論文

査読有り
2016年10月

Chronic Kidney Disease Is Positively and Diabetes Mellitus Is Negatively Associated with Abdominal Aortic Aneurysm

PLOS ONE
  • Hidemi Takeuchi
  • ,
  • Michihiro Okuyama
  • ,
  • Haruhito A. Uchida
  • ,
  • Yuki Kakio
  • ,
  • Ryoko Umebayashi
  • ,
  • Yuka Okuyama
  • ,
  • Yasuhiro Fujii
  • ,
  • Susumu Ozawa
  • ,
  • Masashi Yoshida
  • ,
  • Yu Oshima
  • ,
  • Shunji Sano
  • ,
  • Jun Wada

11
10
開始ページ
e0164015
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0164015
出版者・発行元
PUBLIC LIBRARY SCIENCE

Background and Aims
Chronic kidney disease (CKD) and diabetes mellitus (DM) are considered as risk factors for cardiovascular diseases. The purpose of this study was to clarify the relationship of CKD and DM with the presence of abdominal aortic aneurysm (AAA).
Methods
We enrolled 261 patients with AAA (AAA+) and age-and-sex matched 261 patients without AAA (AAA-) at two hospitals between 2008 and 2014, and examined the association between the risk factors and the presence of AAA. Furthermore, in order to investigate the prevalence of AAA in each group, we enrolled 1126 patients with CKD and 400 patients with DM.
Results
The presence of CKD in patients with AAA+ was significantly higher than that in patients with AAA-(AAA+; 65%, AAA-; 52%, P = 0.004). The presence of DM in patients with AAA+ was significantly lower than that in patients with AAA-(AAA+; 17%, AAA-; 35%, P < 0.001). A multivariate logistic regression analysis demonstrated that hypertension, ischemic heart disease and CKD were independent determinants, whereas, DM was a negatively independent determinant, for the presence of AAA. The prevalence of AAA in patients with CKD 65 years old and above was 5.1%, whereas, that in patients with DM 65 years old and above was only 0.6%.
Conclusion
CKD is a positively associated with the presence of AAA. In contrast, DM is a negatively associated with the presence of AAA in Japanese population.

Web of Science ® 被引用回数 : 8

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0164015
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000386204500014&DestApp=WOS_CPL
URL
https://www.ncbi.nlm.nih.gov/pubmed/27764090
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.1371/journal.pone.0164015
  • ISSN : 1932-6203
  • ORCIDのPut Code : 43365878
  • Web of Science ID : WOS:000386204500014

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