論文

査読有り
2016年1月

The efficacy of add-on tacrolimus for minor flare in patients with systemic lupus erythematosus: a retrospective study

LUPUS
  • H. Watanabe
  • ,
  • R. Yamanaka
  • ,
  • K-E Sada
  • ,
  • S. Zeggar
  • ,
  • E. Katsuyama
  • ,
  • T. Katsuyama
  • ,
  • M. T. Narazaki
  • ,
  • N. T. Tatebe
  • ,
  • K. Sugiyama
  • ,
  • K. S. Watanabe
  • ,
  • H. Wakabayashi
  • ,
  • T. Kawabata
  • ,
  • J. Wada
  • ,
  • H. Makino

25
1
開始ページ
54
終了ページ
60
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/0961203315600538
出版者・発行元
SAGE PUBLICATIONS LTD

Objective We have assessed the effectiveness of tacrolimus for minor flares in systemic lupus erythematosus (SLE) patients.
Methods The medical records of 313 patients were retrospectively reviewed over a period of seven years, from 2006 to 2013. We enrolled patients with minor flare treated with add-on tacrolimus, without glucocorticoid (GC) intensification (tacrolimus group). Minor flare was defined as a 1-point increase in a total score between 3 and 11 in the SLE Disease Activity Index (SLEDAI). We enrolled as controls patients who were administered increased doses of GC for minor flare (GC group). All patients were followed for one year. The primary outcome measure was the proportion of responders.
Results There were 14 eligible patients in the tacrolimus group and 20 eligible patients in the GC group. The mean SLEDAI at flare tended to be higher in the tacrolimus group than in the GC group (7.5 vs. 6.2, p=0.085). A mean dose of 1.6mg tacrolimus/day was administered for flare, while the mean GC dose was 13.7mg/day in the GC group. The proportion of responders was 86% (12/14) in the tacrolimus group and 75% (15/20) in the GC group (p=0.67). The mean dose of GC at 12 months was higher in the GC group than in the tacrolimus group (9.7mg/day vs. 7.1mg/day, p<0.05). Only one patient discontinued tacrolimus because of fatigue after three months.
Conclusion Adding tacrolimus without increasing the GC dose may provide an effective treatment option for minor flares in patients with SLE.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1177/0961203315600538
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000366601700007&DestApp=WOS_CPL
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.1177/0961203315600538
  • ISSN : 0961-2033
  • eISSN : 1477-0962
  • ORCIDのPut Code : 23021133
  • Web of Science ID : WOS:000366601700007

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