J-GLOBAL         Last updated: Dec 6, 2018 at 16:52
Kyoto Prefectural University of Medicine
Graduate School of Medical Science
Master of Physical Education(Juntendo Univ.), Ph D.(Kyoto Pref. Univ. of Med.)

Research Areas


Academic & Professional Experience

Kyoto prefectural University of Medicine, Reseach Assistant


Graduate School, Division of Medicine, Kyoto Prefectural University of Medicine
Faculty of Physical Education, Juntendo University

Published Papers

Yoichi Minami, Munehiro Ohashi, Eri Hotta, Moe Hisatomi, Nobunaga Okada, Eiichi Konishi, Satoshi Teramukai, Hitoshi Inokawa, Kazuhiro Yagita
Sleep and Biological Rhythms   16(1) 63-68   Jan 2018   [Refereed]
© 2017, Japanese Society of Sleep Research. Shift work is indispensable in our modern society; therefore, measures for maintaining the health of shift workers are urgently required. In this prospective study observing the effects of different type...
Masayuki Hara, Masayuki Hara, Yoichi Minami, Munehiro Ohashi, Yoshiki Tsuchiya, Tetsuro Kusaba, Keiichi Tamagaki, Nobuya Koike, Yasuhiro Umemura, Hitoshi Inokawa, Kazuhiro Yagita
Scientific Reports   7    Dec 2017   [Refereed]
© 2017 The Author(s). Circadian clocks in mammals function in most organs and tissues throughout the body. Various renal functions such as the glomerular filtration and excretion of electrolytes exhibit circadian rhythms. Although it has been repo...
Yoshiki Tsuchiya, Yasuhiro Umemura, Yoichi Minami, Nobuya Koike, Toshihiro Hosokawa, Toshihiro Hosokawa, Masayuki Hara, Masayuki Hara, Hiroshi Ito, Hitoshi Inokawa, Kazuhiro Yagita
Journal of Biological Rhythms   31(1) 48-56   Feb 2016   [Refereed]
© 2015 The Author(s). Most organisms have cell-autonomous circadian clocks to coordinate their activity and physiology according to 24-h environmental changes. Despite recent progress in circadian studies, it is not fully understood how the period...
Hiroshi Yamada, Hiroshi Yamada, Hiroshi Yamada, Hiroshi Yamada, Hitoshi Inokawa, Yukiko Hori, Yukiko Hori, Xiaochuan Pan, Xiaochuan Pan, Ryuichi Matsuzaki, Kae Nakamura, Kae Nakamura, Kazuyuki Samejima, Munetaka Shidara, Munetaka Shidara, Minoru Kimura, Minoru Kimura, Masamichi Sakagami, Takafumi Minamimoto, Takafumi Minamimoto, Takafumi Minamimoto
Neuroscience Research   105 2-18   Apr 2016   [Refereed]
© 2015 The Authors. Inhibitory interneurons are the fundamental constituents of neural circuits that organize network outputs. The striatum as part of the basal ganglia is involved in reward-directed behaviors. However, the role of the inhibitory ...
Yasumasa Ueda, Yasumasa Ueda, Ko Yamanaka, Ko Yamanaka, Atsushi Noritake, Kazuki Enomoto, Kazuki Enomoto, Naoyuki Matsumoto, Naoyuki Matsumoto, Hiroshi Yamada, Hiroshi Yamada, Hiroshi Yamada, Kazuyuki Samejima, Hitoshi Inokawa, Yukiko Hori, Yukiko Hori, Kae Nakamura, Minoru Kimura, Minoru Kimura
Frontiers in Neuroanatomy   11    Aug 2017   [Refereed]
