論文

2008年4月

Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

JOURNAL OF NATURAL MEDICINES
  • Toru Yagura
  • ,
  • Tomoko Motomiya
  • ,
  • Michiho Ito
  • ,
  • Gisho Honda
  • ,
  • Akira Iida
  • ,
  • Fumiyuki Kiuchi
  • ,
  • Harukuni Tokuda
  • ,
  • Hoyoku Nishino

62
2
開始ページ
174
終了ページ
178
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s11418-007-0223-y
出版者・発行元
SPRINGER TOKYO

An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

リンク情報
DOI
https://doi.org/10.1007/s11418-007-0223-y
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000253896900008&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s11418-007-0223-y
  • ISSN : 1340-3443
  • Web of Science ID : WOS:000253896900008

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