KOKETSU Mamoru

J-GLOBAL         Last updated: Jul 2, 2019 at 15:00
 
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Name
KOKETSU Mamoru
URL
https://www1.gifu-u.ac.jp/~kulab/koketsu/index_e.html
Affiliation
Gifu University
Section
Faculty of Engineering
Job title
Professor

Research Areas

 

Academic & Professional Experience

 
Apr 2018
 - 
Today
Adviser to the President, Gfu University
 
Apr 2015
 - 
Mar 2017
Vice-Dean (accademic Affairs), Faculty of Engineering, Gfu University
 
Apr 2013
 - 
Mar 2014
Head of Department, Department of Chemistry and Biomolecular Science Faculty of Engineering, Gifu University
 
May 1985
 - 
Mar 1987
Gifu University, Assistant Professor
 
Apr 1987
 - 
Nov 1996
Taiyo Kagaku Co. Ltd.
 
May 1999
 - 
Aug 2000
The University of Iowa, College of Pharmacy
 
 
   
 
visiting assistant professor
 
Apr 1997
 - 
Mar 2003
Gifu University, Assistant Professor
 
Apr 2003
 - 
Mar 2009
Gifu University, Associate Professor
 
Apr 2013
 - 
Today
Professor, Faculty of Engineering, Gifu Universty
 

Published Papers

 
Fadhila Utari, Mai Efdi, Masayuki Ninomiya, Kaori Tanaka, Khin Myat Noe Win, Atsuyoshi Nishina and Mamoru Koketsu
Medicinal Chemistry Research   28(5) 797-803   2019   [Refereed]
Mimusops elengi L. belonging to the Sapotaceae family is used in various folk systems of medicine in South and Southeast Asia. This study aims to identify the potential constituents responsible for anticancer activity of M. elengi flowers. The EtO...
Moaz M. Abdou, Zeynel Seferoğlu, Mahmoud Fathy, Takashiro Akitsu, Mamoru Koketsu, Ruba Kellow, Eric Amigues
Research and Chemical Intermediates   45(3) 919-934   2019   [Refereed]
The chemistry of 3-acetyl-4-hydroxyquinolin-2(1H)-ones has attracted increased attention in both synthetic organic and medicinal chemistry, as numerous advancements in the use of this family of important compounds seems to be of considerable value...
Amol D. Sonawane, Yunnus B. Shaikh, R. Garud and Mamoru Koketsu
Synthesis   51(2) 500-507   2019   [Refereed]
A new route for the expedient synthesis of a specific regioisomer of isoquinoline-fused quinazolinones is reported. Silver(I)-catalyzed cascade cyclization of 2-aminobenzamides and 2-alkynylbenzaldehydes followed by in situ oxidation gives 12-buty...
Gideon Ampoma Gyebi, Joseph Oluwatope Adebayo, Olufunke Esan Olorundare, Antoni Pardede, Masayuki Ninomiya, Afolabi Olanrewaju Saheed, Abiola Samuel Babatunde and Mamoru Koketsu
Natural Product Research   32(24) 2873-2881   2018   [Refereed]
Gongronema latifolium Benth (Asclepiadaceae) is an edible-green-leafy vegetable with known medicinal value. A chemical investigation of the 80% methanolic extract of the leaves led to the isolation of a new pregnane glycoside: iloneoside (3-O-[6-d...
Antoni Pardede, Morina Adfa, Arif Juliari Kusnanda, Masayuki Ninomiya and Mamoru Koketsu
Holzforschung   72(10) 899-904   2018   [Refereed]
Stenochlaena palustris is an edible fern, belonging to the Blechnaceae family and is called kelakai in South Kalimantan, Indonesia. The effects of fractions of S. palustris stems and isolated constituents on termite mortality and paper disc consum...
Mohamed E. Khalifa, Elham A. Elkhawass, Antoni Pardede, Masayuki Ninomiya, Kaori Tanaka and Mamoru Koketsu
Monatshefte für Chemie−Chemical Monthly   149(12) 2195-2206   2018   [Refereed]
A series of 1,5-bis(4-aryl/heteryl)-3-cyanoformazan derivatives was synthesized and characterized by spectral analysis. The synthesis strategy involved an easy and practical diazo coupling of different aryl (heteryl) diazonium salts with cyanoacet...
Masahiro Kurita, Toshimitsu Nakayama, Satoru Asami, Taketo Uchiyama, Shinichi Ono, Atsuyoshi Nishina, Mamoru Koketsu and Takashi Suzuki
Journal of Pharmacology and Therapeutic Research   2(3) 6-12   2018   [Refereed]
Introduction: Neuroblastoma is one of the most commonly encountered malignant solid tumors in the pediatric age group. We examined the antitumor effects of chalcone glycosides derived from Brassica rapa L against neuroblastoma cell lines.
Material...
Tomohiro Itoh, Kousuke Katsuyama, Mai Efdi, Masayuki Ninomiya and Mamoru Koketsu
Bioorganic & Medicinal Chemistry Letters   28(22) 3496-3501   2018   [Refereed]
A seco-triterpenoid, sentulic acid (SA) isolated from Sandoricum koetjape Merr attenuated nitric oxide (NO) production following co-stimulation with lipopolysaccharide (LPS) and interferon-gamma (IFNγ) in RAW264.7 macrophage cells. The mRNA expres...
Amol D. Sonawane, Dinesh R. Garud, Taro Udagawa, Yasuhiro Kubota and Mamoru Koketsu
New Journal of Chemistry   42(18) 15315-15324   2018   [Refereed]
In this paper, we report the novel synthesis of thieno[2,3-c]acridine and furo[2,3-c]acridine derivatives via an intramolecular iodocyclization reaction. The thieno[2,3-c]acridine derivatives exhibited blue fluorescence in hexane. DFT and time-dep...
Kenji Suzuki, Itsuki Nomura, Masayuki Ninomiya, Kaori Tanaka and Mamoru Koketsu
Bioorganic & Medicinal Chemistry Letters   28(17) 2976-2978   2018   [Refereed]
β-Carbolines constitute a vast group of indole alkaloids and exhibit various biological actions. The objective of this study was to investigate the structure–activity relationships of β-carboline derivatives on in vitro inhibitory effects against ...
Interaction study of binary solvent systems ionic liquid and deep eutectic solvent with rotenone
Zetty Shafiqa Othman, Mamoru Koketsu, Nurul Huda Abd Karim, Saiful Irwan Zubairi, and Nur Hasyareeda Hassan
Sains Malaysiana   47(7) 1473-1482   2018   [Refereed]
Tomomi Ando, Mina Nagumo, Masayuki Ninomiya, Kaori Tanaka, Robert J. Linhardt and Mamoru Koketsu
Bioorganic & Medicinal Chemistry Letters   28(14) 2422-2425   2018   [Refereed]
Coumarins are ubiquitous in higher plants and exhibit various biological actions. The aim of this study was to investigate the structure-activity relationships of coumarin derivatives on tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in...
Tomohiro Itoh, Akito Ono, Kaori Kawaguchi, Sayaka Teraoka, Mayo Harada, Keitaro Sumi, Masashi Ando, Yasuyuki Tsukamasa, Masayuki Ninomiya, Mamoru Koketsu, Toshiharu Hashizume
Food and Chemical Toxicology   115 425-435   2018   [Refereed]
The phytol isolated from watermelon (Citrullus lanatus) sprouts inhibited the growth of a human T-cell leukemia line Jurkat cell and suppressed tumor progression in a xenograft model of human lung adenocarcinoma epithelial cell line A549 in nude m...
Kazuhiro J. Fujimoto, Daiki Nema, Masayuki Ninomiya, Mamoru Koketsu, Hidetaka Sadanari, Masaya Takemoto, Tohru Daikoku and Tsugiya Murayama
Antiviral Research   154 10-16   2018   [Refereed]
A novel type of antiviral agent for human cytomegalovirus (HCMV) is required, because the appearance of ganciclovir (GCV) resistant viruses has been reported. Tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone) has been shown to suppress significant...
Antoni Pardede, Morina Adfa, Arif Juliari Kusnanda, Masayuki Ninomiya and Mamoru Koketsu
Journal of Economic Entomology   111(2) 803-807   2018   [Refereed]
Coreopsis lanceolata is an Asteraceous plant known to contain semiochemicals active against nematodes and leukemic agents. The objective of the study was to discover termite resistant constituents from C. lanceolata stems. Five compounds were isol...
Amol D. Sonawane, Dinesh R. Garud, Taro Udagawa and Mamoru Koketsu
Organic & Biomolecular Chemistry   16(2) 245-255   2018   [Refereed]
In this letter, we report the regioselective iodocyclization reaction of 3-alkynyl-2-(methylthio)quinolines and 3-alkynyl-2-(methylseleno)quinolines for the synthesis of thieno[2,3-b]quinoline and selenopheno[2,3-b]quinoline derivatives. Furthermo...
Bubun Banerjee and Mamoru Koketsu
Coordination Chemistry Reviews   339(15) 104-127   2017   [Refereed]
Recent, many methods have been reported for the synthesis of selenium-containing bioactive scaffolds because of their interesting reactivity and potential pharmaceutical applications. This review describes developments in the synthesis of selenium...
Chemical constituents of Aglaia odorata Lour. leaves and their anti-inflammatory effects
Mai Efdi, Antoni Pardede, Akinori Kakumu, Hirokazu Hara, Syafrizayanti, Dessy Arisanti, Masayuki Ninomiya and Mamoru Koketsu
Natural Product Communications   12(11) 1717-1720   2017   [Refereed]
Caitlin P. Mencio, Vy My Tran, Maritza V. Quintero, Mamoru Koketsu, Franz Goller and Balagurunathan Kuberan
Developmental Neurobiology   77(12) 1401-1412   2017   [Refereed]
In the brain, the extracellular matrix (ECM) plays a central role during neural development and thus modulates critical-period regulated behavioral ontogeny. The major components of the ECM are glycosaminoglycans (GAGs) including chondroitin sulfa...
Caitlin P Mencioa, Dinesh R Garud, Yosuke Doi, Yiling Bi, Hariprasad Vankayalapati, Mamoru Koketsu and Balagurunathan Kuberan
Bioorganic & Medicinal Chemistry Letters   27(22) 5027-5030   2017   [Refereed]
Xylosides are small molecules that serve as primers of glycosaminoglycan biosynthesis. Xyloside mediated modulation of biological functions depends on the extent of priming activity and fine structures of primed GAG chains. In earlier studies, cop...
Saheed Afolabi, Olufunke Olorundare, Masayuki Ninomiya, Abiola Babatunde, Hasan Mukhta and Mamoru Koketsu
Journal of Oleo Science   66(10) 1169-1174   2017   [Refereed]
The discovery of potent cytotoxic isolates from botanicals provides an opportunity to explore this viable tool for cancer chemoprevention. The antileukemic potential of clerodane diterpene from Polyalthia longifolia leaves has already been establi...
Tsubasa Yonezawa, Masahito Yamaguchi, Masayuki Ninomiya and Mamoru Koketsu
Tetrahedron   73(42) 6085-6091   2017   [Refereed]
Selenium-containing amino acids play a pivotal role as biomaterials for the synthesis of Se-dependent enzymes and repair proteins. Especially, selenocysteine and selenoglutathione are prominently involved in fundamental biological processes. In th...
Atsuyoshi Nishina, Masaya Itagaki, Yusuke Suzuki, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Takashi Suzuki, Satoshi Hayakawa, Makoto Kuroda, Hirokazu Kimura
Molecules   22(4) 671/1-671/14   2017   [Refereed]
Eleutherococcus sieboldianus (Makino) Koidz. is a local product from the area in and around Yonezawa City in Yamagata Prefecture, Japan. It has been used as a medicinal plant for a long time. We isolated and identified four types of flavonoid glyc...
