論文

査読有り 国際誌
2018年1月

Anti-SS-A/Ro antibody positivity as a risk factor for relapse in patients with polymyositis/dermatomyositis.

Modern rheumatology
  • Noriko Tatebe
  • ,
  • Ken-Ei Sada
  • ,
  • Yosuke Asano
  • ,
  • Sonia Zeggar
  • ,
  • Sumie Hiramatsu
  • ,
  • Yoshia Miyawaki
  • ,
  • Keiji Ohashi
  • ,
  • Michiko Morishita
  • ,
  • Takayuki Katsuyama
  • ,
  • Eri Katsuyama
  • ,
  • Haruki Watanabe
  • ,
  • Mariko Narazaki
  • ,
  • Katsue Watanabe
  • ,
  • Tomoko Kawabata
  • ,
  • Jun Wada

28
1
開始ページ
141
終了ページ
146
記述言語
英語
掲載種別
DOI
10.1080/14397595.2017.1317377

OBJECTIVE: The objective of this study is to elucidate predictors of relapse in patients with polymyositis and dermatomyositis (PM/DM). METHODS: Fifty PM/DM patients who achieved disease stabilization at Okayama University Hospital in 2004-2014 were enrolled retrospectively. Candidate predictors such as demographic factors, clinical symptoms, laboratory data, and treatment status were compared. RESULTS: The mean age of enrolled patients was 58 years; 34 were female. The patient groupings were as follows: 21 with PM, 27 with DM, and two with clinically amyopathic DM. During a mean observation period of 685 d, 5 patients (10%) died and 20 (40%) relapsed. The relapsed patients displayed baseline muscle weakness less frequently (85% versus 100%, p = .03) and anti-SS-A/Ro antibody more frequently (65% versus 27%, p = .007). Anti-SS-A/Ro-positive patients exhibited a higher relapse rate than anti-SS-A/Ro-negative patients (log-rank test, p = .03). Anti-SS-A/Ro-positive patients also exhibited higher anti-Jo-1 antibody positivity and lower levels of serum complement. After adjusting anti-Jo-1 antibody positivity, age, sex, CK <500 IU/L, and lung involvement, anti-SS-A/Ro positivity was still an independent risk factor for higher relapse-rate (odds ratio, 5.5; 95% confidence interval, 1.4-25.1). CONCLUSIONS: Anti-SS-A/Ro antibody positivity may be a useful biomarker for prediction of relapse.

リンク情報
DOI
https://doi.org/10.1080/14397595.2017.1317377
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28463039
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.1080/14397595.2017.1317377
  • ORCIDのPut Code : 43365837
  • PubMed ID : 28463039

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