論文

査読有り
2016年9月

The possible involvement of intestine-derived IgA(1): a case of IgA nephropathy associated with Crohn's disease

BMC NEPHROLOGY
  • Tomohiro Terasaka
  • ,
  • Haruhito A. Uchida
  • ,
  • Ryoko Umebayashi
  • ,
  • Keiko Tsukamoto
  • ,
  • Keiko Tanaka
  • ,
  • Masashi Kitagawa
  • ,
  • Hitoshi Sugiyama
  • ,
  • Hiroaki Tanioka
  • ,
  • Jun Wada

17
1
開始ページ
122
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s12882-016-0344-1
出版者・発行元
BIOMED CENTRAL LTD

Background: A link between IgA nephropathy and Crohn's disease has recently been reported. Other researchers hypothesize that intestine-derived IgA complexes deposit in glomerular mesangial cells, eliciting IgA nephropathy. Intestinal mucosal plasma cells mainly secrete IgA(2). Nevertheless, IgA(1) deposition is strongly implicated as being the primary cause of IgA nephropathy.
Case presentation: A 46-year-old Japanese man developed IgA nephropathy 29 years ago, following tonsillectomy. As a result, a normal urinalysis was obtained. The patient previously suffered Crohn's disease followed by urinary occult blood and proteinuria six years ago. Exacerbation of IgA nephropathy was highly suspected. Therefore a renal biopsy was performed. A diagnosis of exacerbation of IgA nephropathy with mesangial cell proliferation and fibrotic cellular crescent was based upon the pathological findings. The patient exhibited a positive clinical course and eventually achieved a remission with immunosuppressive therapy including prednisolone treatment. Immunostaining for the detection of IgA subtypes was performed on both of his kidney and excised ileum. The results revealed IgA(1) and IgA(2) deposition by submucosal cells in intestine. Furthermore, IgA(1) deposition of mesangial areas in the patient's kidney, indicated an association of IgA(1) with the exacerbation of IgA nephropathy.
Conclusion: This case represents the possibility that the intestine-derived IgA(1) can be the origin of galactose-deficient IgA which is known to cause IgA nephropathy exacerbation.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1186/s12882-016-0344-1
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000382741800001&DestApp=WOS_CPL
URL
https://www.ncbi.nlm.nih.gov/pubmed/27596164
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.1186/s12882-016-0344-1
  • ISSN : 1471-2369
  • ORCIDのPut Code : 43365885
  • Web of Science ID : WOS:000382741800001

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