2008年4月
Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum
JOURNAL OF NATURAL MEDICINES
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- 巻
- 62
- 号
- 2
- 開始ページ
- 174
- 終了ページ
- 178
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s11418-007-0223-y
- 出版者・発行元
- SPRINGER TOKYO
An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.
- リンク情報
- ID情報
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- DOI : 10.1007/s11418-007-0223-y
- ISSN : 1340-3443
- Web of Science ID : WOS:000253896900008