論文

査読有り
2004年2月

Update of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
  • YS Kanwar
  • ,
  • J Wada
  • ,
  • S Lin
  • ,
  • FR Danesh
  • ,
  • SS Chugh
  • ,
  • QW Yang
  • ,
  • T Banerjee
  • ,
  • JW Lomasney

286
2
開始ページ
F202
終了ページ
F215
記述言語
英語
掲載種別
DOI
10.1152/ajprenal.00157.2003
出版者・発行元
AMER PHYSIOLOGICAL SOC

One of the hallmarks of mammalian nephrogenesis includes a mesenchymalepithelial transition that is accomplished by intercalation of the ureteric bud, an epithelium-lined tubelike structure, into an undifferentiated mesenchyme, and the latter then undergoes an inductive transformation and differentiates into an epithelial phenotype. At the same time, the differentiating mesenchyme reciprocates by inducing branching morphogenesis of the ureteric bud, which forms a treelike structure with dichotomous iterations. These reciprocal inductive interactions lead to the development of a functioning nephron unit made up of a glomerulus and proximal and distal tubules. The inductive interactions and differentiation events are modulated by a number of transcription factors, protooncogenes, and growth factors and their receptors, which regulate the expression of target morphogenetic modulators including the ECM, integrin receptors, and cell adhesion molecules. These target macromolecules exhibit spatiotemporal and stage-specific developmental regulation in the metanephros. The ECM molecules expressed at the epithelial-mesenchymal interface are perhaps the most relevant and conducive to the paracrine-juxtacrine interactions in a scenario where the ligand is expressed in the mesenchyme while the receptor is located in the ureteric bud epithelium or vice versa. In addition, expression of the target ECM macromolecules is regulated by matrix metalloproteinases and their inhibitors to generate a concentration gradient at the interface to further propel epithelial-mesenchymal interactions so that nephrogenesis can proceed seamlessly. In this review, we discuss and update our current understanding of the role of the ECM and related macromolecules with respect to metanephric development.

リンク情報
DOI
https://doi.org/10.1152/ajprenal.00157.2003
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000187791300002&DestApp=WOS_CPL
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • DOI : 10.1152/ajprenal.00157.2003
  • ISSN : 1931-857X
  • ORCIDのPut Code : 17913095
  • Web of Science ID : WOS:000187791300002

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