2001年6月
Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1
IMMUNOLOGY AND CELL BIOLOGY
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- 巻
- 79
- 号
- 3
- 開始ページ
- 298
- 終了ページ
- 302
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1046/j.1440-1711.2001.01004.x
- 出版者・発行元
- BLACKWELL SCIENCE ASIA
A newly identified CX3C-chemokine, fractalkine, expressed on activated endothelial cells plays an important role in leucocyte adhesion and migration. Co-immobilized fractalkine with fibronectin or intercellular adhesion molecule-1 enhanced adhesion of THP-1 cells, which express the fractalkine receptor (CX(3)CR1), compared with that observed for each alone. That adherence was fractalkine-dependent and was confirmed in blocking studies. However, soluble fractalkine induced little chemotaxis in THP-1 cells in comparison to monocyte chemotstatic protein-1 (MCP-1), which induced a strong chemotactic response. Moreover, the membrane form of fractalkine expressed on ECV304 cells reduced MCP-1 mediated chemotaxis of THP-1 cells. These results indicate that fractalkine may function as an adhesion molecule between monocytes and endothelial cells rather than as a chemotactic factor.
- リンク情報
- ID情報
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- DOI : 10.1046/j.1440-1711.2001.01004.x
- ISSN : 0818-9641
- Web of Science ID : WOS:000169756900014