Kanakura Yuzuru (Yuzuru Kanakura) - マイポータル - researchmap

基本情報

所属: 大阪大学

学位: 博士(医学)(大阪大学)

J-GLOBAL ID: 200901094288813640
researchmap会員ID: 1000220614

研究分野

1

ライフサイエンス / 血液、腫瘍内科学 /

経歴

5

1997年

-: - 大阪大学医学部教授
1997年

-: - Professor, Osaka University Medical School
1985年 - 1996年

: 大阪大学医学部助手
1985年 - 1996年

: Assistant professor Osaka University Medical
School

学歴

4

MISC

24

Shibayama, H., Takai, E., Matsumura, I., Kouno, M., Morii, E., Kitamura, Y., Takeda, J., and Kanakura, Y. Identification of a cytokine-induced anti-apoptotic molecule Anamorsin essential for definitive hematopoiesis.

J. Exp. Med. 199: 581-592 2004年
Hashimoto, K., Matsumura, I., Tsujimura, T., Kim, D., Ogihara, H., Ikeda, H., Kitayama, H., Odajima, J., Ueda, S., Mizuki, M., Kitamura, Y., and Kanakura, Y. Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in cons・・・

Blood 101: 1094-1102 2003年
Ueda, S., Mizuki, M., Ikeda, H., Tujimura, T., Matsumura, I., Nakano, K., Daino, H., Honda, Z., Sonoyama, J., Shibayama, H., Sugahara, H., Machii, T., and Kanakura, Y. Critical roles of c-kit tyrosine residues 567 and 719 in stem cell factor-induced ・・・

Blood 99:3342-3349 2002年
Tanaka、H., Matsumura, I., Ezoe, S., Sato, Y., Sakamaki, T., Albanese, C., Machii, T., Pestell, R. G., and Kanakura, Y. E2F-1 and c-Myc potentiate apoptosis through inhibition of NFkB activity that facilitates MnSOD-mediated ROS elimination.

Mol. Cell 9:1017-1029 2002年
Kawasaki, A., Matsumura, I., Miyagawa, J., Ezoe, S., Tanaka, H., Terada, Y., Tatsuka, M., Machii, T., Miyazaki, H., Furukawa, Y., and Kanakura. Y. Down-regulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic ・・・

J. Cell Biol. 152:275-287 2001年
Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells

H Daino, Matsumura, I, K Takada, J Odajima, H Tanaka, S Ueda, H Shibayama, H Ikeda, M Hibi, T Machii …

BLOOD 95(8) 2577-2585 2000年4月
GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and Bcl-2 in a murine myeloid cell line M1

H Tanaka, Matsumura, I, K Nakajima, H Daino, J Sonoyama, H Yoshida, K Oritani, T Machii, M Yamamoto, T Hirano …

BLOOD 95(4) 1264-1273 2000年2月
Matsumura, I., Kitamura, T.,Wakao, H., Tanaka, H., Hashimoto, K., Albanese, C., Downward, J., Pestell, R. G., and Kanakura, Y. Transcriptional regulation of cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells.

EMBO J 18:1367-1377 1999年
Constitutively activating mutation in the catalytic domain of c-kit receptor tyrosine kinase elicits hematopoietic transformation by receptor self-asociation not at the ligand-dependent dimerization site.

Blood 93 1319-1329 1999年
Transcriptional regulation of cyclin D1 promoter by STAT5 : its involvement in cytokine-dependent growth of hematopoietic cells.

EMBO J. 18(5) 1367-1377 1999年
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene

T Nishida, S Hirota, M Taniguchi, K Hashimoto, K Isozaki, H Nakamura, Y Kanakura, T Tanaka, A Takabayashi, H Matsuda …

NATURE GENETICS 19(4) 323-324 1998年8月
Involvement of prolonged ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line

Matsumura, I, K Nakajima, H Wakao, S Hattori, K Hashimoto, H Sugahara, T Kato, H Miyazaki, T Hirano, W Kanakura

MOLECULAR AND CELLULAR BIOLOGY 18(7) 4282-4290 1998年7月
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

S Hirota, K Isozaki, Y Moriyama, K Hashimoto, T Nishida, S Ishiguro, K Kawano, M Hanada, A Kurata, M Takeda …

SCIENCE 279(5350) 577-580 1998年1月
Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia

Y Horikawa, Matsumura, I, K Hashimoto, M Shiraga, S Kosugi, S Tadokoro, T Kato, H Miyazaki, Y Tomiyama, Y Kurata …

BLOOD 90(10) 4031-4038 1997年11月
A new protein containing an SH2 domain that inhibits JAK kinases

TA Endo, M Masuhara, M Yokouchi, R Suzuki, H Sakamoto, K Mitsui, A Matsumoto, S Tanimura, M Ohtsubo, H Misawa …

NATURE 387(6636) 921-924 1997年6月
Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5

Matsumura, I, J Ishikawa, K Nakajima, K Oritani, Y Tomiyama, JI Miyagawa, T Kato, H Miyazaki, Y Matsuzawa, Y Kanakura

MOLECULAR AND CELLULAR BIOLOGY 17(5) 2933-2943 1997年5月
Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase

H Kitayama, T Tsujimura, Matsumura, I, K Oritani, H Ikeda, J Ishikawa, M Okabe, M Suzuki, K Yamamura, Y Matsuzawa …

BLOOD 88(3) 995-1004 1996年8月
Role of aspartic aced 814 in the function and expression of c-kit receptor tyrosine kinase

J. Biol. Chem 271(7) 3347-3350 1996年
Constitutive activation of c-kit in FMA3 murine mastocytoma cells caused by deletion of seven amino acids at the juxtamembrane domain

T Tsujimura, M Morimoto, K Hashimoto, Y Moriyama, H Kitayama, Y Matsuzawa, Kitamura, V, Y Kanakura

BLOOD 87(1) 273-283 1996年1月
GROWTH-RESPONSE OF ACUTE MYELOBLASTIC-LEUKEMIA CELLS TO RECOMBINANT HUMAN THROMBOPOIETIN

MATSUMURA, I, Y KANAKURA, T KATO, H IKEDA, J ISHIKAWA, Y HORIKAWA, K HASHIMOTO, Y MORIYAMA, T TSUJIMURA, T NISHIURA …

BLOOD 86(2) 703-709 1995年7月

もっとみる

所属学協会

5

共同研究・競争的資金等の研究課題

2