Toshihisa Tanaka - My portal

Profile Information

Affiliation: Graduate School of Medicine, Graduate School of Medicine, Osaka University

Degree: Doctor(Medicine)(Osaka University)

J-GLOBAL ID: 200901078691947871
researchmap Member ID: 1000220406

Research Interests

Research History

2002 - 2004

: 大阪大学医学部講師
2002 - 2004

: Assistant Professor, Faculty of Medicine,
1997 - 2002

: 大阪大学医学部助手
1997 - 2002

: Research Associate, Faculty of Medicine,
Osaka University

Education

- 1993

Osaka University
- 1993

Graduate School, Division of Medicine, Osaka University
- 1988

Medical School, Faculty of Medicine, Osaka University
- 1988

Faculty of Medicine, Osaka University

Committee Memberships

Misc.

Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3 zeta protein

Golam Sadik, Toshihisa Tanaka, Kiyoko Kato, Kentaro Yanagi, Takashi Kudo, Masatoshi Takeda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 383(1) 37-41, May, 2009
Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3 zeta protein

Golam Sadik, Toshihisa Tanaka, Kiyoko Kato, Kentaro Yanagi, Takashi Kudo, Masatoshi Takeda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 383(1) 37-41, May, 2009
Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor

Naohiro Itoh, Masayasu Okochi, Shinji Tagami, Kouhei Nishitomi, Taisuke Nakayama, Kanta Yanagida, Akio Fukumori, Jingwei Jiang, Kohji Mori, Motoko Hosono …

NEURODEGENERATIVE DISEASES, 6(5-6) 230-239, 2009
Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation

Golam Sadik, Toshihisa Tanaka, Kiyoko Kato, Hidenaga Yamamori, Begum Nurun Nessa, Takashi Morihara, Masatoshi Takeda

JOURNAL OF NEUROCHEMISTRY, 108(1) 33-43, Jan, 2009
Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor

Naohiro Itoh, Masayasu Okochi, Shinji Tagami, Kouhei Nishitomi, Taisuke Nakayama, Kanta Yanagida, Akio Fukumori, Jingwei Jiang, Kohji Mori, Motoko Hosono …

NEURODEGENERATIVE DISEASES, 6(5-6) 230-239, 2009
Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation

Golam Sadik, Toshihisa Tanaka, Kiyoko Kato, Hidenaga Yamamori, Begum Nurun Nessa, Takashi Morihara, Masatoshi Takeda

JOURNAL OF NEUROCHEMISTRY, 108(1) 33-43, Jan, 2009
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon 4 carriers

Nuripa Jenishbekovna Aidaralieva, Kouzin Kamino, Ryo Kimura, Mitsuko Yamamoto, Takeshi Morihara, Hiroaki Kazui, Ryota Hashimoto, Toshihisa Tanaka, Takashi Kudo, Tomoyuki Kida …

JOURNAL OF HUMAN GENETICS, 53(4) 296-302, Apr, 2008
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon 4 carriers

Nuripa Jenishbekovna Aidaralieva, Kouzin Kamino, Ryo Kimura, Mitsuko Yamamoto, Takeshi Morihara, Hiroaki Kazui, Ryota Hashimoto, Toshihisa Tanaka, Takashi Kudo, Tomoyuki Kida …

JOURNAL OF HUMAN GENETICS, 53(4) 296-302, Apr, 2008
Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-1.

Mol Cell Biol, 28:165-176, 2008
Mild Cognitive Impairment (MCI) and Subjective Cognitive Impairment (SCI).

Psycogeriatrics, 8;155-160, 2008
Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-1.

Mol Cell Biol, 28:165-176, 2008
Mild Cognitive Impairment (MCI) and Subjective Cognitive Impairment (SCI).

Psycogeriatrics, 8;155-160, 2008
Biological markers as outcome measures for Alzheimer's disease interventions - real problems and future possibilities

Masatoshi Takeda, Masayasu Okochi, Shinji Tagami, Toshihisa Tanaka, Takashi Kudo

INTERNATIONAL PSYCHOGERIATRICS, 19(3) 391-400, Jun, 2007
Biological markers as outcome measures for Alzheimer's disease interventions - real problems and future possibilities

Masatoshi Takeda, Masayasu Okochi, Shinji Tagami, Toshihisa Tanaka, Takashi Kudo

INTERNATIONAL PSYCHOGERIATRICS, 19(3) 391-400, Jun, 2007
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

Ryo Kimura, Kouzin Kamino, Mitsuko Yamamoto, Aidaralieva Nuripa, Tomoyuki Kida, Hiroaki Kazui, Ryota Hashimoto, Toshihisa Tanaka, Takashi Kudo, Hidehisa Yamagata …

HUMAN MOLECULAR GENETICS, 16(1) 15-23, Jan, 2007
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

Ryo Kimura, Kouzin Kamino, Mitsuko Yamamoto, Aidaralieva Nuripa, Tomoyuki Kida, Hiroaki Kazui, Ryota Hashimoto, Toshihisa Tanaka, Takashi Kudo, Hidehisa Yamagata …

HUMAN MOLECULAR GENETICS, 16(1) 15-23, Jan, 2007
Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.

Psychiatry Clin Neurosci., 60 Suppl. 1; S27-S33., 2006
Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.

Psychiatry Clin Neurosci., 60 Suppl. 1; S27-S33., 2006
Amyloid-β down-regulates XIAP expression in human SH-SY5Y neuroblastoma cells

Hidenaga Yamamori, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda

NeuroReport, 15(5) 851-854, Apr 9, 2004
Amyloid-β down-regulates XIAP expression in human SH-SY5Y neuroblastoma cells.

NeuroReport, 15;851-854., 2004

Books and Other Publications

100 Papers Selection ANNUAL REPORT OF OSAKA UNIVERSITY-Academic Achievement-/2007-2008

Osaka University, 2009
100 Papers Selection ANNUAL REPORT OF OSAKA UNIVERSITY-Academic Achievement-/2007-2008

Osaka University, 2009
現代老年精神医療

永井書店, 2005
現代老年精神医療

永井書店, 2005
Activated protein kinases and phosphorylated tau protein in Alzheimer disease

Molecalar neurobiology of Alzheimer disease and related disorders, 2004
Actirated protein kinases and phosphorylated tau protein in Alzheimer disease

Molecalar neurobiology of Alzheimer disease and related disrders, 2004

Professional Memberships

Research Projects

アルツハイマー病脳における細胞骨格蛋白の変化に関する研究

未来開拓学術研究推進事業
Study on Alteration of Cytoskeletal proteins in Alzheiner disease

Research for the Future Program