論文

査読有り
2016年2月

Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis

SCIENTIFIC REPORTS
  • Atsuko Nakatsuka
  • ,
  • Makoto Matsuyama
  • ,
  • Satoshi Yamaguchi
  • ,
  • Akihiro Katayama
  • ,
  • Jun Eguchi
  • ,
  • Kazutoshi Murakami
  • ,
  • Sanae Teshigawara
  • ,
  • Daisuke Ogawa
  • ,
  • Nozomu Wada
  • ,
  • Tetsuya Yasunaka
  • ,
  • Fusao Ikeda
  • ,
  • Akinobu Takaki
  • ,
  • Eijiro Watanabe
  • ,
  • Jun Wada

6
開始ページ
21721
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep21721
出版者・発行元
NATURE PUBLISHING GROUP

Although obesity is undoubtedly major risk for non-alcoholic steatohepatitis (NASH), the presence of lean NASH patients with normal body mass index has been recognized. Here, we report that the insufficiency of phosphatidylethanolamine N-methyltransferase (PEMT) is a risk for the lean NASH. The Pemt-/-mice fed high fat-high sucrose (HFHS) diet were protected from diet-induced obesity and diabetes, while they demonstrated prominent steatohepatitis and developed multiple liver tumors. Pemt exerted inhibitory effects on p53-driven transcription by forming the complex with clathrin heavy chain and p53, and Pemt-/-mice fed HFHS diet demonstrated prominent apoptosis of hepatocytes. Furthermore, hypermethylation and suppressed mRNA expression of F-box protein 31 and hepatocyte nuclear factor 4 alpha resulted in the prominent activation of cyclin D1. PEMT mRNA expression in liver tissues of NASH patients was significantly lower than those with simple steatosis and we postulated the distinct clinical entity of lean NASH with insufficiency of PEMT activities.

Web of Science ® 被引用回数 : 16

リンク情報
DOI
https://doi.org/10.1038/srep21721
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000370323100001&DestApp=WOS_CPL
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.1038/srep21721
  • ISSN : 2045-2322
  • ORCIDのPut Code : 23021131
  • Web of Science ID : WOS:000370323100001

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