Lenny Anwar, Mai Efdi, Masayuki Ninomiya, Sanusi Ibrahim, Deddi Prima Putra, Kaori Tanaka, and Mamoru Koketsu
Medicinal Chemistry Research   26(10) 2357-2362   2017   [Refereed]
Vitex pubescens belonging to the Verbenaceae family, has been historically used as a folk medicine in Indonesia. The dichloromethane extract of V. pubescens stembarks interfered cell proliferation and induced apoptosis in human leukemia HL-60 cell...
Antoni Pardede, Morina Adfa, Arif Juliari Kusnanda, Masayuki Ninomiya, and Mamoru Koketsu
Medicinal Chemistry Research   26(9) 2074-2079   2017   [Refereed]
Cinnamomum parthenoxylon tree belongs to the Lauraceae family. In this study, flavonoid rutinosides were isolated from C. parthenoxylon leaves and their hepatoprotective and antioxidant activity were evaluated. The EtOAc fraction of C. parthenoxyl...
Atsuyoshi Nishina, Kazue Shimizu, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Takashi Suzuki, Satoshi Hayakawa, and Hirokazu Kimura
Evidence-Based Complementary and Alternative Medicine   2017    2017   [Refereed]
We studied the anti-inflammatory activity of twelve 5,7-dihydroxyflavone analogues in lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophages. We found that chrysin (1) and 4′-methoxytricetin (9) showed relatively significant anti-inflammatory...
Insecticidal activity of Toona sinensis against Coptotermes curvignathus Holmgren
Morina Adfa, Arif J. Kusnanda, Fio Livandri, Rizki Rahmad, Welly Darwis, Mai Efdi, Masayuki Ninomiya, and Mamoru Koketsu
Rasayan Journal of Chemistry   10(1) 153-159   2017   [Refereed]
Shota Fukuno, Masayuki Ninomiya and Mamoru Koketsu
Synlett   28(7) 831-834   2017   [Refereed]
2′-O-Methylation of nucleotides is well-known to increase siRNA stability against nuclease activities. Recently, selenium-containing biomolecules have been recognized as unique biological and medicinal agents for humans. In this study, 2′-alkylsel...
Antoni Pardede, and Mamoru Koketsu
Comparative Clinical Pathology   26(3) 499-504   2017   [Refereed]
In this study, antioxidant and antileukemic activity of chemical components from bark of Mangifera casturi was investigated. Research findings have shown that several extracts of M. casturi have potent bioactivity. The methanol extract of M. castu...
Masakazu Kogami, Darrell R. Davis, Mamoru Koketsu
Heterocycles   92(1) 64-74   Jan 2016   [Refereed]
© 2016 The Japan Institute of Heterocyclic Chemistry. We describe an efficient and scalable synthetic route to the natural occurring 2-selenouridine (Se2U) and its suitably protected derivative for phosphoramidite synthesis. From known fully TBDMS...
Syuko Kakuda, Masayuki Ninomiya, Kaori Tanaka, and Mamoru Koketsu
Chemistry SELECT   1(14) 4203-4208   2016   [Refereed]
Pterocarpans are rare isoflavone derivatives that occur in limited Fabaceous plants. The Heck oxyarylation of 2H‐chromenes with o‐iodophenols offered access to several naturally occurring pterocarpans. Among them, medicarpin showed antifungal acti...
Inhibitory effects of echinochrome A, isolated from shell of the sea urchin Anthocidaris crassispina, on antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells through suppression of Lyn activation
Tomohiro Itoh, Azusa Fujiwara, Masayuki Ninomiya, Toshimichi Maeda, Masashi Ando, Yasuyuki Tsukamasa, and Mamoru Koketsu
Natural Product Communications   11(9) 1303-1306   2016   [Refereed]
Echinochrome A (Echi-A) was isolated from the sea urchin Anthocidaris crassispina and its structure determined using ID and 2D-NMR. In the present study, we examined the inhibitory effect of Echi-A on antigen-stimulated degranulation in rat basoph...
Shuhei Hattori, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, and Tetsuo Adachi
Biological and Pharmaceutical Bulletin   39(12) 2036-2041   2016   [Refereed]
Extracellular-superoxide dismutase (EC-SOD), one of the SOD isozymes, is negatively regulated under hypoxic conditions, and decreases in its expression may exacerbate vascular diseases. Moreover, epigenetics, such as DNA methylation and histone mo...
Junya Makino, Rei Asai, Mao Hashimoto, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, and Tetsuo Adachi
Journal of Cellular Biochemistry   117(11) 2496-2505   2016   [Refereed]
Reactive oxygen species (ROS) produced by endothelial cells and macrophages play important roles in atherogenesis because they promote the formation of oxidized low‐density lipoproteins (oxLDL). Extracellular‐superoxide dismutase (EC‐SOD) is mainl...
Komei Kato, Masayuki Ninomiya, Kaori Tanaka, and Mamoru Koketsu
Journal of Natural Products   79(7) 1808-1814   2016   [Refereed]
Quercetin derivatives are widespread in the plant kingdom and exhibit various biological actions. The aim of this study was to investigate the structure–activity relationships of quercetin derivatives, with a focus on the influence of functional g...
Antoni Pardede, Koharu Mashita, Masayuki Ninomiya, Kaori Tanaka, and Mamoru Koketsu
Bioorganic & Medicinal Chemistry Letters   26(12) 2784-2787   2016   [Refereed]
Coreopsis lanceolata is a perennial plant belonging to the Asteraceae family. In this study, flavonoid profile and antileukemic potential of yellow flowers of the plant were investigated. The total flavonoid content in EtOAc fraction of the flower...
Yuji Yamaguchi, Yuji Yamaguchi, Mamoru Koketsu
Journal of Bioscience and Bioengineering   121(3) 345-348   2016   [Refereed]
© 2015 The Society for Biotechnology, Japan. An active substance with high hyaluronidase inhibitory effect was isolated from the edible cyanobacterium Nostochopsis lobatus MAC0804NAN strain and characterized. The active component in the hot water ...
Morina Adfa, Rizki Rahmad, Masayuki Ninomiya, Salprima Yudha S., Kaori Tanaka, Kaori Tanaka, Mamoru Koketsu
Bioorganic and Medicinal Chemistry Letters   26(3) 761-764   2016   [Refereed]
© 2015 Elsevier Ltd. In this study, we evaluated the in vitro cytotoxicity of fractions and isolated constituents from Cinnamomum parthenoxylon woods against human leukemia HL-60 and U937 cells. The n-Hex, EtOAc, and MeOH-H2O fractions of the wood...
Comparison of anti-hyaluronidase activities and sugar compositions of extracts from four edible species of Nostoc (cyanobacteria)
Yuji Yamaguchi, Toshio Sakamoto and Mamoru Koketsu
Algal Resources   8(2) 137-142   2015   [Refereed]
Dinesh R. Garud, Navnath D. Rode, Sagar R. Bathe, Vinod S. Ranpise, Ramesh A. Joshi, Rohini R. Joshi, Mamoru Koketsu
Synthesis (Germany)   47 3956-3962   2015   [Refereed]
© 2015 Georg Thieme Verlag Stuttgart New York Synthesis. The key N-homopropargylthiourea intermediates, N-substituted 2-oxo-4-propargylazetidine-1-carbothioamides, were prepared by the reaction of a 4-propargylazetidin-2-one with isothiocyanates. ...
Atsuyoshi Nishina, Motohiko Ukiya, Makoto Fukatsu, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Junpei Yamamoto, Kazuo Kobayashi-Hattori, Takeshi Okubo, Hideyo Tokuoka, Hirokazu Kimura
Biological and Pharmaceutical Bulletin   38(11) 1794-1800   2015   [Refereed]
© 2015 The Pharmaceutical Society of Japan. We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the accu...
Atsuyoshi Nishina, Kodai Ebina, Motohiko Ukiya, Makoto Fukatsu, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Hirokazu Kimura
Journal of Food Science   80(10) H2354-H2359   2015   [Refereed]
© 2015 Institute of Food Technologists®. This study aimed to chemically isolate and explore an antimelanogenesis inducer in extracts of Solanum melongena L. "Usukawamarunasu" eggplant. We successfully identified dioscin ([25R]-Spirost-5-en-3β-yl) ...
Masakazu Kogami, Mamoru Koketsu
Organic and Biomolecular Chemistry   13(36) 9405-9417   2015   [Refereed]
© The Royal Society of Chemistry. In this paper, we report that a versatile method for the synthesis of 5′-selenium modified nucleosides has been explored on the basis of a 2-(trimethylsilyl)ethyl (TSE) selenyl group as a selenating donor. We demo...
Ryuta Inagaki, Masayuki Ninomiya, Masayuki Ninomiya, Kaori Tanaka, Kaori Tanaka, Mamoru Koketsu, Mamoru Koketsu
ChemMedChem   10(8) 1413-1423   2015   [Refereed]
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Naphthoquinones are considered privileged structures for anticancer drug molecules. The Heck reaction of 2-hydroxy-1,4-naphthoquinone (lawsone) with 1-bromo-3-methyl-2-butene offered easy access t...
Morina Adfa, Fio Livandri, Neva Putri Meita, Syalfinaf Manaf, Masayuki Ninomiya, Irfan Gustian, Agus Martono Hadi Putranto, Rochmah Supriati, Mamoru Koketsu
Journal of Asia-Pacific Entomology   18 47-50   2015   [Refereed]
© 2014 Korean Society of Applied Entomology, Taiwan Entomological Society and Malaysian Plant Protection Society. The termiticidal activity of n-hexane and methanol fractions of Acorus calamus Linn rhizomes against Coptotermes curvignathus Holmgre...
Akira Ohnuma, Akira Ohnuma, Tomohiro Nagata, Kenichi Komura, Hiromune Ando, Hideharu Ishihara, Mamoru Koketsu
Journal of Heterocyclic Chemistry   52 513-517   2015   [Refereed]
© 2014 HeteroCorporation. Various 2H-5,6-dihydroselenine derivatives were synthesized by the reaction of α-alkoxy carbonylselenoacetamides with α,β-unsaturated ketones in the presence of BF3•Et2O.
Yuki Kato, Masayuki Ninomiya, Masayuki Ninomiya, Yuji Yamaguchi, Yuji Yamaguchi, Mamoru Koketsu, Mamoru Koketsu
Medicinal Chemistry Research   24 1180-1188   2015   [Refereed]
© 2014 Springer Science+Business Media New York. Hyaluronidase is one of the most important enzymes in the development of many diseases. In this study, a series of xyloside analogues bearing a triazole and tetrazole at the anomeric position were p...
Tomohiro Itoh, Mamoru Koketsu, Naoto Yokota, Shota Touho, Masashi Ando, Yasuyuki Tsukamasa
Food and Chemical Toxicology   69 330-338   Jan 2014   [Refereed]
Reduced scytonemin (R-scy) and scytonemin (Scy) isolated from Nostoc commune exhibit anti-tumor and ultraviolet-absorbing properties. In this study, we examined the effects of R-scy and Scy on the induction of nitric oxide (NO) production by lipop...
Hirokazu Hara, Ryoko Ikeda, Masayuki Ninomiya, Tetsuro Kamiya, Mamoru Koketsu, Tetsuo Adachi
Biological and Pharmaceutical Bulletin   37(6) 1042-1049   Jan 2014   [Refereed]
