論文

査読有り
2016年5月

Antiobesity Action of ACAM by Modulating the Dynamics of Cell Adhesion and Actin Polymerization in Adipocytes

DIABETES
  • Kazutoshi Murakami
  • ,
  • Jun Eguchi
  • ,
  • Kazuyuki Hida
  • ,
  • Atsuko Nakatsuka
  • ,
  • Akihiro Katayama
  • ,
  • Miwa Sakurai
  • ,
  • Haruki Choshi
  • ,
  • Masumi Furutani
  • ,
  • Daisuke Ogawa
  • ,
  • Kohji Takei
  • ,
  • Fumio Otsuka
  • ,
  • Jun Wada

65
5
開始ページ
1255
終了ページ
1267
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2337/db15-1304
出版者・発行元
AMER DIABETES ASSOC

Coxsackie virus and adenovirus receptor-like membrane protein (CLMP) was identified as the tight junction-associated transmembrane protein of epithelial cells with homophilic binding activities. CLMP is also recognized as adipocyte adhesion molecule (ACAM), and it is upregulated in mature adipocytes in rodents and humans with obesity. Here, we present that aP2 promoter-driven ACAM transgenic mice are protected from obesity and diabetes with the prominent reduction of adipose tissue mass and smaller size of adipocytes. ACAM is abundantly expressed on plasma membrane of mature adipocytes and associated with formation of phalloidin-positive polymerized form of cortical actin (F-actin). By electron microscopy, the structure of zonula adherens with an intercellular space of approximate to 10-20 nm was observed with strict parallelism of the adjoining cell membranes over distances of 1-20 m, where ACAM and -actin are abundantly expressed. The formation of zonula adherens may increase the mechanical strength, inhibit the adipocyte hypertrophy, and improve the insulin sensitivity.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.2337/db15-1304
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000375028000016&DestApp=WOS_CPL
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.2337/db15-1304
  • ISSN : 0012-1797
  • eISSN : 1939-327X
  • ORCIDのPut Code : 23021132
  • Web of Science ID : WOS:000375028000016

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