論文

査読有り
2017年10月

Immunohistochemistry of Vasohibin-2 in Human Kidney Disease: Implications in Impaired Glucose Tolerance and Reduced Renal Function

ACTA MEDICA OKAYAMA
  • Yuka Arata
  • ,
  • Katsuyuki Tanabe
  • ,
  • Norikazu Hinamoto
  • ,
  • Hiroko Yamasaki
  • ,
  • Hitoshi Sugiyama
  • ,
  • Yohei Maeshima
  • ,
  • Naoki Kanomata
  • ,
  • Yasufumi Sato
  • ,
  • Jun Wada

71
5
開始ページ
369
終了ページ
380
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18926/AMO/55434
出版者・発行元
OKAYAMA UNIV MED SCHOOL

Several angiogenesis-related factors are known to play important roles in the pathogenesis of kidney disease. Vasohibin-2 (VASH-2) was recently reported as a novel proangiogenic factor. Although VASH-2 was demonstrated to accelerate tumor angiogenesis, its roles in non-tumor processes including renal disease have not been well elucidated yet. Here, we performed a retrospective study including an immunohistochemical analysis of human kidney biopsy specimens from 82 Japanese patients with a variety of kidney diseases, and we evaluated the correlations between the immunoreactivity of VASH-2 and the patients' clinicopathological parameters. VASH-2 immunoreactivity was detected in varying degrees in renal tubules as well as in peritubular capillaries and vasa recta. The cortical and medullary tubule VASH-2(+) scores were correlated with the presence of hypertension, and the medullary tubule VASH-2(+) score was significantly correlated with the blood glucose (p=0.029, r=0.35) and hemoglobin A1c levels (p=0.0066, r=0.39). Moreover, decreased VASH-2(+) scores in the vasa recta were associated with reduced renal function (p=0.0003). These results suggest that VASH-2 could play an important role in the pathogenesis of renal diseases, and that VASH-2 is closely associated with hypertension and impaired glucose tolerance.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.18926/AMO/55434
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000418747700002&DestApp=WOS_CPL
URL
https://www.ncbi.nlm.nih.gov/pubmed/29042694
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.18926/AMO/55434
  • ISSN : 0386-300X
  • ORCIDのPut Code : 43365859
  • Web of Science ID : WOS:000418747700002

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