Chalcones are open-chain flavonoids that are biosynthesized in various plants. Some of them possess anti-inflammatory activity. We previously found that chalcone glycosides from Brassica rapa L. 'hidabeni' suppress lipopolysaccharide (LPS)-induced...
Tomohiro Itoh, Akihiro Tsuchida, Yuji Muramatsu, Masayuki Ninomiya, Masayuki Ninomiya, Masashi Ando, Yasuyuki Tsukamasa, Mamoru Koketsu, Mamoru Koketsu
Anaerobe   27 56-63   Jan 2014   [Refereed]
Propionibacterium acnes is the primary pathogenic agent responsible for acne vulgaris on the skin and hair follicles. Overgrowth of this bacterium inhibits growth and promotes follicular inflammation, with an associated increase in pro-inflammator...
Masayuki Ninomiya, Tatsuyuki Aoki, Morina Adfa, Tsuyoshi Yoshimura, Mamoru Koketsu, Mamoru Koketsu
Holzforschung   68(3) 361-365   Jan 2014   [Refereed]
The antitermite effects of several thione analogues of naturally occurring coumarins have been tested against Coptotermes formosanus by the no-choice test. 2-Thioxogrevillone exhibited the strongest antitermite potential. The thione analogues prov...
Tomohiro Itoh, Yuji Muramatsu, Masayo Masu, Ayaka Tsuge, Masaki Taniguchi, Masayuki Ninomiya, Masashi Ando, Yasuyuki Tsukamasa, Mamoru Koketsu
Nutrition and cancer   66 1414-1423   2014   [Refereed]
Nostocionone (Nost), a compound isolated from Nostoc commune, and its synthesized derivatives (NostDs) were evaluated for in vitro cytotoxicity against human T-cell leukemia Jurkat cells. NostD3 [(1E,4E)-1-(3,4-dihydroxyphenyl)-5-(2,6,6-trimethylc...
Hyun Kyung Lee, Ha Eun Song, Haeng Byung Lee, Cheol Soo Kim, Mamoru Koketsu, Luong Thi My Ngan, Young Joon Ahn
PLoS ONE   9(4) e95530   2014   [Refereed]
Helicobacter pylori is associated with various diseases of the upper gastrointestinal tract, such as gastric inflammation and duodenal and gastric ulcers. The aim of the study was to assess anti-H. pylori effects of the sesquiterpene lactone dehyd...
Dinesh R. Garud, Amol R. Jadhav, Santosh V. Lahore, Nilesh M. Kahar, Rohini R. Joshi, Ramesh A. Joshi, Mamoru Koketsu
Tetrahedron Letters   55(43) 5998-6000   2014   [Refereed]
© 2014 Elsevier Ltd. All rights reserved. The regioselective iodocyclization reaction of allene-thioureas is described, for the first time, for the synthesis of bicyclic β-lactams. The substitution at the allenyl part heavily influenced the iodocy...
Akinori Kakumu, Masayuki Ninomiya, Masayuki Ninomiya, Mai Efdi, Morina Adfa, Masahiro Hayashi, Kaori Tanaka, Kaori Tanaka, Mamoru Koketsu, Mamoru Koketsu
Bioorganic and Medicinal Chemistry Letters   24(17) 4286-4290   2014   [Refereed]
Toona sinensis is a traditional Chinese medicine belonging to the Meliaceae family. The aim of this study was to identify the potential compounds responsible for anticancer activity of T. sinensis. The EtOAc extracts of leaves and woods of T. sine...
Masanori Menjo, Hideki Tamai, Hiromune Ando, Hideharu Ishida, Mamoru Koketsu, and Makoto Kiso
Heterocycles   88(2) 1587-1594   2014   [Refereed]
p-Methoxybenzyl (PMB), and p-nitrobenzyl (PNB) selenoglycosides of glucose were synthesized, and their glycosidation reactions were investigated. The Bn and PNB derivatives were successfully activated with IBr-AgClO4 to provide the glycosylated pr...
Himiko Suzuki, Yuki Ito, Yuki Noro, Mamoru Koketsu, Michihiro Kamijima, Motohiro Tomizawa, Motohiro Tomizawa
Toxicology Letters   225(1) 153-157   2014   [Refereed]
Diverse serine hydrolases including endocannabinoid metabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) have been suggested as secondary targets for organophosphate (OP) agents to exert adverse toxic effects s...
Venu Srinivas, Mamoru Koketsu
Journal of Organic Chemistry   78(22) 11612-11617   Nov 2013   [Refereed]
Utilizing aldehyde-substituted vinylogous carbonates and 1,3-diketones, a simple protocol is presented for the synthesis of 2,8-dioxabicyclo[3.3.1]nonane derivatives via Knoevenagel condensation followed by a hetero-Diels-Alder reaction under gree...
Morina Adfa, Morina Adfa, Yosuke Hattori, Masayuki Ninomiya, Yasuhiro Funahashi, Tsuyoshi Yoshimura, Mamoru Koketsu
Natural Product Research   27(3) 270-273   2013   [Refereed]
In the continuing study of antifeedant compounds in Protium javanicum Burm. f. against Coptotermes formosanus Shiraki, 6-desacetylnimbin (1), quercitrin (2) and myricitrin (3) were isolated from P. javanicum extract. All compounds were characteris...
Yosuke Toyoda, Yosuke Toyoda, Masayuki Ninomiya, Masahiro Ebihara, Mamoru Koketsu
Organic and Biomolecular Chemistry   11(16) 2652-2659   2013   [Refereed]
The Staudinger ketene-imine [2 + 2] cycloaddition reaction for conversion of α-heteroatom-substituted exocyclic imines to C4 heterocyclic spiro-β-lactams has rarely been investigated due to their instability. Herein, we describe the Staudinger rea...
Atsuyoshi Nishina, Hirokazu Kimura, Hiroyuki Tsukagoshi, Kunihisa Kozawa, Mamoru Koketsu, Masayuki Ninomiya, Shoei Furukawa
Evidence-based Complementary and Alternative Medicine   2013    2013
Components from Dendranthema × grandiflorum cv. " Mottenohoka" that promote neurite outgrowth of PC12 cells were identified and the mechanism of neurite outgrowth stimulated by isolated components was studied. Components that promoted the phosphor...
Screening, identification and fatty acid composition: analysis of mercury resistance microalgae from freshwater pond in Kuranji, Padang, West Sumatera, Indonesia
Rezky Lastinov Amza, Abdi Dharma, Edison Munaf, Kentaro Oh-Hashi, Yuji Yamaguchi, Kaori Tanaka, Satoshi Yoshida and Mamoru Koketsu
Research Journal of Pharmaceutical Biological and Chemical Sciences   4(4) 1392-1399   2013   [Refereed]
Yusuke Hiramatsu, Morina Adfa, Masayuki Ninomiya, Masayuki Ninomiya, Tsuyoshi Yoshimura, Mamoru Koketsu, Mamoru Koketsu
Journal of Pesticide Science   38(4) 228-231   2013   [Refereed]
Precocene I and II are naturally occurring 2,2-dimethylchromenes that have a great influence on various insects. Using phenylboronic acid in acidic conditions, precocenes, natural products octandrenolone, clusiaphenone A, and relatives were prepar...
Hamza M. Abosadiya, Siti Aishah Hasbullah, Mukram Mohamed Mackeen, Mukram Mohamed Mackeen, Seow Chew Low, Nazlina Ibrahim, Mamoru Koketsu, Bohari M. Yamin
Molecules   18(11) 13369-13384   2013   [Refereed]
Abstract: C-5-bromo-2-hydroxyphenylcalix[4]-2-methylresorcinarene (I) was synthesized by cyclocondensation of 5-bromo-2-hydroxybenzaldehyde and 2-methylresorcinol in the presence of concentrated HCl. Compound I was characterized by infrared and nu...
Atsuyoshi Nishina, Hirokazu Kimura, Hiroyuki Tsukagoshi, Kunihisa Kozawa, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Yutaro Obara, Shoei Furukawa
Neurochemical Research   38(11) 2397-2407   2013   [Refereed]
The cellular effects of eleven compounds including chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives were studied in rat pheochromocytoma PC12 cells. Of the compounds tested, 4′-O-β-d-glucopyranosyl-3′,4...
Venu Srinivas and Mamoru Koketsu
Tetrahedron   69(37) 8025-8033   2013   [Refereed]
A simple and efficient route to indole-2-, 3-, or 5-substituted propargylamines by three component-coupling of substituted indole carboxaldehydes, terminal alkyne, and secondary amine in the presence of AuBr3 catalyst in aqueous medium, is describ...
(Dina Permata Sari, Masayuki Ninomiya, Mai Efdi, Adlis Santoni, Sanusi Ibrahim, Kaori Tanaka and Mamoru Koketsu
Journal of Oleo Science   62(10) 843-848   2013   [Refereed]
Polyalthia is a versatile genus of shrubs and trees found in tropic and sub-tropic regions. In this study, three clerodane diterpenes, kolavenic acid (1), polyalthialdoic acid (2), and 16α-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide (3) isolated fr...
Isolation, identification and fatty acid analysis of microalgae from West Sumatera, Indonesia
D. Susanty, K. Oh-Hashi, Y. Yamaguchi, K. Tanaka, S. Yoshida, A. Dharma, E. Munaf and M. Koketsu
Journal of Algal Biomass Utilization   4(4) 7-13   2013   [Refereed]
Tomohiro Itoh, Ryosuke Tsuzuki, Toshiomi Tanaka, Masayuki Ninomiya, Yuji Yamaguchi, Hiroyuki Takenaka, Masashi Ando, Yasuyuki Tsukamasa, Mamoru Koketsu
Food and Chemical Toxicology   60 76-82   2013   [Refereed]
Nostoc commune is a terrestrial benthic blue-green alga that often forms an extended mucilaginous layer on the soil, accumulates on stones and mud in aquatic environments. Reduced-scytonemin (R-scy), isolated from N. commune Vaucher, has been show...
Junya Makino, Ryohei Nakanishi, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, Tetsuo Adachi
Journal of Natural Products   76(7) 1285-1290   2013   [Refereed]
Luteolin (1), a natural product occurring in many vegetables and fruits, is known to have several biological activities. Cluster for differentiation (CD) families, such as CD11b, -14, and -36, are expressed during pathological processes of atheros...
Naomi Tanigawa, Naomi Tanigawa, Makoto Hagiwara, Hiroyuki Tada, Toshinori Komatsu, Shinsuke Sugiura, Kaoru Kobayashi, Yoshiko Kato, Naoyuki Ishida, Kyohei Nishida, Masayuki Ninomiya, Mamoru Koketsu, Kenji Matsushita, Kenji Matsushita
Immunopharmacology and Immunotoxicology   35(4) 471-477   2013   [Refereed]
Since E-selectin-mediated adhesion of leukocytes or tumor cells to the vascular endothelium is a key early event in the initiation of inflammatory response and cancer metastasis, E-selectin inhibition is thought to be a good target for therapeutic...
Masayuki Ninomiya, Kyohei Nishida, Kaori Tanaka, Kaori Tanaka, Kunitomo Watanabe, Kunitomo Watanabe, Mamoru Koketsu
Journal of Natural Medicines   67(3) 460-467   2013   [Refereed]
Flavonoids are widely occurring polyphenols that are found in plants. The aim of this study was to investigate the structure-activity relationships of 5,7-dihydroxyflavones, with a focus on the effect of B ring structure substitution on the antipr...
Ryuta Inagaki, Masayuki Ninomiya, Kaori Tanaka, Kaori Tanaka, Kunitomo Watanabe, Kunitomo Watanabe, Mamoru Koketsu
Chemical and Pharmaceutical Bulletin   61(6) 670-673   2013   [Refereed]
Furonaphthoquinones are promising skeletons for anticancer drug molecules. In particular, methoxylated furonaphthoquinones are characteristic constituents of Tabebuia plants. In this research, we synthesized the furonaphthoquinones by effective on...
