論文

査読有り
2018年3月1日

Serum cystatin C is an independent biomarker associated with the renal resistive index in patients with chronic kidney disease

PLoS ONE
  • Ayu Ogawa-Akiyama
  • ,
  • Hitoshi Sugiyama
  • ,
  • Masashi Kitagawa
  • ,
  • Keiko Tanaka
  • ,
  • Akifumi Onishi
  • ,
  • Toshio Yamanari
  • ,
  • Hiroshi Morinaga
  • ,
  • Haruhito Adam Uchida
  • ,
  • Kazufumi Nakamura
  • ,
  • Hiroshi Ito
  • ,
  • Jun Wada

13
3
開始ページ
e0193695
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0193695
出版者・発行元
Public Library of Science

Cystatin C is a cysteine protease inhibitor that is produced by nearly all human cells. The serum level of cystatin C is a stronger predictor of the renal outcome and the risk of cardiovascular events than the creatinine level. The resistive index (RI) on renal Doppler ultrasonography is a good indicator of vascular resistance as well as the renal outcomes in patients with chronic kidney disease (CKD). However, it is unclear whether serum cystatin C is associated with signs of vascular dysfunction, such as the renal RI. We measured the serum cystatin C levels in 101 CKD patients and investigated the relationships between cystatin C and markers of vascular dysfunction, including the renal RI, ankle-brachial pulse wave velocity (baPWV), intima-media thickness (IMT), and cardiac function. The renal RI was significantly correlated with the serum cystatin C level (p &lt
0.0001, r = 0.6920). The serum cystatin C level was found to be a significant determinant of the renal RI (p &lt
0.0001), but not the baPWV, in a multivariate regression analysis. The multivariate odds ratio of the serum cystatin C level for a renal RI of more than 0.66 was statistically significant (2.92, p = 0.0106). The area under the receiver-operating characteristic curve comparing the sensitivity and specificity of cystatin C for predicting an RI of more than 0.66 was 0.882 (cutoff value: 2.04 mg/L). In conclusion, the serum cystatin C level is an independent biomarker associated with the renal RI in patients with CKD.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0193695
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29513723
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.1371/journal.pone.0193695
  • ISSN : 1932-6203
  • ORCIDのPut Code : 43365849
  • PubMed ID : 29513723
  • SCOPUS ID : 85043272980

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