2005年11月
Canine mdr1 gene mutation in japan
JOURNAL OF VETERINARY MEDICAL SCIENCE
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- ,
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- 巻
- 67
- 号
- 11
- 開始ページ
- 1103
- 終了ページ
- 1107
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1292/jvms.67.1103
- 出版者・発行元
- JAPAN SOC VET SCI
Frequency of the 4-bp deletion mutant in canine mdr1 gene was examined in 193 dogs of eight breeds in Japan. The mutant allele was found in Collies, Australian Shepherds, and Shetland Sheepdogs, where its respective frequencies were 58.3%, 33.3%, and 1.2%. The MDR1 protein was detected on peripheral blood mononuclear cells (PBMC) from a MDR1/MDR1 dog, but not on PBMC from a mdr1-1 Delta/mdr1-1 Delta Collie. Rhodamine 123 was extruded from MDR1/MDR1 lymphocytes. That excretion was inhibited by a MDR1 inhibitor, verapamil. On the other hand, Rh123 excretion was not observed from lymphocytes derived from a mdr1-1 Delta/mdr1-1 Delta Collie. These results indicated that the mutant mdr1 allele also existed in Collie-breed dogs in Japan at high rates and that mdr1-1 Delta /mdr1-1 Delta dogs have no functional MDR1.
- リンク情報
- ID情報
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- DOI : 10.1292/jvms.67.1103
- ISSN : 0916-7250
- CiNii Articles ID : 130000448406
- Web of Science ID : WOS:000233835800004