Thao K N Nguyen, Vy M. Tran, Venkataswamy Sorna, Inger Eriksson, Akinori Kojima, Mamoru Koketsu, Duraikkannu Loganathan, Lena Kjellén, Richard I. Dorsky, Richard I. Dorsky, Chi Bin Chien, Chi Bin Chien, Chi Bin Chien, Balagurunathan Kuberan, Balagurunathan Kuberan
ACS Chemical Biology   8(5) 939-948   2013   [Refereed]
Proteoglycans (PGs) modulate numerous signaling pathways during development through binding of their glycosaminoglycan (GAG) side chains to various signaling molecules, including fibroblast growth factors (FGFs). A majority of PGs possess two or m...
Yosuke Toyoda, Mamoru Koketsu
Tetrahedron   68(51) 10391-10620   Dec 2012
Morina Adfa, Yosuke Hattori, Tsuyoshi Yoshimura, and Mamoru Koketsu
74 129-135   Aug 2012
M. Efdi, M. Ninomiya, E. Suryani,K. Tanaka, S. Ibrahim, K. Watanabe, and M. Koketsu
Bioorganic&Medicinal Chemistry Letters   22 4242-4245   Mar 2012
M. Adfa, T. Itoh, Y. Hattori, and M. Koketsu
Biological and Pharmaceutical Bulletin   35 963-966   Feb 2012
N. Seki, U. Toh, K. Kawaguchi, M. Ninomiya, M. Koketsu, K. Watanabe, M.Aoki, T. Fujii, A. Nakamura, Y. Akagi, J. Kusukawa, M. Kage, K. Shirouzu, and H. Yamana
Journal of Cellular Biochemistry   113 2346-2355   Jan 2012
Atsuyoshi Nishina, Hirokazu Kimura, Kunihisa Kozawa, Geoffroy Sommen, Takao Nakamura, Heinz Heimgartner, Mamoru Koketsu, Shoei Furukawa
Toxicology and Applied Pharmacology   257(3) 388-395   Dec 2011   [Refereed]
Masayuki Ninomiya, Hitoshi Satoh, Yuji Yamaguchi, Hiroyuki Takenaka, and Mamoru Koketsu
Bioscience, Biotechnology, and Biochemistry   75(11) 2175-2177   Nov 2011   [Refereed]
Atsuyoshi Nishina, Hirokazu Kimura, Kunihisa Kozawa, Geoffroy Sommen, Francesco Favero, Heinz Heimgartner, Mamoru Koketsu and Shoei Furukawa
International Journal of Toxicology   30(6) 690-699   Sep 2011   [Refereed]
Hirokazu Hara, Yoko Nakamura, Masayuki Ninomiya, Ryosuke Mochizuki, Tetsuro Kamiya, Elias Aizenman, Mamoru Koketsu, Tetsuo Adachi
Bioorganic&Medicinal Chemistry   19(18) 5559-5568   Sep 2011   [Refereed]
Activation of microglia induces the production of various inflammatory mediators including nitric oxide (NO), leading to neurodegeneration in many central nervous system diseases. In this study, we examined the effects of chalcone glycosides isola...
Tanahashi Nobuhito(Department of Chemistry, Faculty of Engineering, Gifu University, Gifu, 501-1193, JAPAN),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
52(36) 4650-4653   Sep 2011   [Refereed]
Akuzawa Kazuhiko(Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University),Yamada Rie(Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University),Li Ying(Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University),Sadanari Hidetaka(Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University),Matsubara Keiko(Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University),Watanabe Kunitomo(Life Science Research Center, Gifu University),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Tuchida Yuuzo(Hououdou Co. Ltd.),Murayama Tsugiya(Department of Microbiology and Immunology,Faculty of Pharmaceutical Sciences, Hokuriku University)
91(3) 296-303   Sep 2011   [Refereed]
Antifeedant and termiticidal activities of 6-alkoxycoumarins and related analogs against Coptotermes formosanus Shiraki
Adfa Morina(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Hattori Yosuke(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Kokmura Kenichi(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Yoshimura Tsuyoshi(Research Institute for Sustainable Humanosphere (RISH), Kyoto University),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
36(7) 720-726   Jun 2011   [Refereed]
Komura Konichi(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Nakano Yu(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
13(4) 828-831   Apr 2011   [Refereed]
Mori Tadashi(Department of Molecular Cell Biology, Graduate School of Agricultural Science, Tohoku University),Takamiya Mari(Department of Molecular Cell Biology, Graduate School of Agricultural Science, Tohoku University),Uchida Takafumi(Department of Molecular Cell Biology, Graduate School of Agricultural Science, Tohoku University),Hidaka Masafumi(Department of Molecular Cell Biology, Graduate School of Agricultural Science, Tohoku University),Lin Yi-Chin(Department of Molecular Cell Biology, Graduate School of Agricultural Science, Tohoku University),Yoshizawa Ibuki(Department of Molecular Cell Biology,Graduate Schoolof Agricultural Science, Tohoku University),Okabe Takayoshi(Chemical Biology Research Initiative, The University of Tokyo),Egashira Shinichiro(Chemical Biology Research Initiative, The University of Tokyo),Kojima Hirotatsu(Chemical Biology Research Initiative, The University of Tokyo),Nagano Tetsuo(Chemical Biology Research Initiative, The University of Tokyo),KoketsuMamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
406(3) 439-443   Mar 2011   [Refereed]
Ninomiya Masayuki (Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Tanaka Kaori(Life Sciences Research Center, Gifu University),Tsuchida Yuzo(Hououdou Co., Ltd.),Muto Yoshinori(Department of Functional Bioscience, Gifu University School of Medicine),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Watanabe Kunitomo(Division of Anaerobe Research, Life Science Research Center, Gifu University)
54(5) 1529-1536   Mar 2011   [Refereed]
Garud Dinesh R(Department of Chemistry, Sir Parashurambhau College, Tilak Road, Pune 411030, India),Makimura Masaki(Department of Chemistry, Faculty of Engineering, Gifu University),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
35(3) 581-586   Mar 2011   [Refereed]
Raman Karthik(Department of Bioengineering, University of Utah),Masayuki Ninomiya(Department of Materials Science and Technology, Faculty of Engineering, Gifu Universit),Nguyen Thao Kim Nu(Department of Bioengineering, University of Utah),Tsuzuki Yasuhiro(Department ofChemistry, Faculty of Engineering, Gifu University),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu Universit),Kuberan Balagurunathan(Department of Bioengineering, University of Utah)
404 86-89   Jan 2011   [Refereed]
Anti-influenza virus activity of tricin, 4',5,7-trihydroxy-3',5'-dimethoxyflavone
Kurumi Yazawa, Masahiko Kurokawa, Masatsugu Obuchi, Ying Li, Rie Yamada, Hidetaka Sadanari, Keiko Matsubara, Kunitomo Watanabe, Mamoru Koketsu, Yuuzo Tuchida, Tsugiya Murayama
Antiviral Chemistry&Chemotherapy   22(1) 1-11   Jan 2011   [Refereed]
Ninomiya Masayuki(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Garud Dinesh R(Department of Chemistry, Sir Parashurambhau College, Tilak Road, Pune 411030, India),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
81(9) 2439-2463   Nov 2010   [Refereed]
Tsuzuki Yasuhiro(Department of Chemistry, Faculty of Engineering, Gifu University),Nguyen Thao Kim Nu(Departments of Bioengineering, University of Utah, Salt Lake City, Utah 84112),Garud Dinesh R(Department of Chemistry, Sir Parashurambhau College, Tilak road, Pune 411030 India),Kuberan Balagurunathan(Departments of Bioengineering, University of Utah,Salt Lake City, Utah 84112),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
20 7269-7273   Oct 2010   [Refereed]
Fujita Satoshi(Department of Chemistry, Faculty of Engineering, Gifu University),Ninomiya Masayuki(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Efdi Mai(Department of Chemistry, Faculty of Engineering, Gifu University),Ohguchi Kenji(Gifu International Institute of Biotechnology),Nozawa Yoshinori(Gifu International Institute of Biotechnology),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
24(17) 1630-1636   Oct 2010   [Refereed]
Inhibitory effects of 5-chloroacetyl-2-piperidino-1,3-selenazole, a novel selenium-containing compound, on skin melanin biosynthesis
Ha Sang Keun(Graduate School of East-West Medical Science, KyungHee University, Yongin, Gyeonggi-do, Korea),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University ),Lee Minjae(Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Gyeonggi-do, Korea),Moon Eunjung(Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Gyeonggi-do, Korea),Kim Sung-Hoon(Cancer PreventiveMaterial Development Research Center, Kyung Hee University,Seoul, Korea),Yoon Tae-Jin(Department of Dermatology, School of Medicine, Gyeongsang National University, Seoul, Korea ),Kim Sun Yeou(Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Gyeonggi-do, Korea)
61 1657-1663   Oct 2010   [Refereed]
Komura Kenichi(Department of Materials Science and Technology, Faculty ofEngineering),Murase Tomoyuki(Department of Materials Science and Technology, Faculty of Engineering),Yoshinori Sugi(Department of Materials Science and Technology, FacultyofEngineering, Gifu University),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
39(9) 948-949   Sep 2010   [Refereed]
Garud Dinesh R(Department of Chemistry, Sir Parashurambhau College, Tilak Road, Pune 411030, India),Ninomiya Masayuki(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
81(9) 2027-2055   Sep 2010   [Refereed]
Terazawa Riyako(Department of Longevity and Aging Research, Gifu International Institute of Biotechnology),Ito Masafumi(Department of Longevity and Aging Research, Gifu International Institute of Biotechnology),Garud Dinesh R.(Department of Chemistry, Faculty of Engineering, Gifu University),Hamada Nanako(Department of Longevity and Aging Research, Gifu International Institute of Biotechnology),Fujita Yasunori(Department of Longevity and Aging Research, Gifu International Institute of Biotechnology),Itoh Tomohiro(Department of Longevity and Aging Research, Gifu International Institute of Biotechnology),Nozawa Yoshinori(Department of Longevityand Aging Research, Gifu International Institute of Biotechnology),Nakane Keita(Department of Urology, Gifu University Graduate School of Medicine),Deguchi Takashi(Department of Urology, Gifu University Graduate School of Medicine),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
18 7001-7008   Aug 2010   [Refereed]
Itoh Tomohiro(Gifu International Institute of Biotechnology),Ninomiya Masayuki(Department of Materials Science and Technology, Faculty of Engineering, Gifu University),Nozawa Yoshinori(Gifu International Institute of Biotechnology),Koketsu Mamoru(Department of Materials Science and Technology, Faculty of Engineering, Gifu University)
18 7052-7057   Aug 2010   [Refereed]