© 2017 Ueda, Yamanaka, Noritake, Enomoto, Matsumoto, Yamada, Samejima, Inokawa, Hori, Nakamura and Kimura. Cortico-basal ganglia circuits are critical regulators of reward-based decision making. Reinforcement learning models posit that action rewa...
Naoki Okubo, Naoki Okubo, Naoki Okubo, Yoichi Minami, Yoichi Minami, Hiroyoshi Fujiwara, Yasuhiro Umemura, Yoshiki Tsuchiya, Toshiharu Shirai, Toshiharu Shirai, Ryo Oda, Hitoshi Inokawa, Toshikazu Kubo, Toshikazu Kubo, Kazuhiro Yagita, Kazuhiro Yagita, Kazuhiro Yagita
PLoS ONE   8(11)    Nov 2013   [Refereed]
The bone is a metabolically active organ which undergoes repeated remodeling cycles of bone resorption and formation. In this study, we revealed a robust and extremely long-lasting circadian rhythm in ex vivo culture maintained for over six months...
Naoki Okubo, Naoki Okubo, Naoki Okubo, Hiroyoshi Fujiwara, Yoichi Minami, Yoichi Minami, Tatsuya Kunimoto, Tatsuya Kunimoto, Tatsuya Kunimoto, Toshihiro Hosokawa, Toshihiro Hosokawa, Toshihiro Hosokawa, Yasuhiro Umemura, Hitoshi Inokawa, Maki Asada, Ryo Oda, Toshikazu Kubo, Toshikazu Kubo, Kazuhiro Yagita
Acta Orthopaedica   86(5) 627-631   Jan 2015   [Refereed]
© 2015 Nordic Orthopaedic Federation. Background and purpose-The circadian clock governs endogenous day-night variations. In bone, the metabolism and growth show diurnal rhythms. The circadian clock is based on a transcription-translation feedback...
Hiroshi Yamada, Hitoshi Inokawa, Naoyuki Matsumoto, Yasumasa Ueda, Kazuki Enomoto, Minoru Kimura
Journal of Neurophysiology   109(4) 1140-1151   Feb 2013   [Refereed]
Decisions maximizing benefits involve a tradeoff between the quantity of a reward and the cost of elapsed time until an animal receives it. The estimation of long-term reward values is critical to attain the most desirable outcomes over a certain ...
Yasuhiro Umemura, Junko Yoshida, Masashi Wada, Yoshiki Tsuchiya, Yoichi Minami, Hitomi Watanabe, Gen Kondoh, Junji Takeda, Hitoshi Inokawa, Kyoji Horie, Kyoji Horie, Kyoji Horie, Kazuhiro Yagita, Kazuhiro Yagita
PLoS ONE   8(6)    Jun 2013   [Refereed]
We previously reported emergence and disappearance of circadian molecular oscillations during differentiation of mouse embryonic stem (ES) cells and reprogramming of differentiated cells, respectively. Here we present a robust and stringent in vit...
Hiroshi Yamada, Hitoshi Inokawa, Naoyuki Matsumoto, Naoyuki Matsumoto, Yasumasa Ueda, Minoru Kimura, Minoru Kimura
European Journal of Neuroscience   34(3) 489-506   Aug 2011   [Refereed]
Humans and animals optimize their behavior by evaluating outcomes of individual actions and predicting how much reward the actions will yield. While the estimated values of actions guide choice behavior, the choices are also governed by other beha...
Kazuki Enomoto, Kazuki Enomoto, Naoyuki Matsumoto, Naoyuki Matsumoto, Sadamu Nakai, Sadamu Nakai, Takemasa Satoh, Takemasa Satoh, Tatsuo K. Sato, Tatsuo K. Sato, Yasumasa Ueda, Hitoshi Inokawa, Masahiko Haruno, Masahiko Haruno, Minoru Kimura, Minoru Kimura
Proceedings of the National Academy of Sciences of the United States of America   108(37) 15462-15467   Sep 2011   [Refereed]
