) 137, Mar 5, 2007

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