Misc

 
M. Koketsu, H. Ishihara
Comprehensive Heterocyclic Chemistry III   4 791-821   Dec 2008
Syed Mashhood Ali, Fahmeena Asmat, Mamoru Koketsu
Journal of Inclusion Phenomena and Macrocyclic Chemistry   59 191-196
The inclusion complexes of β-CD and parecoxib [PRB] in aqueous solution were investigated using 1H NMR spectroscopic study revealed the existence of four different equilibria for 1:1 inclusion complexes in which both the aromatic rings of the gues...
Atsuyoshi Nishina, Hirokazu Kimura, Kunihisa Kozawa, Geoffroy Sommen, Francesco Favero, Heinz Heimgartner, Mamoru Koketsu, Shoei Furukawa
International Journal of Toxicology   30 690-699   Dec 2011
We newly synthesized organic selenium compounds (5-membered ring compounds) including 2-selenoxo-1,3-thiazolidin-4-ones (compounds A) and 3-alkoxy-4,5-dihydro-5-selenoxo-1H-1,2,4-triazole-1-carboxylates (compounds B). To address whether these comp...
Yasuhiro Tsuzuki, Thao Kim Nu Nguyen, Dinesh R. Garud, Balagurunathan Kuberan, Balagurunathan Kuberan, Balagurunathan Kuberan, Mamoru Koketsu
Bioorganic and Medicinal Chemistry Letters   20(24) 7269-7273
Various 4-deoxy-4-fluoro-xylosides were prepared using click chemistry for evaluating their potential utility as inhibitors of glycosaminoglycan biosynthesis. 2,3-Di-O-benzoyl-4-deoxy-4-fluoro-β-d-xylopyranosylazide, obtained from l-arabinopyranos...
Kyong Nyon Nam, Mamoru Koketsu, Eunjoo H. Lee
European Journal of Pharmacology   589 53-57
Microglia are the prime effector cells involved in immune and inflammatory responses in the central nervous system (CNS). In pathological conditions, microglia are activated to restore CNS homeostasis. However, chronic microglial activation endang...
Morina Adfa, Mamoru Koketsu, Masahiro Ebihara
Acta Crystallographica Section E: Structure Reports Online   E66 o2190
In the title compound, 6-benzyloxy-2H-1-benzopyran-2-one, C 16H 12O 3, the coumarin unit and benzyl plane in the mol-ecule are perpendicular to each other [86.92 (7)°]. The crystal packing is stabilized by π-π stacking inter-actions, with an inter...
Tadashi Mori, Masafumi Hidaka, Yi Chin Lin, Ibuki Yoshizawa, Takayoshi Okabe, Shinichiro Egashira, Hirotatsu Kojima, Tetsuo Nagano, Mamoru Koketsu, Mari Takamiya, Takafumi Uchida
Biochemical and Biophysical Research Communications   406(3) 439-443
Pin1, a peptidyl prolyl cis/trans isomerase (PPIase), is a potential target molecule for cancer, infectious disease, and Alzheimer's disease. We established a high-throughput screening method for Pin1 inhibitors, which employs a real-time fluoresc...
Atsuyoshi Nishina, Hirokazu Kimura, Kunihisa Kozawa, Geoffroy Sommen, Takao Nakamura, Heinz Heimgartner, Mamoru Koketsu, Shoei Furukawa
Toxicology and Applied Pharmacology   257 388-395
Synthetic organic selenium compounds, such as ebselen, may show glutathione peroxidase-like antioxidant activity and have a neurotrophic effect. We synthesized 1,3-selenazolidin-4-ones, new types of synthetic organic selenium compounds (five-membe...
Morina Adfa, Morina Adfa, Yosuke Hattori, Tsuyoshi Yoshimura, Kenichi Komura, Mamoru Koketsu
Journal of Chemical Ecology   37(6) 598-606   1978
We synthesized 23 6-alkoxycoumarin derivatives, 20 of which are novel compounds. The structures of all compounds were confirmed by NMR, MS, and elemental analysis, and their antifeedant and termiticidal activities against Coptotermes formosanus Sh...
Asumi Sakai, Kunitomo Watanabe, Mamoru Koketsu, Kazuhiko Akuzawa, Rie Yamada, Zhuan Li, Hidetaka Sadanari, Keiko Matsubara, Tsugiya Murayama
Antiviral Chemistry and Chemotherapy   19 125-132
Background: Effective new anti-human cytomegalovirus (HCMV) agents and regimens need to be developed. We examined the anti-HCMV properties of crude extract (True World Extract of Bambuseae sasa [TWEBS]) and five compounds (p-coumaric acid, 3-hydro...
Kurumi Yazawa, Masahiko Kurokawa, Masatsugu Obuchi, Ying Li, Rie Yamada, Hidetaka Sadanari, Keiko Matsubara, Kunitomo Watanabe, Mamoru Koketsu, Yuuzo Tuchida, Tsugiya Murayama
Antiviral chemistry & chemotherapy   22 1-11   Dec 2011
We examined the anti-influenza virus activity of tricin, 4',5,7-trihydroxy-3',5'-dimethoxyflavone, against five viruses: A/Solomon islands/3/2006 (H1N1), A/Hiroshima/52/2005 (H3N2), A/California/07/2009 (H1N1pdm), A/Narita/1/2009 (H1N1pdm) and B/M...
Kurumi Yazawa, Masahiko Kurokawa, Masatsugu Obuchi, Ying Li, Rie Yamada, Hidetaka Sadanari, Keiko Matsubara, Kunitomo Watanabe, Mamoru Koketsu, Yuuzo Tuchida, Tsugiya Murayama
Antiviral Chemistry and Chemotherapy   22 1-11
Background: We examined the anti-influenza virus activity of tricin, 4′,5,7-trihydroxy-3′,5′-dimethoxyfavone, against five viruses: A/Solomon islands/3/2006 (H1N1), A/Hiroshima/52/2005 (H3N2), A/California/07/2009 (H1N1pdm), A/Narita/1/2009 (H1N1p...
T. Toyosaki, T. Toyosaki, M. Koketsu
British Poultry Science   48(4) 449-453   Aug 2007
1.The antioxidant effects of the water-soluble fraction of baked sponge cakes made with silky fowl eggs and White Leghorn eggs were studied. The mechanism of the antioxidant effect was also investigated. 2. The antioxidant effect on the oxidation ...
Masayuki Ninomiya, Hitoshi Satoh, Yuji Yamaguchi, Hiroyuki Takenaka, Mamoru Koketsu
Bioscience, Biotechnology and Biochemistry   75 2175-2177
The extract of terrestrial alga Nostoc commune Vauch. has high antioxidative activity. Our study on N. commune Vauch. resulted in the isolation of two β-ionone derivatives, nostocionone and 3-oxo-β-ionone, together with four indole alkaloids, scyt...
Morina Adfa, Morina Adfa, Tsuyoshi Yoshimura, Kenichi Komura, Mamoru Koketsu
Journal of Chemical Ecology   36(7) 720-726
The antitermite (termiticidal and antifeedant) activity of Protium javanicum Burm. f. extract was investigated. The ethyl acetate fraction was active. Scopoletin (1), quercetin, and stigmasterol were isolated by bioassay-guided fractionation. Scop...
Morina Adfa, Morina Adfa, Yosuke Hattori, Tsuyoshi Yoshimura, Mamoru Koketsu
International Biodeterioration and Biodegradation   74 129-135
Twenty-three 7-alkoxycoumarins and related analogs were synthesized from 7-hydroxycoumarin by treatment with various alkyl/aryl/acyl halides and potassium carbonate in DMF. Their antifeedant and termiticidal activities against Coptotermes formosan...
Masayuki Ninomiya, Dinesh R. Garud, Mamoru Koketsu
Coordination Chemistry Reviews   255 2968-2990   Dec 2011
Selenium represents an essential element for organisms as various diseases can result from selenium deficiency. As a consequence, selenium-containing heterocycles are of considerable biochemical and pharmacological relevance. Selenium-containing h...
M. Ninomiya, M. Efdi, T. Inuzuka and M. Koketsu
Phytochemistry Lett.   3 96-99
A phytochemical investigation of the aerial parts of Brassica rapa L. 'hidabeni', turnip resulted in the isolation of three new chalcone glycosides, 4′-O-β-d-glucopyranosyl-4-hydroxy-3′-methoxychalcone (1), 4′-O-β-d-glucopyranosyl-3′,4-dimethoxych...
Tomohiro Itoh, Masayuki Ninomiya, Yoshinori Nozawa, Yoshinori Nozawa, Mamoru Koketsu
Bioorganic and Medicinal Chemistry   18(19) 7052-7057   Oct 2010
We isolated three chalcone glycosides along with other glycoside constituents from the aerial parts of Brassica rapa L. 'hidabeni' and examined the effects of these compounds on the antigen-stimulated degranulation in rat basophilic leukemia RBL-2...
M. A. Metwally, Bakr F. Abdel-Wahab, M. Koketsu
Phosphorus, Sulfur and Silicon and the Related Elements   184 3038-3074
The data on the methods of synthesis and chemical properties of the thiophene ring in 2-acetylthiophenes published over the last several years until mid 2007 are reviewed for the first time. Many of the synthesized compounds exhibit interesting bi...
M. Efdi, S. Fujita, T. Inuzuka and M. Koketsu
Nat. Prod. Res.   24 657-662   Apr 2010
Ten secondary metabolites were identified from Goniothalamus tapis Miq. The structures of these compounds were elucidated using spectroscopic analyses. It was revealed for the first time that 3-methyl-1H-benz[f]indole-4,9-dione was produced by the...
Takeru Oyama, Yumiko Yasui, Shigeyuki Sugie, Mamoru Koketsu, Kunitomo Watanabe, Takuji Tanaka, Takuji Tanaka
Cancer Prevention Research   2 1031-1038   May 2011
The flavone 4′,5,7-trihydroxy-3′,5′-dimethoxyflavone (tricin) present in rice, oats, barley, and wheat exhibits antigrowth activity in several human cancer cell lines and anti-inflammatory potential. However, the chemopreventive activity has not y...
Atsuyoshi Nishina, Atsuyoshi Nishina, Akihiro Sekiguchi, Yuxi He, Mamoru Koketsu, Shoei Furukawa
Journal of Neuroscience Research   86 720-725
We found that ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one] caused phosphorylation of mitogen-activated protein kinase (MAPK), followed by expression of neurofilament-M, a neuron-specific protein, in cultured PC12 rat pheochromocytoma cells. T...
Deepali B. Bankar, Mamoru Koketsu
European Journal of Organic Chemistry   2742-2745
Novel selenium-containing bicyclic β-lactams were obtained through stereoselective insertion of (but-3-enyl)seleno and propargylseleno moieties at the C(4) positions of azetidinones with subsequent ring-closing enyne metathesis. © 2010 Wiley-VCH V...
Dinesh R. Garud, Masaki Makimura, Hiromune Ando, Hideharu Ishihara, Mamoru Koketsu
Tetrahedron Letters   48(44) 7764-7768
4-Alkyl-2-imino-1,3-oxaselenolanes were prepared in good yields with high regioselectivity under mild conditions by the reaction of selenocarbamates with I2 or NIS. The resulting 4-alkyl-2-imino-1,3-oxaselenolanes on dehydrohalogenation gave 4-alk...
