論文

査読有り
2015年11月

Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis

SCIENTIFIC REPORTS
  • Akihiro Katayama
  • ,
  • Atsuko Nakatsuka
  • ,
  • Jun Eguchi
  • ,
  • Kazutoshi Murakami
  • ,
  • Sanae Teshigawara
  • ,
  • Motoko Kanzaki
  • ,
  • Tomokazu Nunoue
  • ,
  • Kazuyuki Hida
  • ,
  • Nozomu Wada
  • ,
  • Tetsuya Yasunaka
  • ,
  • Fusao Ikeda
  • ,
  • Akinobu Takaki
  • ,
  • Kazuhide Yamamoto
  • ,
  • Hiroshi Kiyonari
  • ,
  • Hirofumi Makino
  • ,
  • Jun Wada

5
開始ページ
16920
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep16920
出版者・発行元
NATURE PUBLISHING GROUP

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Gpnmb is classified as a type 1 membrane protein and its soluble form is secreted by ADAM10-mediated cleavage. Gpnmb mRNA was found in the Kupffer cells and white adipose tissues (WATs) and its upregulation in obesity was recently found. Here, we generated aP2 promoter-driven Gpnmb transgenic (Tg) mice and the overexpression of Gpnmb ameliorated the fat accumulation and fibrosis of the liver in diet-induced obesity model. Soluble form of Gpnmb in sera was elevated in Gpnmb Tg mice and Gpnmb concentrated in hepatic macrophages and stellate cells interacted with calnexin, which resulted in the reduction of oxidative stress. In the patients with non-alcoholic steatohepatitis, serum soluble GPNMB concentrations were higher compared with the patients with simple steatosis. The GPNMB is a promising biomarker and therapeutic target for the development and progression of NAFLD in obesity.

Web of Science ® 被引用回数 : 24

リンク情報
DOI
https://doi.org/10.1038/srep16920
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000364934900002&DestApp=WOS_CPL
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.1038/srep16920
  • ISSN : 2045-2322
  • ORCIDのPut Code : 23021135
  • Web of Science ID : WOS:000364934900002

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