2012年2月
Genetic variation in the C-terminal domain of arginine vasotocin receptor in avian species
GENE
- ,
- ,
- 巻
- 494
- 号
- 2
- 開始ページ
- 174
- 終了ページ
- 180
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.gene.2011.12.019
- 出版者・発行元
- ELSEVIER SCIENCE BV
Arginine vasotocin (AVT) is a neurohypophysial hormone that plays an essential role in various social behaviours. We investigated the degree of polymorphisms in the C-terminal domain of the AVT V2-type receptor (AVT2R) among avian species to determine the mechanism by which genetic polymorphisms in the neuropeptide receptor may contribute to different levels of signal transduction. In passerine birds. AVT2R was characterised by 2 variable regions, both of which were managed by insertion/deletion (indel): however, indels were rarely found in other avian taxa. The presence or absence of deletions in passerines largely affected the properties of the predicted palmitoylation sites at the proximal part of the C-terminal tail. Moreover, we detected intraspecific polymorphisms in estrildid finches based on the number of tri-amino acid (GHQ/EHQ/EHR) repeats in another variable region. Our results indicate that amino acid substitutions and length variation at the C-terminus may impact subsequent signal transduction and affect behavioural traits in wild birds. (C) 2011 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.gene.2011.12.019
- ISSN : 0378-1119
- PubMed ID : 22197655
- Web of Science ID : WOS:000301096900004