論文

査読有り 国際誌
2019年2月

Effect of an enhanced recovery after surgery protocol in patients undergoing pancreaticoduodenectomy: A randomized controlled trial.

Clinical nutrition (Edinburgh, Scotland)
  • Kosei Takagi
  • Ryuichi Yoshida
  • Takahito Yagi
  • Yuzo Umeda
  • Daisuke Nobuoka
  • Takashi Kuise
  • Shiro Hinotsu
  • Takashi Matsusaki
  • Hiroshi Morimatsu
  • Jun Eguchi
  • Jun Wada
  • Masuo Senda
  • Toshiyoshi Fujiwara
  • 全て表示

38
1
開始ページ
174
終了ページ
181
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.clnu.2018.01.002

BACKGROUND & AIMS: Evidence of the advantages of enhanced recovery after surgery (ERAS) protocols following pancreaticoduodenectomy (PD) is limited. The aim of this study was to examine the efficiency of ERAS protocols in patients following PD. METHODS: Between June 2014 and October 2016, patients undergoing PD were randomly assigned to receive ERAS protocols or standard care. The primary endpoint was the postoperative length of stay. Secondary endpoints included postoperative complications, postoperative quality-of-life (QoR-40J), readmission, and medical cost. RESULTS: Of 80 eligible patients, 74 were analyzed in intention-to-treat principles: 37 in the control group and 37 in the ERAS group. The mean length of stay in the ERAS group was significantly shorter than that in the control group (20.1 ± 5.4 vs 26.9 ± 13.5 days, P < 0.001). The ERAS group had a significantly lower percentage of postoperative complications (32.4% vs 56.8%, P = 0.034) and readmissions (0% vs 8.1%, P = 0.038). Quality-of-life was also significantly better in the ERAS group (184 ± 12.4 vs 177 ± 14.5, P = 0.022). The total medical cost was lower in the ERAS group, but not significantly ($25,445 ± 5065 vs $28,384 ± 9999, P = 0.085). CONCLUSIONS: The optimization of ERAS protocols in patients undergoing PD is safe and accelerates perioperative recovery and quality-of-life, thereby reducing the length of stay. Morbidity was significantly decreased in the ERAS group without compromising surgical outcome. REGISTRATION NUMBER: UMIN000014068.

リンク情報
DOI
https://doi.org/10.1016/j.clnu.2018.01.002
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29373148
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.1016/j.clnu.2018.01.002
  • ORCIDのPut Code : 43365841
  • PubMed ID : 29373148

エクスポート
BibTeX RIS