Midbrain dopamine neurons signal reward value, their prediction error, and the salience of events. If they play a critical role in achieving specific distant goals, long-term future rewards should also be encoded as suggested in reinforcement lear...
Manabu Muranishi, Hitoshi Inokawa, Hiroshi Yamada, Hiroshi Yamada, Yasumasa Ueda, Naoyuki Matsumoto, Masanori Nakagawa, Minoru Kimura, Minoru Kimura
Experimental Brain Research   209(2) 235-246   Mar 2011   [Refereed]
Behavioral decisions and actions are directed to achieve specific goals and to obtain rewards and escape punishments. Previous studies involving the recording of neuronal activity suggest the involvement of the cerebral cortex, basal ganglia, and ...
H. Inokawa, H. Yamada, H. Yamada, N. Matsumoto, M. Muranishi, M. Muranishi, M. Kimura
Neuroscience   168 395-404   Jun 2010
Tonically active neurons (TANs) and phasically active neurons (PANs) are widely believed to be the cholinergic interneurons and GABAergic projection neurons, respectively, in the striatum based on in vivo intracellular recordings coupled with morp...
Inokawa Hitoshi, Yamada Hiroshi, Matsumoto Naoyuki, Ueda Yasumasa, Kimura Minoru
NEUROSCIENCE RESEARCH   68 E296   2010   [Refereed]
Yukio Imamura, Hitoshi Inokawa, Atsushi Ito, Atsushi Ito, Hiroshi Kadotani, Keisuke Toyama, Makoto Noda, Shigetada Nakanishi, Tomoo Hirano, Tomoo Hirano
Neuroscience Research   38(3):289-301. 289-301   Jan 2000
The cerebellar cortex consists of relatively small numbers of identified neuronal types, which form simple and well-defined layers. However, a direct high-resolution demonstration of spatio-temporal pattern of information transmission there has be...
S. Higashi, M. C. Crair, T. Kurotani, H. Inokawa, K. Toyama
Neuroscience   91(2):439-52 439-452   Jun 1999
In rodents, the somatosensory cortex has a cell aggregation cluster termed the barrel, reflecting a whisker vibrissa, and this barrel formation is disrupted by infraorbital nerve cut at birth. In the present study, we prepared thalamocortical slic...
Dai Watanabe, Hitoshi Inokawa, Kouichi Hashimoto, Norimitsu Suzuki, Masanobu Kano, Ryuichi Shigemoto, Tomoo Hirano, Keisuke Toyama, Satoshi Kaneko, Mineto Yokoi, Koki Moriyoshi, Misao Suzuki, Kazuto Kobayashi, Toshiharu Nagatsu, Robert J. Kreitman, Ira Pastan, Shigetada Nakanishi
Cell   95(1):17-27 17-27   Oct 1998
The role of inhibitory Golgi cells in cerebellar function was investigated by selectively ablating Golgi cells expressing human interleukin-2 receptor α subunit in transgenic mice, using the immunotoxin- mediated cell targeting technique. Golgi ce...
Tohru Kurotani, Shuji Higashi, Hitoshi Inokawa, Keisuke Toyama
NeuroReport   8 35-39   May 1997
Multiple forms of synaptic potentiation have been described, but their involvement in development versus learning is unknown. To address this, we examined whether long-term potentiation (LTP) in visual cortex requires protein or RNA synthesis usin...