Dinesh R. Garud, Yosuke Toyoda, Mamoru Koketsu
Tetrahedron Letters   50(25) 3035-3037
The first synthesis of 1,3-oxaselenepane derivatives by the reaction of aryl isoselenocyanates with 4-bromobutanol in the presence of sodium hydride in THF as a one-pot reaction is described. The Z/E isomerism for the exocyclic carbon-nitrogen dou...
M. Koketsu, H. Ishihara
Comprehensive Heterocyclic Chemistry III   2 463-477   Dec 2008
Riyako Terazawa, Dinesh R. Garud, Dinesh R. Garud, Nanako Hamada, Yasunori Fujita, Tomohiro Itoh, Yoshinori Nozawa, Yoshinori Nozawa, Keita Nakane, Takashi Deguchi, Mamoru Koketsu, Masafumi Ito
Bioorganic and Medicinal Chemistry   18(19) 7001-7008   Oct 2010
The process of cancer development consists of three sequential stages termed initiation, promotion, and progression. Oxidative stress damages DNA and introduces mutations into oncogenes or tumor suppressor genes, thus contributing to cancer develo...
Masayuki Ninomiya, Kaori Tanaka, Kaori Tanaka, Yuzo Tsuchida, Yoshinori Muto, Mamoru Koketsu, Kunitomo Watanabe, Kunitomo Watanabe
Journal of Medicinal Chemistry   54(5) 1529-1536
Tricin (4′,5,7-trihydroxy-3′,5′-dimethoxyflavone) has demonstrated diverse biological activities. This compound has a high anti-human cytomegalovirus (HCMV) activity; however, its oral availability is low. To improve its bioavailability, we synthe...
Dinesh R. Garud, Vy M. Tran, Xylophone V. Victor, Mamoru Koketsu, Balagurunathan Kuberan, Balagurunathan Kuberan, Balagurunathan Kuberan
Journal of Biological Chemistry   283(43) 28881-28887
Proteoglycans (PGs) are composed of a protein moiety and a complex glycosaminoglycan (GAG) polysaccharide moiety. GAG chains are responsible for various biological activities. GAG chains are covalently attached to serine residues of the core prote...
Sang Keun Ha, Mamoru Koketsu, Minjae Lee, Eunjung Moon, Sung Hoon Kim, Tae Jin Yoon, Sun Yeou Kim, Sun Yeou Kim, Sun Yeou Kim
Journal of Pharmacy and Pharmacology   61 1657-1663   May 2011
Objectives: The aim of this study was to identify a novel skin-depigmenting agent from synthetic 1,3-thiazine derivatives. Methods: We investigated the inhibitory effects of six kinds of 1,3-thiazine derivative on melanogenesis by examining their ...
Eunjoo H. Lee, Eunjoo H. Lee, Yu Ji Lim, Sang Keun Ha, Tong Ho Kang, Mamoru Koketsu, Chulhun Kang, Chulhun Kang, Sun Yeou Kim, Sun Yeou Kim, Sun Yeou Kim, Ji Ho Park, Ji Ho Park
Journal of Pharmacy and Pharmacology   62(3) 352-359
Objectives Increased production and accumulation of melanin leads to many hyperpigmentation disorders such as melasma, freckles and geriatric pigment spots. Thus, there is a need for the development of depigmenting agents. Based on our previous re...
Morina Adfa, Morina Adfa, Tomohiro Itoh, Yosuke Hattori, Mamoru Koketsu
Biological and Pharmaceutical Bulletin   35 963-966   2013
Coumarin and its derivatives are well known for their anti-inflammatory and anti-oxidative effects. In this study, we synthesized 32 coumarin derivatives from commercially available 6-hydroxycoumarin (6HC) and 7-hydroxycoumarin (7HC) and examined ...
Hirokazu Hara, Yoko Nakamura, Masayuki Ninomiya, Ryosuke Mochizuki, Tetsuro Kamiya, Elias Aizenman, Mamoru Koketsu, Tetsuo Adachi
Bioorganic and Medicinal Chemistry   19 5559-5568
Activation of microglia induces the production of various inflammatory mediators including nitric oxide (NO), leading to neurodegeneration in many central nervous system diseases. In this study, we examined the effects of chalcone glycosides isola...
Tomohiro Itoh, Masayuki Ninomiya, Masaharu Yasuda, Kaneyuki Koshikawa, Yoshihiro Deyashiki, Yoshinori Nozawa, Yoshinori Nozawa, Yukihiro Akao, Yukihiro Akao, Mamoru Koketsu
Bioorganic and Medicinal Chemistry   17 5374-5379
We isolated the 4 kinds of flavonoids from strawberry 'Nohime' and examined the effect of these flavonoids on the degranulation in RBL-2H3 cells. The flavonoids were found to suppress the degranulation from Ag-stimulated RBL-2H3 cells to different...
Kazuhiko Akuzawa, Rie Yamada, Zhuan Li, Ying Li, Hidetaka Sadanari, Keiko Matsubara, Kunitomo Watanabe, Mamoru Koketsu, Yuuzo Tuchida, Tsugiya Murayama
Antiviral Research   91(3) 296-303
The anti-human cytomegalovirus (HCMV) activity of tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative from Sasa albo-marginata, was studied in the human embryonic fibroblast cell line MRC-5. In a plaque assay, tricin and ganciclovir (G...
Fortunatus Sunghwa, Hiroaki Sakurai, Ikuo Saiki, Mamoru Koketsu
Chemical and Pharmaceutical Bulletin   57(1) 112-115   Jan 2009
In this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours und...
S. Fujita, M. Ninomiya, M. Efdi, K. Ohguchi, Y. Nozawa and M. Koketsu
Nat. Prod. Res.   24 1630-1636
Six chemical constituents were isolated from Enicosanthum cupulare (King) Airy-Shaw. The structures of the isolated compounds were determined using 1D, 2D-NMR and were found to be identical to those previously reported for these compounds. Three a...
Dinesh Ramesh Garud, Mamoru Koketsu, Hideharu Ishihara
Molecules   12 504-535
Selenium-containing heterocyclic compounds have been well recognized, not only because of their remarkable reactivities and chemical properties, but also because of their diverse pharmaceutical applications. In this context, isoselenocyanates have...
Kenichi Komura, Yu Nakano, Mamoru Koketsu
Green Chemistry   13 828-831   Apr 2011
Direct amidation of fatty acids with long-chain amines was successfully performed by mesoporous silica MCM-41, which showed the highest catalytic activity among other used homo- and heterogeneous catalysts. It was found that MCM-41 can be easily r...
Yoshinori Takeda, Naomi Tanigawa, Fortunatus Sunghwa, Masayuki Ninomiya, Makoto Hagiwara, Kenji Matsushita, Mamoru Koketsu
Bioorganic and Medicinal Chemistry Letters   20(16) 4855-4857
A morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell-cell adhesion as an important role in inflammatory processes. 7-O-Cinnamoylmorroniside exhibited excellent anti-inflammatory activity (IC50 = 49.3 μM) by ...
Naomi Tanigawa, Naomi Tanigawa, Yoshinori Takeda, Fortunatus Sunghwa, Masayuki Ninomiya, Makoto Hagiwara, Mamoru Koketsu, Kenji Matsushita, Kenji Matsushita
Interface Oral Health Science 2011   161-163
© Springer 2012. E-selectin is particularly of interest in the case of inflammatory diseases owing to its expression in the activated endothelium. E-selectin mediates cell tethering and rolling interactions through the recognition of sialofucosyla...
Karthik Raman, Masayuki Ninomiya, Thao Kim Nu Nguyen, Yasuhiro Tsuzuki, Mamoru Koketsu, Balagurunathan Kuberan, Balagurunathan Kuberan, Balagurunathan Kuberan
Biochemical and Biophysical Research Communications   404(1) 86-89
Heparan sulfate proteoglycans (HSPGs) are essential players in several steps of tumor-associated angiogenesis. As co-receptors for several pro-angiogenic factors such as VEGF and FGF, HSPGs regulate receptor-ligand interactions and play a vital ro...
Mai Efdi, Kenji Ohguchi, Yukihiro Akao, Yoshinori Nozawa, Mamoru Koketsu, Hideharu Ishihara
Biological and Pharmaceutical Bulletin   30(10) 1972-1974
In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibit...
Yosuke Toyoda, Dinesh R. Garud, Mamoru Koketsu
Heterocycles   78(2) 449-456
One-pot synthesis of 2-imino-1,3-oxaselenolanes has been achieved by reactions of isoselenocyanates with 2-bromoethanol in good to excellent yields. The structure of the 2-imino-1,3-oxaselenolanes was confirmed by spectroscopic and X-ray analysis....
Kenichi Komura, Yuta Mishima, Mamoru Koketsu
Applied Catalysis A: General   445-446 128-132
The organic-inorganic hybrid catalyst was prepared by immobilizing 3-methylaminopropyl moiety onto mesoporous silica, MCM-41, and applied for solid base catalyst of three-component one-pot reaction, i.e. Knoevenagel condensation of aldehyde with t...
Fortunatus Sunghwa, Mamoru Koketsu
Natural Product Research   23 1408-1415   Oct 2009
A new bis-iridoid glucoside, cocculoside (1), has been isolated, together with five known compounds from Strychnos cocculoides (Loganiaceae), collected in Tanzania. The structure of cocculoside (1) has been determined as an ester dimer of loganin ...
Masayuki Ninomiya, Tomohiro Itoh, Suguru Ishikawa, Miho Saiki, Kenji Narumiya, Masaharu Yasuda, Kaneyuki Koshikawa, Yoshinori Nozawa, Yoshinori Nozawa, Mamoru Koketsu
Bioorganic and Medicinal Chemistry   18(16) 5932-5937
We isolated eight phenolic constituents from Fragaria ananassa Duch. (strawberry) and determined their structures using 1D, 2D-NMR. Among the isolated compounds, linocinnamarin (LN), 1-O-trans-cinnamoyl-β-d- glucopyranose (CG), and cinnamic acid (...
Koichi Kanoh, Hideharu Ishihara, Mamoru Koketsu
Synthesis   2617-2620
2-Dialkylamino-4H-5,6-dihydro-1,3-selenazin-4-ones were obtained by the reaction of N,N-unsubstituted selenoureas with α,β-unsaturated acid chlorides at room temperature. © Georg Thieme Verlag Stuttgart.
R. L. Amza, K. Oh-Hashi, Y. Yamaguchi, K. Tanaka, K. Tanaka, S. Yoshida, S. Dharma, E. Munaf, M. Koketsu
Research Journal of Pharmaceutical, Biological and Chemical Sciences   4 1392-1399   Oct 2013
A The use of microalgae for the bioremoval of heavy metals has been observed for last decades. This encourages the investigation of biomolecular study of microalgae which absorb the heavy metals. This study concerns on the biomolecular effect of m...
Dinesh R. Garud, Masayuki Ninomiya, Mamoru Koketsu
Heterocycles   81(11) 2439-2463   Dec 2010
The first β-lactam ring system was synthesized by H. Staudinger in 1907, but β-lactams as a class of compounds became attractive only after it was established that penicillin contained a β-lactam unit as the structural feature. Over the years, cou...
Masayuki Ninomiya, Dinesh R. Garud, Mamoru Koketsu
Heterocycles   81(9) 2027-2055   Dec 2010
In recent years, considerable attention has been devoted to the synthesis of selenium-containing heterocycles because of their interesting reactivities and potential pharmaceutical applications. The significant starting materials for the selenium-...
Mai Efdi, Masayuki Ninomiya, Erma Suryani, Kaori Tanaka, Kaori Tanaka, Sanusi Ibrahim, Kunitomo Watanabe, Kunitomo Watanabe, Mamoru Koketsu
Bioorganic and Medicinal Chemistry Letters   22 4242-4245
A new ring A-seco triterpenoid, sentulic acid, along with a known oleanane-type triterpenoid, 3-oxoolean-12-en-27-oic acid, were isolated from the Indonesian plant Sandoricum koetjape Merr. Their chemical structures were elucidated by spectroscopi...
Hidenori Tanaka, Hiromune Ando, Hideharu Ishihara, Mamoru Koketsu
Carbohydrate Research   343(10-11) 1585-1593
A 5-N,7-O-carbonyl-protected sialyl donor was synthesized, and, unexpectedly, this donor showed β-selectivity (α/β = 1/2.4-1/20) on coupling with sugar acceptors in acetonitrile upon treatment with various promoter systems. For the coupling reacti...
Hiroyuki Tsukagoshi, Mamoru Koketsu, Masahiko Kato, Masahiko Kurabayashi, Atsuyoshi Nishina, Hirokazu Kimura, Hirokazu Kimura
FEBS Journal   274(23) 6046-6054
Synthetic organic selenium compounds such as 2-phenyl-1,2-benzisoselenazol- 3(2H)-one may show glutathione peroxidase-like antioxidant activity. Recently, we synthesized new organic selenium compounds that are thought to be effective antioxidants....
Yosuke Toyoda, Yosuke Toyoda, Mamoru Koketsu
Tetrahedron   68 10496-10501
Selenium-containing heterocycles have been interested because of their unique reactivity and potential biological activity. Recently, several selenium-containing heterocycles bearing an exocyclic imine have been synthesized by isoselenocyanates. H...
Dinesh R. Garud, Nobuhito Tanahashi, Masayuki Ninomiya, Mamoru Koketsu
Tetrahedron   65(24) 4775-4780
The reactions of the diselenocarbamates, generated from isoselenocyanates and sodium hydroselenide, with acryloyl chlorides afforded 2-selenoxoperhydro-1,3-selenazin-4-ones. The structure of the product was confirmed by X-ray diffraction analysis....
Dinesh R. Garud, Mamoru Koketsu
Organic Letters   10(15) 3319-3322   Dec 2008
(Chemical Equation Presented) A convenient approach to synthesize novel selenium-β-lactams, 3-selena-1-dethiacephems and selenazepines, was accomplished via the regioselective iodocyclization reaction. The substituent of allenyl moieties dramatica...
Nobuhito Tanahashi, Mamoru Koketsu
Tetrahedron Letters   52(36) 4650-4653
Reaction of isoselenocyanates with aminoacetonitriles afforded 4-amino-2-selenoxo-1,3-imidazole-2-selenones, whereas reaction with aminopropionitriles led to selenoureas. We confirmed that it is easy to distinguish between selenoamides and selenou...
Kenichi Komura, Tomoyuki Murase, Yoshihiro Sugi, Mamoru Koketsu
Chemistry Letters   39(9) 948-949
Boron-containing CDS-1 zeolite with CDO topology can be obtained from the layered borosilicate PLS-1 which was prepared from layered silicate H-LDS by dry-gel conversion. Pure crystals of [B]-PLS-1 can be formed in the range of Si/B ratio from ∞ t...
Dinesh R. Garud, Hiromune Ando, Yumiko Kawai, Hideharu Ishihara, Mamoru Koketsu
Organic Letters   9(22) 4455-4458
(Chemical Equation Presented) Selenapenams, selenacephems, and selenazepines were synthesized using a 2-(trimethylsilyl)ethyl (TSE) protection approach in an extremely simple way. TSE protection for selenium is used for the first time in the synth...
Caitlin Mencio, Dinesh R. Garud, Balagurunathan Kuberan, Mamoru Koketsu
Methods in Molecular Biology   1229 69-78
© Springer Science+Business Media New York 2015. Glycosaminoglycan (GAG) side chains of proteoglycans are involved in a wide variety of developmental and pathophysiological functions. Similar to a gene knockout, the ability to inhibit GAG biosynth...
Dinesh R. Garud, Deepali D. Garud, Mamoru Koketsu
Organic and Biomolecular Chemistry   7(12) 2591-2598
The stereoselective insertion of allyl-seleno moieties at the C(4) position of azetidinones and further ring-closing metathesis afforded novel selenium-containing bicyclic β-lactams. © The Royal Society of Chemistry 2009.
Dinesh R. Garud, Dinesh R. Garud, Masaki Makimura, Mamoru Koketsu
New Journal of Chemistry   35(3) 581-586
The bis-2-(trimethylsilyl)ethyl diselenide was prepared and used as a selenating reagent for the insertion of the 2-(trimethylsilyl)ethylseleno group at the C-4 position of the azetidinones. Bis-4-(azetidin-2-one) diselenides were used for the fir...
Hidenori Tanaka, Hiromune Ando, Hiromune Ando, Hideharu Ishida, Makoto Kiso, Makoto Kiso, Hideharu Ishihara, Mamoru Koketsu
Tetrahedron Letters   50(31) 4478-4481
An attempt to synthesize α(2→8)-linked oligosialic acid utilizing a 1,5-lactamized sialyl acceptor is described. 1,5-Lactamization was experimentally proven to proceed only for α-sialoside, which was integrated into the synthetic cycle of oligosia...
Mai Efdi, Tomohiro Itoh, Yukihiro Akao, Yoshinori Nozawa, Mamoru Koketsu, Hideharu Ishihara
Bioorganic and Medicinal Chemistry   15 3667-3671   Dec 2008
Four compounds were isolated from Enicosanthum membranifolium. The structures of the compounds were confirmed by spectroscopic data. Their structures were determined as N-trans-feruloyltyramine, R-(-)-mellein, clerodermic acid, and salicifoline ch...
Naoko Seki, Naoko Seki, Uhi Toh, Uhi Toh, Koji Kawaguchi, Masayuki Ninomiya, Mamoru Koketsu, Kunitomo Watanabe, Masatora Aoki, Teruhiko Fujii, Teruhiko Fujii, Teruhiko Fujii, Anna Nakamura, Yoshito Akagi, Jingo Kusukawa, Masayoshi Kage, Masayoshi Kage, Kazuo Shirouzu, Hideaki Yamana, Hideaki Yamana, Hideaki Yamana
Journal of Cellular Biochemistry   113 2346-2355
4',5,7-Trihydroxy-3',5'-dimethoxyflavone (Tricin), a naturally occurring flavone, has anti-inflammatory potential and exhibits diverse biological activities including antigrowth activity in several human cancer cell lines and cancer chemopreventiv...
H. Ishihara, M. Koketsu, Y. Fukuta and F. Nada
J. Am. Chem. Soc.   123(34) 8408-8409   2001
M. Koketsu, M. Ishida, N. Takakura and H. Ishihara
J. Org. Chem.   67(2) 486-490   2002
M. Koketsu, Y. Fukuta and H. Ishihara
Tetrahedron Lett.   42(36) 6333-6335   2001
M. Koketsu, M. Kanoh, E. Itoh and H. Ishihara
J. Org. Chem.   66(11) 4099-4101   2001
M. Koketsu, H. O. Yang, Y. M. Kim, M. Ichihashi and H. Ishihara
Org. Lett.   3(11) 1705-1707   2001
M. Koketsu, Y. Takenaka and H. Ishihara
Synthesis   (5) 731-734   2001
M. Koketsu, B. Kuberan and Robert J. Linhardt
Org. Lett.   2(21) 3361-3363   2000
Facile preparation of 1,3-selenazine derivatives by reaction of primary selenoamides with α,β-unsaturated aldehydes of in the presence of BF3-Et2O
M. Koketsu, Y. Takenaka, S. Hiramatsu and H. Ishihara
Heterocycles   55 1181-1188   2001
S. I. Cho, M. Koketsu, H. Ishihara, M. Matsushita, A. C. Nairn, H. Fukazawa and Y. Uehara
Biochim. Biophys. Acta   1475 207-215   2000
M. Koketsu and R. J. Linhardt
Anal. Biochem.   283(2) 136-145   2000
Induction of apoptosis in human gastric adenocarcinoma cells by two novel organoselenium compounds, TS-2 and TS-6.
W. Wu, K. Murakami, M. Koketsu, Y. Yamada and I. Saiki
Anticancer Res.   19 5375-5381   1999
K. Ichimura, K. Kohata, Y. Yamaguchi, M. Douzono, H. Ikeda and M. Koketsu
Biosci. Biotechnol. Biochem.   64(4) 865-868   2000
M. Koketsu, N. Suzuki and H. Ishihara
J. Org. Chem.   64(17) 6473-6475   1999
M. Koketsu, H. Ishihara, W. Wu, K. Murakami and I. Saiki
Eur. J. Pharm. Sci.   9(2) 157-161   1999
Synthesis and characterization of novel 1,3-selenazine derivatives. BF3-Et2O-assisted reaction of primary selenoamides with α,β-unsaturated ketones
M. Koketsu, T. Senda, K. Yoshimura and H. Ishihara
J. Chem. Soc., Perkin Trans. 1   453-456   1999
Absolute configuration of the active stereoisomer of new rice fungicide carpropamid.
M. Koketsu, S. Kagabu and M. Matsuoka
Acta Crystallogr.   C55 1025-1027   1999
M. Koketsu
J. Food Process Eng.   22(5) 359-366   1999
M. Koketsu, Y. Miyajima and H. Ishihara
Chem. Lett.   (7) 645-646   1998
Novel compounds, 1,3-selenazine derivatives, as antibacterial agents against Escherichia coli and Staphylococcus aureus.
M. Koketsu, H. Ishihara and M. Hatsu
Res. Commun. Mol. Pathol. Pharmacol.   101 179-186   1998
Facile synthesis of N,N-dialkylselenoamide from amide.
M. Koketsu, Y. Okayama, H. Aoki and H. Ishihara
Heteroatom Chem.   13 195-198   2002
M. Koketsu, F. Nada, S. Hiramatsu and H. Ishihara
J. Chem. Soc., Perkin Trans. 1   (6) 737-740   2002
Synthesis of 3-alkylseleno-2-cylcobutenone via [2+2] cycloaddition reaction of alkyneselenolate with diphenylketene.
M. Koketsu, M. Kanoh and H. Ishihara
Synlett   805-807   2002
M. Koketsu, K. Tanaka, Y. Takenaka, C. D. Kwong and H. Ishihara
Eur. J. Pharm. Sci.   15 307-310   2002
M. Koketsu, M. Okumura and H. Ishihara
Heteroatom Chem.   13 377-379   2002
B. Kuberan, Q. Wang, M. Koketsu, R.J. Linhardt
Synthetic Commun.   32(9) 1421-1426   2002
M. Koketsu, N. Takakura and H. Ishihara
Synthetic Commun.   32(19) 3075-3079   2002
L. R. Juneja, M. Koketsu, K. Nishimoto, M. Kim, T. Yamamoto and T. Itoh
Carbohydr. Res.   214(1) 179-186   1991
Antioxidant from green tea extract.
M. Koketsu
Food Ingredients Europe Conference   288-292   1991