八木田和弘, 井之川仁
アンチ・エイジング医学   14(4) 466‐469-469   Aug 2018
哺乳類の概日リズム表現型のES細胞ベース評価システム(ES cell-based evaluation system of circadian phenotypes in mammals)
梅村 康浩, 吉田 純子, 和田 雅史, 土谷 佳樹, 南 陽一, 渡邊 仁美, 近藤 玄, 竹田 潤二, 井之川 仁, 堀江 恭二, 八木田 和弘
日本生化学会大会プログラム・講演要旨集   86回 2LBA-059   Sep 2013
京都府立医科大学雑誌   119(8) 575   Aug 2010
ラット線条体における持続性発火神経細胞と相同性発火神経細胞の傍細胞記録染色(Juxtacellular Labeling of Tonically Active Neurons and Phasically Active Neurons in the Rat Striatum)
井之川 仁
京都府立医科大学雑誌   119(8) 575-575   Aug 2010
Muranishi Manabu, Inokawa Hitoshi, Yamada Hiroshi, Kimura Minoru
NEUROSCIENCE RESEARCH   65 S192   2009   [Refereed]
Muscimol injection into the putamen selectively impairs reward value-based action selection
Muranishi Manabu, Inokawa Hitoshi, Yamada Hiroshi, Kimura Minoru
NEUROSCIENCE RESEARCH   61 S195   2008   [Refereed]
Yamada Hiroshi, Inokawa Hitoshi, Kimura Minoru
NEUROSCIENCE RESEARCH   58 S114   2007   [Refereed]
Inokawa Hitoshi, Yamada Hiroshi, Kimura Minoru
NEUROSCIENCE RESEARCH   58 S229   2007   [Refereed]
Encoding of reinforcement after reward-based action selection by tonically active neurons in the striatum
Inokawa Hitoshi, Yamada Hiroshi, Kimura Minoru
NEUROSCIENCE RESEARCH   55 S230   2006   [Refereed]
Striatal neuron activity during decisions and action selections for probabilistic, scheduled rewards
Yamada Hiroshi, Inokawa Hitoshi, Kimura Minoru
NEUROSCIENCE RESEARCH   55 S229   2006   [Refereed]
井之川仁, 木村実
日本生理学雑誌   66(2) 58-59   Feb 2004
タスク戦略の適応転換における線条体アセチルコリン伝達の役割(Roles of cholinergic signal transmission in the striatum in adaptive shift of task strategy)
井之川 仁, 山田 洋, 松本 直幸, 上田 康雅, 木村 實
神経化学   49(2-3) 660-660   Aug 2010
Yamada Hiroshi, Inokawa Hitoshi, Matsumoto Naoyuki, Enomoto Kazuki, Kimura Minoru
Proceedings of Annual Meeting of the Physiological Society of Japan   2007(0) 8-8   2007
Recent studies suggested involvement of the striatum in decision-making and action selection. Striatal projection neurons receive action-related inputs from the cerebral cortices, reward prediction error signal from dopamine neurons and signals fr...
井之川 仁
日本生理学雜誌 = JOURNAL OF THE PHYSIOLOGICAL SOCIETY OF JAPAN   68(2) 63-64   Feb 2006
Inokawa Hitoshi, Yamada Hiroshi, Kimura Minoru
Proceedings of Annual Meeting of the Physiological Society of Japan   2005(0) S185-S185   2005
Activity of striatal projection neurons represents reward expectation, and that dopamine neurons code reward expectation error and an incentive to work for reward, the basal ganglia have been supposed to be involved in adaptive reward-based action...
井之川仁, 木村実
日本神経科学大会プログラム・抄録集   25th 256   Jul 2002
東秀二, 黒谷亨, 井之川仁
日本神経科学大会プログラム・抄録集   23rd 81   Sep 2000
井之川仁, 東秀二, 黒谷亨
日本神経科学大会プログラム・抄録集   23rd 217   Sep 2000
WATANABE Dai, INOKAWA Hitoshi, HASHIMOTO Kouichi, SUZUKI Norimitsu, KANO Masanobu, SHIGEMOTO Ryuichi, HIRANO Tomoo, TOYAMA Keisuke, KANEKO Satoshi, YOKOI Mineto, MORIYOSHI Koki, SUZUKI Misao, KOBAYASHI Kazuto, NAGATSU Toshiharu, KREITMAN Robert j., PASTAN Ira, NAKANISHI Shigetada
日本分子生物学会年会プログラム・講演要旨集   21    Dec 1998
渡辺大, 井之川仁, 橋本浩一, 平野丈夫, 鈴木操, 小林和人, 永津俊治, KREITMAN R J, 中西重忠
日本分子生物学会年会プログラム・講演要旨集   21st 216   Nov 1998