Books etc

 
Synthesis of selective inhibitors of heparan sulfate and chondroitin sulfate proteoglycan biosynthesis in Methods in molecular biology
Mencio Caitlin; Garud Dinesh R; Kuberan Balagurunathan; and Mamoru Koketsu
Springer New York   2015   
Compounds containing the carbon-chalcogen C-E (E = S, Se, Te) bond in Handbook of Chalcogen Chemistry
M. Koketsu
Royal Society of Chemistry, London, UK   2013   
Minor Flavonoids in Natural Products
Chalcones, Flavanones, Dihydrochalcones, and Aurones, M. Ninomiya and M. Koketsu
Springer, Heidelberg, Germany   2013   
1,3-Selenazoles, in Comprehensive Heterocyclic Chemistry III
M. Koketsu and H. Ishihara
Elsevier, Oxford, UK   2008   
Four-membered rings with one Selenium or Tellurium atom, in Comprehensive Heterocyclic Chemistry III
M. Koketsu and H. Ishihara
Elsevier, Oxford, UK   2008   
Chapter 2.09 Four-membered rings with one Selenium or Tellurium atom, (M. Koketsu and H. Ishihara) in Comprehensive Heterocyclic Chemistry III, p 463-477
A. R. Katritzky, C. A. Ramsden, E. F. V. Scriven, R. Taylor EDs, Elsevier, Oxford, UK   2008   
Chapter 4.08 1,3-Selenazoles, (M. Koketsu and H. Ishihara) in Comprehensive Heterocyclic Chemistry III, p 791-821
A. R. Katritzky, C. A. Ramsden, E. F. V. Scriven, R. Taylor EDs, Elsevier, Oxford, UK   2008   
Thioamides, thioureas and related selenium and tellurium compoundsin Handbook of Chalcogen Chemistry
M. Koketsu and H. Ishihara
Royal Society of Chemistry, London, UK   2006   
Thioamides, thioureas and related selenium and tellurium compounds (M. Koketsu and H. Ishihara) in Handbook of Chalcogen Chemistry: New Perspectives in Sulfur, Selenium and Tellurium、p 145-194
F. A. Devillanova ED, Royal Society of Chemistry, London, UK   2006   
Antioxidative activity of tea polyphenols, in Chemistry and applications of green tea
M. Koketsu
CRC Press, New York, USA   1997   
Glycochemistry of hen eggs, in Hen eggs - Their basic and applied science,
M. Koketsu
CRC Press, New York, USA   1997   
Antioxidative activity of tea polyphenols (M. Koketsu) in Chemistry and application of green tea, T. Yamamoto ED.
CRC Press, Florida, USA   1997   
Glycochemistry of hen eggs (M. Koketsu) in Hen eggs - Their basic and applied science, T. Yamamoto ED.
CRC Press, Florida, USA   1997   
Guide to Instrumental Analysis
Aug 2006   
Large-scale preparation of sialic acid and its derivatives from chalaza and delipidated egg yolk, in Egg uses and processing technologies
L. R. Juneja, M. Koketsu, H. Kawanami, K. Sasaki, M. Kim and T. Yamamoto
CAB INTERNATIONAL, Oxon, UK   1994   
Large-scale preparation of sialic acid and its derivatives from chalaza and egg yolk (L. R. Juneja, M. Koketsu, H. Kawanami, K. Sasaki, M. Kim and, T. Yamamoto) in Egg uses and processing technologies, New Developments, J.S. Sim and S. Nakai eds.
CAB INTERNATIONAL, Oxon, UK   1994   
Thioamides, thioureas and related selenium and tellurium compounds
Koketsu Mamoru (Division of Instrumental Analysis, Life Science Research Center, Gifu University), Ishihara Hideharu (Department of Chemistry, Faculty of Engineering, Gifu University)
Oct 2006   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2011 - 2013    Investigator(s): Mamoru KOKETSU
This study investigated the development of various GAG biosynthesis inhibitors introducing hydrophobic moieties into xylose.The current study demonstrates that fluoro-xylosides are effective inhibitors of endothelial tube formation in vitro using ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010    Investigator(s): Mamoru KOKETSU
Recently, there is a tremendous amount of preparation of selenium-containing compounds because of not only interesting reactivity but also biological activity. In this study, we have developed novel selenating reagent prepared by the reaction of p...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2006    Investigator(s): Mamoru KOKETSU
Compounds bearing multiple active sites are very useful as starting materials for heterocyclic compounds. However, there are limited number of reports of applications using selenium compounds such as selenourea, selenoamide, selenazadiene, and ace...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2002 - 2003    Investigator(s): Mamoru KOTETSU
Recently, we have developed novel selenating reagent (LiAlHSeH) which is simple method, capable of preparing it only by stirring two kinds of agent in organic solvent. The LiAlHSeH formed in situ was ready for further reaction without concentratio...
Synthesis of novel compounds including selenium

Patents

 
5557045 : ISOPRENOID COMPOUND, METHOD FOR PRODUCING THE SAME, AND ANTIOXIDANT
KOKETSU MAMORU,NINOMIYA MASAYUKI,YAMAGUCHI YUJI,TAKENAKA HIROYUKI
US Patent 登録番号 US7,033,564 B2 : Lithium Aluminum Hydride-Based Selenating Reagent and Preparation Methods Using Same
M. Koketsu and H. Ishihara
5765687 : AUTOPHAGICCELLDEATHINDUCER
KOKETSUMAMORU,ITOTOMOHIRO,TAKENAKAHIROYUKI
US Patent Application, Pub. No. US 2003/0158239 A1 : Novel 1,3-selenazolin derivatives and process for preparing the same
M. Koketsu and H. Ishihara
0420303(韓国) : 1,4-Oxaselenin derivatives, the method thereof and antitumor agents containing them
H. O. Yang, Y. M. Kim, M. Koketsu and H. Ishihara